About 665 results

ALLMedicine™ Aldolase Center

Research & Reviews  257 results

Homocitrullination of lysine residues mediated by myeloid-derived suppressor cells in t...
Journal for Immunotherapy of Cancer; Cook KW, Xue W et. al.

Jul 30th, 2021 - Homocitrullination is the post-translational modification of lysine that is recognized by T cells. This study identified homocitrullinated peptides from aldolase, enolase, cytokeratin and binding immunoglobulin protein and used human leukocyte ant...

ALDOB depletion promotes hepatocellular carcinogenesis through activating insulin recep...
Hepatology (Baltimore, Md.); Liu G, Wang N et. al.

Jul 23rd, 2021 - Insulin receptor (IR) transduces cell surface signal via phosphoinositide-3-kinase (PI3K)-AKT pathways, or translocates to nucleus and binds to the promoters to regulate genes associated with insulin actions including de novo lipogenesis (DNL). Ch...

Primary Hyperoxaluria Type 3 Can Also Result in Kidney Failure: A Case Report.
American Journal of Kidney Diseases : the Official Journa... Singh P, Granberg CF et. al.

Jul 11th, 2021 - Primary hyperoxaluria (PH) is a group of genetic disorders that result in an increased hepatic production of oxalate. PH type 3 (PH3) is the most recently identified subtype and results from mutations in the mitochondrial 4-hydroxy-2-oxoglutarate ...

The moonlighting protein fructose 1,6-bisphosphate aldolase as a potential vaccine cand...
Developmental and Comparative Immunology; Pham TH, Rao S et. al.

Jun 30th, 2021 - Vaccination is the most effective, safe, and environmentally friendly method to prevent the outbreak of Photobacterium damselae subsp. piscicida (Phdp), a dangerous pathogen in aquaculture worldwide. Here, recombinant proteins of catalase, superox...

Glycogen storage disease type XII; an ultra rare cause of hemolytic anemia and rhabdomy...
Journal of Pediatric Endocrinology & Metabolism : JPEM; Kara E, Kor D et. al.

Jun 26th, 2021 - Aldolase A deficiency also known as glycogen storage disease (GSD) XII, is an ultra rare autosomal recessively inherited GSD, associated with hemolytic anemia and rhabdomyolysis. Here, we first report a patient with dermatological findings, hemodi...

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Clinicaltrials.gov  2 results

Validation of RealAmp Method for the Diagnosis of Malaria in Endemic Areas of Brazil

Oct 23rd, 2018 - Worldwide, approximately 2 billion people live in areas at risk for malaria with morbidity surpassing 250 million cases, with approximately 800,000 deaths, per year. Of the four species of malaria parasites that cause human infection, P. falciparu...

Fructose Supplementation in Carriers for Hereditary Fructose Intolerance

Jun 4th, 2018 - A high fructose intake also increases blood lactate and uric acid concentrations. It has been proposed that uric acid may contribute to insulin resistance by impairing endothelium-dependent vasodilation, promoting pro-inflammatory effects and dysl...

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News  7 results

Anti-TIF1-Ab-Positive Dermatomyositis Linked to Higher Cancer Risk

Dec 13th, 2018 - Action Points Anti-TNF1-Ab positive dermatomyositis (DM) is linked to an elevated risk of cancer, especially ovarian cancer. This risk is present approximately 3 years on either side of DM onset. The link between DM and cancer is present for patie...

Gottron Papules Mimicking Dermatomyositis: An Unusual Manifestation of Systemic Lupus Erythematosus
Ji Won Ahn, MD, Sherry Yang, MD et. al.

Jul 26th, 2018 - To the Editor: An 11-year-old girl presented to the dermatology clinic with an asymptomatic rash on the bilateral forearms, dorsal hands, and ears of 1 month’s duration. Recent history was notable for persistent low-grade fevers, dizziness, headac.

Amyopathic Dermatomyositis With Plantar Keratoderma Responding to Methotrexate Therapy

Aug 24th, 2017 - Comment Amyopathic DM is a subset of DM that accounts for 10% to 20% of DM cases. 1,2 Sontheimer’s3 diagnostic criteria for ADM require histopathologic confirmation of the hallmark skin findings of classic DM and lack of muscle weakness or muscle e.

CPG Sec. 400.335 Fructose-Containing Drugs

Issued by: Guidance Issuing Office Office of Regulatory Affairs BACKGROUND: Hereditary fructose intolerance is a metabolic error due to the deficiency of fructose 1-phosphate aldolase in the liver. It is thought to be inherited as an autosomal rec...

Widespread Poikilodermatous Dermatomyositis Associated With Chronic Lymphocytic Leukemia
Daniel J. Ventarola, MD, Paul C. Contard, MD, PhD et. al.

Feb 8th, 2017 - To the Editor: Dermatomyositis represents a rare idiopathic inflammatory process presenting with cutaneous lesions and muscular weakness. It often represents a paraneoplastic syndrome.

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