About 2,025 results

ALLMedicine™ Transferrin Receptor Center

Research & Reviews  783 results

Iron deficiency as promoter of heavy metals-induced acute myeloid leukemia.
Leukemia Research; Cirovic A, Cirovic A

Nov 30th, 2021 - Iron deficiency (ID) and iron deficiency anemia (IDA) have many adverse effects on human health. Also, iron deficiency anemia and anemia in general are linked with an increased risk of various cancers, particularly blood cancers. It is known that ...

Effect of Insulin Receptor-Knockdown on the Expression Levels of Blood-Brain Barrier Fu...
Pharmaceutical Research; Nagano H, Ito S et. al.

Nov 24th, 2021 - The insulin receptor (INSR) mediates insulin signaling to modulate cellular functions. Although INSR is expressed at the blood-brain barrier (BBB), its role in the modulation of BBB function is poorly understood. Therefore, in this study, we aimed...

Effect of curcumin on lung epithelial injury and ferroptosis induced by cigarette smoke.
Human & Experimental Toxicology; Tang X, Li Z et. al.

Nov 18th, 2021 - Cigarette smoke (CS)-caused ferroptosis was involved in the pathogenesis of COPD, but the role of ferroptosis in lung epithelial injury and inflammation is not clear. Rats were treated with CS or CUR and BEAS-2B cells were exposed to CS extract (C...

Individualized risk trajectories for iron-related adverse outcomes in repeat blood donors.
Transfusion Russell WA, Scheinker D et. al.

Nov 17th, 2021 - Despite a fingerstick hemoglobin requirement and 56-day minimum donation interval, repeat blood donation continues to cause and exacerbate iron deficiency. Using data from the REDS-II Donor Iron Status Evaluation study, we developed multiclass pre...

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Guidelines  1 results

EASL clinical practice guidelines for HFE hemochromatosis.
Journal of Hepatology;

May 18th, 2010 - Iron overload in humans is associated with a variety of genetic and acquired conditions. Of these, HFE hemochromatosis (HFE-HC) is by far the most frequent and most well-defined inherited cause when considering epidemiological aspects and risks fo...

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Clinicaltrials.gov  18 results

Effect of Intravenous Iron Supplementation on Celiac Disease Remission (IRONCEL)

Nov 9th, 2021 - Celiac disease is an autoimmune-like disorder induced in genetically predisposed individuals by dietary proteins from wheat (gluten). Its frequency reaches 1% in Europe. In celiac patients, gluten induces small intestinal villous atrophy and, as a...

Lactoferrin in Treatment of Fe Deficient Anemia In Cirrhosis

Nov 8th, 2021 - Lactoferrin is a highly conserved, monomeric 80 kDa single polypeptide chain contained in most mammalian exocrine secretions, such as milk, saliva and tears, bronchial, and intestinal secretions. LTF is also found in the secondary granules of neut...

Prospective Observational Study of Erythropoietin-Iron Interaction in Anemia of Renal Disease

Jul 2nd, 2021 - Data will be collected from 120 subjects undergoing hemodialysis treatment at 3 clinical sites across United States (40 per site).5.5 mL blood specimen will be drawn during midweek treatment (Wed/Thu) to measure: Hemoglobin Concentration Hematocri...

Anemia in Patients With Endocarditis

Apr 9th, 2021 - Anemia is an adverse prognostic marker in both cardiac diseases and infectious diseases. In patients with bacterial endocarditis (IE), anemia has a prevalence of 55-80%. In a sub-study to our POET I trial (RCT with 400 patients with IE, published ...

Inflammatory Anemia Associated Parameters in Septic Patients

Feb 24th, 2020 - Anemia is one of the most common complications in patients with sepsis in the intensive care unit (ICU), as well as sepsis is a major cause of high mortality in ICU. Studies demonstrated that sepsis-related anemia can be caused by fluid loading re...

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News  8 results

Beti-Cel Results in Impressive Activity in Pediatric Transfusion-Dependent Beta-Thalassemia

Feb 13th, 2021 - Treatment with the investigative gene cell therapy betibeglogene autotemcel (beti-cel) led to durable transfusion independence in 87% of pediatric patients less than 18 years of age with transfusion-dependent beta-thalassemia (TDT) with a median a...

Gene plays key role in iron homeostasis
HT Staff

Jun 1st, 2017 - Red blood cells A gene known to prevent autoimmune diseases is a key regulator in iron uptake, according to research published in Cell Reports. “We found previously that, when mice lack the gene Regnase-1, they suffer from severe autoimmune diseas.

Hemochromatosis: More Common Than You Think?

Oct 22nd, 2012 - Hereditary HFE Hemochromatosis Hereditary HFE hemochromatosis accounts for most cases of excess body iron that result from increased iron absorption. Clinical disease in HFE hemochromatosis has variable penetrance; women are less likely to develop...

Hemochromatosis: More Common Than You Think?

Oct 22nd, 2012 - Screening and Diagnosis of Hemochromatosis At the present time, screening of all patients for hemochromatosis is not recommended. However, patients with liver disease and those who have a positive family history, suggestive symptoms, or abnormal i...

Biological Response Modifiers in Cancer

Nov 14th, 2006 - Epratuzumab Epratuzumab (LL2) is a murine IgG2a antibody targeted against CD22 antigen (transferrin receptor). It is widely expressed during B-cell development and is present in most of NHL tumours[64] Juweid and colleagues[65] compared 131ILL2 wi...

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