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About 68,433 results

ALLMedicine™ Tuberculosis Center

Research & Reviews  24,271 results

NAT2 and CYP2E1 polymorphisms and antituberculosis drug-induced hepatotoxicity in Peruv...
https://doi.org/10.1002/mgg3.1987
Molecular Genetics & Genomic Medicine; Jaramillo-Valverde L, Levano KS et. al.

Jun 26th, 2022 - In Peru, 32,970 people were diagnosed with tuberculosis (TB) in 2019. Although TB treatment is effective, 3.4%-13% is associated with significant adverse drug reactions (ADR), considering drug-induced liver injury (DILI) as the most prevalent. Amo...

Development and Validation of the Tuberculosis Risk Score for Smokers (TBRSS).
https://doi.org/10.3390/ijerph19126959
International Journal of Environmental Research and Publi... Tengku Khalid TNF, Wan Mohammad WMZ et. al.

Jun 25th, 2022 - Tuberculosis (TB) remains a significant public health issue worldwide. However, the effectiveness of TB screening programmes among smokers is still questionable. There is a need for a simple, reliable, and validated screening system for this risk ...

A glycine-rich PE_PGRS protein governs mycobacterial actin-based motility.
https://doi.org/10.1038/s41467-022-31333-0 10.1083/jcb.201103148 10.1016/j.chom.2013.08.011 10.1093/femspd/ftv078 10.1111/cmi.13190 10.1016/j.mib.2016.11.007 10.1111/j.1462-5822.2008.01133.x 10.1084/jem.20031072 10.1073/pnas.0504663102 10.1128/AEM.06965-11 10.1038/s41564-017-0090-6 10.1111/j.1365-2958.2009.06783.x 10.1371/journal.ppat.1000430 10.1111/j.1462-5822.2011.01581.x 10.15252/embr.201541832 10.1038/ncb1967 10.1128/IAI.00110-15 10.1038/s41580-018-0085-z 10.1126/science.aay8085 10.1093/bioinformatics/btn392 10.1128/IAI.69.12.7326-7333.2001 10.1111/j.1365-2958.2004.04007.x 10.1074/jbc.M604379200 10.1371/journal.pone.0150800 10.1371/journal.pgen.1005190 10.1038/nature10719 10.1016/S0092-8674(00)81050-8 10.1073/pnas.93.11.5615 10.1080/21505594.2020.1785815 10.1111/mmi.14409 10.1371/journal.ppat.1006095 10.1016/j.cell.2010.02.013 10.1371/journal.ppat.1006874 10.1371/journal.ppat.1000204 10.1016/j.chom.2012.09.012 10.1155/2011/497203 10.1111/mmi.12981 10.1038/nmicrobiol.2016.133 10.1111/cmi.12606 10.1038/s41467-019-09955-8 10.1128/mBio.01017-18 10.4049/jimmunol.0903299 10.1074/jbc.271.36.21878 10.1038/34208 10.1016/S0092-8674(00)80732-1 10.1038/35004513 10.1038/nature07160 10.1038/nature07170 10.1074/jbc.M116.758003 10.1083/jcb.146.6.1319 10.1371/journal.ppat.1008878 10.1172/JCI66576 10.1083/jcb.150.6.1311 10.1016/j.molcel.2004.11.054 10.1128/iai.62.8.3222-3229.1994 10.1007/978-1-59745-207-6_13 10.1038/s41564-020-0673-5 10.1091/mbc.e09-01-0083 10.1016/j.cell.2016.09.023 10.1038/nmeth.2089 10.1128/IAI.00614-08 10.1046/j.1365-2958.2003.03425.x 10.1007/978-1-59745-207-6_21 10.1016/j.gene.2010.09.005 10.1038/351456a0 10.1128/AEM.03695-12 10.1016/j.molcel.2018.07.010 10.1021/ac9810516 10.1093/nar/gkaa1074 10.1007/978-1-62703-538-5_16 10.1016/j.devcel.2017.12.011
Nature Communications; Hill NS, Welch MD

Jun 25th, 2022 - Many key insights into actin regulation have been derived through examining how microbial pathogens intercept the actin cytoskeleton during infection. Mycobacterium marinum, a close relative of the human pathogen Mycobacterium tuberculosis, polyme...

Whole genome sequencing analysis to evaluate the influence of T2DM on polymorphisms ass...
https://doi.org/10.1186/s12864-022-08709-z
BMC Genomics; Bermudez-Hernández GA, Pérez-Martínez DE et. al.

Jun 25th, 2022 - Type 2 diabetes mellitus (T2DM) has been associated with treatment failure, and the development of drug resistance in tuberculosis (TB). Also, whole-genome sequencing has provided a better understanding and allowed the growth of knowledge about po...

Serial T-SPOT.TB responses in Tanzanian adolescents: Transient, persistent and irregula...
https://doi.org/10.1371/journal.pone.0268685
PloS One; Amour MA, Rees CA et. al.

Jun 25th, 2022 - Prospective studies of interferon-gamma release assays (IGRA) on healthy subjects in tuberculosis-endemic regions have not examined the long-term variability of serial assays. This issue is relevant to the interpretation of tuberculosis (TB) vacci...

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Guidelines  28 results

WHO consolidated guidelines on tuberculosis Module 5: Management of tuberculosis in children and adolescents
https://www.who.int/publications/i/item/9789240046764
World Health Organization (WHO)

Mar 21st, 2022 - The Updated guidelines on Management of tuberculosis in children and adolescents include new recommendations that cover diagnostic approaches for TB, shorter treatment for children with non-severe drug-susceptible TB, a new option for the treatmen...

Interim Guidance: 4-Month Rifapentine-Moxifloxacin Regimen for the Treatment of Drug-Su...
https://doi.org/10.15585/mmwr.mm7108a1
MMWR. Morbidity and Mortality Weekly Report; Carr W, Kurbatova E et. al.

Feb 25th, 2022 - On May 5, 2021, CDC's Tuberculosis Trials Consortium and the National Institutes of Health (NIH)-sponsored AIDS Clinical Trials Group (ACTG) published results from a randomized controlled trial indicating that a 4-month regimen containing rifapent...

Cancer immunotherapy in special challenging populations: recommendations of the Advisor...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8009216
Journal for Immunotherapy of Cancer; Gonzalez-Cao M, Puertolas T et. al.

Mar 31st, 2021 - Cancer immunotherapy based on the use of antibodies targeting the so-called checkpoint inhibitors, such as programmed cell death-1 receptor, its ligand, or CTLA-4, has shown durable clinical benefit and survival improvement in melanoma and other t...

Multisystem inflammatory syndrome in an adult with SARS-CoV-2 infection.
https://doi.org/10.1016/j.arbres.2020.03.021
European Heart Journal. Cardiovascular Imaging; Chowdhary A, Joy E et. al.

Sep 6th, 2020 - New evidence and knowledge about the clinical management of drug-resistant tuberculosis (TB) in the last 3 years, makes it necessary to update the recent guideline published by SEPAR in 2017, mainly in relation to new diagnostic methods, drug clas...

2019 update of the European AIDS Clinical Society Guidelines for treatment of people li...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7754379
HIV Medicine; Ryom L, Cotter A et. al.

Sep 5th, 2020 - The European AIDS Clinical Society (EACS) Guidelines cover key aspects of HIV management with major updates every two years. The 2019 Guidelines were extended with a new section focusing on drug-drug interactions and other prescribing issues in pe...

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Drugs  386 results see all →

Clinicaltrials.gov  1,325 results

Using Biomarkers to Predict TB Treatment Duration
https://clinicaltrials.gov/ct2/show/NCT02821832

Jun 24th, 2022 - Shortening the duration of treatment for patients with drug sensitive tuberculosis from 6 to 4 months has been attempted many times in clinical trials but thus far all have failed. These failures reveal our incomplete understanding of factors driv...

The Influence of Malnutrition, Diabetes Mellitus, and Helminth Infections on Biosignatures in Latent Tuberculosis in a South Indian Population
https://clinicaltrials.gov/ct2/show/NCT04526613

Jun 24th, 2022 - Approximately 2 billion people worldwide are infected with Mycobacterium tuberculosis (TB), with 90% of individuals having latent infection (LTBI). The control of TB requires clearly delineated helper T cell (Th) 1 responses and, to a lesser exten...

Impact of Weekly Administration of Rifapentine and Isoniazid on Steady State Pharmacokinetics of Tenofovir Alafenamide in Healthy Volunteers (YODA)
https://clinicaltrials.gov/ct2/show/NCT03510468

Jun 24th, 2022 - Rifapentine (RPT) is a long-acting rifamycin that can be used weekly with isoniazid (INH) as a first-line regimen in the treatment of latent tuberculosis infection (LTBI). Although this regimen offers several potential benefits, the use of weekly ...

Aerosol BCG Challenge Study in Historically BCG-vaccinated Volunteers
https://clinicaltrials.gov/ct2/show/NCT04777721

Jun 24th, 2022 - Tuberculosis (TB) remains one of the deadliest infectious disease killers worldwide. Key research priorities include the development of an effective vaccine. Currently, the only licensed vaccine against TB is the BCG (Bacille Calmette-Guérin). Thi...

PREVAIL VIIIa: Evaluation of Latent Tuberculosis Infection Screening Methods in People Living With Retroviral Infection in Liberia
https://clinicaltrials.gov/ct2/show/NCT04926922

Jun 24th, 2022 - Despite the high burden of disease attributable to tuberculosis (TB) in Liberia and concerns about its effect on HIV disease, screening for latent TB infection (LTBI) among people living with HIV is not routinely performed in the country. This is ...

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News  1,333 results

GSK, Novartis Pledge Funds for Neglected Tropical Diseases
https://www.medscape.com/viewarticle/976095

Jun 24th, 2022 - LONDON (Reuters) - GSK and Novartis reinforced commitments on Thursday to tackle neglected tropical diseases, as world leaders and health experts gather in Rwanda to discuss ways to better combat illnesses affecting more than a billion people, mos...

Harry Potter's World Offers View Into Magic of Endocrinology
https://www.medscape.com/viewarticle/975847

Jun 22nd, 2022 - Clinicians don't cease diagnosing patients once our clinical work is done. Most of us can recall debating whether to point out an atypical mole or another concerning finding to a stranger in public. Like the doctor back in 2018, who saw a lump on ...

Visa Delays a Worry for International AIDS Conference in Montreal
https://www.medscape.com/viewarticle/975984

Jun 21st, 2022 - Canadian visa delays are casting a shadow over preparations for the upcoming 24th International AIDS Society (IAS) Conference scheduled to begin in Montreal July 29. Jean-Pierre Routy, MD, local cochair of the meeting, has predicted "a catastrophe...

Ancient Human Teeth Revise the History of Microbial Evolution
https://www.medscape.com/viewarticle/975668

Jun 15th, 2022 - The cupboard in Nicolás Rascovan's microbial paleogenomics lab at Institut Pasteur in Paris, France, is filled up with cardboard boxes that look as if they were shipped from an office supply store. Yet, instead of pencils and Post-it notes, the bo...

Tuberculosis Still a Challenge in Canada's Indigenous Populations
https://www.medscape.com/viewarticle/974813

May 31st, 2022 - Tuberculosis (TB) remains a serious — and possibly underreported — health problem for indigenous people in Canada, data suggest. Ongoing efforts have helped reduce disease incidence, however. The World Health Organization (WHO) estimates that abou...

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Patient Education  30 results see all →