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About 3,865 results

ALLMedicine™ Apolipoprotein B Center

Research & Reviews  1,200 results

The difference of lipid profiles between psoriasis with arthritis and psoriasis without...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8740478
Arthritis Research & Therapy; Wang B, Deng H et. al.

Jan 9th, 2022 - Methotrexate (MTX) has a protective effect against cardiovascular diseases (CVD), but the mechanism is unclear. To investigate the effect of MTX on lipid profiles and the difference between psoriasis without arthritis (PsO) and psoriatic arthritis...

Sex-specific associations of adiposity with cardiometabolic traits in the UK: A multi-l...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8735621
PLoS Medicine; O'Keeffe LM, Bell JA et. al.

Jan 7th, 2022 - Sex differences in cardiometabolic disease risk are commonly observed across the life course but are poorly understood and may be due to different associations of adiposity with cardiometabolic risk in females and males. We examined whether adipos...

Lipid-Lowering Agents
https://emedicine.medscape.com/article/2172172-overview

Jan 7th, 2022 - Lipid-Lowering Agents HMG-CoA reductase inhibitors (statins) These agents inhibit the rate-limiting step in cholesterol biosynthesis by competitively inhibiting HMG-CoA reductase. [1, 2, 3] Note the following: Low-density lipoprotein (LDL) reducti...

Serum apolipoprotein B to apolipoprotein A-I ratio is an independent predictor of liver...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8722169
BMC Cancer; Chen C, Yi W et. al.

Jan 5th, 2022 - The ratio of serum apolipoprotein B (apoB) to apolipoprotein A-I (apoAI) had been reported as a prognostic factor in colorectal cancer. This retrospective study aimed to assess the implication of apoB-to-apoAI ratio in predicting liver metastasis ...

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Guidelines  3 results

Menopause symptom management in women with dyslipidemias: An EMAS clinical guide.
https://doi.org/10.1016/j.maturitas.2020.03.007
Maturitas Anagnostis P, Bitzer J et. al.

Mar 27th, 2020 - Dyslipidemias are common and increase the risk of cardiovascular disease. The menopause transition is associated with an atherogenic lipid profile, with an increase in the concentrations of total cholesterol (TC) and low-density lipoprotein choles...

Association of apolipoprotein B and nuclear magnetic resonance spectroscopy-derived LDL...
https://doi.org/10.1373/clinchem.2012.196733
Clinical Chemistry; , Cole TG et. al.

Feb 7th, 2013 - The number of circulating LDL particles is a strong indicator of future cardiovascular disease (CVD) events, even superior to the concentration of LDL cholesterol. Atherogenic (primarily LDL) particle number is typically determined either directly...

Apolipoprotein B and cardiovascular disease risk: position statement from the AACC Lipo...
https://doi.org/10.1373/clinchem.2008.118356
Clinical Chemistry; Contois JH, McConnell JP et. al.

Jan 27th, 2009 - Low-density lipoprotein cholesterol (LDL-C) has been the cornerstone measurement for assessing cardiovascular risk for nearly 20 years. Recent data demonstrate that apolipoprotein B (apo B) is a better measure of circulating LDL particle number (L...

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Drugs  189 results see all →

Clinicaltrials.gov  42 results

Atherogenic Lipoproteins in Ischemic Stroke
https://clinicaltrials.gov/ct2/show/NCT05090878

Oct 25th, 2021 - Apolipoprotein B (apoB) levels (which encompass all atherogenic lipoproteins, including LDL), Lp(a) levels, and carotid IPH are associated with both first-ever and recurrent ischemic stroke. This cohort research project is to analyze: Among patien...

Investigating the Production of Lipoproteins and Acetyl-CoA During a Ketogenic Diet
https://clinicaltrials.gov/ct2/show/NCT03901014

Oct 6th, 2021 - Participants will consume a standard American diet for one week followed by a very-low carbohydrate ketogenic diet (VLCKD, <50 grams carbohydrate/day) for two weeks. Participants will undergo an oral stable isotope tracer study during each diet to...

Epidemiology of Genetic Factors in Lipid Metabolism
https://clinicaltrials.gov/ct2/show/NCT00005214

Oct 1st, 2021 - BACKGROUND: Altered plasma lipid, lipoprotein, and apolipoprotein levels are associated with the occurrence of coronary heart disease, non-insulin dependent diabetes, and gallbladder disease. Although there are many other environmental and biologi...

Pharmacodynamic Biomarkers to Support Biosimilar Development: PCSK9 Inhibitors
https://clinicaltrials.gov/ct2/show/NCT04189484

Aug 23rd, 2021 - This study is designed to assess pharmacokinetics and pharmacodynamics of evolocumab and alirocumab, two monoclonal antibodies that inhibit proprotein convertase subtilisin/kexin type 9 (PCSK9), across an appropriate dose range to inform clinical ...

HYPOCHOL : A Genetically-based Strategy to Identify New Targets in Cholesterol Metabolism
https://clinicaltrials.gov/ct2/show/NCT02354079

Jul 27th, 2021 - The goal is to recruit 400 subjects: 200 adult subjects with familial hypobetalipoproteinemia (FHBL) (index cases) plus 200 additional related subjects in at least 10 large informative FHBL families, in which there is no known mutation in FHBL gen...

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News  112 results

Lipid Levels Tied to ALS Risk
https://www.medscape.com/viewarticle/958730

Sep 14th, 2021 - Elevated levels of high-density lipoprotein (HDL) and apolipoprotein A1 (apoA1) are associated with a reduced risk for amyotrophic lateral sclerosis (ALS), new research shows. The study also linked a higher ratio of total cholesterol to HDL with a...

An Expert's Guide to Managing Familial Hypercholesterolemia
https://www.medscape.com/viewarticle/948546

Apr 21st, 2021 - This transcript has been edited for clarity. Hi. I'm Seth Baum, a preventive cardiologist and clinical lipidologist in Boca Raton, Florida. I'm also the past president of the American Society for Preventive Cardiology and on the faculty at the Flo...

An Expert's Guide to Managing Familial Hypercholesterolemia
https://www.medscape.com/viewarticle/948546?src=sapfe

Apr 21st, 2021 - This transcript has been edited for clarity. Hi. I'm Seth Baum, a preventive cardiologist and clinical lipidologist in Boca Raton, Florida. I'm also the past president of the American Society for Preventive Cardiology and on the faculty at the Flo...

Menopause Transition and CVD: A Window of Opportunity
https://www.medscape.com/viewarticle/942982

Dec 28th, 2020 - This transcript has been edited for clarity. Hello. This is Dr JoAnn Manson, professor of medicine at Harvard Medical School and Brigham and Women's Hospital. I'd like to talk with you about a recent report in Circulation, an American Heart Associ...

LDL Not the Primary Culprit in ASCVD?
https://www.medscape.com/viewarticle/942629

Dec 14th, 2020 - Two new studies suggest that low-density lipoprotein cholesterol (LDL-C) may be not the main driver of atherosclerotic cardiovascular disease (ASCVD). The findings instead implicate remnant cholesterol (remnant-C) and very low-density lipoprotein ...

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