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About 598 results

ALLMedicine™ Acetoacetate Center

Research & Reviews  202 results

HMGCS2-Induced Autophagic Degradation of Tau Involves Ketone Body and ANKRD24.
https://doi.org/10.3233/JAD-220640
Journal of Alzheimer's Disease : JAD; Hu LT, Xie XY et. al.

Nov 29th, 2022 - Accumulation of hyperphosphorylated Tau (pTau) contributes to the formation of neurofibrillary tangles in Alzheimer's disease (AD), and targeting Tau/pTau metabolism has emerged as a therapeutic approach. We have previously reported that mitochond...

Tumour catabolism independent of malnutrition and inflammation in upper GI cancer patie...
https://doi.org/10.1002/jcsm.13131
Journal of Cachexia, Sarcopenia and Muscle; von Renesse J, von Bechtolsheim F et. al.

Nov 24th, 2022 - The detrimental impact of malnutrition and cachexia in cancer patients subjected to surgical resection is well established. However, how systemic and local metabolic alterations in cancer patients impact the serum metabolite signature, thereby lea...

Early metabolomic, lipid and lipoprotein changes in response to medical and surgical th...
https://doi.org/10.1016/j.metabol.2022.155346
Metabolism: Clinical and Experimental; Angelidi AM, Kokkinos A et. al.

Nov 15th, 2022 - Glucagon-like peptide-1 receptor agonists (GLP-1RA) and bariatric surgery have proven to be effective treatments for obesity and cardiometabolic conditions. We aimed to explore the early metabolomic changes in response to GLP-1RA (liraglutide) the...

Longitudinal Changes in Circulating Ketone Body Levels in Patients With Acute Heart Fai...
https://doi.org/10.1016/j.cardfail.2022.09.009
Journal of Cardiac Failure; Voorrips SN, Boorsma EM et. al.

Oct 17th, 2022 - Ketone bodies are endogenous fuels produced by the liver under conditions of metabolic or neurohormonal stress. Circulating ketone bodies are increased in patients with chronic heart failure (HF), yet little is known about the effect of acute HF o...

Nuclear Magnetic Resonance Spectroscopy Metabolomics in Idiopathic Intracranial Hyperte...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9620805
Neurology Grech O, Seneviratne SY et. al.

Oct 15th, 2022 - We evaluated the metabolomic profile in CSF, serum and urine of participants with idiopathic intracranial hypertension (IIH) compared to controls and measured changes in metabolism associated with clinical markers of disease activity and treatment...

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Clinicaltrials.gov  33 results

Towards the Validation of a New Blood Biomarker for the Early Diagnosis of Parkinson's Disease
https://clinicaltrials.gov/ct2/show/NCT05385315

Oct 14th, 2022 - Parkinson's disease (PD) affects more than 7 million people worldwide and represents a growing health and socio-economic burden. It is an incurable neurodegenerative disease, and the search for biomarkers that allow reliable early diagnosis and pr...

Ketone Ester Effects on Biomarkers of Brain Metabolism and Cognitive Performance in Cognitively Intact Adults 55 Years Old or Older
https://clinicaltrials.gov/ct2/show/NCT04421014

Oct 14th, 2022 - Study Description: We hypothesize that supplementation with a ketone ester drink [Ketone Ester (KE)] compared to placebo, in cognitively intact adults >= 55 years old with Metabolic Syndrome (MetS), will (i) increase peripheral and brain ketone le...

Intestinal Ketone Bodies Interfere With the Glycemic Control
https://clinicaltrials.gov/ct2/show/NCT05154461

Sep 30th, 2022 - It has been shown in man that a fatty diet in people with obesity stimulated the release of ketone bodies (KB) in the small intestinal mucosa. This observation was partly explained by an increased level of the ketogenic enzyme 3-hydroxy-3-methylgl...

Imaging of Traumatic Brain Injury Metabolism Using Hyperpolarized Carbon-13 Pyruvate
https://clinicaltrials.gov/ct2/show/NCT03502967

Sep 29th, 2022 - Aim 1: Investigators will quantify changes in [1-13C]lactate and H13CO3- labeling following a bolus injection of hyperpolarized [1-13C]pyruvate during the time window of secondary injury to assess upregulated glycolysis. Due to heterogeneous prese...

Ketone Monitoring in T1D: Effect of SGLT2i During Usual Care and With Insulin Deficiency
https://clinicaltrials.gov/ct2/show/NCT05541484

Sep 15th, 2022 - The study will consist of 4 distinct segments that include routine testing of ketones during usual care, during insulin deficiency, and while taking a SGLT2i in addition to usual care, then with insulin deficiency after the SGLT2i has reached stea...

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News  4 results

Circulating Post-STEMI Ketones Elevated, Hints at Treatment Role
https://www.medscape.com/viewarticle/960040

Sep 30th, 2021 - Circulating ketone bodies (KBs) are substantially elevated at presentation and 24 hours after ST-segment elevation myocardial infarction (STEMI), according to new research. The study also showed that greater KB levels measured after 24 hours of re...

Liraglutide prevents ketogenesis in type 1 diabetes
https://www.mdedge.com/endocrinology/article/109401/diabetes/liraglutide-prevents-ketogenesis-type-1-diabetes
Daniel M. Keller

Jun 3rd, 2016 - ORLANDO – A single injection of liraglutide can prevent ketogenesis in fasting patients with type 1 diabetes who were on basal insulin, findings from a small study have shown. Husam Ghanim, Ph.

Liraglutide Prevents Ketogenesis in Type 1 Diabetes
https://www.mdedge.com/clinicianreviews/article/109452/diabetes/liraglutide-prevents-ketogenesis-type-1-diabetes
Daniel M. Keller

Jun 3rd, 2016 - ORLANDO – A single injection of liraglutide can prevent ketogenesis in fasting patients with type 1 diabetes who were on basal insulin, findings from a small study have shown. Husam Ghanim, Ph.

American Association Of Clinical Endocrinologists and American College Of Endocrinology Position Statement on the Association of SGLT-2 Inhibitors and Diabetic Ketoacidosis
https://www.medscape.com/viewarticle/871633_5

Which Pathophysiologic Factors Contribute to SGLT-2 Inhibitor–Associated DKA? Ketones such as acetoacetate and β-hydroxybutyrate are acidic alternate fuel molecules produced in the liver through the oxidation of fatty acids when dietary carbohydra...

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