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About 550 results

ALLMedicine™ Acetoacetate Center

Research & Reviews  184 results

Metabolomics profile in acute respiratory distress syndrome by nuclear magnetic resonan...
https://doi.org/10.1186/s12931-022-02075-w 10.1177/0885066619855021 10.1002/elps.201700112 10.1097/CCM.0000000000003715 10.1152/ajplung.00132.2019 10.1164/ajrccm.149.3.7509706 10.1007/s10565-016-9322-4 10.1038/nrm.2016.25 10.1016/j.bpc.2020.106462 10.1097/SHK.0000000000001099 10.1016/j.ebiom.2020.103154 10.1111/crj.12674 10.1186/s13020-019-0229-x 10.1371/journal.pone.0012655 10.3390/biom11030390 10.1042/BCJ20210263 10.1080/15376510701611032 10.1038/s42255-020-0243-4 10.1152/physrev.2000.80.3.1107 10.3390/nu12092834 10.1007/s00726-009-0263-6 10.1016/j.jesf.2021.08.001 10.1016/j.celrep.2021.109701 10.3389/fimmu.2018.00141 10.1016/j.bbcan.2019.188332 10.2174/0929867325666180510124558 10.1016/0003-9861(90)90609-3 10.2174/092986706776361058 10.1183/09031936.00025107 10.1186/s10020-021-00376-2 10.1186/s12986-022-00653-9 10.1111/j.1753-4887.2012.00479.x 10.1002/nbm.4637 10.1002/mnfr.201100291 10.3390/molecules26010145 10.1016/j.isci.2020.101645 10.1038/srep24930 10.1371/journal.ppat.1009243 10.1016/j.neulet.2017.01.039 10.1007/s11306-019-1615-1 10.1186/s40104-016-0139-z 10.3748/wjg.v20.i23.7298 10.1016/j.cmet.2019.03.011 10.1371/journal.pone.0221595 10.1038/s41416-018-0357-6 10.1016/j.imbio.2009.09.004 10.3389/fimmu.2021.660342 10.1073/pnas.2017762118 10.1016/j.conb.2020.01.017
Respiratory Research; Yan Y, Chen J et. al.

Jun 28th, 2022 - Acute respiratory distress syndrome (ARDS) is a challenging clinical problem. Discovering the potential metabolic alterations underlying the ARDS is important to identify novel therapeutic target and improve the prognosis. Serum and urine metaboli...

Ketone Ester Effects on Biomarkers of Brain Metabolism and Cognitive Performance in Cognitively Intact Adults 55 Years Old or Older
https://clinicaltrials.gov/ct2/show/NCT04421014

Jun 24th, 2022 - Study Description: We hypothesize that supplementation with a ketone ester drink [Ketone Ester (KE)] compared to placebo, in cognitively intact adults >= 55 years old with Metabolic Syndrome (MetS), will (i) increase peripheral and brain ketone le...

Fasting Substrate Concentrations Predict Cardiovascular Outcomes in the CANagliflozin c...
https://doi.org/10.2337/dc21-2398
Diabetes Care; Ferrannini E, Baldi S et. al.

Jun 21st, 2022 - To examine whether the circulating substrate mix may be related to the incidence of heart failure (HF) and cardiovascular (CV) mortality and how it is altered by canagliflozin treatment. We measured fasting glucose, free fatty acids (FFA), glycero...

Acute Effects of Oral Ketone Ester on Cardiac Function in Patients With COVID-19
https://clinicaltrials.gov/ct2/show/NCT04573764

Jun 1st, 2022 - Based on Chinese studies, cardiac injury occurs in 20-30% of hospitalized patients and contributes to 40% of deaths. There are many possible mechanisms of cardiac injury in COVID-19 patients and increased myocardial oxygen demand and decreased myo...

Towards the Validation of a New Blood Biomarker for the Early Diagnosis of Parkinson's Disease
https://clinicaltrials.gov/ct2/show/NCT05385315

May 27th, 2022 - Parkinson's disease (PD) affects more than 7 million people worldwide and represents a growing health and socio-economic burden. It is an incurable neurodegenerative disease, and the search for biomarkers that allow reliable early diagnosis and pr...

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Clinicaltrials.gov  32 results

Ketone Ester Effects on Biomarkers of Brain Metabolism and Cognitive Performance in Cognitively Intact Adults 55 Years Old or Older
https://clinicaltrials.gov/ct2/show/NCT04421014

Jun 24th, 2022 - Study Description: We hypothesize that supplementation with a ketone ester drink [Ketone Ester (KE)] compared to placebo, in cognitively intact adults >= 55 years old with Metabolic Syndrome (MetS), will (i) increase peripheral and brain ketone le...

Acute Effects of Oral Ketone Ester on Cardiac Function in Patients With COVID-19
https://clinicaltrials.gov/ct2/show/NCT04573764

Jun 1st, 2022 - Based on Chinese studies, cardiac injury occurs in 20-30% of hospitalized patients and contributes to 40% of deaths. There are many possible mechanisms of cardiac injury in COVID-19 patients and increased myocardial oxygen demand and decreased myo...

Towards the Validation of a New Blood Biomarker for the Early Diagnosis of Parkinson's Disease
https://clinicaltrials.gov/ct2/show/NCT05385315

May 27th, 2022 - Parkinson's disease (PD) affects more than 7 million people worldwide and represents a growing health and socio-economic burden. It is an incurable neurodegenerative disease, and the search for biomarkers that allow reliable early diagnosis and pr...

Exogenous Ketones in People With Type 1 Diabetes
https://clinicaltrials.gov/ct2/show/NCT04487678

May 23rd, 2022 - The ketone bodies acetoacetate, β-hydroxybutyrate (βHB) and acetone are small lipid-derived molecules that are produced in the liver under certain conditions such as starvation, very low carbohydrate intake and prolonged glycogen-depleting exercis...

Validation of 3-[11C]-OHB
https://clinicaltrials.gov/ct2/show/NCT05232812

May 18th, 2022 - Background: Ketone bodies consists of 3-hydroxybutyrat, acetoacetate, and acetone. They are produced in the liver at high levels of fatty acids, and act as an important source of energy for the heart, brain and skeletal muscle during fasting. Ener...

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News  4 results

Circulating Post-STEMI Ketones Elevated, Hints at Treatment Role
https://www.medscape.com/viewarticle/960040

Sep 30th, 2021 - Circulating ketone bodies (KBs) are substantially elevated at presentation and 24 hours after ST-segment elevation myocardial infarction (STEMI), according to new research. The study also showed that greater KB levels measured after 24 hours of re...

Liraglutide prevents ketogenesis in type 1 diabetes
https://www.mdedge.com/endocrinology/article/109401/diabetes/liraglutide-prevents-ketogenesis-type-1-diabetes
Daniel M. Keller

Jun 3rd, 2016 - ORLANDO – A single injection of liraglutide can prevent ketogenesis in fasting patients with type 1 diabetes who were on basal insulin, findings from a small study have shown. Husam Ghanim, Ph.

Liraglutide Prevents Ketogenesis in Type 1 Diabetes
https://www.mdedge.com/clinicianreviews/article/109452/diabetes/liraglutide-prevents-ketogenesis-type-1-diabetes
Daniel M. Keller

Jun 3rd, 2016 - ORLANDO – A single injection of liraglutide can prevent ketogenesis in fasting patients with type 1 diabetes who were on basal insulin, findings from a small study have shown. Husam Ghanim, Ph.

American Association Of Clinical Endocrinologists and American College Of Endocrinology Position Statement on the Association of SGLT-2 Inhibitors and Diabetic Ketoacidosis
https://www.medscape.com/viewarticle/871633_5

Which Pathophysiologic Factors Contribute to SGLT-2 Inhibitor–Associated DKA? Ketones such as acetoacetate and β-hydroxybutyrate are acidic alternate fuel molecules produced in the liver through the oxidation of fatty acids when dietary carbohydra...

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