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About 868 results

ALLMedicine™ Methemoglobin Center

Research & Reviews  279 results

Testing the Addition of an Anti-cancer Drug, Triapine, to the Usual Radiation-Based Treatment (Lutetium Lu 177 Dotatate) for Neuroendocrine Tumors
https://clinicaltrials.gov/ct2/show/NCT04234568

Jan 20th, 2023 - PRIMARY OBJECTIVE: I. To evaluate the safety and to determine the recommended phase 2 dose (RP2D) of lutetium Lu 177 dotatate in combination with triapine. SECONDARY OBJECTIVES: I. To observe and record anti-tumor activity. II. To determine the ov...

Triapine With Chemotherapy and Radiation Therapy in Treating Patients With IB2-IVA Cervical or Vaginal Cancer
https://clinicaltrials.gov/ct2/show/NCT02595879

Jan 11th, 2023 - PRIMARY OBJECTIVES: I. To determine the maximum tolerable dose (MTD) and recommended phase II dose (RP2D) of oral triapine when used in combination with cisplatin plus radiation therapy. II. To determine the oral bioavailability of triapine. III. ...

A Case Report of Hypotension and Methemoglobinemia Associated With Gunshot Residue Pois...
https://doi.org/10.1213/XAA.0000000000001631
A&A Practice; Pugh DB, Saxena A et. al.

Jan 5th, 2023 - A patient with gunshots within inches of the skin developed intraoperative vasodilatory hypotension and methemoglobinemia, both recognized consequences of nitrite poisoning. A 1- mg/kg dose of methylene blue transiently and partially reversed meth...

Clinical and laboratory presentation of first-time antenatal care visits of pregnant wo...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9812315
PloS One; Abuku VG, Allotey EA et. al.

Jan 5th, 2023 - The WHO recommends pregnant women attend antenatal clinic at least three times during pregnancy; during the first, second and third trimesters. During these visits, an array of clinical and laboratory tests is conducted. The information obtained p...

Topical Sodium Nitrite in Sickle Cell Disease and Leg Ulcers
https://clinicaltrials.gov/ct2/show/NCT02863068

Jan 4th, 2023 - Chronic leg ulcers are a complication of many blood disorders such as sickle cell disease, thalassemia, and other red blood cell disorders. In these disorders, red blood cells break down earlier than normal, which researchers suspect may cause or ...

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Drugs  12 results see all →

Clinicaltrials.gov  45 results

Testing the Addition of an Anti-cancer Drug, Triapine, to the Usual Radiation-Based Treatment (Lutetium Lu 177 Dotatate) for Neuroendocrine Tumors
https://clinicaltrials.gov/ct2/show/NCT04234568

Jan 20th, 2023 - PRIMARY OBJECTIVE: I. To evaluate the safety and to determine the recommended phase 2 dose (RP2D) of lutetium Lu 177 dotatate in combination with triapine. SECONDARY OBJECTIVES: I. To observe and record anti-tumor activity. II. To determine the ov...

Triapine With Chemotherapy and Radiation Therapy in Treating Patients With IB2-IVA Cervical or Vaginal Cancer
https://clinicaltrials.gov/ct2/show/NCT02595879

Jan 11th, 2023 - PRIMARY OBJECTIVES: I. To determine the maximum tolerable dose (MTD) and recommended phase II dose (RP2D) of oral triapine when used in combination with cisplatin plus radiation therapy. II. To determine the oral bioavailability of triapine. III. ...

Topical Sodium Nitrite in Sickle Cell Disease and Leg Ulcers
https://clinicaltrials.gov/ct2/show/NCT02863068

Jan 4th, 2023 - Chronic leg ulcers are a complication of many blood disorders such as sickle cell disease, thalassemia, and other red blood cell disorders. In these disorders, red blood cells break down earlier than normal, which researchers suspect may cause or ...

Testing the Addition of a New Anti-Cancer Drug, Triapine, to the Usual Chemotherapy Treatment (Cisplatin) During Radiation Therapy for Advanced-stage Cervical and Vaginal Cancers
https://clinicaltrials.gov/ct2/show/NCT02466971

Jan 3rd, 2023 - PRIMARY OBJECTIVE: I. To evaluate the efficacy of the experimental regimen of triapine (3AP), cisplatin, and radiation to increase overall survival relative to the standard/control regimen of cisplatin and radiation in women with uterine cervix or...

Methemoglobin Concentration in High Dose Inhaled Nitric Oxide
https://clinicaltrials.gov/ct2/show/NCT05612074

Nov 14th, 2022 - The current proposed physiologic study is a single center, open-label clinical trial in healthy subjects. The primary aim is to describe kinetics of methemoglobin (MetHb) formation and reduction during exposure to high dose inhaled nitric oxide (i...

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News  11 results

Nitric Oxide Eases Respiratory Distress in Pregnant COVID-19 Patients
https://www.medscape.com/viewarticle/936949

Sep 8th, 2020 - NEW YORK (Reuters Health) - High-dose inhaled nitric oxide (iNO) rapidly improves breathlessness and oxygenation in pregnant women with severe COVID-19, according to a new report. Five of the six patients in the study did not receive antiviral the...

Stop Using OTC Benzocaine Teething Products, FDA Says
https://www.medscape.com/viewarticle/897136

May 23rd, 2018 - The US Food and Drug Administration (FDA) is warning consumers to immediately stop using benzocaine-containing over-the-counter drug products, including those used to treat teething pain, in infants and children under 2 years of age as they can po...

Hemoglobin nanoparticles could serve as blood substitute
https://www.mdedge.com/hematology-oncology/article/185737/blood-banking/hemoglobin-nanoparticles-could-serve-blood-substitute
HT Staff

Apr 20th, 2017 - Photo by Daniel Gay Blood in bags and vials A new type of hemoglobin-based oxygen carrier has shown early promise as a potential blood substitute, according to researchers. The team created nanoparticles consisting of bovine hemoglobin coated with.

Table of Surrogate Endpoints That Were the Basis of Drug Approval or Licensure
http://www.fda.gov/drugs/development-resources/table-surrogate-endpoints-were-basis-drug-approval-or-licensure

What is the purpose of the Surrogate Endpoint Table? FDA’s surrogate endpoint table provides valuable information for drug developers on endpoints that may be considered and discussed with FDA for individual development programs. This table also f...

Sequential laser therapy clears basal cell carcinomas
https://www.mdedge.com/surgery/article/58706/melanoma/sequential-laser-therapy-clears-basal-cell-carcinomas
Neil Osterweil

May 8th, 2013 - BOSTON – Sequential application of pulsed dye and Nd:YAG lasers is safe and effective for treating small basal cell carcinomas, based on data from a prospective study of patients with nodular and superficial BCC subtypes on the trunk and extremiti.

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