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About 9,353 results

ALLMedicine™ Platelet Aggregation Center

Research & Reviews  3,061 results

The diagnostic accuracy of Sysmex XN for identification of pseudothrombocytopenia using...
https://doi.org/10.1111/ijlh.13920
International Journal of Laboratory Hematology; Lunde HE, Hjelmtvedt AN et. al.

Jun 26th, 2022 - The aim of this study was to investigate the diagnostic accuracy of the flag PLT-Clumps from the WNR/WDF and the PLT-F channels from Sysmex XN and to study how different cut-offs for investigation for pseudothrombocytopenia (PTCP) and the definiti...

Controls and Healthy Vasculature Initiative
https://clinicaltrials.gov/ct2/show/NCT05403151

Jun 24th, 2022 - Study Description: This study will serve to provide tissue samples from individuals with healthy vasculature for mechanistic studies of vascular inflammation and thrombosis. Objectives: Primary Objective: To collect samples from healthy volunteers...

Liver to lung microembolic NETs promote Gasdermin-D-dependent inflammatory lung injury ...
https://doi.org/10.1182/blood.2021014552
Blood Vats R, Kaminski TW et. al.

Jun 24th, 2022 - Acute lung injury, referred to as the acute chest syndrome, is a major cause of morbidity and mortality in patients with sickle cell disease (SCD), which often occurs in the setting of a vaso-occlusive painful crisis. P-selectin antibody therapy r...

Panax Notoginseng Saponins Combined with Dual Antiplatelet Drugs Potentiates Anti-Throm...
https://doi.org/10.1016/j.jstrokecerebrovasdis.2022.106597
Journal of Stroke and Cerebrovascular Diseases : the Offi... Wu Y, Wang W et. al.

Jun 19th, 2022 - To observe the combination effects of Panax notoginseng saponins (PNS)and dual antiplatelet drugs (DAPT), and to explore the mechanism via cyclooxygenase /prostaglandin pathway. Right carotid artery thrombosis was induced in Wistar rats by infiltr...

PIKfyve-Dependent Phosphoinositide Dynamics in Megakaryocyte/Platelet Granule Integrity...
https://doi.org/10.1161/ATVBAHA.122.317559
Arteriosclerosis, Thrombosis, and Vascular Biology; Caux M, Mansour R et. al.

Jun 17th, 2022 - Secretory granules are key elements for platelet functions. Their biogenesis and integrity are regulated by fine-tuned mechanisms that need to be fully characterized. Here, we investigated the role of the phosphoinositide 5-kinase PIKfyve and its ...

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Guidelines  1 results

Prophylaxis and management of venous thromboembolism in patients with myeloproliferativ...
https://doi.org/10.1007/s00277-014-2224-8
Annals of Hematology; Kreher S, Ochsenreither S et. al.

Oct 14th, 2014 - Patients with Philadelphia chromosome-negative myeloproliferative neoplasms (MPN) like polycythemia vera and essential thrombocythemia are at increased risk of arterial and venous thrombosis. Strategies of prevention may consist of platelet aggreg...

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Drugs  56 results see all →

Clinicaltrials.gov  443 results

Controls and Healthy Vasculature Initiative
https://clinicaltrials.gov/ct2/show/NCT05403151

Jun 24th, 2022 - Study Description: This study will serve to provide tissue samples from individuals with healthy vasculature for mechanistic studies of vascular inflammation and thrombosis. Objectives: Primary Objective: To collect samples from healthy volunteers...

Impact of Evolocumab on the Antiplatelet Effects of Ticagrelor and Aspirin in Patients With Acute Coronary Syndrome
https://clinicaltrials.gov/ct2/show/NCT05418166

Jun 14th, 2022 - Ticagrelor is a commercially available antiplatelet adenosine diphosphate (ADP) antagonists. They exert their antiplatelet effects by binding to P2Y12 receptors on the platelet surface. Ticagrelor is used in combination with aspirin to prevent and...

Effect of Differently Fed Farmed Gilthead Sea Bream Consumption
https://clinicaltrials.gov/ct2/show/NCT05417191

Jun 14th, 2022 - The trial was a double-blind randomized dietary intervention study with a 1:1 allocation ratio, conducted in accordance with the Declaration of Helsinki. This study compared two treatments, i.e., farmed fish fed with olive pomace enriched diet (en...

Genetic and Dietary Predictors of Anti-platelet Response
https://clinicaltrials.gov/ct2/show/NCT04456608

Jun 13th, 2022 - Purpose: In this aim, the investigators will test the hypothesis that n-3 PUFAs modify aspirin anti-platelet response, by measuring and comparing three different indicators of aspirin response in individuals with extremely high and low RBC n-3 PUF...

Platelet Function in Patients With Ischemic Stroke Treated With Anti-thrombotic or Thrombolytic
https://clinicaltrials.gov/ct2/show/NCT05415150

Jun 10th, 2022 - In the past we used 30% lower dose of abciximab compared to the cardiac trials and the discontinued ABESTT stroke trial. There were no symptomatic intracranial hemorrhages or thromboyctopenia in our study. Based on the safety and efficacy results ...

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News  180 results

FDA Declines to Authorize Common Antidepressant as COVID Treatment
https://www.medscape.com/viewarticle/974075

May 18th, 2022 - (Reuters) - The U.S. Food and Drug Administration has decided not to authorize the antidepressant fluvoxamine to treat COVID-19, saying that the data has not shown the drug to be an effective therapeutic for fighting the virus. "Based on the revie...

Experimental Agents for ITP
https://www.onclive.com/view/experimental-agents-for-itp

Feb 23rd, 2022 - Craig Kessler, MD: Sutimlimab is a humanized monoclonal antibody that selectively inhibits activation of the complement pathway by binding to complement 1S. This drug, which is not approved, will be marketed by Sanofi. It was originally developed ...

Ticagrelor reversal agent achieves quick hemostasis: REVERSE-IT
https://www.mdedge.com/cardiology/article/248819/acute-coronary-syndromes/ticagrelor-reversal-agent-achieves-quick
Ted Bosworth

Nov 17th, 2021 - The experimental monoclonal antibody bentracimab, which reverses the antiplatelet effects of ticagrelor, appears to be heading toward regulatory approval, on the basis of an interim analysis of the phase 3 REVERSE-IT trial. Dr.

Pot Smokers Face Distinct Risks After Coronary Procedures
https://www.medpagetoday.com/cardiology/pci/94060

Aug 16th, 2021 - Patients undergoing percutaneous coronary intervention (PCI) after recent marijuana smoking tended to have different complications than non-users, researchers found. Marijuana users -- representing a modest 3.5% of PCI recipients in the Blue Cross...

Self-Injected Antiplatelet for Acute MI Enters Phase 3 Testing
https://www.medscape.com/viewarticle/954030

Jun 30th, 2021 - A phase 3 study testing the safety and efficacy of the fast-acting, self-administered P2Y12 receptor antagonist selatogrel (Idorsia Pharmaceuticals) for the treatment of suspected acute myocardial infarction (AMI) is underway, the company has anno...

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