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ALLMedicine™ Activated Protein C Resistance Center

Research & Reviews  10 results

A multi-laboratory assessment of congenital thrombophilia assays performed on the ACL T...
https://doi.org/10.1515/cclm-2021-0499
Clinical Chemistry and Laboratory Medicine; Favaloro EJ, Mohammed S et. al.

Jun 12th, 2021 - Thrombophilia testing is commonly performed within hemostasis laboratories, and the ACL TOP 50 family of instruments represent a new 'single platform' of hemostasis instrumentation. The study objective was to evaluate these instruments and manufac...

Insight into the hypercoagulable state of high-risk thrombotic APS patients: Contributi...
https://doi.org/10.1111/jth.15199
Journal of Thrombosis and Haemostasis : JTH; Pontara E, Cattini MG et. al.

Nov 30th, 2020 - Most high-risk thrombotic antiphospholipid syndrome (APS) patients test positive for anti-β2-glycoprotein I (aβ2GPI) and anti-phosphatidylserine/prothrombin (aPS/PT) antibodies. Information on the influence of these antibodies on thrombin generati...

Laboratory testing for activated protein C resistance: rivaroxaban induced interference...
https://doi.org/10.1515/cclm-2019-1160
Clinical Chemistry and Laboratory Medicine; Favaloro EJ, Gilmore G et. al.

Mar 4th, 2020 - Background Investigation of hemostasis is problematic when patients are on anticoagulant therapy. Rivaroxaban especially causes substantial interference, extending many clot-based tests, thereby leading to false positive or negative events. In par...

Apixaban Does Not Interfere With Protein S or Activated Protein C Resistance (Factor V ...
https://doi.org/10.5858/arpa.2019-0497-OA
Archives of Pathology & Laboratory Medicine; Maryamchik E, Van Cott EM

Feb 27th, 2020 - Apixaban causes a false increase in activated protein C resistance (APCR) ratios and possibly protein S activity. To investigate whether this increase can mask a diagnosis of factor V Leiden (FVL) or protein S deficiency in an actual population of...

Proof of concept of a new scale for the harmonization and the standardization of the ET...
https://doi.org/10.1111/jth.14745
Journal of Thrombosis and Haemostasis : JTH; Morimont L, Bouvy C et. al.

Jan 28th, 2020 - The evaluation of the activated protein C resistance (APCr) based on the endogenous thrombin potential (ETP) is recommended during the development of steroid contraceptives. Results are usually expressed as "normalized APC sensitivity ratio" (nAPC...

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