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About 4,935 results

ALLMedicine™ Apolipoprotein B Center

Research & Reviews  1,413 results

LDLR missense variants disturb structural conformation and LDLR activity in T-lymphocyt...
https://doi.org/10.1016/j.gene.2022.147084
Gene Kristini Almendros Barbosa T, Dominguez Crespo Hirata R et. al.

Dec 5th, 2022 - Familial hypercholesterolemia (FH) is caused by deleterious mutations in the LDLR that increase markedly low-density lipoprotein (LDL) cholesterol and cause premature atherosclerotic cardiovascular disease. Functional effects of pathogenic LDLR va...

Correlation Analysis of Plasma Lipid Profiles and the Prognosis of Head and Neck Squamo...
https://doi.org/10.1111/odi.14456
Oral Diseases; Wang S, Wang L et. al.

Nov 30th, 2022 - This study aims to clarify whether blood lipid profiles are indicators of prognosis in patients with head and neck squamous cell carcinoma (HNSCC). This retrospective study included 512 T1/2N0M0 HNSCC patients. The correlation between blood lipid ...

Whole-exome sequencing identifies novel protein-altering variants associated with serum...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9685920
Genome Medicine; Sandholm N, Hotakainen R et. al.

Nov 25th, 2022 - Dyslipidemia is a major risk factor for cardiovascular disease, and diabetes impacts the lipid metabolism through multiple pathways. In addition to the standard lipid measurements, apolipoprotein concentrations provide added awareness of the burde...

Polygenic risk in Type III hyperlipidaemia and risk of cardiovascular disease: An epide...
https://doi.org/10.1016/j.ijcard.2022.11.024
International Journal of Cardiology; Pieri K, Trichia E et. al.

Nov 22nd, 2022 - Type III hyperlipidaemia (T3HL) is characterised by equimolar increases in plasma triglycerides (TG) and cholesterol in <10% of APOE22 carriers conveying high cardiovascular disease (CVD) risk. We investigate the role of a weighted triglyceride-ra...

Clinical significance of neutrophil gelatinase-associated lipocalin and sdLDL-C for cor...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9682485
Cardiovascular Diabetology; Chen Y, Fu Y et. al.

Nov 19th, 2022 - Although type 2 diabetes mellitus (T2DM) and coronary artery disease (CAD) share many common pathological and physiological characteristics, there are few studies assessing the predictive capacity of novel biomarkers in occurrence and development ...

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Guidelines  3 results

Menopause symptom management in women with dyslipidemias: An EMAS clinical guide.
https://doi.org/10.1016/j.maturitas.2020.03.007
Maturitas Anagnostis P, Bitzer J et. al.

Mar 27th, 2020 - Dyslipidemias are common and increase the risk of cardiovascular disease. The menopause transition is associated with an atherogenic lipid profile, with an increase in the concentrations of total cholesterol (TC) and low-density lipoprotein choles...

Association of apolipoprotein B and nuclear magnetic resonance spectroscopy-derived LDL...
https://doi.org/10.1373/clinchem.2012.196733
Clinical Chemistry; , Cole TG et. al.

Feb 7th, 2013 - The number of circulating LDL particles is a strong indicator of future cardiovascular disease (CVD) events, even superior to the concentration of LDL cholesterol. Atherogenic (primarily LDL) particle number is typically determined either directly...

Apolipoprotein B and cardiovascular disease risk: position statement from the AACC Lipo...
https://doi.org/10.1373/clinchem.2008.118356
Clinical Chemistry; Contois JH, McConnell JP et. al.

Jan 27th, 2009 - Low-density lipoprotein cholesterol (LDL-C) has been the cornerstone measurement for assessing cardiovascular risk for nearly 20 years. Recent data demonstrate that apolipoprotein B (apo B) is a better measure of circulating LDL particle number (L...

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Drugs  325 results see all →

Clinicaltrials.gov  92 results

Metabolism of Fibrinogen and Apolipoprotein B-100 in Childhood Obesity and Cardiovascular Disease
https://clinicaltrials.gov/ct2/show/NCT02613741

Oct 14th, 2022 - A. SPECIFIC AIMS: Evidence from the literature suggests that: childhood onset of obesity increases the risk of obesity and cardiovascular disease (CVD) in adulthood; plasma fibrinogen and apolipoprotein B-100 (apoB-100) levels are elevated in obes...

Fructose-induced Hepatic De Novo Lipogenesis in Adolescents With Obesity
https://clinicaltrials.gov/ct2/show/NCT03567837

Sep 19th, 2022 - Hypothesis: Hepatic DNL in response to the ingestion of fructose:glucose 1:1 is significantly greater in adolescents with obesity and prediabetes compared to adolescents with obesity who are metabolically healthy. Thirty obese adolescents, ages 12...

Time-restricted Eating to Improve Metabolic Abnormalities in Polycystic Ovarian Syndrome
https://clinicaltrials.gov/ct2/show/NCT05126199

Sep 19th, 2022 - Background: Polycystic ovarian syndrome (PCOS) is the most common reproductive endocrinopathy in women of reproductive age with many associated metabolic symptoms, in particular hyperinsulinemia, insulin resistance and a high lifetime risk of type...

Impact of the Genetic Background as a Risk Factor for Atherosclerotic Cardiovascular Disease in the Brazilian Population
https://clinicaltrials.gov/ct2/show/NCT05515653

Aug 30th, 2022 - The study will be carried out in about 50 centers, comprising the five Brazilian regions. The study will be conducted from July 2022 to December 2023. Data collection will be performed at each center consecutively, for cases and controls, through ...

The Very Large Database of Lipids (VLDL)
https://clinicaltrials.gov/ct2/show/NCT01698489

Aug 3rd, 2022 - Closer examination of granular lipid data in a large population offers numerous opportunities to generate new knowledge, ranging from studies examining concordance between commonly used lipid parameters to phenotypic characterization of rare or ex...

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News  141 results

The Skinny on Ultralow LDL-C
https://www.medscape.com/viewarticle/979412

Sep 19th, 2022 - This transcript has been edited for clarity. Melissa Walton-Shirley, MD: Hi, I'm Dr Melissa Walton-Shirley, today, with Dr Bob Giugliano. We're going to be talking about low-density lipoprotein cholesterol (LDL-C). Welcome to this conversation for...

How Long COVID May Reshape the Brain; EEG as Fentanyl Biomarker; Novel ALS Target?
https://www.medpagetoday.com/neurology/generalneurology/100468

Aug 30th, 2022 - Vanderbilt University's Wes Ely, MD, looked at ways long COVID may reshape the brain and how that might be treated. (Washington Post) A deep learning model showed that predicting response to anti-seizure medications based on clinical information w...

Jul 8, 2022 This Week in Cardiology Podcast
https://www.medscape.com/viewarticle/976733

Jul 8th, 2022 - Please note that the text below is not a full transcript and has not been copyedited. For more insight and commentary on these stories, subscribe to the This Week in Cardiology podcast on Apple Podcasts, Spotify, or your preferred podcast provider...

Xenotransplant Trials Coming; Avocado Diet a Dud; EMS Defers CPR to Bystander
https://www.medpagetoday.com/cardiology/prevention/99572

Jul 5th, 2022 - The FDA is reportedly paving the way for clinical trials of xenotransplantation. (Wall Street Journal) One large avocado a day for 6 months did not reduce excess visceral adiposity or other cardiometabolic measures in the HAT randomized trial. (Jo...

Monkeypox Outbreak Strain Has Far More Mutations Than Expected
https://www.medpagetoday.com/infectiousdisease/generalinfectiousdisease/99408

Jun 24th, 2022 - The strain of monkeypox involved in the current global outbreak differs from its parent strain by about 50 single nucleotide polymorphisms (SNPs) -- far more than would be expected for an orthopoxvirus, researchers reported. There's also evidence ...

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