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About 19,733 results

ALLMedicine™ Amyotrophic Lateral Sclerosis Center

Research & Reviews  6,919 results

Impact of the Combined Treatment of Liposomed Polyphenols With G04CB02 on the ALS Patients
https://clinicaltrials.gov/ct2/show/NCT04654689

Aug 5th, 2022 - Amyotrophic lateral sclerosis (ALS) is the most common neurodegenerative disease of an inflammatory nature among those affecting motor neurons, with a life expectancy of 3 to 5 years. It is characterised by the loss of motor neurons, and can be of...

Medication use and risk of amyotrophic lateral sclerosis-a systematic review.
https://doi.org/10.1186/s12916-022-02442-w
BMC Medicine; Cui C, Sun J et. al.

Aug 5th, 2022 - Studying whether medications act as potential risk factors for amyotrophic lateral sclerosis (ALS) can contribute to the understanding of disease etiology as well as the identification of novel therapeutic targets. Therefore, we conducted a system...

A Study to Evaluate the Efficacy, Safety, Pharmacokinetics and Pharmacodynamics of ION363 in Amyotrophic Lateral Sclerosis Participants With Fused in Sarcoma Mutations (FUS-ALS)
https://clinicaltrials.gov/ct2/show/NCT04768972

Aug 4th, 2022 - This is a multi-center, two-part study of ION363 in up to 77 participants. Part 1 will consist of participants that will be randomized in a 2:1 ratio to receive a multi-dose regimen of ION363 or placebo for a period of 61 weeks, followed by Part 2...

The contribution of brain banks to knowledge discovery in amyotrophic lateral sclerosis...
https://doi.org/10.1111/nan.12845
Neuropathology and Applied Neurobiology; Mazumder S, Kiernan MC et. al.

Aug 4th, 2022 - Over the past decade considerable efforts have been made to accelerate pathophysiological understanding of fatal neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS) with brain banks at the forefront. In addition to exploratory d...

Pilot Study of Respiratory-Swallow Coordination in Amyotrophic Lateral Sclerosis.
https://doi.org/10.1044/2022_JSLHR-21-00619
Journal of Speech, Language, and Hearing Research : JSLHR; Garand KLF, Bhutada AM et. al.

Aug 4th, 2022 - Amyotrophic lateral sclerosis (ALS) impacts bulbar and respiratory musculature, which may contribute to impaired swallow function (dysphagia) and respiratory-swallow coordination. The purpose of this pilot study was to examine if respiratory-swall...

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Guidelines  3 results

Provisional best practices guidelines for the evaluation of bulbar dysfunction in amyot...
https://doi.org/10.1002/mus.26408
Muscle & Nerve; Pattee GL, Plowman EK et. al.

Jan 9th, 2019 - Universally established comprehensive clinical bulbar scales objectively assessing disease progression in amyotrophic lateral sclerosis (ALS) are currently lacking. The goal of this working group project is to design a best practice set of provisi...

ESPEN guideline clinical nutrition in neurology.
https://doi.org/10.1016/j.clnu.2017.09.003
Clinical Nutrition (Edinburgh, Scotland); Burgos R, Bretón I et. al.

Dec 25th, 2017 - Neurological diseases are frequently associated with swallowing disorders and malnutrition. Moreover, patients with neurological diseases are at increased risk of micronutrient deficiency and dehydration. On the other hand, nutritional factors may...

Practice parameter update: the care of the patient with amyotrophic lateral sclerosis: ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2764728
Neurology Miller RG, Jackson CE et. al.

Oct 14th, 2009 - To systematically review evidence bearing on the management of patients with amyotrophic lateral sclerosis (ALS). The authors analyzed studies from 1998 to 2007 to update the 1999 practice parameter. Topics covered in this section include breaking...

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Drugs  17 results see all →

Clinicaltrials.gov  539 results

Impact of the Combined Treatment of Liposomed Polyphenols With G04CB02 on the ALS Patients
https://clinicaltrials.gov/ct2/show/NCT04654689

Aug 5th, 2022 - Amyotrophic lateral sclerosis (ALS) is the most common neurodegenerative disease of an inflammatory nature among those affecting motor neurons, with a life expectancy of 3 to 5 years. It is characterised by the loss of motor neurons, and can be of...

A Study to Evaluate the Efficacy, Safety, Pharmacokinetics and Pharmacodynamics of ION363 in Amyotrophic Lateral Sclerosis Participants With Fused in Sarcoma Mutations (FUS-ALS)
https://clinicaltrials.gov/ct2/show/NCT04768972

Aug 4th, 2022 - This is a multi-center, two-part study of ION363 in up to 77 participants. Part 1 will consist of participants that will be randomized in a 2:1 ratio to receive a multi-dose regimen of ION363 or placebo for a period of 61 weeks, followed by Part 2...

Clinical Trial of Glatiramer Acetate in Amyotrophic Lateral Sclerosis (ALS)
https://clinicaltrials.gov/ct2/show/NCT00326625

Aug 3rd, 2022 - Teva is developing 40 mg/ml Glatiramer Acetate (GA) Injection , administered once daily under the skin, for the treatment of ALS. The study drug is a higher dose formulation of Copaxone® (20 mg/ml GA), a marketed medication, approved for the treat...

A Study to Evaluate the Efficacy and Safety of Reldesemtiv in Patients With Amyotrophic Lateral Sclerosis (ALS)
https://clinicaltrials.gov/ct2/show/NCT04944784

Aug 3rd, 2022 - COURAGE-ALS is a Phase 3, double-blind, randomized, placebo-controlled trial of reldesemtiv in patients aged 18 to 80 with ALS. The screening and qualification period for the trial will be no more than 14 days in duration. Approximately 555 eligib...

Effects of Remote Ischemic Conditioning on Hand Use in Individuals With Spinal Cord Injury and Amyotrophic Lateral Sclerosis
https://clinicaltrials.gov/ct2/show/NCT03851302

Aug 3rd, 2022 - Most spinal cord injuries (SCI) are not full transections, indicating that there are residual nerve circuits after injury. Rehabilitation interventions after SCI, including physical training and neural stimulation, have been shown to reorganize mo...

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News  399 results

Hope, help, and humor when facing a life-threatening illness
https://www.mdedge.com/psychiatry/article/256621/hope-help-and-humor-when-facing-life-threatening-illness
Sarah D. Sosland, BS, Morton D. Sosland, MD

Aug 1st, 2022 - Editor’s note: Readers’ Forum is a department for correspondence from readers that is not in response to articles published in Current Psychiatry. All submissions to Readers’ Forum undergo peer review and are subject to editing for length and sty.

US FDA Accepts Biogen's ALS Therapy for Review
https://www.medscape.com/viewarticle/977954

Jul 27th, 2022 - (Reuters) -Biogen Inc's treatment for a rare type of amyotrophic lateral sclerosis (ALS) was accepted for review by the U.S. health regulator, weeks after follow-up analyses of data from a failed late-stage study suggested the drug was likely to w...

The Hidden Dangers of Pathologizing Grief
https://www.medscape.com/viewarticle/977681

Jul 21st, 2022 - The Weekend That I graduated from law school, my mother told me that she had amyotrophic lateral sclerosis, also known as ALS or Lou Gehrig’s disease, a neurological disease for which there is currently no cure. As I recalled in a recent essay, I ...

US FDA to Reconvene Experts' Meeting for Amylyx ALS Drug
https://www.medscape.com/viewarticle/976643

Jul 6th, 2022 - (Reuters) -The U.S. Food and Drug Administration will reconvene a meeting of its outside experts to review Amylyx Pharmaceuticals' application for its amyotrophic lateral sclerosis (ALS) treatment, the company said on Tuesday. A panel of outside a...

FDA Unveils 5-Year Plan for ALS, Other Neurodegenerative Diseases
https://www.medscape.com/viewarticle/976169

Jun 24th, 2022 - The US Food and Drug Administration (FDA) has unveiled a 5-year strategy aimed at improving and extending the lives of people with rare neurodegenerative diseases. The agency's Action Plan for Rare Neurodegenerative Diseases including Amyotrophic ...

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Patient Education  16 results see all →