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About 14,415 results

ALLMedicine™ Amyotrophic Lateral Sclerosis Center

Research & Reviews  5,464 results

Higher blood high density lipoprotein and apolipoprotein A1 levels are associated with ...
https://doi.org/10.1136/jnnp-2021-327133
Journal of Neurology, Neurosurgery, and Psychiatry; Thompson AG, Talbot K et. al.

Sep 15th, 2021 - Premorbid body mass index, physical activity, diabetes and cardiovascular disease have been associated with an altered risk of developing amyotrophic lateral sclerosis (ALS). There is evidence of shared genetic risk between ALS and lipid metabolis...

De novo mutations in SOD1 are a cause of ALS.
https://doi.org/10.1136/jnnp-2021-327520
Journal of Neurology, Neurosurgery, and Psychiatry; Müller K, Oh KW et. al.

Sep 15th, 2021 - The only identified cause of amyotrophic lateral sclerosis (ALS) are mutations in a number of genes found in familial cases but also in sporadic cases. De novo mutations occurring in a parental gonadal cell, in the zygote or postzygotic during emb...

Factors Affecting Energy Metabolism and Prognosis in Patients with Amyotrophic Lateral ...
https://doi.org/10.1159/000518908
Annals of Nutrition & Metabolism; Kurihara M, Bamba S et. al.

Sep 14th, 2021 - Nutritional status is a factor affecting prognosis in patients with amyotrophic lateral sclerosis (ALS). Here, we aimed to clarify the factors associated with hypermetabolism and the prognosticators of ALS. Forty-two inpatients (22 men, 20 women) ...

An optimized MP2RAGE sequence for studying both brain and cervical spinal cord in a sin...
https://doi.org/10.1016/j.mri.2021.08.011
Magnetic Resonance Imaging; Forodighasemabadi A, Rasoanandrianina H et. al.

Sep 14th, 2021 - Magnetization Prepared 2 Rapid Acquisition Gradient Echo (MP2RAGE) is a T1 mapping technique that has been used broadly on brain and recently on cervical spinal cord (cSC). The growing interest for combined investigation of brain and SC in numerou...

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Guidelines  3 results

Provisional best practices guidelines for the evaluation of bulbar dysfunction in amyot...
https://doi.org/10.1002/mus.26408
Muscle & Nerve; Pattee GL, Plowman EK et. al.

Jan 9th, 2019 - Universally established comprehensive clinical bulbar scales objectively assessing disease progression in amyotrophic lateral sclerosis (ALS) are currently lacking. The goal of this working group project is to design a best practice set of provisi...

ESPEN guideline clinical nutrition in neurology.
https://doi.org/10.1016/j.clnu.2017.09.003
Clinical Nutrition (Edinburgh, Scotland); Burgos R, Bretón I et. al.

Dec 25th, 2017 - Neurological diseases are frequently associated with swallowing disorders and malnutrition. Moreover, patients with neurological diseases are at increased risk of micronutrient deficiency and dehydration. On the other hand, nutritional factors may...

Practice parameter update: the care of the patient with amyotrophic lateral sclerosis: ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2764728
Neurology Miller RG, Jackson CE et. al.

Oct 14th, 2009 - To systematically review evidence bearing on the management of patients with amyotrophic lateral sclerosis (ALS). The authors analyzed studies from 1998 to 2007 to update the 1999 practice parameter. Topics covered in this section include breaking...

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Drugs  17 results see all →

Clinicaltrials.gov  9 results

3K3A-APC for Treatment of Amyotrophic Lateral Sclerosis (ALS)
https://clinicaltrials.gov/ct2/show/NCT05039268

Sep 9th, 2021 - This Phase 2 open label trial seeks to investigate whether a novel therapy named 3K3A-APC is safe and potentially effective in patients with Amyotrophic Lateral Sclerosis (ALS). A total of 16 patients with ALS will be enrolled into 2 dose cohorts ...

Clinical Manifestations and Biomarkers in Amyotrophic Lateral Sclerosis Type 4 and Other Inherited Neurological Disorders of RNA Processing
https://clinicaltrials.gov/ct2/show/NCT04394871

Aug 27th, 2021 - Objective: Amyotrophic lateral sclerosis type 4 (ALS4) is an inherited form of motor neuron disease caused by mutation in the senataxin (SETX) gene. The main goal of this study will be to collect clinical and molecular biomarkers from patients wit...

Olfactory Deficits in Neurologic Disease
https://clinicaltrials.gov/ct2/show/NCT05019014

Aug 24th, 2021 - The goal of this study is to examine olfactory function in preclinical subjects [n = 150] or individuals with neurological diseases such as Probable Alzheimer's Disease (PRAD) [n = 50], Mild Cognitive Impairment [n = 50], Frontotemporal Dementias ...

PET Imaging of Cyclooxygenases in Neurodegenerative Brain Disease
https://clinicaltrials.gov/ct2/show/NCT04396873

Aug 23rd, 2021 - Study Description: This pilot/exploratory study will examine whether cyclooxygenase 1 (COX-1) and COX-2 are elevated in the brains of individuals with neurodegenerative brain disease compared to healthy volunteers. Objectives: Primary Objective: T...

Evaluation of Vision-Guided Shared Control for Assistive Robotics Manipulators
https://clinicaltrials.gov/ct2/show/NCT04323449

Jul 27th, 2021 - Veterans who use powered mobility devices including those with high-level spinal cord injury (SCI), amyotrophic lateral sclerosis (ALS), and multiple sclerosis (MS) often experience serious upper extremity impairments. Management and care of upper...

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News  272 results

A Quick Tour of the New Lyme Disease Guideline
https://www.medscape.com/viewarticle/951589

Jun 14th, 2021 - This transcript has been edited for clarity. Hello. This is Paul Auwaerter for Medscape Infectious Diseases, speaking from Johns Hopkins University School of Medicine. Spring is in full swing and tick season has certainly returned. I thought I wou...

Scientists Discover New Genetic Form of ALS in 11 Children
https://www.medscape.com/viewarticle/952489

Jun 7th, 2021 - (Reuters Health) - Scientists have identified four specific, dominant variants of the SPTLC1 gene in 11 children from seven different families who appear to have a new and unique form of amyotrophic lateral sclerosis (ALS). The findings suggest th...

Twofold Increased ALS Risk in Manual Laborers
https://www.medscape.com/viewarticle/949580

Apr 20th, 2021 - Blue-collar workers, particularly carpenters and construction workers, have a significantly increased risk for amyotrophic lateral sclerosis (ALS) compared with white-collar workers, new research shows. Investigators found manual laborers had a tw...

Theatrics, Hypnosis, and the Roots of Modern Neurology
https://www.medscape.com/viewarticle/947504

Mar 15th, 2021 - "Symptoms, then, are in reality nothing but a cry from suffering organs" – Jean-Martin Charcot Nearly 130 years after his death, Jean-Martin Charcot's name still resonates with modern neurologists. The famed 19th century French physician made myri...

New Compound Promising for ALS, Other Upper Motor Neuron Diseases
https://www.medscape.com/viewarticle/947056

Mar 11th, 2021 - NEW YORK (Reuters Health) - A new compound, NU-9, improved diseased upper motor neurons (UMN) in mice and shows promise for treating amyotrophic lateral sclerosis (ALS) in humans, though more work is needed before a clinical trial can be started, ...

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Patient Education  1 results see all →