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About 3,643 results

ALLMedicine™ Gastrin Center

Research & Reviews  1,801 results

GRPr antagonist 68Ga-SB3 PET/CT-imaging of primary prostate cancer in therapy-naive pat...
https://doi.org/10.2967/jnumed.120.258814
Journal of Nuclear Medicine : Official Publication, Socie... Bakker IL, Fröberg AC et. al.

Apr 1st, 2021 - The gastrin releasing peptide receptor (GRPr) is overexpressed in prostate cancer (PCa) cells, making it an excellent tool for targeted imaging. The gallium-68 labeled GRPr antagonist SB3 (68Ga SB3) has shown excellent results in (pre)clinical stu...

Randomized Controlled Trial of the Gastrin/CCK2 Receptor Antagonist Netazepide in Patie...
https://doi.org/10.1158/1940-6207.CAPR-21-0050
Cancer Prevention Research (Philadelphia, Pa.); Abrams JA, Del Portillo A et. al.

Mar 30th, 2021 - Hypergastrinemia has been associated with high grade dysplasia and adenocarcinoma in patients with Barrett's esophagus (BE), and experimental studies suggest pro-inflammatory and pro-neoplastic effects of gastrin on BE. This is of potential concer...

A Parathyroid-Gut Axis: Hypercalcemia and the Pathogenesis of Gastrinoma in Multiple En...
https://doi.org/10.1158/1541-7786.MCR-21-0073
Molecular Cancer Research : MCR; Hackeng WM, Dreijerink KMA et. al.

Mar 27th, 2021 - Patients with multiple endocrine neoplasia 1 (MEN1) syndrome have a germline mutation in the MEN1 gene. Loss of the wildtype allele can initiate endocrine tumorigenesis. Microscopic and macroscopic pituitary, parathyroid, and pancreatic tumors (re...

PSMA- and GRPR-targeted PET: Results from 50 Patients with Biochemically Recurrent Pros...
https://doi.org/10.2967/jnumed.120.259630
Journal of Nuclear Medicine : Official Publication, Socie... Baratto L, Song H et. al.

Mar 6th, 2021 - Rationale: Novel radiopharmaceuticals for positron emission tomography (PET) are evaluated for the diagnosis of biochemically recurrent prostate cancer (BCR PC). Here, we compare the gastrin releasing peptide receptors (GRPR) - targeting 68Ga-RM2 ...

Significance of pepsinogen in screening for gastric intestinal metaplasia in Guangdong,...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7917884
The Journal of International Medical Research; Liu X, Zhang M et. al.

Feb 26th, 2021 - Diagnosis of gastric intestinal metaplasia (GIM) relies on gastroscopy and histopathologic biopsy, but their application in screening for GIM is limited. We aimed to identify serological biomarkers of GIM via screening in Guangdong, China. Cross-s...

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Drugs  1 results see all →

Clinicaltrials.gov  1,823 results

GRPr antagonist 68Ga-SB3 PET/CT-imaging of primary prostate cancer in therapy-naive pat...
https://doi.org/10.2967/jnumed.120.258814
Journal of Nuclear Medicine : Official Publication, Socie... Bakker IL, Fröberg AC et. al.

Apr 1st, 2021 - The gastrin releasing peptide receptor (GRPr) is overexpressed in prostate cancer (PCa) cells, making it an excellent tool for targeted imaging. The gallium-68 labeled GRPr antagonist SB3 (68Ga SB3) has shown excellent results in (pre)clinical stu...

Randomized Controlled Trial of the Gastrin/CCK2 Receptor Antagonist Netazepide in Patie...
https://doi.org/10.1158/1940-6207.CAPR-21-0050
Cancer Prevention Research (Philadelphia, Pa.); Abrams JA, Del Portillo A et. al.

Mar 30th, 2021 - Hypergastrinemia has been associated with high grade dysplasia and adenocarcinoma in patients with Barrett's esophagus (BE), and experimental studies suggest pro-inflammatory and pro-neoplastic effects of gastrin on BE. This is of potential concer...

A Parathyroid-Gut Axis: Hypercalcemia and the Pathogenesis of Gastrinoma in Multiple En...
https://doi.org/10.1158/1541-7786.MCR-21-0073
Molecular Cancer Research : MCR; Hackeng WM, Dreijerink KMA et. al.

Mar 27th, 2021 - Patients with multiple endocrine neoplasia 1 (MEN1) syndrome have a germline mutation in the MEN1 gene. Loss of the wildtype allele can initiate endocrine tumorigenesis. Microscopic and macroscopic pituitary, parathyroid, and pancreatic tumors (re...

PSMA- and GRPR-targeted PET: Results from 50 Patients with Biochemically Recurrent Pros...
https://doi.org/10.2967/jnumed.120.259630
Journal of Nuclear Medicine : Official Publication, Socie... Baratto L, Song H et. al.

Mar 6th, 2021 - Rationale: Novel radiopharmaceuticals for positron emission tomography (PET) are evaluated for the diagnosis of biochemically recurrent prostate cancer (BCR PC). Here, we compare the gastrin releasing peptide receptors (GRPR) - targeting 68Ga-RM2 ...

Significance of pepsinogen in screening for gastric intestinal metaplasia in Guangdong,...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7917884
The Journal of International Medical Research; Liu X, Zhang M et. al.

Feb 26th, 2021 - Diagnosis of gastric intestinal metaplasia (GIM) relies on gastroscopy and histopathologic biopsy, but their application in screening for GIM is limited. We aimed to identify serological biomarkers of GIM via screening in Guangdong, China. Cross-s...

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News  13 results

DDSEP® 8 Quick Quiz - February 2018 Question 1
https://www.mdedge.com/gihepnews/article/157422/ddsepr-8-quick-quiz-february-2018-question-1

Feb 1st, 2018 - Answer: B Rationale Hypergastrinemia is normally a physiologic response to hypochlorhydria. When hypergastrinemia occurs in the setting of acidic gastric pH, it is considered inappropriate.

August 2015 Quiz 2
https://www.mdedge.com/gihepnews/article/102088/august-2015-quiz-2

Aug 21st, 2015 - ANSWER: D Critique This patient has vitamin B12 deficiency, which is common in the elderly. In addition, gastrectomy can produce cobalamin deficiency due to lack of gastrin and pepsin resulting in impaired release of dietary B12 from ingested prot.

A 47-Year-Old Man With Acute Epigastric Pain
https://reference.medscape.com/viewarticle/847160_4

Jun 29th, 2015 - Uncomplicated peptic ulcer disease is highly prevalent in the United States. When combined with duodenal ulcers, the incidence is 1.8%, or approximately 500,000 new cases annually. In addition, about 4 million recurrences are noted annually. Appro...

Novel genetic marker predicts pancreatic cancer risk
https://www.mdedge.com/gihepnews/article/59029/gastroenterology/novel-genetic-marker-predicts-pancreatic-cancer-risk
Sharon Worcester, MDedge News

Jun 4th, 2013 - ORLANDO – Researchers have identified a novel genetic marker for increased pancreatic cancer risk. The marker, a single nucleotide polymorphism (SNP) of the cholecystokinin-B (CCK-B) receptor, could serve as a screening test for high-risk subjects.

Proton Pump Inhibitors Raise Hip Fracture Risk Over Time
https://www.medscape.com/viewarticle/757826

Jan 30th, 2012 - January 31, 2012 — A new study strengthens the association of long-term use of proton pump inhibitors (PPIs) with increased risk for hip fracture in postmenopausal women, particularly those who smoke. PPIs can affect fracture risk by increasing se...

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Patient Education  5 results see all →