ALLMedicine™ Transferrin Receptor Center

Apr 24th, 2021 - Many studies have found that ruthenium complexes possess unique biochemical characteristics and inhibit tumor growth or metastasis. Here, we report the novel dual-targeting ruthenium candidate 2b, which has both antitumor and antimetastatic proper...

Apr 21st, 2021 - The de novo design of polar protein-protein interactions is challenging because of the thermodynamic cost of stripping water away from the polar groups. Here, we describe a general approach for designing proteins which complement exposed polar bac...

Mar 31st, 2021 - Hereditary hemochromatosis (HH) is a hereditary disorder of iron metabolism. It is classified into 4 main types depending on the underlying genetic mutation: human hemochromatosis protein (HFE) (type 1), hemojuvelin (HJV) (type 2A), HAMP (type 2B)...

Mar 30th, 2021 - In Hunter syndrome (mucopolysaccharidosis II [MPS-II]), systemic accumulation of glycosaminoglycans (GAGs) due to a deficiency of iduronate-2-sulfatase (IDS), caused by mutations in the IDS gene, leads to multiple somatic manifestations and in pat...

Mar 24th, 2021 - Iron deficiency (ID) is the most common nutritional deficiency affecting children worldwide. Most traditional laboratory parameters to assess ID can be altered by infections or other inflammatory states, including obesity. The aims of this study w...

Apr 24th, 2021 - Many studies have found that ruthenium complexes possess unique biochemical characteristics and inhibit tumor growth or metastasis. Here, we report the novel dual-targeting ruthenium candidate 2b, which has both antitumor and antimetastatic proper...

Apr 21st, 2021 - The de novo design of polar protein-protein interactions is challenging because of the thermodynamic cost of stripping water away from the polar groups. Here, we describe a general approach for designing proteins which complement exposed polar bac...

Mar 31st, 2021 - Hereditary hemochromatosis (HH) is a hereditary disorder of iron metabolism. It is classified into 4 main types depending on the underlying genetic mutation: human hemochromatosis protein (HFE) (type 1), hemojuvelin (HJV) (type 2A), HAMP (type 2B)...

Mar 30th, 2021 - In Hunter syndrome (mucopolysaccharidosis II [MPS-II]), systemic accumulation of glycosaminoglycans (GAGs) due to a deficiency of iduronate-2-sulfatase (IDS), caused by mutations in the IDS gene, leads to multiple somatic manifestations and in pat...

Mar 24th, 2021 - Iron deficiency (ID) is the most common nutritional deficiency affecting children worldwide. Most traditional laboratory parameters to assess ID can be altered by infections or other inflammatory states, including obesity. The aims of this study w...

Nov 13th, 2006 - Epratuzumab Epratuzumab (LL2) is a murine IgG2a antibody targeted against CD22 antigen (transferrin receptor). It is widely expressed during B-cell development and is present in most of NHL tumours[64] Juweid and colleagues[65] compared 131ILL2 wi...