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About 9,150 results

ALLMedicine™ Creatinine Clearance Center

Research & Reviews  2,623 results

Safety of oral tenofovir disoproxil - emtricitabine for HIV preexposure prophylaxis in ...
https://doi.org/10.1097/COH.0000000000000747
Current Opinion in HIV and AIDS; Liegeon G

Jun 29th, 2022 - This review focuses on the safety of oral tenofovir disoproxil and emtricitabine (FTC) combination for HIV preexposure prophylaxis (PrEP) in adults. Gastrointestinal adverse events are common after treatment initiation but usually resolve within w...

Therapeutic Drug Monitoring of Vancomycin in Jordanian Patients. Development of Physiol...
https://doi.org/10.1055/a-1852-5391
Drug Research; Arabyat M, Abdul-Sattar A et. al.

Jun 28th, 2022 - Vancomycin is a commonly used antibiotic for multi-drug resistant gram-positive infections treatment, especially methicillin-resistant Staphylococcus aureus (MRSA). Despite that, it has wide individual pharmacokinetic variability and nephrotoxic e...

Estimation of glomerular filtration rate for drug dosing in patients with very high or ...
https://doi.org/10.1111/cts.13354
Clinical and Translational Science; Donker E, Bet P et. al.

Jun 26th, 2022 - An accurate estimated glomerular filtration rate (eGFR) is essential in drug dosing. This study demonstrates the limitations of indexed (mL/min/1.73m2 ) and de-indexed (mL/min) eGFR based drug dosing in patients with obesity or underweight. This s...

Population Pharmacokinetics of Tigecycline: A Systematic Review.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9211078
Drug Design, Development and Therapy; Zhou CC, Huang F et. al.

Jun 25th, 2022 - Although tigecycline is widely used in clinical practice, its efficiency and optimal dosage regimens remain controversial. The purpose of this article was to help guide tigecycline dosing in different patient subpopulations through comparing the p...

Altered intravenous drug disposition in people living with cystic fibrosis: A meta-anal...
https://doi.org/10.1002/psp4.12832
CPT: Pharmacometrics & Systems Pharmacology; De Sutter PJ, Van Haeverbeke M et. al.

Jun 25th, 2022 - Cystic fibrosis (CF) has been linked to altered drug disposition in various studies. However, the magnitude of these changes, influencing factors, and underlying mechanisms remain a matter of debate. The primary aim of this work was therefore to q...

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Guidelines  1 results

KDIGO 2012 Clinical Practice Guideline CKD classification rules out creatinine clearanc...
https://doi.org/10.1016/j.clinbiochem.2015.07.030
Clinical Biochemistry; Ognibene A, Grandi G et. al.

Aug 2nd, 2015 - The recent guideline for the evaluation and management of Chronic Kidney Disease recommends assessing GFR employing equations based on serum creatinine; despite this, creatinine clearance 24-hour urine collection is used routinely in many settings...

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Drugs  226 results see all →

Clinicaltrials.gov  463 results

Best Noninvasive Predictor of Renal Function in Assessing Adult Sickle Nephropathy
https://clinicaltrials.gov/ct2/show/NCT03958643

Jun 24th, 2022 - The characteristic sickling of red blood cells in hypoxic conditions is the root cause of pathology in sickle cell disease (SCD). When this sickling occurs in the renal microvasculature, and is compounded by chronic vasculopathy related to hemolys...

Search for New Methods to Detect Acute Renal Failure
https://clinicaltrials.gov/ct2/show/NCT00026702

Jun 24th, 2022 - The mortality of acute renal failure (ARF) remains high despite advances in supportive care. There are no established effective drug therapies, and dialysis may promote renal injury via hypotension or neutrophil activation. Many agents [e.g., mann...

Gemcitabine, Carboplatin, and Lenalidomide for Treatment of Advanced/Metastatic Urothelial Cancer and Other Solid Tumors
https://clinicaltrials.gov/ct2/show/NCT01352962

Jun 24th, 2022 - BACKGROUND: Gemcitabine plus carboplatin is an accepted first-line therapy in patients unfit for cisplatin chemotherapy with metastatic urothelial carcinoma or other solid tumor malignancies. Both non-clinical and clinical data support targeting a...

Urinary Vitamin C Loss in Diabetic Subjects
https://clinicaltrials.gov/ct2/show/NCT00071526

Jun 24th, 2022 - Several studies have reported that diabetic subjects have lower plasma vitamin C concentrations than non-diabetic subjects. Although urinary vitamin C loss in diabetic subjects was reported to be increased in two studies, these are difficult to in...

Study of Baricitinib, a JAK1/2 Inhibitor, in Chronic Graft-Versus-Host Disease After Allogeneic Hematopoietic Stem Cell Transplantation
https://clinicaltrials.gov/ct2/show/NCT02759731

Jun 24th, 2022 - Background: Chronic graft-versus-host disease (cGVHD) is the leading cause of non-relapse morbidity and mortality in persons after allogeneic hematopoietic stem cell transplantation (SCT). Approximately 50% of patients with cGVHD have disease refr...

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News  347 results

Nab-Paclitaxel Plus Pembrolizumab Produces Promising Responses in Advanced Urothelial Cancer
https://www.onclive.com/view/nab-paclitaxel-plus-pembrolizumab-produces-promising-responses-in-advanced-urothelial-cancer

May 2nd, 2022 - The combination of nab-paclitaxel (Abraxane) and pembrolizumab (Keytruda) produced an encouraging overall response rate (ORR) with manageable safety in patients with advanced urothelial cancer who were refractory to platinum-based chemotherapy or ...

Lisocabtagene Maraleucel Approved in Europe for Select Relapsed/Refractory LBCL
https://www.onclive.com/view/lisocabtagene-maraleucel-approved-in-europe-for-select-relapsed-refractory-lbcl

Apr 22nd, 2022 - The European Commission has granted marketing authorization to the CD19-directed CAR T-cell therapy lisocabtagene maraleucel (liso-cel; Breyanzi) for use in adult patients with relapsed or refractory diffuse large B-cell lymphoma (DLBCL), primary ...

Dr. Iacovelli on Eligibility Criteria of the ARIES Trial in Urothelial Cancer
https://www.onclive.com/view/dr-iacovelli-on-eligibility-criteria-of-the-aries-trial-in-urothelial-cancer

Apr 13th, 2022 - Roberto Iacovelli, MD, PhD, medical oncologist, the Fondazione Policlinico Gemelli IRCCS, Rome, Italy, discusses the patient eligibility criteria of the phase 2 ARIES trial (NCT03891238) in urothelial cancer. The ARIES trial evaluated first-line ...

Is bicarbonate therapy effective in preventing CKD progression?
https://www.mdedge.com/familymedicine/article/253713/nephrology/bicarbonate-therapy-effective-preventing-ckd-progression
MDedge Family Medicine; Haris Ahmad, DO, Theresa Wertin, MD et. al.

Apr 13th, 2022 - Evidence summary Bicarbonate therapy demonstrates benefit in 2 meta-analyses Two recent meta-analyses evaluated studies of bicarbonate therapy in patients with CKD, and both found benefit. 1,2 A 2020 meta-analysis included 15 RCTs (N = 2445) of adu.

PrEP Kidney Function Monitoring to Be Fine-Tuned, Updated WHO Guidance Planned
https://www.medscape.com/viewarticle/970525

Mar 18th, 2022 - NEW YORK (Reuters Health) - The risk of kidney-related adverse events among patients receiving tenofovir disoproxil fumarate (TDF)-based oral HIV pre-exposure prophylaxis (PrEP) is small, a systematic review and meta-analysis revealed. Therefore, ...

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