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About 568 results

ALLMedicine™ Methemoglobin Center

Research & Reviews  200 results

Elevated methemoglobin levels in patients treated with hydroxocobalamin: a case series ...
https://doi.org/10.1080/15563650.2022.2072315
Clinical Toxicology (Philadelphia, Pa.); Kiernan EA, Carpenter JE et. al.

May 14th, 2022 - Historically, the first step in treating cyanide (CN-) toxicity utilized antidotes to induce methemoglobinemia. This is concerning in patients who are already hypoxemic or have elevated carboxyhemoglobin. Hydroxocobalamin (OHCbl) is now the first-...

Testing the Addition of an Anti-cancer Drug, Triapine, to the Usual Radiation-Based Treatment (Lutetium Lu 177 Dotatate) for Neuroendocrine Tumors
https://clinicaltrials.gov/ct2/show/NCT04234568

May 4th, 2022 - PRIMARY OBJECTIVE: I. To evaluate the safety and to determine the recommended phase 2 dose (RP2D) of lutetium Lu 177 dotatate in combination with triapine. SECONDARY OBJECTIVES: I. To observe and record anti-tumor activity. II. To determine the ov...

Inhaled Nitric Oxide After Out-of-Hospital Cardiac Arrest
https://clinicaltrials.gov/ct2/show/NCT03079102

Apr 25th, 2022 - Subjects will be identified upon emergency department (ED) arrival or upon transfer from an outside facility and screened for enrollment by a PCAS physician as soon as possible. Eligible patients will have receive any required resuscitation (inclu...

Acquired methemoglobinemia in children presenting to Italian pediatric emergency depart...
https://doi.org/10.1080/15563650.2022.2061986
Clinical Toxicology (Philadelphia, Pa.); Raucci U, Stanco M et. al.

Apr 14th, 2022 - Methemoglobinemia (MetHb) is a rare inherited or acquired cause of cyanosis in children. Owing to its rarity, case reports and case series are mostly available in the current literature. This study reports data on a large sample of children with a...

Two cases of fatal methemoglobinemia caused by self-poisoning with sodium nitrite: A ca...
https://doi.org/10.1097/MD.0000000000028810
Medicine Mun SH, Park GJ et. al.

Apr 2nd, 2022 - Sodium nitrite intoxication reportedly causes severe methemoglobinemia. Recent studies reported that most clinically significant cases resulted from intentional exposure in suicidal attempts. We describe 2 cases of severe methemoglobinemia seconda...

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Drugs  6 results see all →

Clinicaltrials.gov  13 results

Testing the Addition of an Anti-cancer Drug, Triapine, to the Usual Radiation-Based Treatment (Lutetium Lu 177 Dotatate) for Neuroendocrine Tumors
https://clinicaltrials.gov/ct2/show/NCT04234568

May 4th, 2022 - PRIMARY OBJECTIVE: I. To evaluate the safety and to determine the recommended phase 2 dose (RP2D) of lutetium Lu 177 dotatate in combination with triapine. SECONDARY OBJECTIVES: I. To observe and record anti-tumor activity. II. To determine the ov...

Inhaled Nitric Oxide After Out-of-Hospital Cardiac Arrest
https://clinicaltrials.gov/ct2/show/NCT03079102

Apr 25th, 2022 - Subjects will be identified upon emergency department (ED) arrival or upon transfer from an outside facility and screened for enrollment by a PCAS physician as soon as possible. Eligible patients will have receive any required resuscitation (inclu...

Safety and Efficacy of Different Regimens of Primaquine on Vivax Malaria Treatment in G6PD Deficient Patients
https://clinicaltrials.gov/ct2/show/NCT03529396

Mar 21st, 2022 - This is an open-label, randomized, phase II, clinical trial of safety and efficacy. Patients will be screened for eligibility and treated at the Fundação de Medicina Tropical Dr Heitor Vieira Dourado in Manaus and the Centro de Pesquisa em Medicin...

Triapine With Chemotherapy and Radiation Therapy in Treating Patients With IB2-IVA Cervical or Vaginal Cancer
https://clinicaltrials.gov/ct2/show/NCT02595879

Mar 14th, 2022 - PRIMARY OBJECTIVES: I. To determine the maximum tolerable dose (MTD) and recommended phase II dose (RP2D) of oral triapine when used in combination with cisplatin plus radiation therapy. II. To determine the oral bioavailability of triapine. III. ...

Nitrite Infusion in Children With Malaria
https://clinicaltrials.gov/ct2/show/NCT04289558

Mar 16th, 2021 - This is a Phase I, open-label, dose-escalation study that will enroll up to 24 patients total, using a 3+3 dose escalation design, with 3 to 6 patients per dose level at up to 4 sequential dose levels (0.16, 0.32, 0.64 and 1.28 mcg/kg/minute). At ...

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News  8 results

Nitric Oxide Eases Respiratory Distress in Pregnant COVID-19 Patients
https://www.medscape.com/viewarticle/936949

Sep 8th, 2020 - NEW YORK (Reuters Health) - High-dose inhaled nitric oxide (iNO) rapidly improves breathlessness and oxygenation in pregnant women with severe COVID-19, according to a new report. Five of the six patients in the study did not receive antiviral the...

Stop Using OTC Benzocaine Teething Products, FDA Says
https://www.medscape.com/viewarticle/897136

May 23rd, 2018 - The US Food and Drug Administration (FDA) is warning consumers to immediately stop using benzocaine-containing over-the-counter drug products, including those used to treat teething pain, in infants and children under 2 years of age as they can po...

Table of Surrogate Endpoints That Were the Basis of Drug Approval or Licensure
http://www.fda.gov/drugs/development-resources/table-surrogate-endpoints-were-basis-drug-approval-or-licensure

What is the purpose of the Surrogate Endpoint Table? FDA’s surrogate endpoint table provides valuable information for drug developers on endpoints that may be considered and discussed with FDA for individual development programs. This table also f...

Topical Benzocaine Associated With Methemoglobinemia
https://www.medscape.com/viewarticle/740431

Apr 7th, 2011 - Topical benzocaine spray April 7, 2011 (UPDATED April 12, 2011) — Topical benzocaine sprays, gels, and liquids used as anesthesia during medical procedures and for analgesia from tooth and gum pain may cause methemoglobinemia, a rare but serious a...

Vomiting, Weakness, and Skin Discoloration in a 9-Year-Old Child
https://www.medscape.com/viewarticle/726070

Aug 4th, 2010 - Case Presentation A previously healthy 9-year-old boy presented to a pediatric emergency department (ED) with chief complaints of protracted vomiting and weakness. His mother reported that he had been weak for the last few days and that his weakne...

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