×
About 6,625 results

ALLMedicine™ Von Willebrand Factor Center

Research & Reviews  2,501 results

Factor VIII as a potential player in cancer pathophysiology.
https://doi.org/10.1111/jth.15611
Journal of Thrombosis and Haemostasis : JTH; Walker GE, Merlin S et. al.

Dec 1st, 2021 - "Trousseau's Sign" was the first demonstration of a close relationship between cancer and thrombosis. Currently, venous thromboembolism (VTE) is 5-6 times more likely to occur in cancer patients, while there is a greater risk of cancer diagnoses f...

Serum levels of laminin and von Willebrand factor in COVID-19 survivors 6 months after ...
https://doi.org/10.1016/j.ijid.2021.11.032
International Journal of Infectious Diseases : IJID : Off... Li H, Wu Q et. al.

Nov 30th, 2021 - To evaluate clinical characteristics, pulmonary diffusion function, chest computerized tomography (CT), and serum lung cell damage indicators of coronavirus disease 2019 (COVID-19) survivors 6 months after discharge. Data of COVID-19 survivors dis...

Fibrin to von Willebrand factor ratio in arterial thrombi is associated with plasma lev...
https://doi.org/10.1016/j.thromres.2021.11.011
Thrombosis Research; Tóth E, Beinrohr L et. al.

Nov 30th, 2021 - The composition of thrombi determines their structure, mechanical stability, susceptibility to lysis, and consequently, the clinical outcome in coronary artery disease (CAD), acute ischemic stroke (AIS), and peripheral artery disease (PAD). Fibrin...

The von Willebrand Factor A-1 domain binding aptamer BT200 elevates plasma levels of VW...
https://doi.org/10.3324/haematol.2021.279948
Haematologica Kovacevic KD, Grafeneder J et. al.

Nov 26th, 2021 - Von Willebrand Factor (VWF) and Factor VIII (FVIII) circulate in a noncovalent complex in blood and promote primary haemostasis and clotting respectively. A new VWF A1-domain binding aptamer, BT200, demonstrated good subcutaneous bioavailability a...

Osteoprotegerin modulates platelet adhesion to von Willebrand factor during release fro...
https://doi.org/10.1111/jth.15598
Journal of Thrombosis and Haemostasis : JTH; Wohner N, Sebastian S et. al.

Nov 25th, 2021 - Platelet-binding Von Willebrand Factor (VWF) strings assemble upon stimulated secretion from endothelial cells. To investigate the efficiency of platelet binding to multi-molecular VWF bundles secreted from endothelial cells and to investigate the...

see more →

Guidelines  4 results

Platelet-dependent von Willebrand factor activity. Nomenclature and methodology: commun...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5576173
Journal of Thrombosis and Haemostasis : JTH; Bodó I, Eikenboom J et. al.

Apr 11th, 2015 - Platelet-dependent von Willebrand factor activity. Nomenclature and methodology: communication from the SSC of the ISTH.|2015|Bodó I,Eikenboom J,Montgomery R,Patzke J,Schneppenheim R,|blood,chemistry,classification,standards,classification,standar...

Evidence-based recommendations on the treatment of von Willebrand disease in Italy.
https://doi.org/10.2450/2008.0052-08
Blood Transfusion = Trasfusione Del Sangue; Mannucci PM, Franchini M et. al.

Jun 9th, 2009 - von Willebrand disease (VWD) is the most common hereditary bleeding disorder affecting both males and females. It arises from quantitative or qualitative defects of von Willebrand factor (VWF) and causes bleeding of mucous membranes and soft tissu...

Clinical and laboratory diagnosis of von Willebrand disease: a synopsis of the 2008 NHL...
https://doi.org/10.1002/ajh.21405
American Journal of Hematology; Nichols WL, Rick ME et. al.

May 6th, 2009 - Von Willebrand factor (VWF) mediates blood platelet adhesion and accumulation at sites of blood vessel injury, and also carries coagulation factor VIII (FVIII) that is important for generating procoagulant activity. Von Willebrand disease (VWD), t...

von Willebrand disease (VWD): evidence-based diagnosis and management guidelines, the N...
https://doi.org/10.1111/j.1365-2516.2007.01643.x
Haemophilia : the Official Journal of the World Federatio... Nichols WL, Hultin MB et. al.

Mar 5th, 2008 - von Willebrand disease (VWD) is a commonly encountered inherited bleeding disorder affecting both males and females, causing mucous membrane and skin bleeding symptoms, and bleeding with surgical or other haemostatic challenges. VWD may be disprop...

see more →

Drugs  14 results see all →

Clinicaltrials.gov  59 results

Biological Factors Associated With Subclinical Valvular Thrombosis
https://clinicaltrials.gov/ct2/show/NCT03847948

Oct 29th, 2021 - For the purpose of the study, platelet reactivity will be measured with the commercial kit PLT VASP/P2Y12 at baseline, 1day and 3 months postprocedure. Secondary objectives include: -Determine the variability of platelet aggregation measured at ba...

Magnesium Sulfate in Thrombotic Thrombocytopenic Purpura in Intensive Care
https://clinicaltrials.gov/ct2/show/NCT03237819

Oct 29th, 2021 - Thrombotic Thrombocytopenic Purpura (TTP) is a potentially life-threatening thrombotic microangiopathy caused by a severe deficiency of ADAMTS13 (a disintegrin and metalloproteinase with a thrombospondin type 1 motif member 13). Decreased ADAMTS13...

Effects of Blood Pulsatility on Von Willebrand Factor During ECCO2R
https://clinicaltrials.gov/ct2/show/NCT05079009

Oct 15th, 2021 - A track of major interest to prevent bleeding complications in ECCO2R, and more generally in extracorporeal circulations, is to prevent acquired Willebrand disease. Indeed, a loss of Willebrand factor high molecular weight multimers (Whmwm) is fre...

Enhancement of the Haemostatic Effect of Platelets in the Presence of High Normal Concentrations of Von Willebrand Factor
https://clinicaltrials.gov/ct2/show/NCT04555785

Oct 5th, 2021 - Von Willebrand Factor (vWF) is a key protein mediating platelet adhesion on the surface of damaged endothelia, initiating platelet-platelet aggregation and supporting platelet activation. It plays also an important role in protecting FVIII from ea...

Primary Hemostasis Pathology in Patients on ECMO During Lung Transplantation
https://clinicaltrials.gov/ct2/show/NCT04456894

Oct 5th, 2021 - ECMO is a type of extracorporeal circulation that has experienced a significant increase in use in the last decade as a substitute for lung or heart functions in patients, both perioperatively - especially extensive thoracic surgery procedures suc...

see more →

News  72 results

2019 Biologics Recalls | FDA
https://www.fda.gov/vaccines-blood-biologics/recalls-biologics/2019-biologics-recalls

Date Notification Brand Name Product Description Reason/Problem Company October 3, 2019 Important Drug Information - Humate-P [Antihemophilic Factor/von Willebrand Factor Complex (Human)] Lots of All Fill Sizes (600, 1200, 2400 IUs) distributed by...

A New Biomarker of Traumatic Brain Injury?
https://www.medscape.com/viewarticle/949972

Apr 26th, 2021 - Plasma levels of von Willebrand factor may be a useful biomarker of traumatic brain injury (TBI) and its severity, new research suggests. "Reliable detection of this biomarker at very early time points may allow for prompt TBI detection and theref...

The Treatment Spectrum in Essential Thrombocythemia
https://www.onclive.com/view/the-treatment-spectrum-in-essential-thrombocythemia

Apr 21st, 2021 - Pankit Vachhani, MD: When I approach treatment for essential thrombocytosis, I keep in mind that there is no single drug or agent that that improves survival. My treatment goals are directed toward the mitigation of the thrombosis risk that these ...

Essential Thrombocythemia: Treatment Optimization
https://www.onclive.com/view/essential-thrombocythemia-treatment-optimization

Apr 2nd, 2021 - Transcript: Harry P. Erba, MD, PhD: Krisstina, we know that there are some patients with ET [essential thrombocytopenia], especially young women, who can present with a high platelet count and be completely asymptomatic. However, is there a pla...

A Retrospective Look at the Management of HSCT-TMA
https://www.onclive.com/view/a-retrospective-look-at-the-management-of-hsct-tma

Apr 2nd, 2021 - Transcript: Sergio A. Giralt, MD: Transplant-associated TMA [thrombotic microangiopathy] is actually a relatively newly identified disorder. It does fall into the thrombotic microangiopathies, which started with thrombocytopenia, thrombotic pu...

see more →