×
About 913 results

ALLMedicine™ Aldolase Center

Research & Reviews  453 results

Aldolase A Enhances Intrahepatic Cholangiocarcinoma Proliferation and Invasion through ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8120471
International Journal of Biological Sciences; Li X, Yu C et. al.

May 17th, 2021 - Energy metabolism reprogramming has been implicated in tumorigenesis and development. Key metabolism enzyme Aldolase A (ALDOA) has been shown to be highly expressed and involved in various kinds of cancers including hepatocellular carcinoma. In th...

Synthesis of a precursor of D-fagomine by immobilized fructose-6-phosphate aldolase.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8062046
PloS One; Masdeu G, Vázquez LM et. al.

Apr 22nd, 2021 - Fructose-6-phosphate aldolase (FSA) is an important enzyme for the C-C bond-forming reactions in organic synthesis. The present work is focused on the synthesis of a precursor of D-fagomine catalyzed by a mutant FSA. The biocatalyst has been immob...

Loss-of-function genetic screening identifies ALDOA as an essential driver for liver ca...
https://doi.org/10.1002/hep.31846
Hepatology (Baltimore, Md.); Niu Y, Lin Z et. al.

Apr 4th, 2021 - Hypoxia is a common feature of tumor microenvironment (TME), which promotes tumor progression, metastasis and therapeutic drug resistance via a myriad of cell activities in tumor and stroma cells. While targeting hypoxic TME is emerging as a promi...

BCDIN3D RNA methyltransferase stimulates Aldolase C expression and glycolysis through l...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8026734
Oncogene Reinsborough CW, Ipas H et. al.

Mar 5th, 2021 - Type II diabetes (T2D) and specific cancers share many risk factors, however, the molecular mechanisms underlying these connections are often not well-understood. BCDIN3D is an RNA modifying enzyme that methylates specific precursor microRNAs and ...

The melanoma brain metastatic microenvironment: aldolase C partakes in shaping the mali...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8096793
Molecular Oncology; Izraely S, Ben-Menachem S et. al.

Dec 4th, 2020 - Previous studies indicated that microglia cells upregulate the expression of aldolase C (ALDOC) in melanoma cells. The present study using brain-metastasizing variants from three human melanomas explores the functional role of ALDOC in the formati...

see more →

Clinicaltrials.gov  457 results

Aldolase A Enhances Intrahepatic Cholangiocarcinoma Proliferation and Invasion through ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8120471
International Journal of Biological Sciences; Li X, Yu C et. al.

May 17th, 2021 - Energy metabolism reprogramming has been implicated in tumorigenesis and development. Key metabolism enzyme Aldolase A (ALDOA) has been shown to be highly expressed and involved in various kinds of cancers including hepatocellular carcinoma. In th...

Synthesis of a precursor of D-fagomine by immobilized fructose-6-phosphate aldolase.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8062046
PloS One; Masdeu G, Vázquez LM et. al.

Apr 22nd, 2021 - Fructose-6-phosphate aldolase (FSA) is an important enzyme for the C-C bond-forming reactions in organic synthesis. The present work is focused on the synthesis of a precursor of D-fagomine catalyzed by a mutant FSA. The biocatalyst has been immob...

Loss-of-function genetic screening identifies ALDOA as an essential driver for liver ca...
https://doi.org/10.1002/hep.31846
Hepatology (Baltimore, Md.); Niu Y, Lin Z et. al.

Apr 4th, 2021 - Hypoxia is a common feature of tumor microenvironment (TME), which promotes tumor progression, metastasis and therapeutic drug resistance via a myriad of cell activities in tumor and stroma cells. While targeting hypoxic TME is emerging as a promi...

BCDIN3D RNA methyltransferase stimulates Aldolase C expression and glycolysis through l...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8026734
Oncogene Reinsborough CW, Ipas H et. al.

Mar 5th, 2021 - Type II diabetes (T2D) and specific cancers share many risk factors, however, the molecular mechanisms underlying these connections are often not well-understood. BCDIN3D is an RNA modifying enzyme that methylates specific precursor microRNAs and ...

The melanoma brain metastatic microenvironment: aldolase C partakes in shaping the mali...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8096793
Molecular Oncology; Izraely S, Ben-Menachem S et. al.

Dec 4th, 2020 - Previous studies indicated that microglia cells upregulate the expression of aldolase C (ALDOC) in melanoma cells. The present study using brain-metastasizing variants from three human melanomas explores the functional role of ALDOC in the formati...

see more →

News  2 results

Amyopathic Dermatomyositis With Plantar Keratoderma Responding to Methotrexate Therapy
https://www.mdedge.com/dermatology/article/145236/rare-diseases/amyopathic-dermatomyositis-plantar-keratoderma-responding/page/0/1

Aug 24th, 2017 - Comment Amyopathic DM is a subset of DM that accounts for 10% to 20% of DM cases. 1,2 Sontheimer’s3 diagnostic criteria for ADM require histopathologic confirmation of the hallmark skin findings of classic DM and lack of muscle weakness or muscle e.

CPG Sec. 400.335 Fructose-Containing Drugs
http://www.fda.gov/regulatory-information/search-fda-guidance-documents/cpg-sec-400335-fructose-containing-drugs

Issued by: Guidance Issuing Office Office of Regulatory Affairs BACKGROUND: Hereditary fructose intolerance is a metabolic error due to the deficiency of fructose 1-phosphate aldolase in the liver. It is thought to be inherited as an autosomal rec...

see more →

Patient Education  1 results see all →