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About 1,910 results

ALLMedicine™ Gastrin Center

Research & Reviews  694 results

Exploring the signaling space of a GPCR using bivalent ligands with a rigid oligoprolin...
https://doi.org/10.1073/pnas.2108776118
Proceedings of the National Academy of Sciences of the Un... Romantini N, Alam S et. al.

Nov 24th, 2021 - G protein-coupled receptors (GPCRs) are one of the most important drug-target classes in pharmaceutical industry. Their diversity in signaling, which can be modulated with drugs, permits the design of more effective and better-tolerated therapeuti...

Trial of a Gastrin Receptor Antagonist in Barrett's Esophagus
https://clinicaltrials.gov/ct2/show/NCT01298999

Nov 23rd, 2021 - The association between gastro-esophageal reflux disease (GERD) and cancer of the esophagus is well-established. Barrett's esophagus (BE) is a condition in which the lining of the part of the esophagus changes to look like small intestine, and thi...

A neuropeptide code for itch.
https://doi.org/10.1038/s41583-021-00526-9 10.1101/2021.01.26.428310
Nature Reviews. Neuroscience; Chen ZF

Oct 20th, 2021 - Itch is one of the most primal sensations, being both ubiquitous and important for the well-being of animals. For more than a century, a desire to understand how itch is encoded by the nervous system has prompted the advancement of many theories. ...

Pancreatic neuroendocrine tumor with ectopic adrenocorticotropic hormone syndrome: a ca...
https://doi.org/10.1507/endocrj.EJ21-0297
Endocrine Journal; Zheng M, Chen L et. al.

Oct 12th, 2021 - Pancreatic neuroendocrine tumors (P-NETs) secreting ectopic adrenocorticotropic hormones (ACTH) are rare and often delayed in diagnosis due to their atypical clinical characteristics. Here, we describe a case of P-NET in the pancreatic tail. The t...

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Drugs  19 results see all →

Clinicaltrials.gov  28 results

Trial of a Gastrin Receptor Antagonist in Barrett's Esophagus
https://clinicaltrials.gov/ct2/show/NCT01298999

Nov 23rd, 2021 - The association between gastro-esophageal reflux disease (GERD) and cancer of the esophagus is well-established. Barrett's esophagus (BE) is a condition in which the lining of the part of the esophagus changes to look like small intestine, and thi...

Vitamin B12 Supplementation to Improve B12 Status and Child Development
https://clinicaltrials.gov/ct2/show/NCT03258385

Oct 1st, 2021 - The investigators aim to conduct a double-blind, randomized trial, to investigate the effects of B12-fortified milk on maternal and infant B12 status, immune function and child development. Pregnant women (n=148) will be randomized to receive B12-...

[68Ga]-NeoBOMB1 Imaging in Patients With Malignancies Known to Overexpress Gastrin Releasing Peptide Receptor (GRPR)
https://clinicaltrials.gov/ct2/show/NCT03724253

Oct 23rd, 2020 - A total of 50 subjects were planned for the study (10 subjects for the dosimetry group and 40 subjects for the non dosimetry group). In total, 22 subjects were screened for eligibility and 19 subjects were enrolled (2 subjects in the dosimetry gro...

177Lu-PP-F11N for Receptor Targeted Therapy and Imaging of Metastatic Thyroid Cancer.
https://clinicaltrials.gov/ct2/show/NCT02088645

Aug 5th, 2020 - The purpose of this study is to determine the use of 177Lu-PP-F11N for imaging and therapy of patients with advanced medullary thyroid carcinoma (MTC). 177Lu-PP-F11N is a gastrin analogon, binding to cholecystokinin-2 receptors. This receptors sho...

Radiolabelled CCK-2/Gastrin Receptor Analogue for Personalized Theranostic Strategy in Advanced MTC
https://clinicaltrials.gov/ct2/show/NCT03246659

Mar 20th, 2020 - The main goal of the study is to expand cancer preclinical research results on the usefulness of CCK-2/gastrin receptor in clinical practice. On the basis of last few years preclinical research outcome on new biomarkers, conjugate CP04 was chosen ...

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News  20 results

Rationale for mTOR Inhibition in pNETs
https://www.onclive.com/view/rationale-for-mtor-inhibition-in-pnets

Apr 2nd, 2021 - Genomic studies have shown that select individuals with pancreatic neuroendocrine tumors (pNETs) express mutations in the mTOR pathway. Building upon this, results from the phase III, placebo-controlled RADIANT-3 study demonstrated improvements in...

Current and Emerging Treatments for Gastroenteropancreatic Neuroendocrine Tumors
https://www.onclive.com/view/current-and-emerging-treatments-for-gastroenteropancreatic-neuroendocrine-tumors

Dec 5th, 2020 - Approximately 175,000 Americans are affected by neuroendocrine tumors (NETs), 65% of which are gastroenteropancreatic (GEP) NETs. GEP-NETs represent a diverse family of tumors that arise in the gastrointestinal (GI) tract or pancreas.1-3 The overa...

April 2019 - Question 2
https://www.mdedge.com/gihepnews/article/197788/april-2019-question-2

Mar 29th, 2019 - Critique: Factors raising suspicion for Zollinger-Ellison syndrome include recurrent peptic ulcer disease, multiple ulcers, post-bulbar ulcer, non-H. pylori/non-NSAID-related duodenal ulcer, diarrhea, erosive esophagitis, and family or personal hi.

Endoscopic Surveillance Detects Early Gastric Cancer
https://www.medpagetoday.com/hematologyoncology/othercancers/73537

Jun 16th, 2018 - Endoscopic surveillance can detect gastric cancer at an early curable stage, Dutch researchers reported in Gut. In the study of patients from a low-incidence region of northern Europe, most had stable disease over 5 years, with a low overall risk ...

DDSEP® 8 Quick Quiz - February 2018 Question 1
https://www.mdedge.com/gihepnews/article/157422/ddsepr-8-quick-quiz-february-2018-question-1

Feb 1st, 2018 - Answer: B Rationale Hypergastrinemia is normally a physiologic response to hypochlorhydria. When hypergastrinemia occurs in the setting of acidic gastric pH, it is considered inappropriate.

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Patient Education  3 results see all →