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About 935 results

ALLMedicine™ Immunofixation Center

Research & Reviews  459 results

Advanced isolated light chain amyloid cardiomyopathy with negative immunofixation and n...
https://doi.org/10.1002/ehf2.13381
ESC Heart Failure; Zach D, Ablasser K et. al.

May 7th, 2021 - Amyloid light chain (AL) cardiomyopathy is the most malignant specific cardiomyopathy. According to international recommendations, it should be ruled out non-invasively using the serum free light chain (FLC) ratio and immunofixation electrophoresi...

Updates in Cardiac Amyloidosis Diagnosis and Treatment.
https://doi.org/10.1007/s11912-021-01028-8 10.1080/13506129.2018.1549825 10.1080/07853890701842988 10.1016/0002-9343(83)90443-6 10.1016/j.mayocp.2019.01.023 10.1186/1750-1172-10-S1-P22 10.1007/s40271-017-0273-5 10.1182/blood.V79.7.1817.1817 10.1016/j.jacc.2016.06.053 10.1161/CIRCULATIONAHA.118.038169 10.1016/j.jacc.2016.06.033 10.2169/internalmedicine.9206-17 10.1002/humu.22619 10.3109/13506129.2015.1051219 10.1093/eurheartj/ehx589 10.1200/JCO.2004.03.029 10.1182/blood-2018-06-858951 10.1016/j.jcmg.2015.04.012 10.1093/eurheartj/ehx350 10.1093/eurheartj/ehv338 10.1016/j.jacc.2016.03.596 10.1016/j.jhsa.2019.06.016 10.1161/CIRCULATIONAHA.115.018852 10.1007/s00392-019-01467-1 10.1002/ejhf.1742 10.1001/jama.2017.9236 10.3109/03009734.2014.895786 10.1016/j.jacc.2018.07.092 10.1080/13506129.2017.1375908 10.1146/annurev-med-052918-020140 10.1016/j.amjcard.2014.07.026 10.1161/CIRCULATIONAHA.113.006242 10.1016/j.hrthm.2019.05.007 10.1007/s12350-013-9800-5 10.1136/heartjnl-2012-302353 10.1016/j.jacc.2017.05.053 10.1016/j.jcmg.2020.05.029 10.1016/j.cardfail.2019.08.002 10.2215/CJN.02290508 10.1016/j.jacc.2020.04.022 10.1161/CIR.0000000000000792 10.1373/clinchem.2008.117143 10.1373/clinchem.2004.046870 10.1161/CIRCULATIONAHA.116.021612 10.1080/13506129.2018.1436048 10.1016/j.jacc.2005.05.073 10.1161/CIRCIMAGING.112.000132 10.1001/jamacardio.2016.2839 10.1007/s12350-018-01552-4 10.1161/CIRCIMAGING.117.007059 10.1007/s12350-019-01760-6 10.1001/jamacardio.2016.2839 10.3109/13506129.2015.1072089 10.1007/s12350-017-0922-z 10.1016/j.jcmg.2019.10.015 10.1182/blood-2012-03-413682 10.1093/eurheartj/ehx047 10.1182/bloodadvances.2019000147 10.1111/j.1365-2141.2007.06936.x 10.1182/blood.2019000834 10.1200/JCO.20.01285 10.1038/leu.2012.100 10.1182/blood.2019004460 10.1056/NEJMoa1805689 10.1056/NEJMoa1716153 10.1056/NEJMoa1716793 10.1080/13506129.2019.1685487 10.1080/13506129.2017.1374946 10.1161/CIRCULATIONAHA.118.035831 10.1001/jamacardio.2019.0849 10.1007/s10557-019-06919-4 10.1080/13506120600960882 10.1001/jama.2013.283815 10.1080/13506129.2018.1519507 10.3109/13506129.2014.997872 10.1111/j.1751-7133.2012.00303.x 10.1161/CIRCULATIONAHA.119.045093 10.1016/j.jacc.2019.03.012 10.1186/1479-5876-8-74 10.1080/13506129.2016.1269739 10.3109/13506129.2012.678508 10.1016/j.febslet.2009.10.062 10.1371/journal.pone.0029933 10.2147/DDDT.S96893 10.1161/CIR.0000000000000509 10.3109/13506129.2015.1028616 10.1161/CIRCULATIONAHA.108.785014 10.1161/CIRCULATIONAHA.107.697763 10.1016/j.jacc.2018.10.079 10.1016/j.jacep.2019.10.013 10.2217/ahe.13.10 10.1161/JAHA.113.000098 10.1016/j.ahj.2012.04.015 10.1111/jce.14180 10.1093/europace/euaa094 10.1016/j.healun.2013.01.987 10.1111/ctr.13663 10.1016/j.healun.2017.11.015 10.1111/ajt.13025
Current Oncology Reports; Stern LK, Kittleson MM

Mar 16th, 2021 - Cardiac amyloidosis is an underrecognized cause of heart failure. We review clinical clues to the diagnoses, a rational approach to testing, and current and emerging therapies. Advances in the diagnosis of amyloid cardiomyopathy include (1) use of...

Not the usual suspect: Polymeric IgA paraprotein causes false positive results in kinet...
https://doi.org/10.1016/j.clinbiochem.2021.03.001
Clinical Biochemistry; Kemble DJ, Lamothe S et. al.

Mar 13th, 2021 - Immunoassays are commonly used by the clinical laboratory, but paraproteins can occasionally produce erroneous results. In this study, we investigated the cause of apparent false positive results for multiple Kinetic Interaction of Microparticles ...

Analysis of Multiple Bands on Serum Protein Immunofixation Electrophoresis: Challenge i...
https://doi.org/10.1093/labmed/lmab001
Laboratory Medicine; Nwogbo OV, Jin Y et. al.

Mar 11th, 2021 - Sera from patients with multiple myeloma usually display a single monoclonal immunoglobulin band on serum protein immunofixation electrophoresis. Multiple bands may be seen if the myeloma is bi- or triclonal or if the monoclonal immunoglobulin has...

MASS-FIX for the detection of monoclonal proteins and light chain N-glycosylation in ro...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7933343
Blood Cancer Journal; Mellors PW, Dasari S et. al.

Mar 5th, 2021 - Immunoenrichment-based matrix assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF-MS), termed MASS-FIX, offers several advantages over immunofixation for the detection and isotyping of serum monoclonal protein, includi...

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Guidelines  2 results

Consensus recommendations for standard investigative workup: report of the Internationa...
https://doi.org/10.1182/blood-2010-10-299529
Blood Dimopoulos M, Kyle R et. al.

Feb 4th, 2011 - A panel of members of the 2009 International Myeloma Workshop developed guidelines for standard investigative workup of patients with suspected multiple myeloma. Both serum and urine should be assessed for monoclonal protein. Measurement of monocl...

International Myeloma Working Group guidelines for serum-free light chain analysis in m...
https://doi.org/10.1038/leu.2008.307
Leukemia Dispenzieri A, Kyle R et. al.

Nov 20th, 2008 - The serum immunoglobulin-free light chain (FLC) assay measures levels of free kappa and lambda immunoglobulin light chains. There are three major indications for the FLC assay in the evaluation and management of multiple myeloma and related plasma...

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Clinicaltrials.gov  463 results

Advanced isolated light chain amyloid cardiomyopathy with negative immunofixation and n...
https://doi.org/10.1002/ehf2.13381
ESC Heart Failure; Zach D, Ablasser K et. al.

May 7th, 2021 - Amyloid light chain (AL) cardiomyopathy is the most malignant specific cardiomyopathy. According to international recommendations, it should be ruled out non-invasively using the serum free light chain (FLC) ratio and immunofixation electrophoresi...

Updates in Cardiac Amyloidosis Diagnosis and Treatment.
https://doi.org/10.1007/s11912-021-01028-8 10.1080/13506129.2018.1549825 10.1080/07853890701842988 10.1016/0002-9343(83)90443-6 10.1016/j.mayocp.2019.01.023 10.1186/1750-1172-10-S1-P22 10.1007/s40271-017-0273-5 10.1182/blood.V79.7.1817.1817 10.1016/j.jacc.2016.06.053 10.1161/CIRCULATIONAHA.118.038169 10.1016/j.jacc.2016.06.033 10.2169/internalmedicine.9206-17 10.1002/humu.22619 10.3109/13506129.2015.1051219 10.1093/eurheartj/ehx589 10.1200/JCO.2004.03.029 10.1182/blood-2018-06-858951 10.1016/j.jcmg.2015.04.012 10.1093/eurheartj/ehx350 10.1093/eurheartj/ehv338 10.1016/j.jacc.2016.03.596 10.1016/j.jhsa.2019.06.016 10.1161/CIRCULATIONAHA.115.018852 10.1007/s00392-019-01467-1 10.1002/ejhf.1742 10.1001/jama.2017.9236 10.3109/03009734.2014.895786 10.1016/j.jacc.2018.07.092 10.1080/13506129.2017.1375908 10.1146/annurev-med-052918-020140 10.1016/j.amjcard.2014.07.026 10.1161/CIRCULATIONAHA.113.006242 10.1016/j.hrthm.2019.05.007 10.1007/s12350-013-9800-5 10.1136/heartjnl-2012-302353 10.1016/j.jacc.2017.05.053 10.1016/j.jcmg.2020.05.029 10.1016/j.cardfail.2019.08.002 10.2215/CJN.02290508 10.1016/j.jacc.2020.04.022 10.1161/CIR.0000000000000792 10.1373/clinchem.2008.117143 10.1373/clinchem.2004.046870 10.1161/CIRCULATIONAHA.116.021612 10.1080/13506129.2018.1436048 10.1016/j.jacc.2005.05.073 10.1161/CIRCIMAGING.112.000132 10.1001/jamacardio.2016.2839 10.1007/s12350-018-01552-4 10.1161/CIRCIMAGING.117.007059 10.1007/s12350-019-01760-6 10.1001/jamacardio.2016.2839 10.3109/13506129.2015.1072089 10.1007/s12350-017-0922-z 10.1016/j.jcmg.2019.10.015 10.1182/blood-2012-03-413682 10.1093/eurheartj/ehx047 10.1182/bloodadvances.2019000147 10.1111/j.1365-2141.2007.06936.x 10.1182/blood.2019000834 10.1200/JCO.20.01285 10.1038/leu.2012.100 10.1182/blood.2019004460 10.1056/NEJMoa1805689 10.1056/NEJMoa1716153 10.1056/NEJMoa1716793 10.1080/13506129.2019.1685487 10.1080/13506129.2017.1374946 10.1161/CIRCULATIONAHA.118.035831 10.1001/jamacardio.2019.0849 10.1007/s10557-019-06919-4 10.1080/13506120600960882 10.1001/jama.2013.283815 10.1080/13506129.2018.1519507 10.3109/13506129.2014.997872 10.1111/j.1751-7133.2012.00303.x 10.1161/CIRCULATIONAHA.119.045093 10.1016/j.jacc.2019.03.012 10.1186/1479-5876-8-74 10.1080/13506129.2016.1269739 10.3109/13506129.2012.678508 10.1016/j.febslet.2009.10.062 10.1371/journal.pone.0029933 10.2147/DDDT.S96893 10.1161/CIR.0000000000000509 10.3109/13506129.2015.1028616 10.1161/CIRCULATIONAHA.108.785014 10.1161/CIRCULATIONAHA.107.697763 10.1016/j.jacc.2018.10.079 10.1016/j.jacep.2019.10.013 10.2217/ahe.13.10 10.1161/JAHA.113.000098 10.1016/j.ahj.2012.04.015 10.1111/jce.14180 10.1093/europace/euaa094 10.1016/j.healun.2013.01.987 10.1111/ctr.13663 10.1016/j.healun.2017.11.015 10.1111/ajt.13025
Current Oncology Reports; Stern LK, Kittleson MM

Mar 16th, 2021 - Cardiac amyloidosis is an underrecognized cause of heart failure. We review clinical clues to the diagnoses, a rational approach to testing, and current and emerging therapies. Advances in the diagnosis of amyloid cardiomyopathy include (1) use of...

Not the usual suspect: Polymeric IgA paraprotein causes false positive results in kinet...
https://doi.org/10.1016/j.clinbiochem.2021.03.001
Clinical Biochemistry; Kemble DJ, Lamothe S et. al.

Mar 13th, 2021 - Immunoassays are commonly used by the clinical laboratory, but paraproteins can occasionally produce erroneous results. In this study, we investigated the cause of apparent false positive results for multiple Kinetic Interaction of Microparticles ...

Analysis of Multiple Bands on Serum Protein Immunofixation Electrophoresis: Challenge i...
https://doi.org/10.1093/labmed/lmab001
Laboratory Medicine; Nwogbo OV, Jin Y et. al.

Mar 11th, 2021 - Sera from patients with multiple myeloma usually display a single monoclonal immunoglobulin band on serum protein immunofixation electrophoresis. Multiple bands may be seen if the myeloma is bi- or triclonal or if the monoclonal immunoglobulin has...

MASS-FIX for the detection of monoclonal proteins and light chain N-glycosylation in ro...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7933343
Blood Cancer Journal; Mellors PW, Dasari S et. al.

Mar 5th, 2021 - Immunoenrichment-based matrix assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF-MS), termed MASS-FIX, offers several advantages over immunofixation for the detection and isotyping of serum monoclonal protein, includi...

see more →

News  11 results

What is your diagnosis? - June 2019
https://www.mdedge.com/gihepnews/article/202110/what-your-diagnosis-june-2019?channel=27662
Lei Miao, MD, XiangRong Chen, MD et. al.

Jun 3rd, 2019 - Multiple myeloma An abdominal CT scan (Figure D) showed gastric and whole intestinal wall thickening of up to 2 cm. Pathology (Figure E) demonstrated that diffuse plasmacytoid cells, eosinophilic granulocytes, and lymphocytes infiltrated into the.

Fast Five Quiz: Can You Diagnose Waldenström Macroglobulinemia?
https://reference.medscape.com/viewarticle/908942_4

Mar 12th, 2019 - Elevated IgM (confirmed with immunofixation), elevated blood viscosity, and lymphoplasmacytic infiltrate on bone marrow biopsy are diagnostic criteria for WM. In addition, WM cells are often positive for the biomarkers CD19, CD20, CD22, and CD79a....

Waldenstrom Macroglobulinemia Clinical Practice Guidelines (2018)
https://reference.medscape.com/viewarticle/905623

Nov 29th, 2018 - The guidelines on the diagnosis, treatment, and follow-up of Waldenstrom macroglobulinemia were released on October 1, 2018, by the European Society for Medical Oncology (ESMO).[1] Diagnosis Waldenstrom macroglobulinemia (WM) is diagnosed based on...

FDA clears assay for myeloma patients
https://www.mdedge.com/hematology-oncology/article/185159/multiple-myeloma/fda-clears-assay-myeloma-patients
HT Staff

Jan 28th, 2018 - Photo courtesy of Janssen Daratumumab (Darzalex) The US Food and Drug Administration (FDA) has granted 510(k) clearance for Sebia’s Hydrashift 2/4 daratumumab immunofixation assay. This in vitro diagnostic test allows for assessment of response in.

Tests can produce confusing results after HSCT in MM
https://www.mdedge.com/hematology-oncology/article/185506/multiple-myeloma/tests-can-produce-confusing-results-after-hsct-mm
HT Staff

Aug 11th, 2017 - Micrograph showing MM Tests used to assess treatment response in multiple myeloma (MM) may often produce confusing results after patients have undergone hematopoietic stem cell transplant (HSCT), a new study suggests. The tests—serum protein elect.

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