ALLMedicine™ Alanine Aminotransferase Center
Research & Reviews 3,968 results
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Archives of Toxicology; Korver S, Bowen J et. al.
Jul 30th, 2021 - Drug-induced liver injury (DILI) is a frequent and dangerous adverse effect faced during preclinical and clinical drug therapy. DILI is a leading cause of candidate drug attrition, withdrawal and in clinic, is the primary cause of acute liver fail...
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Nature Communications; Ward LD, Tu HC et. al.
Jul 29th, 2021 - Understanding mechanisms of hepatocellular damage may lead to new treatments for liver disease, and genome-wide association studies (GWAS) of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) serum activities have proven useful f...
https://doi.org/10.1016/j.trim.2021.101439
Transplant Immunology; Chen L, Zhang WL et. al.
Jul 29th, 2021 - Sulforaphane (SFN)displays both anti-oxidative stress and anti-inflammatory activity. Given that inflammation and oxidative stress play important roles in hepatic ischemia-reperfusion injury (HI/RI), we examined the protective effect and potential...
https://doi.org/10.1536/ihj.20-793
International Heart Journal; Shirakabe A, Okazaki H et. al.
Jul 20th, 2021 - The Fibrosis-4 (FIB4) index could indicate the liver fibrosis in patients with chronic hepatic diseases. It was calculated using the following formula: (age × aspartate aminotransferase [U/L]) / (platelet count [103/μL] × √alanine aminotransferase...
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Gene Therapy; Ali HG, Ibrahim K et. al.
Jul 20th, 2021 - Spinal muscular atrophy (SMA) is an autosomal recessive neuromuscular disorder characterized by hypotonia, progressive muscle weakness, and wasting. Onasemnogene abeparvovec (Zolgensma®) is a novel gene therapy medicine, FDA-approved in May 2019 f...
Guidelines 2 results
https://doi.org/10.1038/ajg.2016.517
The American Journal of Gastroenterology; Kwo PY, Cohen SM et. al.
Dec 21st, 2016 - Clinicians are required to assess abnormal liver chemistries on a daily basis. The most common liver chemistries ordered are serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase and bilirubin. These tests sh...
https://doi.org/10.1002/hep.23934
Hepatology (Baltimore, Md.); Jonas MM, Block JM et. al.
Oct 5th, 2010 - Chronic hepatitis B virus (HBV) infection in children presents a therapeutic challenge for the practitioner. Decisions regarding selection of patients who may benefit from treatment, appropriate timing of treatment, and the choice of antiviral the...
Drugs 41 results see all →
Clinicaltrials.gov 95 results
https://clinicaltrials.gov/ct2/show/NCT01369199
Feb 28th, 2020 - To determine the efficacy of treatment with 8 weeks of entecavir followed by 40 weeks of both entecavir and peginterferon in the treatment of chronic hepatitis B in hepatitis B "e" antigen (HBeAg) positive adults who are in the immune tolerant pha...
https://clinicaltrials.gov/ct2/show/NCT02556372
Jan 29th, 2020 - This is a Phase 2, pilot study in which JKB-122 is given once daily for 24 weeks to subjects with AIH who have liver enzymes that are 1.25 to 10 times the upper limit of normal (ULN) and who have had a failed response to, incomplete response to, i...
https://clinicaltrials.gov/ct2/show/NCT03323346
Jan 18th, 2020 - Inclusion criteria: Patients with stage IV breast cancer with metastases demonstrated by appropriate imaging techniques Histologically or cytologically confirmed tumor Age of 18 years or more Eastern Cooperative Oncology Group (ECOG) performance s...
https://clinicaltrials.gov/ct2/show/NCT03666832
Dec 30th, 2019 - Inclusion Subjects who are males or females ≥ 19 years of age Subjects who have the following history of first-line gemcitabine and nab-paclitaxel among patients with cytologically or histologically proven metastatic pancreatic ductal adenocarcino...
https://clinicaltrials.gov/ct2/show/NCT01298037
Oct 10th, 2019 - Aim 1: The clinical and virological status of chronic Hepatitis B (HBV) infection is defined by distinct patterns of immune effector and regulatory responses: The investigators propose that one or more immune regulatory are induced during chronic ...
News 212 results
https://www.medscape.com/viewarticle/941149
Nov 17th, 2020 - Editor's note: Find the latest COVID-19 news and guidance in Medscape's Coronavirus Resource Center. There is a link between liver injury and a tendency toward excessive clotting in patients with COVID-19, and the organ's own blood vessels could b...
https://www.staging.medscape.com/viewarticle/936368
Aug 26th, 2020 - Clinical data for the first-ever RET inhibitor, selpercatinib (Retevmo), show efficacy in two groups of patients with cancer ― those with RET fusion–positive non–small cell lung cancer (NSCLC), and those with RET-mutant medullary thyroid cancer (M...
https://www.staging.medscape.com/viewarticle/936296
Aug 26th, 2020 - NEW YORK (Reuters Health) - For children with spinal muscular atrophy (SMA), gene therapy with onasemnogene abeparvovec-xioi (Zolgensma) is safe and provides improvements in motor function, report clinicians from Ohio. SMA is a rare genetic diseas...
https://www.medscape.com/viewarticle/935660
Aug 19th, 2020 - As I listened to our fellow present the case of a 5-month-old infant referred for evaluation of persistent jaundice, painful memories of several similar cases flashed by, causing me to ask, "Is this another late diagnosis of biliary atresia?" This...
https://www.medscape.com/viewarticle/933529
Jul 8th, 2020 - NEW YORK (Reuters Health) - Although remdesivir treatment may shorten time to recovery in patients with COVID-19, it may also induce liver injury, possibly in combination with P-glycoprotein inhibitors, according to a case report by Dutch investig...
