About 7,923 results

ALLMedicine™ Von Willebrand Factor Center

Research & Reviews  2,861 results

Structures of VWF tubules before and after concatemerization reveal a mechanism of disu...
Blood Anderson JR, Li J et. al.

Jul 2nd, 2022 - von Willebrand Factor (VWF) is an adhesive glycoprotein that circulates in the blood as disulfide-linked concatemers and functions in primary hemostasis. The loss of long VWF concatemers is associated with the excess bleeding of type 2A von Willeb...

Fontan Associated Liver Disease and the Evaluation of Biomarkers for Disease Severity Assessment

Jul 1st, 2022 - Study Description: Up to 100 subjects who completed the Fontan procedure for severe Congenital Heart Disease (CHD) and are at risk for congestive hepatopathy or Fontan Associated Liver Disease (FALD) will be offered inclusion in the study. During ...

The VWF binding aptamer rondoraptivon pegol increases platelet counts and VWF/FVIII in ...
Blood Advances; Ay C, Pabinger I et. al.

Jul 1st, 2022 - Type 2B von Willebrand disease (VWD) is characterised by an increased binding affinity of von Willebrand factor (VWF) to platelet glycoprotein Ib. This can lead to clearance of high molecular weight (HMW) multimers and thrombocytopenia with a resu...

Defective VWF secretion due to the expression of MYH9-RD E1841K mutant in endothelial c...
Blood Advances; Cao Y, Sun Y et. al.

Jun 29th, 2022 - Mutations in MYH9, the gene encoding the heavy chain of non-muscle myosin IIa (NMII-A), cause MYH9-related disease (MYH9-RD) that is an autosomal-dominant thrombocytopenia with bleeding tendency. Previously, we showed that NMII-A in endothelial ce...

Contribution of ADAMTS13-independent VWF regulation in sickle cell disease.
Journal of Thrombosis and Haemostasis : JTH; Hunt RC, Katneni U et. al.

Jun 27th, 2022 - Von Willebrand factor (VWF) is elevated in sickle cell disease (SCD) and contributes to vaso-occlusion through its thrombogenic properties. VWF is regulated by ADAMTS13, a plasma protease that cleaves VWF into less bioactive multimers. Independent...

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Guidelines  4 results

Platelet-dependent von Willebrand factor activity. Nomenclature and methodology: commun...
Journal of Thrombosis and Haemostasis : JTH; Bodó I, Eikenboom J et. al.

Apr 11th, 2015 - Platelet-dependent von Willebrand factor activity. Nomenclature and methodology: communication from the SSC of the ISTH.|2015|Bodó I,Eikenboom J,Montgomery R,Patzke J,Schneppenheim R,|blood,chemistry,classification,standards,classification,standar...

Evidence-based recommendations on the treatment of von Willebrand disease in Italy.
Blood Transfusion = Trasfusione Del Sangue; Mannucci PM, Franchini M et. al.

Jun 9th, 2009 - von Willebrand disease (VWD) is the most common hereditary bleeding disorder affecting both males and females. It arises from quantitative or qualitative defects of von Willebrand factor (VWF) and causes bleeding of mucous membranes and soft tissu...

Clinical and laboratory diagnosis of von Willebrand disease: a synopsis of the 2008 NHL...
American Journal of Hematology; Nichols WL, Rick ME et. al.

May 6th, 2009 - Von Willebrand factor (VWF) mediates blood platelet adhesion and accumulation at sites of blood vessel injury, and also carries coagulation factor VIII (FVIII) that is important for generating procoagulant activity. Von Willebrand disease (VWD), t...

von Willebrand disease (VWD): evidence-based diagnosis and management guidelines, the N...
Haemophilia : the Official Journal of the World Federatio... Nichols WL, Hultin MB et. al.

Mar 5th, 2008 - von Willebrand disease (VWD) is a commonly encountered inherited bleeding disorder affecting both males and females, causing mucous membrane and skin bleeding symptoms, and bleeding with surgical or other haemostatic challenges. VWD may be disprop...

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Drugs  17 results see all →

Clinicaltrials.gov  165 results

Fontan Associated Liver Disease and the Evaluation of Biomarkers for Disease Severity Assessment

Jul 1st, 2022 - Study Description: Up to 100 subjects who completed the Fontan procedure for severe Congenital Heart Disease (CHD) and are at risk for congestive hepatopathy or Fontan Associated Liver Disease (FALD) will be offered inclusion in the study. During ...

Efficacy of Ursodeoxycholic Acid (UDCA) in Patients With Type 2 Diabetes

Jun 13th, 2022 - This is a Phase 3, randomized, double-blind, placebo-controlled, evaluation of the efficacy of UDCA on oxidative stress, inflammation, and endothelial dysfunction in combination with metformin after 8 weeks in patients with T2DM who did not meet H...

Performance Evaluation of Von Willebrand:Collagen-Binding Assays to Diagnose Von Willebrand Factor Deficiency in Patients With Increased Risk of Bleeding

Jun 10th, 2022 - Von Willebrand Disease (VWD) is defined as an inherited bleeding disorder that is caused by deficiency or dysfunction of von Willebrand factor (VWF), a plasma protein that mediates the initial adhesion of platelets at sites of vascular injury and ...

Von Willebrand Factor Point-of-care Testing to Improve Minimally Invasive TAVI Outcomes

May 18th, 2022 - Paravalvular regurgitation (PVR) is an important complication of Transcatheter Aortic Valve Implantation (TAVI) that is associated with a 2.5-fold increase risk of mortality. Transesophageal echocardiographic (TEE) is considered as the gold standa...

Effects of Blood Pulsatility on Von Willebrand Factor During ECCO2R

May 13th, 2022 - A track of major interest to prevent bleeding complications in ECCO2R, and more generally in extracorporeal circulations, is to prevent acquired Willebrand disease. Indeed, a loss of Willebrand factor high molecular weight multimers (Whmwm) is fre...

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News  120 results

Women with von Willebrand disease: Managing menstrual and postpartum bleeding
Heidi Splete

Feb 23rd, 2022 - Hormonal therapy remains the most effective strategy for managing heavy menstrual bleeding in women with von Willebrand disease, based on data from one of three systematic reviews. Women with von Willebrand disease (VWD) experience many obstetric.

Infusion shown effective for acquired von Willebrand disease
Mark S. Lesney, PhD

Aug 10th, 2021 - Acquired von Willebrand disease (aVWD) is a rare and serious condition associated with lymphoproliferative disorders, malignancy, autoimmune disorders, and cardiovascular disease. It is most commonly caused by monoclonal gammopathy of undetermined.

Novel molecule prolongs half-life of bleeding disorder treatments
Neil Osterweil

Jun 23rd, 2021 - A novel therapeutic approach using aptamers – short single strands of DNA or RNA designed to selectively bind to a target – shows promise for treating von Willebrand Disease (VWD), and other congenital bleed disorders such as hemophilia A, investi.

2019 Biologics Recalls | FDA

Date Notification Brand Name Product Description Reason/Problem Company October 3, 2019 Important Drug Information - Humate-P [Antihemophilic Factor/von Willebrand Factor Complex (Human)] Lots of All Fill Sizes (600, 1200, 2400 IUs) distributed by...

A New Biomarker of Traumatic Brain Injury?

Apr 26th, 2021 - Plasma levels of von Willebrand factor may be a useful biomarker of traumatic brain injury (TBI) and its severity, new research suggests. "Reliable detection of this biomarker at very early time points may allow for prompt TBI detection and theref...

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Patient Education  2 results see all →