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About 10,914 results

ALLMedicine™ Von Willebrand Factor Center

Research & Reviews  5,353 results

Endothelial colony forming cells generated from cryopreserved peripheral blood mononucl...
https://doi.org/10.1016/j.humimm.2021.02.009
Human Immunology; Béland S, Désy O et. al.

Mar 2nd, 2021 - Derivation of endothelial colony forming cells (ECFCs) from peripheral blood mononuclear cells (PBMCs) is a technique that could provide access to donor endothelial cells to study donor endothelium/recipient immune cells interactions. The success ...

Gut microbiota and their metabolites in cardiovascular disease.
https://doi.org/10.1016/j.beem.2021.101492
Best Practice & Research. Clinical Endocrinology & Metabo... Jansen VL, Gerdes VE et. al.

Mar 1st, 2021 - The gut microbiome affects the development and progress of various types of disease such as obesity, diabetes, atherosclerosis and arterial thrombosis. Gut microbiome derived metabolites have been established to be predictive of arterial thrombosi...

Uremic serum induces prothrombotic changes in venous endothelial cells and inflammatory...
https://doi.org/10.1080/0886022X.2021.1890617
Renal Failure; Sosińska-Zawierucha P, Bręborowicz A

Mar 1st, 2021 - Uremia induces various pathologic changes in the endothelium. However, there is limited information about the differences of these effects in endothelial cells originating from different parts of the vascular tree. The effect of uremic serum obtai...

Toward Personalized Treatment for Patients with Low von Willebrand Factor and Quantitat...
https://doi.org/10.1055/s-0041-1722864
Seminars in Thrombosis and Hemostasis; O'Donnell JS

Feb 26th, 2021 - The biological mechanisms involved in the pathogenesis of type 2 and type 3 von Willebrand disease (VWD) have been studied extensively. In contrast, although accounting for the majority of VWD cases, the pathobiology underlying partial quantitativ...

Current Challenges in the Peripartum Management of Women with von Willebrand Disease.
https://doi.org/10.1055/s-0041-1723797
Seminars in Thrombosis and Hemostasis; Byrne B, Ryan K et. al.

Feb 26th, 2021 - For many women, pregnancy and childbirth represent their first major hemostatic challenges. Despite advancements in obstetric care, up to 2 to 5% of all deliveries are complicated by postpartum hemorrhage (PPH). To mitigate bleeding risk, physiolo...

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Guidelines  13 results

CABLIVI (caplacizumab-yhdp) Prescribing Information
http://products.sanofi.us/cablivi/cablivi.pdf

Feb 5th, 2019 - CABLIVI is a von Willebrand factor (vWF)-directed antibody fragment indicated for the treatment of adult patients with acquired thrombotic thrombocytopenic purpura (aTTP), in combination with plasma exchange and immunosuppressive therapy.

Caplacizumab Treatment for Acquired Thrombotic Thrombocytopenic Purpura
https://www.nejm.org/doi/10.1056/NEJMoa1806311
Scully,M.,et al

Jan 23rd, 2019 - In acquired thrombotic thrombocytopenic purpura (TTP), an immune-mediated deficiency of the von Willebrand factor–cleaving protease ADAMTS13 allows unrestrained adhesion of von Willebrand factor multimers to platelets and microthrombosis, which re...

Caplacizumab for Acquired Thrombotic Thrombocytopenic Purpura
https://www.jwatch.org/na48305/2019/01/17/caplacizumab-acquired-thrombotic-thrombocytopenic-purpura
Green,David

Jan 16th, 2019 - Patients with acquired thrombotic thrombocytopenic purpura (TTP) have von Willebrand factor (VWF)–mediated platelet aggregates that ...HERCULES Trial

Platelet-dependent von Willebrand factor activity. Nomenclature and methodology: commun...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5576173
Journal of Thrombosis and Haemostasis : JTH; Bodó I, Eikenboom J et. al.

Apr 10th, 2015 - Platelet-dependent von Willebrand factor activity. Nomenclature and methodology: communication from the SSC of the ISTH.|2015|Bodó I,Eikenboom J,Montgomery R,Patzke J,Schneppenheim R,|blood,chemistry,classification,standards,classification,standar...

Evidence-based recommendations on the treatment of von Willebrand disease in Italy.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2689066
Blood Transfusion = Trasfusione Del Sangue; Mannucci PM, Franchini M et. al.

Jun 8th, 2009 - von Willebrand disease (VWD) is the most common hereditary bleeding disorder affecting both males and females. It arises from quantitative or qualitative defects of von Willebrand factor (VWF) and causes bleeding of mucous membranes and soft tissu...

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Drugs  17 results see all →

Clinicaltrials.gov  5,415 results

Endothelial colony forming cells generated from cryopreserved peripheral blood mononucl...
https://doi.org/10.1016/j.humimm.2021.02.009
Human Immunology; Béland S, Désy O et. al.

Mar 2nd, 2021 - Derivation of endothelial colony forming cells (ECFCs) from peripheral blood mononuclear cells (PBMCs) is a technique that could provide access to donor endothelial cells to study donor endothelium/recipient immune cells interactions. The success ...

Gut microbiota and their metabolites in cardiovascular disease.
https://doi.org/10.1016/j.beem.2021.101492
Best Practice & Research. Clinical Endocrinology & Metabo... Jansen VL, Gerdes VE et. al.

Mar 1st, 2021 - The gut microbiome affects the development and progress of various types of disease such as obesity, diabetes, atherosclerosis and arterial thrombosis. Gut microbiome derived metabolites have been established to be predictive of arterial thrombosi...

Uremic serum induces prothrombotic changes in venous endothelial cells and inflammatory...
https://doi.org/10.1080/0886022X.2021.1890617
Renal Failure; Sosińska-Zawierucha P, Bręborowicz A

Mar 1st, 2021 - Uremia induces various pathologic changes in the endothelium. However, there is limited information about the differences of these effects in endothelial cells originating from different parts of the vascular tree. The effect of uremic serum obtai...

Toward Personalized Treatment for Patients with Low von Willebrand Factor and Quantitat...
https://doi.org/10.1055/s-0041-1722864
Seminars in Thrombosis and Hemostasis; O'Donnell JS

Feb 26th, 2021 - The biological mechanisms involved in the pathogenesis of type 2 and type 3 von Willebrand disease (VWD) have been studied extensively. In contrast, although accounting for the majority of VWD cases, the pathobiology underlying partial quantitativ...

Current Challenges in the Peripartum Management of Women with von Willebrand Disease.
https://doi.org/10.1055/s-0041-1723797
Seminars in Thrombosis and Hemostasis; Byrne B, Ryan K et. al.

Feb 26th, 2021 - For many women, pregnancy and childbirth represent their first major hemostatic challenges. Despite advancements in obstetric care, up to 2 to 5% of all deliveries are complicated by postpartum hemorrhage (PPH). To mitigate bleeding risk, physiolo...

see more →

News  113 results

Important Drug Information - Humate-P [Antihemophilic Factor/von Willebrand Factor Complex (Human)] | FDA
https://www.fda.gov/vaccines-blood-biologics/recalls-biologics/important-drug-information-humate-p-antihemophilic-factorvon-willebrand-factor-complex-human

DATE NOTIFICATION INITIATED:  October 3, 2019 PRODUCT / LOT NUMBER: Humate-P [Antihemophilic Factor/von Willebrand Factor Complex (Human)] Lots of All Fill Sizes (600, 1200, 2400 IUs) distributed by CSL Behring since February 2019  MANUFACTURER:  ...

2019 at a glance: Hem-onc U.S. drug approvals
https://www.mdedge.com/jcomjournal/article/211340/mixed-topics/2019-glance-hem-onc-us-drug-approvals/page/0/1?channel=325

Oct 31st, 2019 - Caplacizumab-yhdp (Cablivi) Class: Monoclonal antibody fragment directed against von Willebrand factor. Disease: Thrombotic thrombocytopenic purpura.

Need for VWF concentrate therapy appears low
https://www.mdedge.com/hematology-oncology/article/202868/bleeding-disorders/need-vwf-concentrate-therapy-appears-low?channel=27970
Caleb Rans

Jun 13th, 2019 - Only a limited number of patients with von Willebrand disease (VWD) are likely to require treatment with von Willebrand factor (VWF) concentrates, according to results from a retrospective analysis. The retrospective, single-center study sought to.

Liver resection appears safe in patients with hemophilia, VWD
https://www.mdedge.com/hematology-oncology/article/202863/bleeding-disorders/liver-resection-appears-safe-patients?channel=27970
Caleb Rans

Jun 13th, 2019 - Undergoing hepatectomy for the treatment of hepatocellular carcinoma in patients with von Willebrand disease or hemophilia A was found to be safe through the use of appropriate von Willebrand factor concentrate or recombinant factor VIII therapy,.

FVIII/W ratio may help predict relapse in hemophilia A
https://www.mdedge.com/hematology-oncology/article/201468/bleeding-disorders/fviii/w-ratio-may-help-predict-relapse?channel=27970
Caleb Rans

May 22nd, 2019 - The FVIII/W (factor VIII:C/von Willebrand factor antigen) ratio appears to be a reliable biological marker to predict recovery and/or relapse in patients with acquired hemophilia A, according to a retrospective analysis. Marc Trossaert, MD, PhD, o.

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Patient Education  3 results see all →