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About 335 results

ALLMedicine™ Acetoacetate Center

Research & Reviews  128 results

Ketogenic diets, physical activity, and body composition: A review.
https://doi.org/10.1017/S0007114521002609
The British Journal of Nutrition; Ashtary-Larky D, Bagheri R et. al.

Jul 13th, 2021 - Obesity remains a serious relevant public health concern throughout the world despite related countermeasures being well understood (i.e., mainly physical activity and an adjusted diet). Among different nutritional approaches, there is a growing i...

Feasibility and Biological Activity of a Ketogenic/Intermittent-Fasting Diet in Patient...
https://doi.org/10.1212/WNL.0000000000012386
Neurology Schreck KC, Hsu FC et. al.

Jul 9th, 2021 - To examine the feasibility, safety, systemic biological activity, and cerebral activity of a ketogenic dietary intervention in patients with glioma. 25 patients with biopsy-confirmed WHO Grade 2-4 astrocytoma with stable disease following adjuvant...

Dietary medium chain triglycerides for management of epilepsy: New data from human, dog...
https://doi.org/10.1111/epi.16972
Epilepsia Han FY, Conboy-Schmidt L et. al.

Jun 26th, 2021 - Many studies show that glucose metabolism in epileptic brain areas can be impaired. Energy is crucial to maintain normal brain function, including ion and neurotransmitter balances. Energy deficits can lead to disruption of ion gradients, which ca...

Genetic and environmental influences on covariation in reproducible diet-metabolite ass...
https://doi.org/10.1093/ajcn/nqaa378
The American Journal of Clinical Nutrition; Bermingham KM, Brennan L et. al.

Apr 8th, 2021 - Early applications of metabolomics in nutrition and health research identified associations between dietary patterns and metabolomic profiles. Twin studies show that diet-related phenotypes and diet-associated metabolites are influenced by genes. ...

Chronic pesticide exposure elicits a subtle carry-over effect on the metabolome of Aure...
https://doi.org/10.1016/j.envpol.2021.116641
Environmental Pollution (Barking, Essex : 1987); Olguín-Jacobson C, Pitt KA et. al.

Feb 22nd, 2021 - Chemical pollutants, such as pesticides, often leach into aquatic environments and impact non-target organisms. Marine invertebrates have complex life cycles with multiple life-history stages. Exposure to pesticides during one life-history stage p...

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Clinicaltrials.gov  4 results

PET Study of Cerebral Metabolism of 11C-acetoacetate and 18F-FDG in Patients Under Moderate Ketosis
https://clinicaltrials.gov/ct2/show/NCT02409784

Feb 15th, 2019 - Regional brain glucose hypometabolism occurs during aging and may contribute to the onset of aging-related cognitive impairment in humans. Ketones are the main alternative energy substrate to glucose for the brain. Several studies show that brain ...

Imaging of Traumatic Brain Injury Metabolism Using Hyperpolarized Carbon-13 Pyruvate
https://clinicaltrials.gov/ct2/show/NCT03502967

Aug 1st, 2018 - Aim 1: Investigators will quantify changes in [1-13C]lactate and H13CO3- labeling following a bolus injection of hyperpolarized [1-13C]pyruvate during the time window of secondary injury to assess upregulated glycolysis. Due to heterogeneous prese...

Substrate Metabolism, Growth Hormone Signaling (GH), and Insulin Sensitivity During GH and Ketone Bodies Infusion
https://clinicaltrials.gov/ct2/show/NCT02655263

Nov 1st, 2017 - Background: Humans naturally produce ketone bodies under daily living conditions. The main ketone bodies are two functioning acids, beta-hydroxybutyric acid (3-OHB) and acetoacetate, and the pH-neutral, but odorous, acetone. In the fed state, leve...

Evaluation of PK of Caprylic Triglyceride Oil, AC-1202, AC-1204, and Axona on Ketone Body Production
https://clinicaltrials.gov/ct2/show/NCT02833012

Apr 11th, 2017 - To compare serum ketone body (i.e., total ketones, β hydroxybutyrate, and estimate of acetoacetate) levels after single dose administration of caprylic triglyceride (CT) oil, AC-1202, AC-1204, and Axona®.

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News  2 results

American Association Of Clinical Endocrinologists and American College Of Endocrinology Position Statement on the Association of SGLT-2 Inhibitors and Diabetic Ketoacidosis
https://www.medscape.com/viewarticle/871633_5

Which Pathophysiologic Factors Contribute to SGLT-2 Inhibitor–Associated DKA? Ketones such as acetoacetate and β-hydroxybutyrate are acidic alternate fuel molecules produced in the liver through the oxidation of fatty acids when dietary carbohydra...

Acute Metabolic Responses to a High-carbohydrate Meal in Outpatients with Type 2 Diabetes Treated with a Low-carbohydrate Diet: A Crossover Meal Tolerance Study
https://www.medscape.com/viewarticle/715720

Abstract and Introduction Abstract Background A low-carbohydrate diet (LCD) achieves good glycemic control in type 2 diabetes (T2DM) compared with a high-carbohydrate diet. With respect to energy metabolism, acute metabolic responses to high-carbo...

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