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About 10,998 results

ALLMedicine™ Von Willebrand Factor Center

Research & Reviews  5,393 results

The association of von willebrand factor and its cleaving protease (ADAMTS13) with heal...
https://doi.org/10.1080/1354750X.2021.1923063
Biomarkers : Biochemical Indicators of Exposure, Response... Navise NH, Lammertyn L et. al.

May 3rd, 2021 - To reduce cardiovascular risks imposed by Von Willebrand factor (vWF) and ADAMTS13 from young ages, knowledge on health behaviours that may affect their concentrations is essential. We therefore determined whether circulating vWF antigen and ADAMT...

Acrolein Induces Systemic Coagulopathy via Autophagy-dependent Secretion of von Willebr...
https://doi.org/10.1007/s12264-021-00681-0
Neuroscience Bulletin; Cui W, Wu X et. al.

May 3rd, 2021 - Traumatic brain injury (TBI)-induced coagulopathy has increasingly been recognized as a significant risk factor for poor outcomes, but the pathogenesis remains poorly understood. In this study, we aimed to investigate the causal role of acrolein, ...

Differential regulation of the platelet GPIb-IX complex by anti-GPIbβ antibodies.
https://doi.org/10.1111/jth.15359
Journal of Thrombosis and Haemostasis : JTH; Quach ME, Chen W et. al.

Apr 29th, 2021 - Platelets' initial recognition of endothelial damage proceeds through the interaction between collagen, plasma von Willebrand factor (VWF), and the platelet glycoprotein (GP)Ib-IX complex (CD42). GPIb-IX complex consists of one GPIbα, one GPIX, an...

Endothelial Markers: Thrombomodulin and Von Willebrand Factor and Risk of Kidney Thromb...
https://doi.org/10.1016/j.transproceed.2021.03.011
Transplantation Proceedings; Ziętek Z

Apr 24th, 2021 - Endothelial disturbance is well known as one of the causes of thrombosis. This study measured von Willebrand factor (vWF) and soluble thrombomodulin (sTM) in renal vein blood to evaluate for the risk of thrombosis after kidney transplantation. A c...

Increased VWF and Decreased ADAMTS-13 in COVID-19: Creating a Milieu for (Micro)Thrombo...
https://doi.org/10.1055/s-0041-1727282
Seminars in Thrombosis and Hemostasis; Favaloro EJ, Henry BM et. al.

Apr 24th, 2021 - von Willebrand factor (VWF) is a large adhesive multimeric protein involved in hemostasis. The larger the size (or number of VWF multimers), the greater the functionality of the protein. A deficiency or defect of VWF can lead to von Willebrand dis...

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Guidelines  13 results

CABLIVI (caplacizumab-yhdp) Prescribing Information
http://products.sanofi.us/cablivi/cablivi.pdf

Feb 5th, 2019 - CABLIVI is a von Willebrand factor (vWF)-directed antibody fragment indicated for the treatment of adult patients with acquired thrombotic thrombocytopenic purpura (aTTP), in combination with plasma exchange and immunosuppressive therapy.

Caplacizumab Treatment for Acquired Thrombotic Thrombocytopenic Purpura
https://www.nejm.org/doi/10.1056/NEJMoa1806311
Scully,M.,et al

Jan 23rd, 2019 - In acquired thrombotic thrombocytopenic purpura (TTP), an immune-mediated deficiency of the von Willebrand factor–cleaving protease ADAMTS13 allows unrestrained adhesion of von Willebrand factor multimers to platelets and microthrombosis, which re...

Caplacizumab for Acquired Thrombotic Thrombocytopenic Purpura
https://www.jwatch.org/na48305/2019/01/17/caplacizumab-acquired-thrombotic-thrombocytopenic-purpura
Green,David

Jan 16th, 2019 - Patients with acquired thrombotic thrombocytopenic purpura (TTP) have von Willebrand factor (VWF)–mediated platelet aggregates that ...HERCULES Trial

Platelet-dependent von Willebrand factor activity. Nomenclature and methodology: commun...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5576173
Journal of Thrombosis and Haemostasis : JTH; Bodó I, Eikenboom J et. al.

Apr 10th, 2015 - Platelet-dependent von Willebrand factor activity. Nomenclature and methodology: communication from the SSC of the ISTH.|2015|Bodó I,Eikenboom J,Montgomery R,Patzke J,Schneppenheim R,|blood,chemistry,classification,standards,classification,standar...

Evidence-based recommendations on the treatment of von Willebrand disease in Italy.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2689066
Blood Transfusion = Trasfusione Del Sangue; Mannucci PM, Franchini M et. al.

Jun 8th, 2009 - von Willebrand disease (VWD) is the most common hereditary bleeding disorder affecting both males and females. It arises from quantitative or qualitative defects of von Willebrand factor (VWF) and causes bleeding of mucous membranes and soft tissu...

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Drugs  17 results see all →

Clinicaltrials.gov  5,457 results

The association of von willebrand factor and its cleaving protease (ADAMTS13) with heal...
https://doi.org/10.1080/1354750X.2021.1923063
Biomarkers : Biochemical Indicators of Exposure, Response... Navise NH, Lammertyn L et. al.

May 3rd, 2021 - To reduce cardiovascular risks imposed by Von Willebrand factor (vWF) and ADAMTS13 from young ages, knowledge on health behaviours that may affect their concentrations is essential. We therefore determined whether circulating vWF antigen and ADAMT...

Acrolein Induces Systemic Coagulopathy via Autophagy-dependent Secretion of von Willebr...
https://doi.org/10.1007/s12264-021-00681-0
Neuroscience Bulletin; Cui W, Wu X et. al.

May 3rd, 2021 - Traumatic brain injury (TBI)-induced coagulopathy has increasingly been recognized as a significant risk factor for poor outcomes, but the pathogenesis remains poorly understood. In this study, we aimed to investigate the causal role of acrolein, ...

Differential regulation of the platelet GPIb-IX complex by anti-GPIbβ antibodies.
https://doi.org/10.1111/jth.15359
Journal of Thrombosis and Haemostasis : JTH; Quach ME, Chen W et. al.

Apr 29th, 2021 - Platelets' initial recognition of endothelial damage proceeds through the interaction between collagen, plasma von Willebrand factor (VWF), and the platelet glycoprotein (GP)Ib-IX complex (CD42). GPIb-IX complex consists of one GPIbα, one GPIX, an...

A New Biomarker of Traumatic Brain Injury?
https://www.medscape.com/viewarticle/949972

Apr 25th, 2021 - Plasma levels of von Willebrand factor may be a useful biomarker of traumatic brain injury (TBI) and its severity, new research suggests. "Reliable detection of this biomarker at very early time points may allow for prompt TBI detection and theref...

Endothelial Markers: Thrombomodulin and Von Willebrand Factor and Risk of Kidney Thromb...
https://doi.org/10.1016/j.transproceed.2021.03.011
Transplantation Proceedings; Ziętek Z

Apr 24th, 2021 - Endothelial disturbance is well known as one of the causes of thrombosis. This study measured von Willebrand factor (vWF) and soluble thrombomodulin (sTM) in renal vein blood to evaluate for the risk of thrombosis after kidney transplantation. A c...

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News  115 results

A New Biomarker of Traumatic Brain Injury?
https://www.medscape.com/viewarticle/949972

Apr 25th, 2021 - Plasma levels of von Willebrand factor may be a useful biomarker of traumatic brain injury (TBI) and its severity, new research suggests. "Reliable detection of this biomarker at very early time points may allow for prompt TBI detection and theref...

Important Drug Information - Humate-P [Antihemophilic Factor/von Willebrand Factor Complex (Human)] | FDA
https://www.fda.gov/vaccines-blood-biologics/recalls-biologics/important-drug-information-humate-p-antihemophilic-factorvon-willebrand-factor-complex-human

DATE NOTIFICATION INITIATED:  October 3, 2019 PRODUCT / LOT NUMBER: Humate-P [Antihemophilic Factor/von Willebrand Factor Complex (Human)] Lots of All Fill Sizes (600, 1200, 2400 IUs) distributed by CSL Behring since February 2019  MANUFACTURER:  ...

2019 at a glance: Hem-onc U.S. drug approvals
https://www.mdedge.com/jcomjournal/article/211340/mixed-topics/2019-glance-hem-onc-us-drug-approvals/page/0/1?channel=325

Oct 31st, 2019 - Caplacizumab-yhdp (Cablivi) Class: Monoclonal antibody fragment directed against von Willebrand factor. Disease: Thrombotic thrombocytopenic purpura.

Need for VWF concentrate therapy appears low
https://www.mdedge.com/hematology-oncology/article/202868/bleeding-disorders/need-vwf-concentrate-therapy-appears-low?channel=27970
Caleb Rans

Jun 13th, 2019 - Only a limited number of patients with von Willebrand disease (VWD) are likely to require treatment with von Willebrand factor (VWF) concentrates, according to results from a retrospective analysis. The retrospective, single-center study sought to.

Liver resection appears safe in patients with hemophilia, VWD
https://www.mdedge.com/hematology-oncology/article/202863/bleeding-disorders/liver-resection-appears-safe-patients?channel=27970
Caleb Rans

Jun 13th, 2019 - Undergoing hepatectomy for the treatment of hepatocellular carcinoma in patients with von Willebrand disease or hemophilia A was found to be safe through the use of appropriate von Willebrand factor concentrate or recombinant factor VIII therapy,.

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Patient Education  3 results see all →