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About 21,208 results

ALLMedicine™ Amyotrophic Lateral Sclerosis Center

Research & Reviews  7,385 results

Nebulized RNS60 for the Treatment of Amyotrophic Lateral Sclerosis
https://clinicaltrials.gov/ct2/show/NCT02988297

Mar 29th, 2023 - The purpose of this study is to determine whether nebulized RNS60 is effective in the treatment of amyotrophic lateral sclerosis (ALS).

Brain metabolic signatures in patients with genetic and nongenetic amyotrophic lateral ...
https://doi.org/10.1111/cns.14193
CNS Neuroscience & Therapeutics; Liu P, Tang Y et. al.

Mar 28th, 2023 - To study the brain metabolic signature in Chinese amyotrophic lateral sclerosis (ALS) patients and compare the difference in brain metabolic patterns between ALS with and without genetic variants. We included 146 patients with ALS and 128 healthy ...

A Study to Evaluate the Efficacy, Safety, Pharmacokinetics and Pharmacodynamics of ION363 in Amyotrophic Lateral Sclerosis Participants With Fused in Sarcoma Mutations (FUS-ALS)
https://clinicaltrials.gov/ct2/show/NCT04768972

Mar 28th, 2023 - This is a multi-center, two-part study of ION363 in up to 77 participants. Part 1 will consist of participants that will be randomized in a 2:1 ratio to receive a multi-dose regimen of ION363 or placebo for a period of 61 weeks, followed by Part 2...

A Study to Evaluate, Safety, Tolerability, Pharmacodynamic (PD) Markers and Pharmacokinetics (PK) of AP-101 in Participants With Amyotrophic Lateral Sclerosis (ALS)
https://clinicaltrials.gov/ct2/show/NCT05039099

Mar 27th, 2023 - The purpose of this study is to evaluate the safety, tolerability, PK, and PD of AP-101 in participants with fALS and sALS.

Lost in local translation: TDP-43 and FUS in axonal/neuromuscular junction maintenance ...
https://doi.org/10.1016/j.neuron.2023.02.028
Neuron Piol D, Robberechts T et. al.

Mar 25th, 2023 - Key early features of amyotrophic lateral sclerosis (ALS) are denervation of neuromuscular junctions and axonal degeneration. Motor neuron homeostasis relies on local translation through controlled regulation of axonal mRNA localization, transport...

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Guidelines  4 results

Respiratory Management of Patients with Neuromuscular Weakness: An American College of ...
https://doi.org/10.1016/j.chest.2023.03.011
Chest Khan A, Frazer-Green L et. al.

Mar 16th, 2023 - Respiratory failure is a significant concern in neuromuscular diseases (NMD). This CHEST guideline examines the literature on the respiratory management of patients with NMD to provide evidence-based recommendations. An expert panel conducted a sy...

Provisional best practices guidelines for the evaluation of bulbar dysfunction in amyot...
https://doi.org/10.1002/mus.26408
Muscle & Nerve; Pattee GL, Plowman EK et. al.

Jan 9th, 2019 - Universally established comprehensive clinical bulbar scales objectively assessing disease progression in amyotrophic lateral sclerosis (ALS) are currently lacking. The goal of this working group project is to design a best practice set of provisi...

ESPEN guideline clinical nutrition in neurology.
https://doi.org/10.1016/j.clnu.2017.09.003
Clinical Nutrition (Edinburgh, Scotland); Burgos R, Bretón I et. al.

Dec 25th, 2017 - Neurological diseases are frequently associated with swallowing disorders and malnutrition. Moreover, patients with neurological diseases are at increased risk of micronutrient deficiency and dehydration. On the other hand, nutritional factors may...

Practice parameter update: the care of the patient with amyotrophic lateral sclerosis: ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2764728
Neurology Miller RG, Jackson CE et. al.

Oct 14th, 2009 - To systematically review evidence bearing on the management of patients with amyotrophic lateral sclerosis (ALS). The authors analyzed studies from 1998 to 2007 to update the 1999 practice parameter. Topics covered in this section include breaking...

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Drugs  18 results see all →

Clinicaltrials.gov  556 results

Nebulized RNS60 for the Treatment of Amyotrophic Lateral Sclerosis
https://clinicaltrials.gov/ct2/show/NCT02988297

Mar 29th, 2023 - The purpose of this study is to determine whether nebulized RNS60 is effective in the treatment of amyotrophic lateral sclerosis (ALS).

A Study to Evaluate the Efficacy, Safety, Pharmacokinetics and Pharmacodynamics of ION363 in Amyotrophic Lateral Sclerosis Participants With Fused in Sarcoma Mutations (FUS-ALS)
https://clinicaltrials.gov/ct2/show/NCT04768972

Mar 28th, 2023 - This is a multi-center, two-part study of ION363 in up to 77 participants. Part 1 will consist of participants that will be randomized in a 2:1 ratio to receive a multi-dose regimen of ION363 or placebo for a period of 61 weeks, followed by Part 2...

A Study to Evaluate, Safety, Tolerability, Pharmacodynamic (PD) Markers and Pharmacokinetics (PK) of AP-101 in Participants With Amyotrophic Lateral Sclerosis (ALS)
https://clinicaltrials.gov/ct2/show/NCT05039099

Mar 27th, 2023 - The purpose of this study is to evaluate the safety, tolerability, PK, and PD of AP-101 in participants with fALS and sALS.

Study of ANX005 in Adults With Amyotrophic Lateral Sclerosis (ALS)
https://clinicaltrials.gov/ct2/show/NCT04569435

Mar 24th, 2023 - In this Phase 2a, multi-center, open label, proof-of-biology study, ANX005 will be administered to participants with ALS. The study consists of approximately 22 weeks of treatment and approximately 14 weeks of follow-up. All participants will be c...

COVID-19 Amyotrophic Lateral Sclerosis (ALS) Registry
https://clinicaltrials.gov/ct2/show/NCT04559009

Mar 24th, 2023 - The purpose of this registry is to assess the incidence and prevalence of COVID-19 in ALS patients, the effect of COVID-19 on ALS disease trajectory, and the impact, if any, of edaravone, riluzole and other concomitant medication used in ALS like ...

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News  492 results

Cognition-Exercise Link; Telomere Length and Dementia; Slow Breathing and Amyloid
https://www.medpagetoday.com/neurology/generalneurology/103757

Mar 28th, 2023 - An umbrella review of meta-analyses showed a positive overall effect of exercise on cognition, but the underlying studies had substantial limitations. (Nature Human Behaviour) SARS-CoV-2 infection during pregnancy was associated with a higher risk...

FDA Panel Supports Tofersen for Rare Genetic ALS
https://www.medpagetoday.com/neurology/generalneurology/103672

Mar 23rd, 2023 - A panel of FDA advisors voted unanimously that plasma neurofilament light chain (NfL), a biomarker of neurodegeneration, is a reasonable surrogate endpoint in amyotrophic lateral sclerosis (ALS) associated with a mutation in the SOD1 gene (SOD1-AL...

Investigational ALS Drug May Have Clinical Benefit, FDA Staff Says
https://www.medpagetoday.com/neurology/generalneurology/103620

Mar 20th, 2023 - Tofersen, an investigational antisense drug developed to treat amyotrophic lateral sclerosis (ALS) associated with a mutation in the SOD1 gene (SOD1-ALS), may have clinical benefit, FDA reviewers indicated in briefing documents ahead of an advisor...

Dementia Risk Higher for Elite Soccer Players
https://www.medpagetoday.com/neurology/dementia/103563

Mar 16th, 2023 - Men who played elite soccer were more likely to develop neurodegenerative diseases -- notably, dementia -- as they aged, a study in Sweden showed. The risk of neurodegenerative disease was 46% higher among soccer players who played in the Swedish ...

CHEST Unveils Guideline for Respiratory Management of Neuromuscular Diseases
https://www.medpagetoday.com/pulmonology/generalpulmonary/103571

Mar 16th, 2023 - Physicians should incorporate respiratory health care in early treatment plans for patients with neuromuscular diseases (NMD), according to new clinical guidelines from the American College of Chest Physicians (CHEST). Non-invasive ventilation, su...

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Patient Education  28 results see all →