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About 26,762 results

ALLMedicine™ Plasminogen Center

Research & Reviews  12,869 results

Preserved structural connectivity mediates the clinical effect of thrombolysis in patie...
https://doi.org/10.1038/s41467-021-22786-w 10.1001/archneur.58.4.613 10.1016/j.nicl.2013.05.009 10.1148/radiol.2018171567 10.1161/STROKEAHA.108.532622 10.1161/01.STR.31.12.2912 10.1161/STROKEAHA.116.015156 10.1161/STROKEAHA.114.006082 10.1161/STROKEAHA.107.485995 10.1056/NEJMoa1713973 10.1056/NEJMoa1804355 10.1161/STROKEAHA.114.005152 10.1093/brain/awv228 10.1016/j.euroneuro.2010.03.008 10.1002/hbm.20737 10.1093/braincomms/fcaa001 10.1016/j.celrep.2019.07.100 10.1002/hbm.23198 10.1212/WNL.0000000000009173 10.1038/jcbfm.2015.74 10.1002/hbm.22761 10.1161/01.STR.0000058480.77236.B3 10.1212/WNL.0000000000000643 10.1161/01.STR.27.4.761 10.1161/01.STR.0000217258.63925.6b 10.1161/01.STR.0000251792.76080.45 10.1212/WNL.0000000000006575 10.1001/jamaneurol.2018.3661 10.1161/STROKEAHA.117.017866 10.1016/j.nicl.2019.101852 10.1093/gigascience/giy004 10.1093/brain/awaa156 10.1161/STROKEAHA.113.003645 10.1002/hbm.22099 10.1089/brain.2013.0147 10.1016/j.neuroimage.2008.01.028 10.1111/biom.12248 10.1146/annurev-publhealth-032315-021402 10.1016/S1474-4422(11)70192-2 10.3414/ME14-01-0007 10.1161/STROKEAHA.119.027390 10.1016/j.neuroimage.2006.01.021 10.1006/nimg.2001.0978 10.1016/j.neuroimage.2014.06.060 10.2307/3001968 10.1080/00031305.2018.1529625 10.1093/aje/kwq332 10.1037/0278-6133.27.2(Suppl.).S101 10.1007/s11749-008-0126-6 10.1093/aje/kwx051 10.1515/2161-962X.1014
Nature Communications; Schlemm E, Ingwersen T et. al.

May 11th, 2021 - Thrombolysis with recombinant tissue plasminogen activator in acute ischemic stroke aims to restore compromised blood flow and prevent further neuronal damage. Despite the proven clinical efficacy of this treatment, little is known about the short...

Stroke in patients with cancer in the era of hyper-acute stroke intervention.
https://doi.org/10.1111/imj.15353
Internal Medicine Journal; Davies A, Van Leer L et. al.

May 11th, 2021 - The natural history of patients with stroke and cancer remains poorly understood in the modern era of hyper-acute stroke therapies (recombinant tissue plasminogen activator (tPA) and endovascular clot retrieval (ECR)). Prior to these advances in s...

uPAR+ extracellular vesicles: a robust biomarker of resistance to checkpoint inhibitor ...
https://doi.org/10.1136/jitc-2021-002372
Journal for Immunotherapy of Cancer; Porcelli L, Guida M et. al.

May 11th, 2021 - Emerging evidence has highlighted the importance of extracellular vesicle (EV)-based biomarkers of resistance to immunotherapy with checkpoint inhibitors in metastatic melanoma. Considering the tumor-promoting implications of urokinase-type plasmi...

Safety of intravenous thrombolysis in stroke of unknown time of onset: A systematic rev...
https://doi.org/10.1007/s11239-021-02476-6 10.1017/s0317167100004029 10.1212/WNL.0b013e318219fb30 10.1016/j.jstrokecerebrovasdis.2012.07.016 10.1212/wnl.56.8.1015 10.1016/S0140-6736(08)61339-2 10.1056/NEJMoa0804656 10.1159/000131083 10.1161/STR.0000000000000211 10.1161/01.str.20.4.473 10.1159/000070592 10.1056/NEJMoa1804355 10.1111/ene.13884 10.1016/j.jstrokecerebrovasdis.2016.06.044 10.1111/jon.12323 10.1017/s0317167100016553 10.1161/STROKEAHA.108.528034 10.1111/j.1747-4949.2010.00410.x 10.1007/s11239-018-1766-3 10.1111/j.1468-1331.2011.03351.x 10.1161/STROKEAHA.112.673145 10.1016/j.jstrokecerebrovasdis.2011.10.003 10.1161/JAHA.119.014265 10.1007/s11239-014-1116-z 10.1155/2019/5406923 10.1136/bmj.g7647 10.1136/bmj.d4002 10.1016/j.ensci.2019.02.002 10.1159/000503379 10.1016/j.neurol.2019.05.004 10.1136/svn-2018-000151 10.1111/j.1468-1331.2011.03504.x 10.1161/STROKEAHA.116.014889 10.1016/j.jstrokecerebrovasdis.2016.03.039 10.1007/s11739-015-1299-0 10.1161/STROKEAHA.111.000757 10.1159/000348552 10.1161/STROKEAHA.119.028127 10.1007/s00234-011-0944-1 10.1016/S0140-6736(10)60491-6 10.1001/jama.283.9.1145 10.1503/cmaj.1041561 10.1016/S0140-6736(07)60149-4 10.1161/01.STR.0000121641.77121.98 10.1136/postgradmedj-2019-136398 10.1016/S1474-4422(11)70192-2 10.1016/j.jns.2010.03.011 10.1148/radiol.10100461 10.1002/ana.21651 10.1007/s00330-019-06270-0 10.1016/s0140-6736(00)02237-6
Journal of Thrombosis and Thrombolysis; Wang C, Wang W et. al.

May 8th, 2021 - The safety of intravenous tissue plasminogen activator (IV-tPA) in patients with stroke of unknown time of onset (SUTO) was unclear and mostly concerned. We sought to investigate the safety in terms of symptomatic intracranial hemorrhage (sICH) an...

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Guidelines  9 results

Clinical Policy: Use of Intravenous Tissue Plasminogen Activator for the Management of ...
https://doi.org/10.1016/j.annemergmed.2015.06.031
Annals of Emergency Medicine; , Brown MD et. al.

Aug 25th, 2015 - Clinical Policy: Use of Intravenous Tissue Plasminogen Activator for the Management of Acute Ischemic Stroke in the Emergency Department.|2015| ,Brown MD,Burton JH,Nazarian DJ,Promes SB,|administration & dosage,adverse effects,therapeutic use,diag...

Guidelines for the intravenous application of recombinant tissue-type plasminogen activ...
https://doi.org/10.1016/j.jstrokecerebrovasdis.2013.04.001
Journal of Stroke and Cerebrovascular Diseases : the Offi... Minematsu K, Toyoda K et. al.

Jun 3rd, 2013 - In Japan, intravenous alteplase, a recombinant tissue-type plasminogen activator (rt-PA), was approved for an indication of ischemic stroke in 2005 on the basis of the results of a clinical trial with a unique dose of the drug (0.6 mg/kg). The Jap...

Consensus statement on the use of intravenous recombinant tissue plasminogen activator ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6493470
CNS Neuroscience & Therapeutics; Xu AD, Wang YJ et. al.

May 28th, 2013 - The last update of the consensus statement on intravenous recombinant tissue plasminogen activator (IV rt-PA) for acute ischemic stroke (AIS) by the Chinese Stroke Therapy Expert Panel was published in 2006. Great progress has been made since then...

Clinical Policy: Use of intravenous tPA for the management of acute ischemic stroke in ...
https://doi.org/10.1016/j.annemergmed.2012.11.005
Annals of Emergency Medicine; ,

Jan 21st, 2013 - This policy was developed by a joint writing panel of the American College of Emergency Physicians and the American Academy of Neurology. The panel reviewed the literature to derive evidence-based recommendations to help clinicians answer the foll...

Antithrombotic and thrombolytic therapy for ischemic stroke: Antithrombotic Therapy and...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3278065
Chest Lansberg MG, O'Donnell MJ et. al.

Feb 14th, 2012 - This article provides recommendations on the use of antithrombotic therapy in patients with stroke or transient ischemic attack (TIA). We generated treatment recommendations (Grade 1) and suggestions (Grade 2) based on high (A), moderate (B), and ...

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Drugs  2 results see all →

Clinicaltrials.gov  13,295 results

Preserved structural connectivity mediates the clinical effect of thrombolysis in patie...
https://doi.org/10.1038/s41467-021-22786-w 10.1001/archneur.58.4.613 10.1016/j.nicl.2013.05.009 10.1148/radiol.2018171567 10.1161/STROKEAHA.108.532622 10.1161/01.STR.31.12.2912 10.1161/STROKEAHA.116.015156 10.1161/STROKEAHA.114.006082 10.1161/STROKEAHA.107.485995 10.1056/NEJMoa1713973 10.1056/NEJMoa1804355 10.1161/STROKEAHA.114.005152 10.1093/brain/awv228 10.1016/j.euroneuro.2010.03.008 10.1002/hbm.20737 10.1093/braincomms/fcaa001 10.1016/j.celrep.2019.07.100 10.1002/hbm.23198 10.1212/WNL.0000000000009173 10.1038/jcbfm.2015.74 10.1002/hbm.22761 10.1161/01.STR.0000058480.77236.B3 10.1212/WNL.0000000000000643 10.1161/01.STR.27.4.761 10.1161/01.STR.0000217258.63925.6b 10.1161/01.STR.0000251792.76080.45 10.1212/WNL.0000000000006575 10.1001/jamaneurol.2018.3661 10.1161/STROKEAHA.117.017866 10.1016/j.nicl.2019.101852 10.1093/gigascience/giy004 10.1093/brain/awaa156 10.1161/STROKEAHA.113.003645 10.1002/hbm.22099 10.1089/brain.2013.0147 10.1016/j.neuroimage.2008.01.028 10.1111/biom.12248 10.1146/annurev-publhealth-032315-021402 10.1016/S1474-4422(11)70192-2 10.3414/ME14-01-0007 10.1161/STROKEAHA.119.027390 10.1016/j.neuroimage.2006.01.021 10.1006/nimg.2001.0978 10.1016/j.neuroimage.2014.06.060 10.2307/3001968 10.1080/00031305.2018.1529625 10.1093/aje/kwq332 10.1037/0278-6133.27.2(Suppl.).S101 10.1007/s11749-008-0126-6 10.1093/aje/kwx051 10.1515/2161-962X.1014
Nature Communications; Schlemm E, Ingwersen T et. al.

May 11th, 2021 - Thrombolysis with recombinant tissue plasminogen activator in acute ischemic stroke aims to restore compromised blood flow and prevent further neuronal damage. Despite the proven clinical efficacy of this treatment, little is known about the short...

Stroke in patients with cancer in the era of hyper-acute stroke intervention.
https://doi.org/10.1111/imj.15353
Internal Medicine Journal; Davies A, Van Leer L et. al.

May 11th, 2021 - The natural history of patients with stroke and cancer remains poorly understood in the modern era of hyper-acute stroke therapies (recombinant tissue plasminogen activator (tPA) and endovascular clot retrieval (ECR)). Prior to these advances in s...

uPAR+ extracellular vesicles: a robust biomarker of resistance to checkpoint inhibitor ...
https://doi.org/10.1136/jitc-2021-002372
Journal for Immunotherapy of Cancer; Porcelli L, Guida M et. al.

May 11th, 2021 - Emerging evidence has highlighted the importance of extracellular vesicle (EV)-based biomarkers of resistance to immunotherapy with checkpoint inhibitors in metastatic melanoma. Considering the tumor-promoting implications of urokinase-type plasmi...

Safety of intravenous thrombolysis in stroke of unknown time of onset: A systematic rev...
https://doi.org/10.1007/s11239-021-02476-6 10.1017/s0317167100004029 10.1212/WNL.0b013e318219fb30 10.1016/j.jstrokecerebrovasdis.2012.07.016 10.1212/wnl.56.8.1015 10.1016/S0140-6736(08)61339-2 10.1056/NEJMoa0804656 10.1159/000131083 10.1161/STR.0000000000000211 10.1161/01.str.20.4.473 10.1159/000070592 10.1056/NEJMoa1804355 10.1111/ene.13884 10.1016/j.jstrokecerebrovasdis.2016.06.044 10.1111/jon.12323 10.1017/s0317167100016553 10.1161/STROKEAHA.108.528034 10.1111/j.1747-4949.2010.00410.x 10.1007/s11239-018-1766-3 10.1111/j.1468-1331.2011.03351.x 10.1161/STROKEAHA.112.673145 10.1016/j.jstrokecerebrovasdis.2011.10.003 10.1161/JAHA.119.014265 10.1007/s11239-014-1116-z 10.1155/2019/5406923 10.1136/bmj.g7647 10.1136/bmj.d4002 10.1016/j.ensci.2019.02.002 10.1159/000503379 10.1016/j.neurol.2019.05.004 10.1136/svn-2018-000151 10.1111/j.1468-1331.2011.03504.x 10.1161/STROKEAHA.116.014889 10.1016/j.jstrokecerebrovasdis.2016.03.039 10.1007/s11739-015-1299-0 10.1161/STROKEAHA.111.000757 10.1159/000348552 10.1161/STROKEAHA.119.028127 10.1007/s00234-011-0944-1 10.1016/S0140-6736(10)60491-6 10.1001/jama.283.9.1145 10.1503/cmaj.1041561 10.1016/S0140-6736(07)60149-4 10.1161/01.STR.0000121641.77121.98 10.1136/postgradmedj-2019-136398 10.1016/S1474-4422(11)70192-2 10.1016/j.jns.2010.03.011 10.1148/radiol.10100461 10.1002/ana.21651 10.1007/s00330-019-06270-0 10.1016/s0140-6736(00)02237-6
Journal of Thrombosis and Thrombolysis; Wang C, Wang W et. al.

May 8th, 2021 - The safety of intravenous tissue plasminogen activator (IV-tPA) in patients with stroke of unknown time of onset (SUTO) was unclear and mostly concerned. We sought to investigate the safety in terms of symptomatic intracranial hemorrhage (sICH) an...

see more →

News  587 results

Direct Thrombectomy in Stroke: Which Groups May Benefit?
https://www.medscape.com/viewarticle/947987

Mar 23rd, 2021 - A new pooled analysis of two smaller trials testing the new approach of dropping thrombolysis before thrombectomy in patients with large vessel occlusion stroke has shown similar outcomes with and without tissue plasminogen activator (tPA), but ha...

Is There a Need for tPA Before Thrombectomy in Stroke?
https://www.medscape.com/viewarticle/947774

Mar 18th, 2021 - In a new randomized trial that investigated the question of whether thrombolysis can be omitted for stroke patients undergoing endovascular thrombectomy for a large-vessel occlusion, results were similar for both approaches. The MR CLEAN NO IV tri...

Mobile Stroke Units Improve Outcomes in Ischemic Stroke
https://www.medscape.com/viewarticle/947736

Mar 17th, 2021 - Updated March 26, 2021 // Editor's note: This story was updated with comments from Dr Mitchell S. V. Elkind of Columbia University. Among patients with acute ischemic stroke, treatment in a mobile stroke unit (MSU) is associated with better functi...

New 'Wake-up' Stroke Analysis Strengthens Case for Thrombolysis
https://www.medscape.com/viewarticle/940587

Nov 8th, 2020 - Evidence supporting the use of thrombolysis for selected stroke patients with unknown time of onset has been strengthened with data from a new individual patient meta-analysis. The meta-analysis combined data from four clinical trials that include...

Protein Predicts Risk of AKI in COVID-19 Patients
https://www.medscape.com/viewarticle/939052

Oct 12th, 2020 - Editor's note: Find the latest COVID-19 news and guidance in Medscape's Coronavirus Resource Center. Admission levels of a specific protein predict the development of acute kidney injury (AKI) as well as the need for dialysis in patients hospitali...

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