ALLMedicine™ Methemoglobin Center

May 14th, 2022 - Historically, the first step in treating cyanide (CN-) toxicity utilized antidotes to induce methemoglobinemia. This is concerning in patients who are already hypoxemic or have elevated carboxyhemoglobin. Hydroxocobalamin (OHCbl) is now the first-...

May 4th, 2022 - PRIMARY OBJECTIVE: I. To evaluate the safety and to determine the recommended phase 2 dose (RP2D) of lutetium Lu 177 dotatate in combination with triapine. SECONDARY OBJECTIVES: I. To observe and record anti-tumor activity. II. To determine the ov...

Apr 25th, 2022 - Subjects will be identified upon emergency department (ED) arrival or upon transfer from an outside facility and screened for enrollment by a PCAS physician as soon as possible. Eligible patients will have receive any required resuscitation (inclu...

Apr 14th, 2022 - Methemoglobinemia (MetHb) is a rare inherited or acquired cause of cyanosis in children. Owing to its rarity, case reports and case series are mostly available in the current literature. This study reports data on a large sample of children with a...

Apr 2nd, 2022 - Sodium nitrite intoxication reportedly causes severe methemoglobinemia. Recent studies reported that most clinically significant cases resulted from intentional exposure in suicidal attempts. We describe 2 cases of severe methemoglobinemia seconda...

May 4th, 2022 - PRIMARY OBJECTIVE: I. To evaluate the safety and to determine the recommended phase 2 dose (RP2D) of lutetium Lu 177 dotatate in combination with triapine. SECONDARY OBJECTIVES: I. To observe and record anti-tumor activity. II. To determine the ov...

Apr 25th, 2022 - Subjects will be identified upon emergency department (ED) arrival or upon transfer from an outside facility and screened for enrollment by a PCAS physician as soon as possible. Eligible patients will have receive any required resuscitation (inclu...

Mar 21st, 2022 - This is an open-label, randomized, phase II, clinical trial of safety and efficacy. Patients will be screened for eligibility and treated at the Fundação de Medicina Tropical Dr Heitor Vieira Dourado in Manaus and the Centro de Pesquisa em Medicin...

Mar 14th, 2022 - PRIMARY OBJECTIVES: I. To determine the maximum tolerable dose (MTD) and recommended phase II dose (RP2D) of oral triapine when used in combination with cisplatin plus radiation therapy. II. To determine the oral bioavailability of triapine. III. ...

Mar 16th, 2021 - This is a Phase I, open-label, dose-escalation study that will enroll up to 24 patients total, using a 3+3 dose escalation design, with 3 to 6 patients per dose level at up to 4 sequential dose levels (0.16, 0.32, 0.64 and 1.28 mcg/kg/minute). At ...

Sep 8th, 2020 - NEW YORK (Reuters Health) - High-dose inhaled nitric oxide (iNO) rapidly improves breathlessness and oxygenation in pregnant women with severe COVID-19, according to a new report. Five of the six patients in the study did not receive antiviral the...

May 23rd, 2018 - The US Food and Drug Administration (FDA) is warning consumers to immediately stop using benzocaine-containing over-the-counter drug products, including those used to treat teething pain, in infants and children under 2 years of age as they can po...

What is the purpose of the Surrogate Endpoint Table? FDA’s surrogate endpoint table provides valuable information for drug developers on endpoints that may be considered and discussed with FDA for individual development programs. This table also f...

Apr 7th, 2011 - Topical benzocaine spray April 7, 2011 (UPDATED April 12, 2011) — Topical benzocaine sprays, gels, and liquids used as anesthesia during medical procedures and for analgesia from tooth and gum pain may cause methemoglobinemia, a rare but serious a...

Aug 4th, 2010 - Case Presentation A previously healthy 9-year-old boy presented to a pediatric emergency department (ED) with chief complaints of protracted vomiting and weakness. His mother reported that he had been weak for the last few days and that his weakne...