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About 206 results

ALLMedicine™ Clot Retraction Center

Research & Reviews  103 results

The metabolic enzyme pyruvate kinase M2 regulates platelet function and arterial thromb...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7995287
Blood Nayak MK, Ghatge M et. al.

Oct 7th, 2020 - Very little is known about the role of metabolic regulatory mechanisms in platelet activation and thrombosis. Dimeric pyruvate kinase M2 (PKM2) is a crucial regulator of aerobic glycolysis that facilitates the production of lactate and metabolic r...

PCSK9 (Proprotein Convertase Subtilisin/Kexin 9) Enhances Platelet Activation, Thrombos...
https://doi.org/10.1161/CIRCULATIONAHA.120.046290
Circulation Qi Z, Hu L et. al.

Sep 29th, 2020 - PCSK9 (proprotein convertase subtilisin/kexin 9), mainly secreted by the liver and released into the blood, elevates plasma low-density lipoprotein cholesterol by degrading low-density lipoprotein receptor. Pleiotropic effects of PCSK9 beyond lipi...

The antithrombotic effect of caffeic acid is associated with a cAMP-dependent pathway a...
https://doi.org/10.1016/j.thromres.2020.07.024
Thrombosis Research; Nam GS, Park HJ et. al.

Jul 18th, 2020 - Caffeic acid (CA) is a polyphenol widely distributed in the plant kingdom. Studies have shown CA possesses antithrombotic activity in mouse cerebral arterioles in vivo and inhibits platelet aggregation in vitro. However, little is known regarding ...

Dominant role of αIIbβ3 in platelet interactions with cross-linked fibrin fragment D-di...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7362365
Blood Advances; Buitrago L, Zafar H et. al.

Jun 30th, 2020 - Although much is known about the interaction of fibrinogen with αIIbβ3, much less is known about the interaction of platelets with cross-linked fibrin. Fibrinogen residue Lys406 plays a vital role in the interaction of fibrinogen with αIIbβ3, but ...

Salidroside inhibits platelet function and thrombus formation through AKT/GSK3β signali...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7244060
Aging Wei G, Xu X et. al.

Apr 30th, 2020 - Salidroside is the main bioactive component in Rhodiola rosea and possesses multiple biological and pharmacological properties. However, whether salidroside affects platelet function remains unclear. Our study aims to investigate salidroside's eff...

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Clinicaltrials.gov  103 results

The metabolic enzyme pyruvate kinase M2 regulates platelet function and arterial thromb...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7995287
Blood Nayak MK, Ghatge M et. al.

Oct 7th, 2020 - Very little is known about the role of metabolic regulatory mechanisms in platelet activation and thrombosis. Dimeric pyruvate kinase M2 (PKM2) is a crucial regulator of aerobic glycolysis that facilitates the production of lactate and metabolic r...

PCSK9 (Proprotein Convertase Subtilisin/Kexin 9) Enhances Platelet Activation, Thrombos...
https://doi.org/10.1161/CIRCULATIONAHA.120.046290
Circulation Qi Z, Hu L et. al.

Sep 29th, 2020 - PCSK9 (proprotein convertase subtilisin/kexin 9), mainly secreted by the liver and released into the blood, elevates plasma low-density lipoprotein cholesterol by degrading low-density lipoprotein receptor. Pleiotropic effects of PCSK9 beyond lipi...

The antithrombotic effect of caffeic acid is associated with a cAMP-dependent pathway a...
https://doi.org/10.1016/j.thromres.2020.07.024
Thrombosis Research; Nam GS, Park HJ et. al.

Jul 18th, 2020 - Caffeic acid (CA) is a polyphenol widely distributed in the plant kingdom. Studies have shown CA possesses antithrombotic activity in mouse cerebral arterioles in vivo and inhibits platelet aggregation in vitro. However, little is known regarding ...

Dominant role of αIIbβ3 in platelet interactions with cross-linked fibrin fragment D-di...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7362365
Blood Advances; Buitrago L, Zafar H et. al.

Jun 30th, 2020 - Although much is known about the interaction of fibrinogen with αIIbβ3, much less is known about the interaction of platelets with cross-linked fibrin. Fibrinogen residue Lys406 plays a vital role in the interaction of fibrinogen with αIIbβ3, but ...

Salidroside inhibits platelet function and thrombus formation through AKT/GSK3β signali...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7244060
Aging Wei G, Xu X et. al.

Apr 30th, 2020 - Salidroside is the main bioactive component in Rhodiola rosea and possesses multiple biological and pharmacological properties. However, whether salidroside affects platelet function remains unclear. Our study aims to investigate salidroside's eff...

see more →