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About 4,176 results
Safety and efficacy of early feeding based on clinical assessment at 4 hours after ERCP...
https://doi.org/10.1016/j.gie.2017.09.021
Gastrointestinal Endoscopy; Park CH, Jung JH et. al.

Oct 1st, 2017 - The optimal timing of refeeding after ERCP is unknown. Some practices keep the patient fasting for 24 hours after ERCP, whereas others resume feeding earlier. We aimed to evaluate the risk of post-ERCP pancreatitis (PEP) in patients who initiate early feeding, based on their clinical assessment, including serum amylase testing performed at 4 hours after ERCP. Patients who were scheduled for ERC...

A randomised controlled trial of the efficacy and safety of allopurinol dose escalation...
https://doi.org/10.1136/annrheumdis-2016-210872
Annals of the Rheumatic Diseases; Stamp LK, Chapman PT et. al.

Mar 20th, 2017 - To determine the efficacy and safety of allopurinol dose escalation using a treat-to-target serum urate (SU) approach. A randomised, controlled, parallel-group, comparative clinical trial was undertaken. People with gout receiving at least creatinine clearance (CrCL)-based allopurinol dose for ≥1 month and SU ≥6 mg/dL were recruited. Participants were randomised to continue current dose (contro...

Dabigatran Reversal With Idarucizumab in Patients With Renal Impairment.
https://doi.org/10.1016/j.jacc.2019.07.070
Journal of the American College of Cardiology; Eikelboom JW, van Ryn J et. al.

Oct 3rd, 2019 - Dabigatran and idarucizumab, its reversal agent, are renally cleared. The purpose of this study was to determine the extent of reversal and outcomes according to baseline renal function in dabigatran-treated nondialysis patients receiving idarucizumab. In 503 patients in RE-VERSE AD (Reversal of Effects of Idarucizumab in Patients on Active Dabigatran), the extent of dabigatran reversal and cli...

CETYLEV® (acetylcysteine)
http://cetylev.com/

Hypersensitivity reactions, including generalized urticaria have been observed in patients receiving oral acetylcysteine overdose. If hypersensitivity reactions occur, Cetylev should be discontinued unless it is deemed essential for patient management and the reactions can be otherwise controlled.

Tolvaptan in Later-Stage Autosomal Dominant Polycystic Kidney Disease.
https://doi.org/10.1056/NEJMoa1710030
The New England Journal of Medicine; Torres VE, Chapman AB et. al.

Nov 6th, 2017 - In a previous trial involving patients with early autosomal dominant polycystic kidney disease (ADPKD; estimated creatinine clearance, ≥60 ml per minute), the vasopressin V2-receptor antagonist tolvaptan slowed the growth in total kidney volume and the decline in the estimated glomerular filtration rate (GFR) but also caused more elevations in aminotransferase and bilirubin levels. The efficacy...

Tenofovir alafenamide versus tenofovir disoproxil fumarate, coformulated with elvitegra...
https://doi.org/10.1016/S0140-6736(15)60616-X
Lancet (London, England); Sax PE, Wohl D et. al.

Apr 21st, 2015 - Tenofovir disoproxil fumarate can cause renal and bone toxic effects related to high plasma tenofovir concentrations. Tenofovir alafenamide is a novel tenofovir prodrug with a 90% reduction in plasma tenofovir concentrations. Tenofovir alafenamide-containing regimens can have improved renal and bone safety compared with tenofovir disoproxil fumarate-containing regimens. In these two controlled,...

Dofetilide dose reductions and discontinuations in women compared with men.
https://doi.org/10.1016/j.hrthm.2018.01.027
Heart Rhythm; Pokorney SD, Yen DC et. al.

Apr 1st, 2018 - Compared with men, women have longer corrected QT (QTc) intervals, lower clearance of dofetilide, and higher rates of drug-induced torsades de pointes, but the dofetilide dosing algorithm is the same for men and women. The purpose of this study was to evaluate the tolerability of the 500 μg twice daily dose of dofetilide for men and women. Men and women admitted to Duke University Medical Cente...

Simplifying Piperacillin/Tazobactam Dosing: Pharmacodynamics of Utilizing Only 4.5 or 3...
https://doi.org/10.1177/0897190016684453
Journal of Pharmacy Practice; Thabit AK, Grupper M et. al.

Nov 10th, 2017 - To evaluate the pharmacodynamic exposure of piperacillin/tazobactam across the renal function range using 4.5 or 3.375 g dosing regimens. A 5000-patient Monte Carlo simulation was conducted to determine the probability of achieving 50% free time above the minimum inhibitory concentration ( fT > MIC) for piperacillin. Proposed regimens, using solely 4.5 or 3.375 g strengths, were compared with r...

Significance of Mini Bronchoalveolar Lavage Fluid Amylase Level in Ventilator-Associate...
https://doi.org/10.1097/CCM.0000000000002774
Critical Care Medicine; Samanta S, Poddar B et. al.

Oct 20th, 2017 - Aspiration of oropharyngeal or gastric contents in intubated patients can lead to ventilator-associated pneumonia. Amylase in respiratory secretion has been reported as a possible marker of aspiration. We studied whether elevated α-amylase in mini bronchoalveolar lavage specimens can be suggestive of ventilator-associated pneumonia in intubated patients with high clinical suspicion. Prospective...

Oral Bicarbonate Slows Decline of Residual Renal Function in Peritoneal Dialysis Patients.
https://doi.org/10.1159/000479641
Kidney & Blood Pressure Research; Liu XY, Gao XM et. al.

Oct 16th, 2017 - Metabolic acidosis is a common consequence of end-stage renal disease (ESRD) which may result in a substantial adverse outcome. The effect of oral bicarbonate on the preservation of residual renal function (RRF) in peritoneal dialysis (PD) patients has been rarely reported. We randomly assigned 40 continuous ambulatory peritoneal dialysis (CAPD) patients to the oral bicarbonate group or placebo...

Augmented Renal Clearance in Patients With Febrile Neutropenia is Associated With Incre...
https://doi.org/10.1097/FTD.0000000000000346
Therapeutic Drug Monitoring; Hirai K, Ishii H et. al.

Sep 29th, 2016 - Augmented renal clearance (ARC) has frequently been observed in critically ill patients. The risk factors for ARC in patients, including those in the general ward, and their influences on vancomycin (VCM) treatment remain unclear. The aims of this study were to investigate the risk factors for ARC and to evaluate the influence of ARC on the pharmacokinetic parameters of VCM. This study included...

Brief Report: Switching to Tenofovir Alafenamide, Coformulated With Elvitegravir, Cobic...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5228610
Journal of Acquired Immune Deficiency Syndromes (1999); Post FA, Tebas P et. al.

Sep 27th, 2016 - Tenofovir disoproxil fumarate is associated with renal and bone toxicity. In a single-arm, open-label study of 242 virologically suppressed, HIV-infected participants with creatinine clearance 30-69 mL/min who switched to elvitegravir/cobicistat/emtricitabine/tenofovir alafenamide, participants had stable creatinine clearance, significant and durable improvements in proteinuria, albuminuria, an...

Reversibility of Glomerular Renal Function Decline in HIV-Uninfected Men and Women Disc...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4770857
Journal of Acquired Immune Deficiency Syndromes (1999); Mugwanya KK, Wyatt C et. al.

Feb 25th, 2016 - Tenofovir disoproxil fumarate (TDF) pre-exposure prophylaxis (PrEP) use is associated with a small but statistically significant decline in estimated glomerular filtration rate (eGFR). We investigated the reversibility of eGFR decline among HIV-uninfected adults discontinuing PrEP. Data were from the Partners PrEP Study, a randomized trial of daily oral TDF and emtricitabine (FTC)-TDF PrEP amon...

Major Bleeding and Hemorrhagic Stroke With Direct Oral Anticoagulants in Patients With ...
https://doi.org/10.1016/j.chest.2015.12.029
Chest Raccah BH, Perlman A et. al.

Feb 2nd, 2016 - Direct oral anticoagulants (DOACs) are used as an alternative for traditional antithrombotic therapy. However, the safety profile of DOACs in patients with renal failure (RF) has not been determined. A systematic review was performed assessing the reported safety of DOACs compared with vitamin K antagonists (VKAs) in patients with RF and estimated creatinine clearance (eCrCL) < 50 mL/min and eC...

Updated US and European Dose Recommendations for Intravenous Colistin: How Do They Perf...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4741361
Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America; Nation RL, Garonzik SM et. al.

Nov 26th, 2015 - The US Food and Drug Administration (FDA) and European Medicines Agency (EMA) have approved updated dose recommendations for intravenous colistin in patients with various degrees of renal function. We assessed the recommendations in relation to their ability to achieve clinically relevant plasma colistin concentrations. Pharmacokinetic data from 162 adult critically ill patients (creatinine cle...

Estimated GFR for Living Kidney Donor Evaluation.
https://doi.org/10.1111/ajt.13540
American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons; Huang N, Foster MC et. al.

Nov 25th, 2015 - All living kidney donor candidates undergo evaluation of GFR. Guidelines recommend measured GFR (mGFR), using either an endogenous filtration marker or creatinine clearance, rather than estimated GFR (eGFR), but measurement methods are difficult, time consuming and costly. We investigated whether GFR estimated from serum creatinine (eGFRcr) with or without sequential cystatin C is sufficiently ...

Evaluation of Vancomycin Prediction Methods Based on Estimated Creatinine Clearance or ...
https://doi.org/10.1097/FTD.0000000000000250
Therapeutic Drug Monitoring; Haeseker M, Croes S et. al.

Sep 29th, 2015 - The aim of this study was to investigate whether vancomycin clearance (CLva) can be adequately predicted with CLva prediction methods. Additionally, other covariates influencing the CLva were investigated and predictivity of monitoring of only trough levels to 24-hour area under the curve (AUC24) was evaluated. Routine vancomycin plasma levels were measured with a fluorescence polarization immu...

A double-blinded, placebo-controlled, multicenter clinical trial of N-acetylcysteine fo...
https://doi.org/10.1517/17425255.2015.1042363
Expert Opinion on Drug Metabolism & Toxicology; Karimzadeh I, Khalili H et. al.

Jun 8th, 2015 - To evaluate the effectiveness of oral N-acetylcysteine (NAC) co-treatment in preventing amphotericin B (AmB)-induced nephrotoxicity (AIN), including creatinine clearance and biomarkers of renal function (cystatin C [Cys C] and kidney injury molecule-1 [KIM-1]). Either placebo or 600 mg oral NAC was given twice daily during the treatment course of AmB. Renal function test, serum as well as urina...

Renal function can be impaired in children with primary hyperoxaluria type 3.
https://doi.org/10.1007/s00467-015-3090-x
Pediatric Nephrology (Berlin, Germany); Allard L, Cochat P et. al.

May 14th, 2015 - Primary hyperoxaluria type 3 (PH3) is characterized by mutations in the 4-hydroxy-2-oxoglutarate aldolase (HOGA1) gene. PH3 patients are believed to present with a less severe phenotype than those with PH1 and PH2, but the clinical characteristics of PH3 patients have yet to be defined in sufficient detail. The aim of this study was to report our experience with PH3. Genetic analysis of HOGA1 w...

Perioperative Management of Dabigatran: A Prospective Cohort Study.
https://doi.org/10.1161/CIRCULATIONAHA.115.015688
Circulation Schulman S, Carrier M et. al.

May 14th, 2015 - The perioperative management of dabigatran in clinical practice is heterogeneous. We performed this study to evaluate the safety of perioperative management of dabigatran using a specified protocol. Patients treated with dabigatran and planned for an invasive procedure were eligible for inclusion. The timing of the last dose of dabigatran before the procedure was based on the creatinine clearan...