ALLMedicine™ Creatinine Clearance Center

Jun 29th, 2022 - This review focuses on the safety of oral tenofovir disoproxil and emtricitabine (FTC) combination for HIV preexposure prophylaxis (PrEP) in adults. Gastrointestinal adverse events are common after treatment initiation but usually resolve within w...

Jun 28th, 2022 - Vancomycin is a commonly used antibiotic for multi-drug resistant gram-positive infections treatment, especially methicillin-resistant Staphylococcus aureus (MRSA). Despite that, it has wide individual pharmacokinetic variability and nephrotoxic e...

Jun 26th, 2022 - An accurate estimated glomerular filtration rate (eGFR) is essential in drug dosing. This study demonstrates the limitations of indexed (mL/min/1.73m2 ) and de-indexed (mL/min) eGFR based drug dosing in patients with obesity or underweight. This s...

Jun 25th, 2022 - Although tigecycline is widely used in clinical practice, its efficiency and optimal dosage regimens remain controversial. The purpose of this article was to help guide tigecycline dosing in different patient subpopulations through comparing the p...

Jun 25th, 2022 - Cystic fibrosis (CF) has been linked to altered drug disposition in various studies. However, the magnitude of these changes, influencing factors, and underlying mechanisms remain a matter of debate. The primary aim of this work was therefore to q...

Aug 2nd, 2015 - The recent guideline for the evaluation and management of Chronic Kidney Disease recommends assessing GFR employing equations based on serum creatinine; despite this, creatinine clearance 24-hour urine collection is used routinely in many settings...

Jun 24th, 2022 - The characteristic sickling of red blood cells in hypoxic conditions is the root cause of pathology in sickle cell disease (SCD). When this sickling occurs in the renal microvasculature, and is compounded by chronic vasculopathy related to hemolys...

Jun 24th, 2022 - The mortality of acute renal failure (ARF) remains high despite advances in supportive care. There are no established effective drug therapies, and dialysis may promote renal injury via hypotension or neutrophil activation. Many agents [e.g., mann...

Jun 24th, 2022 - BACKGROUND: Gemcitabine plus carboplatin is an accepted first-line therapy in patients unfit for cisplatin chemotherapy with metastatic urothelial carcinoma or other solid tumor malignancies. Both non-clinical and clinical data support targeting a...

Jun 24th, 2022 - Several studies have reported that diabetic subjects have lower plasma vitamin C concentrations than non-diabetic subjects. Although urinary vitamin C loss in diabetic subjects was reported to be increased in two studies, these are difficult to in...

Jun 24th, 2022 - Background: Chronic graft-versus-host disease (cGVHD) is the leading cause of non-relapse morbidity and mortality in persons after allogeneic hematopoietic stem cell transplantation (SCT). Approximately 50% of patients with cGVHD have disease refr...

May 2nd, 2022 - The combination of nab-paclitaxel (Abraxane) and pembrolizumab (Keytruda) produced an encouraging overall response rate (ORR) with manageable safety in patients with advanced urothelial cancer who were refractory to platinum-based chemotherapy or ...

Apr 22nd, 2022 - The European Commission has granted marketing authorization to the CD19-directed CAR T-cell therapy lisocabtagene maraleucel (liso-cel; Breyanzi) for use in adult patients with relapsed or refractory diffuse large B-cell lymphoma (DLBCL), primary ...

Apr 13th, 2022 - Roberto Iacovelli, MD, PhD, medical oncologist, the Fondazione Policlinico Gemelli IRCCS, Rome, Italy, discusses the patient eligibility criteria of the phase 2 ARIES trial (NCT03891238) in urothelial cancer. The ARIES trial evaluated first-line ...

Apr 13th, 2022 - Evidence summary Bicarbonate therapy demonstrates benefit in 2 meta-analyses Two recent meta-analyses evaluated studies of bicarbonate therapy in patients with CKD, and both found benefit. 1,2 A 2020 meta-analysis included 15 RCTs (N = 2445) of adu.

Mar 18th, 2022 - NEW YORK (Reuters Health) - The risk of kidney-related adverse events among patients receiving tenofovir disoproxil fumarate (TDF)-based oral HIV pre-exposure prophylaxis (PrEP) is small, a systematic review and meta-analysis revealed. Therefore, ...