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About 12,468 results

ALLMedicine™ Growth Hormone Center

Research & Reviews  4,382 results

Discovery of an exosite on the SOCS2-SH2 domain that enhances SH2 binding to phosphoryl...
https://doi.org/10.1038/s41467-021-26983-5
Nature Communications; Linossi EM, Li K et. al.

Dec 4th, 2021 - Suppressor of cytokine signaling (SOCS)2 protein is a key negative regulator of the growth hormone (GH) and Janus kinase (JAK)-Signal Transducers and Activators of Transcription (STAT) signaling cascade. The central SOCS2-Src homology 2 (SH2) doma...

Manipulating Ghrelin Signaling Via GOAT Inhibition in Alcohol Use Disorder
https://clinicaltrials.gov/ct2/show/NCT03896516

Dec 3rd, 2021 - Background and Objective: Acyl-ghrelin is a 28-amino acid peptide that stimulates appetite and food intake. It is an endogenous ligand for the growth hormone secretagogue receptor (GHS-R1a). Preclinical studies suggest that acyl-ghrelin increases ...

The Potential Prognostic and Therapeutic Implications of Prolactin Receptor and Growth ...
https://doi.org/10.1097/PGP.0000000000000844
International Journal of Gynecological Pathology : Offici... Jones TE, La HS et. al.

Dec 3rd, 2021 - The management of uterine leiomyosarcomas (uLMS) remains challenging. The rate of recurrence and metastasis is high, with 5-yr survival reaching only 40% to 50% in patients with tumor confined to the uterus (FIGO stage I or II). Prolactin receptor...

Hexarelin attenuates abdominal aortic aneurysm formation by inhibiting SMC phenotype sw...
https://doi.org/10.1016/j.mvr.2021.104280
Microvascular Research; Jiang B, Wang M et. al.

Dec 3rd, 2021 - Hexarelin, a synthetic growth hormone-releasing peptide, is shown to be protective in cardiovascular diseases such as myocardial infraction and atherosclerosis. However, the functional role of hexarelin in abdominal aortic aneurysm (AAA) remains u...

Comparative study of human growth hormone measurements: impact on clinical interpretation.
https://doi.org/10.1515/cclm-2021-1109
Clinical Chemistry and Laboratory Medicine; Lotierzo M, Olaru-Soare F et. al.

Dec 2nd, 2021 - Human growth hormone (hGH) provocation test is an essential tool to assess growth hormone deficiency (GHD) in children and young adults. It is important to have a robust method to determine the hGH peak of stimulation. This work aimed to compare t...

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Guidelines  8 results

Clinical practice recommendations for growth hormone treatment in children with chronic...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7136166
Nature Reviews. Nephrology; Drube J, Wan M et. al.

Jun 15th, 2019 - Achieving normal growth is one of the most challenging problems in the management of children with chronic kidney disease (CKD). Treatment with recombinant human growth hormone (GH) promotes longitudinal growth and likely enables children with CKD...

Congress of Neurological Surgeons Systematic Review and Evidence-Based Guideline for Pr...
https://doi.org/10.1227/NEU.0000000000001387
Neurosurgery Fleseriu M, Bodach ME et. al.

Sep 17th, 2016 - Nonfunctioning pituitary adenomas (NFPAs) are among the most common pituitary lesions and may present with hypopituitarism and/or hyperprolactinemia. To review the existing literature as it pertains to preoperative endocrine assessment in the work...

Italian Society for the Study of Diabetes (SID)/Italian Endocrinological Society (SIE) ...
https://doi.org/10.1016/j.numecd.2016.02.001
Nutrition, Metabolism, and Cardiovascular Diseases : NMCD; Baroni MG, Giorgino F et. al.

Feb 26th, 2016 - Hyperglycemia is a common feature associated with states of increased growth hormone secretion and glucocorticoid levels. The purpose of these guidelines is to assist clinicians and other health care providers to take evidence-based therapeutic de...

British Fertility Society Policy and Practice Committee: adjuvants in IVF: evidence for...
https://doi.org/10.3109/14647273.2015.985454
Human Fertility (Cambridge, England); Nardo LG, El-Toukhy T et. al.

Dec 23rd, 2014 - Optimisation of the environment favourable for satisfactory ovarian response to stimulation and successful embryo implantation remains at the core of assisted conception programmes. The evidence base for the routine use of different adjuvants, alo...

Expert consensus document: A consensus on the medical treatment of acromegaly.
https://doi.org/10.1038/nrendo.2014.21
Nature Reviews. Endocrinology; Giustina A, Chanson P et. al.

Feb 26th, 2014 - In March 2013, the Acromegaly Consensus Group met to revise and update guidelines for the medical treatment of acromegaly. The meeting comprised experts skilled in the medical management of acromegaly. The group considered treatment goals covering...

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Drugs  86 results see all →

Clinicaltrials.gov  248 results

Manipulating Ghrelin Signaling Via GOAT Inhibition in Alcohol Use Disorder
https://clinicaltrials.gov/ct2/show/NCT03896516

Dec 3rd, 2021 - Background and Objective: Acyl-ghrelin is a 28-amino acid peptide that stimulates appetite and food intake. It is an endogenous ligand for the growth hormone secretagogue receptor (GHS-R1a). Preclinical studies suggest that acyl-ghrelin increases ...

Growth Hormone Treatment in Patients With Aggrecan (ACAN) Deficiency
https://clinicaltrials.gov/ct2/show/NCT03288103

Nov 29th, 2021 - This is a single center study. All participants will be recruited from the USA. The study intends to recruit pre-pubertal children for inclusion in the 1 year growth hormone treatment trial. The study also plans to collect the following detailed p...

Growth Hormone and Intrahepatic Lipid Content in Patients With Nonalcoholic Fatty Liver Disease
https://clinicaltrials.gov/ct2/show/NCT02217345

Nov 26th, 2021 - Nonalcoholic fatty liver disease (NAFLD), fatty infiltration of the liver in the absence of alcohol use, is an increasingly recognized complication of obesity, with prevalence estimates of about 30% of individuals in the United States. A subset of...

Safety Profile of Insulin Like Growth Factor-1 (IGF-I) Administration in Adolescents
https://clinicaltrials.gov/ct2/show/NCT00516386

Nov 18th, 2021 - Adolescents with anorexia nervosa (AN) are at high risk for low bone mineral density at a time when healthy adolescents are rapidly accruing bone, with implications for peak bone mass and fracture risk in later life. They are also deficient in ins...

Effectiveness of Recombinant Human Growth Hormone Therapy for Children With PMS
https://clinicaltrials.gov/ct2/show/NCT05105685

Nov 10th, 2021 - Compared with the placebo, rhGH treatment significantly decreased the total scores and subscale scores of GDS (P <0.05), while the total scores and subscale scores of SC-ABC significantly decreased (P < 0.05) following three-months rhGH treatment....

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News  251 results

EU Green Light for Once-Weekly Growth Hormone for Kids
https://www.medscape.com/viewarticle/963032

Nov 16th, 2021 - The European Medicines Agency (EMA) has given the 'green light' to lonapegsomatropin (TransCon hGH, Ascendis Pharma), a long-acting, once-weekly formulation of human growth hormone, for growth failure in children and adolescents, aged 3 to 18 year...

MC3R Mutations Linked to Timing of Puberty
https://www.medpagetoday.com/pediatrics/generalpediatrics/95418

Nov 3rd, 2021 - People who carry loss-of-function mutations in MC3R have later onset of puberty, researchers found. Over 800 females carrying a MC3R mutation had a 4.7-month delay in age at menarche compared with non-carriers, reported Stephen O'Rahilly, MD, of t...

FDA Approves First Once-Weekly Growth Hormone for Children
https://www.medscape.com/viewarticle/958043

Sep 2nd, 2021 - The US Food and Drug Administration (FDA) has approved lonapegsomatropin (Skytrofa, Ascendis Pharma), the first weekly subcutaneous injectable growth hormone for children with growth hormone deficiency (GHD). The approval was based on the findings...

HER2-positive breast cancer: Add-on trastuzumab lowers recurrence and mortality
https://www.mdedge.com/hematology-oncology/article/245092/breast-cancer/her2-positive-breast-cancer-add-trastuzumab-lowers

Aug 31st, 2021 - Key clinical point: Adding trastuzumab to chemotherapy in patients with early-stage, epidermal growth hormone receptor 2 (HER2)-positive breast cancer lowers the rate of recurrence and mortality from breast cancer. Major finding: Trastuzumab plus.

HER2CLIMB: Brain Metastases Data
https://www.onclive.com/view/her2climb-brain-metastases-data

Apr 2nd, 2021 - Transcript: Adam Brufsky, MD, PhD: Virginia, what are your first- and second-line standards of care right now for metastatic HER2 [human epidermal growth hormone receptor 2]–breast cancer? Virginia Kaklamani, MD:Assuming somebody has not ju...

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Patient Education  12 results see all →