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About 73,314 results

ALLMedicine™ Osteoporosis Center

Research & Reviews  33,917 results

SLPI is a critical mediator that controls PTH-induced bone formation.
https://doi.org/10.1038/s41467-021-22402-x 10.1038/206489a0 10.1038/s41467-017-02541-w 10.1056/NEJM200105103441904 10.1210/jc.2011-3479 10.1359/JBMR.0301226 10.1128/MCB.00356-06 10.1210/en.2002-220221 10.1210/en.2005-0333 10.1056/NEJMoa031975 10.1056/NEJMoa035725 10.1038/80489 10.1074/jbc.M203710200 10.1128/IAI.72.6.3684-3687.2004 10.1084/jem.20050768 10.1016/S0092-8674(02)01141-8 10.1016/j.bone.2005.11.005 10.1359/jbmr.2002.17.5.808 10.1016/j.bbrc.2006.01.044 10.1210/endo-110-2-506 10.1371/journal.pone.0040321 10.1182/blood-2011-11-395418 10.1084/jem.20021824 10.1073/pnas.89.7.2732 10.1074/jbc.M513380200 10.1002/j.1460-2075.1988.tb02819.x 10.1016/S0092-8674(00)80258-5 10.1016/S0092-8674(00)80257-3 10.1016/S0002-9440(10)65270-4 10.1038/nm.1954 10.1016/j.bbrc.2015.08.077 10.1172/JCI6610 10.1038/nm1197-1285 10.1007/BF02571316 10.1002/jcp.1041500202 10.1515/bchm3.1995.376.6.379 10.1166/jnn.2015.8383 10.1111/j.1440-1843.2010.01901.x 10.1359/jbmr.040910 10.1007/s00774-016-0773-8 10.1038/nm.2489 10.1038/s41467-017-01928-z 10.1073/pnas.0610819104 10.1016/j.bbrc.2007.02.121 10.1359/jbmr.2000.15.10.1912 10.1002/jcb.25746 10.1002/jez.1401280105 10.1016/j.abb.2014.05.015 10.1146/annurev.immunol.021908.132603 10.1016/j.bcp.2009.04.011 10.1016/S0021-9258(18)61316-X 10.1074/jbc.M212670200 10.1073/pnas.1315153111 10.1210/en.2008-1597 10.1038/sj.bjc.6601327 10.1002/jcb.24824 10.1038/s41598-017-15311-x 10.1016/j.ajpath.2011.02.017 10.1016/j.bone.2011.07.017 10.1002/jbmr.1820 10.1016/j.cmet.2009.07.010 10.1677/joe.1.06270 10.1096/fj.201800948RR 10.1007/978-1-61779-415-5_2 10.1038/nature11000 10.1038/sj.gt.3301206 10.1073/pnas.1704030114 10.1038/bonekey.2014.65
Nature Communications; Morimoto A, Kikuta J et. al.

Apr 10th, 2021 - Osteoclastic bone resorption and osteoblastic bone formation/replenishment are closely coupled in bone metabolism. Anabolic parathyroid hormone (PTH), which is commonly used for treating osteoporosis, shifts the balance from osteoclastic to osteob...

Sphingosine 1-phosphate and osteoporosis: pathophysiology and therapeutic aspects-a nar...
https://doi.org/10.21037/apm-20-1255
Annals of Palliative Medicine; Tian J, Ma S et. al.

Apr 9th, 2021 - Sphingosine 1-phosphate (S1P) regulates many cellular functions, such as differentiation, proliferation, migration, morphogenesis, cytoskeletal organization, adhesion, tight junction assembly, apoptosis and the localization of different cell types...

Postmenopausal osteoporosis coexisting with other metabolic diseases: Treatment conside...
https://doi.org/10.1016/j.maturitas.2021.02.007
Maturitas Polyzos SA, Anastasilakis AD et. al.

Apr 9th, 2021 - In postmenopausal women, osteoporosis may coexist with other metabolic diseases, including, but not limited to, obesity, diabetes, nonalcoholic fatty liver disease (NAFLD), dyslipidemia and cardiovascular disease (CVD). This association may lie be...

A Systematic Review and Meta-Analysis on the Incidence of Osteoporosis and Fractures af...
https://doi.org/10.1111/tri.13863
Transplant International : Official Journal of the Europe... Lim WH, Ng CH et. al.

Apr 9th, 2021 - Following liver transplant (LT), osteoporosis is a severe complication that causes morbidity. However, the incidence and risk factors of osteoporosis and fractures have not been well described. Single-arm meta-analysis of studies reporting osteope...

Machine learning for automated abdominal aortic calcification scoring of DXA vertebral ...
https://doi.org/10.1016/j.bone.2021.115943
Bone Reid S, Schousboe JT et. al.

Apr 9th, 2021 - Abdominal aortic calcification (AAC) identified on dual-energy x-ray absorptiometry (DXA) vertebral fracture assessment (VFA) lateral spine images is predictive of cardiovascular outcomes, but is time-consuming to perform manually. Whether this pr...

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Guidelines  207 results

Bone Mineral Density, Osteoporosis, and Fracture Risk in Adult Patients with Psoriasis or Psoriatic Arthritis: A Systematic Review and Meta-Analysis of Observational Studies
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7699147/
Journal of Clinical Medicine; Chen TL

Nov 18th, 2020 - Awareness of psoriasis-related comorbidities has been established in the current guidelines; however, evidence regarding the association of bone density or bone fragility with psoriatic disease remains inconclusive.

Osteoporosis 'largely ignored' in older men
https://www.healio.com/news/rheumatology/20201110/osteoporosis-largely-ignored-in-older-men

Nov 6th, 2020 - Less than 3% of older men who had experienced an osteoporosis-related fracture had been properly diagnosed and treated, according to findings presented at ACR Convergence 2020.

Ankle fractures in the elderly: Current concepts.
https://doi.org/10.1016/j.injury.2020.10.093
Injury Pearce O, Al-Hourani K et. al.

Nov 6th, 2020 - Ankle fractures remain the third most common musculoskeletal injury in the elderly population. The presence of osteoporosis, significant multiple comorbidities and limited functional independence makes treatment of such injuries challenging. Early...

Osteoporosis: A Long-Term and Late-Effect of Breast Cancer Treatments
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7690788/
Cancers Shapiro CL

Oct 22nd, 2020 - Osteoporosis is a prevalent condition affecting 200 million individuals world-wide. Estimates are about one in three women will experience a fragility fracture of hip, spine or wrist. Common breast cancer treatments, such as aromatase inhibitors i...

Core principles for fracture prevention: North American Consensus from the National Ost...
https://doi.org/10.1007/s00198-020-05541-7
Osteoporosis International : a Journal Established as Res... Lewiecki EM, Binkley N et. al.

Jul 17th, 2020 - Core principles for fracture prevention address fundamental concepts for the evaluation and management of patients at risk for fracture. These are intended to form the foundation of clinical practice guidelines and represent a first step toward gu...

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Drugs  421 results see all →

Clinicaltrials.gov  35,963 results

SLPI is a critical mediator that controls PTH-induced bone formation.
https://doi.org/10.1038/s41467-021-22402-x 10.1038/206489a0 10.1038/s41467-017-02541-w 10.1056/NEJM200105103441904 10.1210/jc.2011-3479 10.1359/JBMR.0301226 10.1128/MCB.00356-06 10.1210/en.2002-220221 10.1210/en.2005-0333 10.1056/NEJMoa031975 10.1056/NEJMoa035725 10.1038/80489 10.1074/jbc.M203710200 10.1128/IAI.72.6.3684-3687.2004 10.1084/jem.20050768 10.1016/S0092-8674(02)01141-8 10.1016/j.bone.2005.11.005 10.1359/jbmr.2002.17.5.808 10.1016/j.bbrc.2006.01.044 10.1210/endo-110-2-506 10.1371/journal.pone.0040321 10.1182/blood-2011-11-395418 10.1084/jem.20021824 10.1073/pnas.89.7.2732 10.1074/jbc.M513380200 10.1002/j.1460-2075.1988.tb02819.x 10.1016/S0092-8674(00)80258-5 10.1016/S0092-8674(00)80257-3 10.1016/S0002-9440(10)65270-4 10.1038/nm.1954 10.1016/j.bbrc.2015.08.077 10.1172/JCI6610 10.1038/nm1197-1285 10.1007/BF02571316 10.1002/jcp.1041500202 10.1515/bchm3.1995.376.6.379 10.1166/jnn.2015.8383 10.1111/j.1440-1843.2010.01901.x 10.1359/jbmr.040910 10.1007/s00774-016-0773-8 10.1038/nm.2489 10.1038/s41467-017-01928-z 10.1073/pnas.0610819104 10.1016/j.bbrc.2007.02.121 10.1359/jbmr.2000.15.10.1912 10.1002/jcb.25746 10.1002/jez.1401280105 10.1016/j.abb.2014.05.015 10.1146/annurev.immunol.021908.132603 10.1016/j.bcp.2009.04.011 10.1016/S0021-9258(18)61316-X 10.1074/jbc.M212670200 10.1073/pnas.1315153111 10.1210/en.2008-1597 10.1038/sj.bjc.6601327 10.1002/jcb.24824 10.1038/s41598-017-15311-x 10.1016/j.ajpath.2011.02.017 10.1016/j.bone.2011.07.017 10.1002/jbmr.1820 10.1016/j.cmet.2009.07.010 10.1677/joe.1.06270 10.1096/fj.201800948RR 10.1007/978-1-61779-415-5_2 10.1038/nature11000 10.1038/sj.gt.3301206 10.1073/pnas.1704030114 10.1038/bonekey.2014.65
Nature Communications; Morimoto A, Kikuta J et. al.

Apr 10th, 2021 - Osteoclastic bone resorption and osteoblastic bone formation/replenishment are closely coupled in bone metabolism. Anabolic parathyroid hormone (PTH), which is commonly used for treating osteoporosis, shifts the balance from osteoclastic to osteob...

Sphingosine 1-phosphate and osteoporosis: pathophysiology and therapeutic aspects-a nar...
https://doi.org/10.21037/apm-20-1255
Annals of Palliative Medicine; Tian J, Ma S et. al.

Apr 9th, 2021 - Sphingosine 1-phosphate (S1P) regulates many cellular functions, such as differentiation, proliferation, migration, morphogenesis, cytoskeletal organization, adhesion, tight junction assembly, apoptosis and the localization of different cell types...

Postmenopausal osteoporosis coexisting with other metabolic diseases: Treatment conside...
https://doi.org/10.1016/j.maturitas.2021.02.007
Maturitas Polyzos SA, Anastasilakis AD et. al.

Apr 9th, 2021 - In postmenopausal women, osteoporosis may coexist with other metabolic diseases, including, but not limited to, obesity, diabetes, nonalcoholic fatty liver disease (NAFLD), dyslipidemia and cardiovascular disease (CVD). This association may lie be...

A Systematic Review and Meta-Analysis on the Incidence of Osteoporosis and Fractures af...
https://doi.org/10.1111/tri.13863
Transplant International : Official Journal of the Europe... Lim WH, Ng CH et. al.

Apr 9th, 2021 - Following liver transplant (LT), osteoporosis is a severe complication that causes morbidity. However, the incidence and risk factors of osteoporosis and fractures have not been well described. Single-arm meta-analysis of studies reporting osteope...

Machine learning for automated abdominal aortic calcification scoring of DXA vertebral ...
https://doi.org/10.1016/j.bone.2021.115943
Bone Reid S, Schousboe JT et. al.

Apr 9th, 2021 - Abdominal aortic calcification (AAC) identified on dual-energy x-ray absorptiometry (DXA) vertebral fracture assessment (VFA) lateral spine images is predictive of cardiovascular outcomes, but is time-consuming to perform manually. Whether this pr...

see more →

News  2,691 results

Does Selenium Supplementation Improve Musculoskeletal Health in Older Women?
https://www.medscape.com/viewarticle/948247

Mar 28th, 2021 - Takeaway Selenium supplementation (200 μg or 50 μg daily) does not affect bone health or physical function in postmenopausal women with osteoporosis or osteopenia.

Denosumab Now Dominant Therapy for Cancer-Associated Osteoporosis
https://www.medscape.com/viewarticle/948213

Mar 25th, 2021 - Amid a substantial expansion of therapies in several drug classes for the treatment of osteoporosis, there has been a notable increase in the prescription of denosumab for patients with a cancer-related indication. In an analysis of claims data fr...

Bone Fragility in Childhood: How Many Fractures Are Too Many?
https://www.medscape.com/viewarticle/947716

Mar 23rd, 2021 - This transcript has been edited for clarity. Hi. I'm Dr Laura Bachrach, a professor of pediatrics in the area of endocrinology. For the past 25 years or more, I've been really interested in the problem of pediatric bone health. In my own practice ...

Total Knee Replacement Cost-Effective, Even With Obesity and Comorbidities
https://www.medscape.com/viewarticle/947897

Mar 22nd, 2021 - (Reuters Health) - Total knee replacement surgery can be a cost-effective procedure for patients with severe obesity and osteoarthritis, even when they also have comorbidities such as cardiovascular disease or type 2 diabetes, a new study suggests...

Primary Ovarian Insufficiency Linked to Osteoporosis
https://www.medscape.com/viewarticle/947390

Mar 14th, 2021 - NEW YORK (Reuters Health) - Primary ovarian insufficiency (POI) was tied to an increased risk of osteoporosis in a large Canadian cohort study. "There is accumulating evidence demonstrating that an earlier menopause, which represents an early loss...

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Patient Education  115 results see all →