ALLMedicine™ Haptoglobin Center

Nov 19th, 2021 - Prosthetic paravalvular leaks (PVL) are associated with congestive heart failure and haemolysis, for which the standard treatment is open-heart surgery with the attendant risks to the patient. Transcatheter closure has emerged as an alternative. P...

Nov 18th, 2021 - The haptoglobin (Hp)2-2 phenotype (∼35-40% of people) is associated with increased oxidation and dysfunctional HDL in hyperglycemia and may explain why drugs designed to pharmacologically raise HDL cholesterol and lower triglycerides have not reli...

Nov 5th, 2021 - The present study compared the accuracy of visually analyzed (VA) and automatically analyzed (AA) ColonView (CV) quick test; a new-generation fecal immunochemical test (FIT) for hemoglobin (Hb) and hemoglobin/haptoglobin (Hb/Hp) (Biohit Oyj, Helsi...

Nov 5th, 2021 - Laboratory Studies Investigations to rule out hemolysis (complete blood count [CBC], reticulocyte count, peripheral smear review, lactate dehydrogenase [LDH], bilirubin, haptoglobin and Heinz body preparation) and end-organ dysfunction or failure ...

Nov 5th, 2021 - Laboratory Studies Investigations to rule out hemolysis (complete blood count [CBC], reticulocyte count, peripheral smear review, lactate dehydrogenase [LDH], bilirubin, haptoglobin and Heinz body preparation) and end-organ dysfunction or failure ...

Nov 19th, 2021 - Prosthetic paravalvular leaks (PVL) are associated with congestive heart failure and haemolysis, for which the standard treatment is open-heart surgery with the attendant risks to the patient. Transcatheter closure has emerged as an alternative. P...

Oct 6th, 2021 - This is a Phase 1b single-center, dose-escalating study to evaluate the pharmacodynamic effect of FeS in healthy volunteers and in subjects with stage 3-4 CKD. The following biomarkers will be used as surrogate measures of protective activity: Hap...

Jan 14th, 2021 - Newborns and children with life-threatening heart and lung failure may require support with ECMO (extracorporeal membrane oxygenation). With ECMO, oxygen and carbon dioxide are exchanged and circulated throughout the body even if the heart is unab...

May 11th, 2020 - This is a Phase 1b, single-center, dose-escalating study to evaluate the safety, tolerability, and pharmacodynamic effect of RBT-1 in healthy volunteers and in subjects with stage 3b-4 CKD. The following biomarkers will be used as surrogate measur...

Feb 28th, 2020 - For patient safety, the investigators will measure the following labs: Blood tests (routine safety and frequency). CBC/platelets: q 1 hr, at HD next day ABGs, including lactate: Q 1 hr x 6 Na, K, Cl, Bicarb, BUN, Creatinine, Ca, ionized Ca, Mg, Ph...

Sep 10th, 2021 - Background Evans’ syndrome is a rare entity characterized by concomitant or sequential multilineage cytopenia particularly autoimmune hemolytic anemia, ITP and very rarely autoimmune neutropenia. Although more common in young adults, it can occur.

Jul 22nd, 2021 - Transplant-associated thrombotic microangiopathy (TA-TMA) is a complication of stem cell transplants that can occur with peripherally mobilized stem cells or bone marrow-derived stem cells. TA-TMA remains a difficult complication to address, with ...

May 21st, 2021 - The FDA has announced that it will need more time to review the biologics license application (BLA) for narsoplimab as a potential therapeutic option in patients with hematopoietic stem cell transplant–associated thrombotic microangiopathy (HSCT-T...

Dec 4th, 2020 - Sangeeta R. Hingorani, MD, MPH Kidney complications often occur following successful hematopoietic stem cell transplantation (HSCT) from a myriad of underlying etiologies, according to up-to-date information provided during an educational session...

Dec 4th, 2020 - Sonata Jodele, MD While complex, criteria for diagnosing transplant-associated thrombotic microangiopathy (TA-TMA) following hematopoietic stem cell transplantation (HSCT) should be closely followed and should begin with screening, according to a...