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About 395 results

ALLMedicine™ Acetoacetate Center

Research & Reviews  145 results

Ketone Ester Effects on Biomarkers of Brain Metabolism and Cognitive Performance in Cognitively Intact Adults 55 Years Old or Older
https://clinicaltrials.gov/ct2/show/NCT04421014

Dec 16th, 2021 - We hypothesize that supplementation with a ketone ester drink [HVMN Ketone Ester (KE)] compared to placebo, in cognitively intact adults 55 years old with Metabolic Syndrome (Mets), will (i) increase peripheral and brain ketone levels [primarily f...

Sodium-glucose Co Transporter 2 (sGLT2) Inhibitor and Endogenous Ketone Production
https://clinicaltrials.gov/ct2/show/NCT03852901

Dec 15th, 2021 - Objective and Specific Aims: The objective of this proof-of-concept study is to demonstrate in non-diabetic men and women age > 55 years that a sGLT2 inhibitor will increase ketone bodies and metabolites used for gluconeogenesis. We also hypothesi...

Intestinal Ketone Bodies Interfere With the Glycemic Control
https://clinicaltrials.gov/ct2/show/NCT05154461

Dec 13th, 2021 - It has been shown in man that a fatty diet in people with obesity stimulated the release of ketone bodies (KB) in the small intestinal mucosa. This observation was partly explained by an increased level of the ketogenic enzyme 3-hydroxy-3-methylgl...

Acetoacetate protects macrophages from lactic acidosis-induced mitochondrial dysfunctio...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8655019
Nature Communications; Adam C, Paolini L et. al.

Dec 10th, 2021 - Lactic acidosis, the extracellular accumulation of lactate and protons, is a consequence of increased glycolysis triggered by insufficient oxygen supply to tissues. Macrophages are able to differentiate from monocytes under such acidotic condition...

Comprehensive biomarker profiling of hypertension in 36 985 Finnish individuals.
https://doi.org/10.1097/HJH.0000000000003051
Journal of Hypertension; Palmu J, Tikkanen E et. al.

Nov 17th, 2021 - Previous studies on the association between metabolic biomarkers and hypertension have been limited by small sample sizes, low number of studied biomarkers, and cross-sectional study design. In the largest study to date, we assess the cross-sectio...

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Clinicaltrials.gov  11 results

Ketone Ester Effects on Biomarkers of Brain Metabolism and Cognitive Performance in Cognitively Intact Adults 55 Years Old or Older
https://clinicaltrials.gov/ct2/show/NCT04421014

Dec 16th, 2021 - We hypothesize that supplementation with a ketone ester drink [HVMN Ketone Ester (KE)] compared to placebo, in cognitively intact adults 55 years old with Metabolic Syndrome (Mets), will (i) increase peripheral and brain ketone levels [primarily f...

Sodium-glucose Co Transporter 2 (sGLT2) Inhibitor and Endogenous Ketone Production
https://clinicaltrials.gov/ct2/show/NCT03852901

Dec 15th, 2021 - Objective and Specific Aims: The objective of this proof-of-concept study is to demonstrate in non-diabetic men and women age > 55 years that a sGLT2 inhibitor will increase ketone bodies and metabolites used for gluconeogenesis. We also hypothesi...

Intestinal Ketone Bodies Interfere With the Glycemic Control
https://clinicaltrials.gov/ct2/show/NCT05154461

Dec 13th, 2021 - It has been shown in man that a fatty diet in people with obesity stimulated the release of ketone bodies (KB) in the small intestinal mucosa. This observation was partly explained by an increased level of the ketogenic enzyme 3-hydroxy-3-methylgl...

Imaging of Traumatic Brain Injury Metabolism Using Hyperpolarized Carbon-13 Pyruvate
https://clinicaltrials.gov/ct2/show/NCT03502967

Sep 28th, 2021 - Aim 1: Investigators will quantify changes in [1-13C]lactate and H13CO3- labeling following a bolus injection of hyperpolarized [1-13C]pyruvate during the time window of secondary injury to assess upregulated glycolysis. Due to heterogeneous prese...

Exogenous Ketones in People With Type 1 Diabetes
https://clinicaltrials.gov/ct2/show/NCT04487678

Jul 30th, 2020 - The ketone bodies acetoacetate, β-hydroxybutyrate (βHB) and acetone are small lipid-derived molecules that are produced in the liver under certain conditions such as starvation, very low carbohydrate intake and prolonged glycogen-depleting exercis...

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News  2 results

Circulating Post-STEMI Ketones Elevated, Hints at Treatment Role
https://www.medscape.com/viewarticle/960040

Sep 30th, 2021 - Circulating ketone bodies (KBs) are substantially elevated at presentation and 24 hours after ST-segment elevation myocardial infarction (STEMI), according to new research. The study also showed that greater KB levels measured after 24 hours of re...

American Association Of Clinical Endocrinologists and American College Of Endocrinology Position Statement on the Association of SGLT-2 Inhibitors and Diabetic Ketoacidosis
https://www.medscape.com/viewarticle/871633_5

Which Pathophysiologic Factors Contribute to SGLT-2 Inhibitor–Associated DKA? Ketones such as acetoacetate and β-hydroxybutyrate are acidic alternate fuel molecules produced in the liver through the oxidation of fatty acids when dietary carbohydra...

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