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About 14,770 results

ALLMedicine™ Plasminogen Center

Research & Reviews  5,257 results

Impact of COVID-19 on thrombus composition and response to thrombolysis: Insights from ...
https://doi.org/10.1111/jth.15646
Journal of Thrombosis and Haemostasis : JTH; Desilles JP, Solo Nomenjanahary M et. al.

Jan 16th, 2022 - Resistance to fibrinolysis, levels of procoagulant/antifibrinolytic neutrophil extracellular traps (NETs), and the severity of acute ischemic stroke (AIS), are increased by COVID-19. Whether NETs are components of AIS thrombi from COVID-19 patient...

Pre-administration of a carboxypeptidase inhibitor enhances tPA-induced thrombolysis in...
https://doi.org/10.1016/j.thromres.2021.12.031
Thrombosis Research; Mathews NS, Suzuki Y et. al.

Jan 15th, 2022 - Thrombolysis using recombinant tissue-type plasminogen activator (rt-PA) is the pharmacological treatment of choice in acute thrombotic events. However, a narrow therapeutic window and bleeding complications limit its use. We describe the role of ...

Tenecteplase use in the management of acute ischemic stroke: Literature review and clin...
https://doi.org/10.1093/ajhp/zxac010
American Journal of Health-system Pharmacy : AJHP : Offic... Hailu K, Cannon C et. al.

Jan 13th, 2022 - In an effort to expedite the publication of articles related to the COVID-19 pandemic, AJHP is posting these manuscripts online as soon as possible after acceptance. Accepted manuscripts have been peer-reviewed and copyedited, but are posted onlin...

The Role of Plasminogen Activator Inhibitor Type 1 (PAI-1) in Placenta-Mediated Pregnan...
https://doi.org/10.1055/s-0041-1742082
Seminars in Thrombosis and Hemostasis; Agersnap I, Nissen PH et. al.

Jan 13th, 2022 - Plasminogen activator inhibitor type 1 (PAI-1) is a main inhibitor of fibrinolysis. The PAI-1 gene (SERPINE1) harbors genetic variants with the potential of modifying plasma levels of PAI-1. A delicate balance exists between the coagulation and fi...

Impact of Apixaban on Clinical Outcome of the Patients With Large Vessel Occlusion or Stenosis Trial
https://clinicaltrials.gov/ct2/show/NCT02818868

Jan 11th, 2022 - Four novel oral anticoagulants (NOACs) have been released to the market ahead of any county in the world. However, no information is available on the clinical results of NOACS and their secondary preventive effects in Japanese population. Medical ...

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Guidelines  5 results

Clinical Policy: Use of Intravenous Tissue Plasminogen Activator for the Management of ...
https://doi.org/10.1016/j.annemergmed.2015.06.031
Annals of Emergency Medicine; , Brown MD et. al.

Aug 26th, 2015 - Clinical Policy: Use of Intravenous Tissue Plasminogen Activator for the Management of Acute Ischemic Stroke in the Emergency Department.|2015| ,Brown MD,Burton JH,Nazarian DJ,Promes SB,|administration & dosage,adverse effects,therapeutic use,diag...

Pediatric hydrocephalus: systematic literature review and evidence-based guidelines. Pa...
https://doi.org/10.3171/2014.7.PEDS14322
Journal of Neurosurgery. Pediatrics; Mazzola CA, Choudhri AF et. al.

May 20th, 2015 - The objective of this systematic review and analysis was to answer the following question: What are the optimal treatment strategies for posthemorrhagic hydrocephalus (PHH) in premature infants? Both the US National Library of Medicine and the Coc...

Consensus statement on the use of intravenous recombinant tissue plasminogen activator ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6493470
CNS Neuroscience & Therapeutics; Xu AD, Wang YJ et. al.

May 29th, 2013 - The last update of the consensus statement on intravenous recombinant tissue plasminogen activator (IV rt-PA) for acute ischemic stroke (AIS) by the Chinese Stroke Therapy Expert Panel was published in 2006. Great progress has been made since then...

Antithrombotic and thrombolytic therapy for ischemic stroke: Antithrombotic Therapy and...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3278065
Chest Lansberg MG, O'Donnell MJ et. al.

Feb 15th, 2012 - This article provides recommendations on the use of antithrombotic therapy in patients with stroke or transient ischemic attack (TIA). We generated treatment recommendations (Grade 1) and suggestions (Grade 2) based on high (A), moderate (B), and ...

Expansion of the time window for treatment of acute ischemic stroke with intravenous ti...
https://doi.org/10.1161/STROKEAHA.109.192535
Stroke Del Zoppo GJ, Saver JL et. al.

May 30th, 2009 - Expansion of the time window for treatment of acute ischemic stroke with intravenous tissue plasminogen activator: a science advisory from the American Heart Association/American Stroke Association.|2009|Del Zoppo GJ,Saver JL,Jauch EC,Adams HP, ,|...

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Drugs  5 results see all →

Clinicaltrials.gov  167 results

Impact of Apixaban on Clinical Outcome of the Patients With Large Vessel Occlusion or Stenosis Trial
https://clinicaltrials.gov/ct2/show/NCT02818868

Jan 11th, 2022 - Four novel oral anticoagulants (NOACs) have been released to the market ahead of any county in the world. However, no information is available on the clinical results of NOACS and their secondary preventive effects in Japanese population. Medical ...

SITS-IVT in Patients >80 Years Study
https://clinicaltrials.gov/ct2/show/NCT04260347

Jan 11th, 2022 - A non-interventional post-approval study on Safe Implementation of Treatment in Stroke - International Stroke Thrombolysis Register (SITS-ISTR) existing data of intravenous recombinant tissue plasminogen Activator (rt-PA) (0.9 mg/kg) in acute isch...

Direct Mechanical Thrombectomy Versus Bridging Therapy
https://clinicaltrials.gov/ct2/show/NCT05155540

Jan 3rd, 2022 - This study compares the efficacy and safety of direct mechanical thrombectomy versus bridging therapy in patients with anterior circulation large vessel occlusion in a cohort of patients treated at the stroke unit of a single centre at Alexandria ...

Compare Between the Effect of Topical Tranexamic Acid Versus Hydrogen Peroxide on Blood Loss in Spine Surgeries
https://clinicaltrials.gov/ct2/show/NCT05152186

Dec 9th, 2021 - Spinal surgery is one of the most commonly performed neuro-surgeries worldwide. Massive blood loss occurs frequently and remains a challenge in complex spinal surgery. Significant intra and postoperative hemorrhage negatively affects patient outco...

Accuracy of Infection Biomarkers in the Investigation of Patients With Suspected Acute Pyelonephritis
https://clinicaltrials.gov/ct2/show/NCT04686318

Nov 29th, 2021 - Acute pyelonephritis (APN) is a severe acute infection in the upper urinary tract, which quite frequently is seen in the emergency department (ED). In our study, we define APN as a urinary tract infection with extension above the bladder, implicat...

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News  470 results

A fair trade-off
https://www.mdedge.com/neurology/article/248863/business-medicine/fair-trade
Allan M. Block, MD

Nov 17th, 2021 - One of the stranger casualties of the COVID pandemic was my inpatient neurology career. Dr.

Tranexamic Acid Found to Reduce Bruising in Blepharoplasty
https://www.medscape.com/viewarticle/962894

Nov 13th, 2021 - Tranexamic acid can reduce bleeding and bruising caused by upper eyelid blepharoplasty while facilitating surgery, researchers say. Administered in a local anesthesia injection, the drug caused no complications in a randomized, controlled trial, s...

Mobile Stroke Units Linked to Reduced Stroke Disability
https://www.medscape.com/viewarticle/958445

Sep 9th, 2021 - Treatment in a mobile stroke unit (MSU) is associated with better functional outcomes, compared with treatment by emergency medical services (EMS), among patients with acute ischemic stroke, a newly published study suggests. In an observational st...

Anakinra Improved Survival in Hospitalized COVID-19 Patients
https://www.medscape.com/viewarticle/958284

Sep 7th, 2021 - Editor's note: Find the latest COVID-19 news and guidance in Medscape's Coronavirus Resource Center. Hospitalized COVID-19 patients at increased risk for respiratory failure showed significant improvement after treatment with anakinra, compared wi...

'No Reason to Drop tPA' in Stroke Thrombectomy: SWIFT DIRECT
https://www.medscape.com/viewarticle/958080

Sep 2nd, 2021 - A new study has failed to show noninferiority of direct thrombectomy compared to bridging therapy with thrombolysis before thrombectomy for patients with large-vessel occlusion ischemic stroke. However, outcomes were very good for both groups. The...

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Patient Education  4 results see all →