×
About 4,232 results
Bicarbonate Resensitization of Methicillin-Resistant Staphylococcus aureus to β-Lactam ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6591647
Antimicrobial Agents and Chemotherapy; Ersoy SC, Abdelhady W et. al.

Apr 23rd, 2019 - Endovascular infections caused by methicillin-resistant Staphylococcus aureus (MRSA) are a major health care concern, especially infective endocarditis (IE). Standard antimicrobial susceptibility testing (AST) defines most MRSA strains as "resistant" to β-lactams, often leading to the use of costly and/or toxic treatment regimens. In this investigation, five prototype MRSA strains, representing...

Ceftriaxone-Resistant Neisseria gonorrhoeae, Canada, 2017.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5782888
Emerging Infectious Diseases; Lefebvre B, Martin I et. al.

Nov 13th, 2017 - We identified a ceftriaxone-resistant Neisseria gonorrhoeae isolate in a patient in Canada. This isolate carried the penA-60 allele, which differs substantially from its closest relative, mosaic penA XXVII (80% nucleotide identity). Epidemiologic and genomic data suggest spread from Asia. Antimicrobial susceptibility surveillance helps prevent spread of highly resistant N. gonorrhoeae strains.

Outbreak of Invasive Infections From Subtype emm26.3 Group A Streptococcus Among Homele...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5862750
Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America; Mosites E, Frick A et. al.

Oct 26th, 2017 - In 2016, we detected an outbreak of group A Streptococcus (GAS) invasive infections among the estimated 1000 persons experiencing homelessness (PEH) in Anchorage, Alaska. We characterized the outbreak and implemented a mass antibiotic intervention at homeless service facilities. We identified cases through the Alaska GAS laboratory-based surveillance system. We conducted emm typing, antimicrobi...

Correcting a Fundamental Flaw in the Paradigm for Antimicrobial Susceptibility Testing.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5478264
EBioMedicine Ersoy SC, Heithoff DM et. al.

Jun 5th, 2017 - The emergence and prevalence of antibiotic-resistant bacteria are an increasing cause of death worldwide, resulting in a global 'call to action' to avoid receding into an era lacking effective antibiotics. Despite the urgency, the healthcare industry still relies on a single in vitro bioassay to determine antibiotic efficacy. This assay fails to incorporate environmental factors normally presen...

Pretreatment antimicrobial susceptibility-guided vs. clarithromycin-based triple therap...
https://doi.org/10.1038/ajg.2014.222
The American Journal of Gastroenterology; Park CS, Lee SM et. al.

Aug 5th, 2014 - Helicobacter pylori eradication rates with clarithromycin-based triple therapy are declining, and an alternative strategy is needed urgently. We sought to compare the efficacy of pretreatment antimicrobial susceptibility-guided vs. clarithromycin-based triple therapy for H. pylori eradication in a region with high rates of multiple drug resistance. Consecutive H. pylori-infected patients with g...

Strain types and antimicrobial resistance patterns of Clostridium difficile isolates fr...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4068552
Antimicrobial Agents and Chemotherapy; Tickler IA, Goering RV et. al.

Apr 22nd, 2014 - We determined the PCR ribotypes and antimicrobial susceptibility patterns of 508 toxigenic Clostridium difficile isolates collected between 2011 and 2013 from 32 U.S. hospitals. Of the 29 PCR ribotypes identified, the 027 strain type was the most common (28.1%), although the rates varied by geographic region. Ribotype 014/020 isolates appear to be emerging. Clindamycin and moxifloxacin resistan...

In-vitro activity of the novel fluorocycline eravacycline against carbapenem non-suscep...
https://doi.org/10.1016/j.ijantimicag.2017.06.022
International Journal of Antimicrobial Agents; Seifert H, Stefanik D et. al.

Jul 14th, 2017 - The activity of eravacycline was compared with that of anti-Acinetobacter reference antimicrobials against carbapenem non-susceptible Acinetobacter baumannii isolates associated with an acquired OXA or up-regulation of the intrinsic OXA-51-like enzyme. Antimicrobial susceptibility testing was performed by broth microdilution of 286 non-duplicate, carbapenem non-susceptible A. baumannii isolates...

In Vitro Susceptibility of the Relapsing-Fever Spirochete Borrelia miyamotoi to Antimic...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5571331
Antimicrobial Agents and Chemotherapy; Koetsveld J, Draga ROP et. al.

Jul 4th, 2017 - Hard-tick-borne relapsing fever (HTBRF) is an emerging infectious disease throughout the temperate zone caused by the relapsing-fever spirochete Borrelia miyamotoi Antibiotic treatment of HTBRF is empirically based on the treatment of Lyme borreliosis; however, the antibiotic susceptibility of B. miyamotoi has not been studied to date. Thus, we set out to determine the in vitro antimicrobial su...

Antimicrobial Susceptibility Trends among Staphylococcus aureus Isolates from U.S. Hosp...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5571371
Antimicrobial Agents and Chemotherapy; Sader HS, Mendes RE et. al.

Jun 20th, 2017 - We evaluated trends in Staphylococcus aureus antimicrobial susceptibility in U.S. hospitals in the 2010-2016 period. A total of 21,056 clinical isolates from 42 medical centers were tested for susceptibility by broth microdilution methods. Methicillin-resistant S. aureus (MRSA) rates decreased from 50.0% (in 2010) to 42.2% (in 2016). Susceptibility to erythromycin, levofloxacin, and clindamycin...

Evaluation of the Accelerate Pheno System for Fast Identification and Antimicrobial Sus...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5483913
Journal of Clinical Microbiology; Marschal M, Bachmaier J et. al.

Apr 27th, 2017 - Bloodstream infections (BSI) are an important cause of morbidity and mortality. Increasing rates of antimicrobial-resistant pathogens limit treatment options, prompting an empirical use of broad-range antibiotics. Fast and reliable diagnostic tools are needed to provide adequate therapy in a timely manner and to enable a de-escalation of treatment. The Accelerate Pheno system (Accelerate Diagno...

Antimicrobial Susceptibility of Neisseria gonorrhoeae in Japan from 2000 to 2015.
https://doi.org/10.1097/OLQ.0000000000000556
Sexually Transmitted Diseases; Yasuda M, Hatazaki K et. al.

Feb 8th, 2017 - Gonococcal infections are difficult to treat because of their multidrug antimicrobial resistance. The outbreak of antimicrobial-resistant Neisseria gonorrhoeae has begun in Asia and particularly in Japan. Therefore, it is very important that we understand the trend of antimicrobial resistance of N. gonorrhoeae in Asia including Japan. Our surveillance of the antimicrobial susceptibility of N. g...

Can Ceftazidime-Avibactam and Aztreonam Overcome β-Lactam Resistance Conferred by Metal...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5365724
Antimicrobial Agents and Chemotherapy; Marshall S, Hujer AM et. al.

Feb 8th, 2017 - Based upon knowledge of the hydrolytic profile of major β-lactamases found in Gram-negative bacteria, we tested the efficacy of the combination of ceftazidime-avibactam (CAZ-AVI) with aztreonam (ATM) against carbapenem-resistant enteric bacteria possessing metallo-β-lactamases (MBLs). Disk diffusion and agar-based antimicrobial susceptibility testing were initially performed to determine the in...

Evaluation of a Semiquantitative Matrix-Assisted Laser Desorption Ionization-Time of Fl...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5078562
Journal of Clinical Microbiology; Jung JS, Hamacher C et. al.

Sep 15th, 2016 - With the increasing prevalence of multidrug-resistant Gram-negative bacteria, rapid identification of the pathogen and its individual antibiotic resistance is crucial to ensure adequate antiinfective treatment at the earliest time point. Matrix-assisted laser desorption ionization-time of flight (MALDI-TOF) mass spectrometry for the identification of bacteria directly from the blood culture bot...

Antimicrobial susceptibility of Streptococcus pneumoniae, Haemophilus influenzae and Mo...
https://doi.org/10.1016/j.jgar.2016.03.002
Journal of Global Antimicrobial Resistance; Zhang Y, Zhang F et. al.

Jul 20th, 2016 - This study investigated the antimicrobial susceptibilities of Streptococcus pneumoniae, Haemophilus influenzae and Moraxella catarrhalis isolates causing adult community-acquired respiratory tract infections (CARTIs) in China. A multicentre resistance surveillance study (CARTIPS) investigating 1046 clinical isolates from 19 hospitals in China was conducted from 2013 to 2014. Based on the minimu...

Nasopharyngeal bacterial carriage in young children in Greenland: a population at high ...
https://doi.org/10.1017/S0950268816001461
Epidemiology and Infection; Navne JE, Børresen ML et. al.

Jul 13th, 2016 - The incidence of childhood respiratory infections in Greenland is among the highest globally. We performed a population-based study of 352 Greenlandic children aged 0-6 years aiming to describe rates and risk factors for carriage of four key bacteria associated with respiratory infections, their antimicrobial susceptibility and inter-bacterial associations. Nasopharyngeal swabs were tested for ...

In Vitro Susceptibility of Global Surveillance Isolates of Pseudomonas aeruginosa to Ce...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4958170
Antimicrobial Agents and Chemotherapy; Nichols WW, de Jonge BL et. al.

May 24th, 2016 - Broth microdilution antimicrobial susceptibility testing was performed for ceftazidime-avibactam and comparator agents against 7,062 clinical isolates of Pseudomonas aeruginosa collected from 2012 to 2014 in four geographic regions (Europe, Asia/South Pacific, Latin America, Middle East/Africa) as part of the International Network for Optimal Resistance Monitoring (INFORM) global surveillance p...

Changing Patterns in Enteric Fever Incidence and Increasing Antibiotic Resistance of En...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5207092
Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America; Date KA, Newton AE et. al.

Apr 19th, 2016 - Enteric fever in the United States has been primarily associated with travel and with worrisome changes in global patterns of antimicrobial resistance. We present the first comprehensive report of National Typhoid and Paratyphoid Fever Surveillance System (NTPFS) data for a 5-year period (2008-2012). We reviewed data on laboratory-confirmed cases reported to NTPFS, and related antimicrobial sus...

Analysis and Presentation of Cumulative Antimicrobial Susceptibility Test Data--The Inf...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4729434
PloS One; Kohlmann R, Gatermann SG

Jan 27th, 2016 - Many clinical microbiology laboratories report on cumulative antimicrobial susceptibility testing (cAST) data on a regular basis. Criteria for generation of cAST reports, however, are often obscure and inconsistent. Whereas the CLSI has published a guideline for analysis and presentation of cAST data, national guidelines directed at clinical microbiology laboratories are not available in Europe...

Antimicrobial Susceptibilities of Abiotrophia defectiva, Granulicatella adiacens, and G...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4776019
Antimicrobial Agents and Chemotherapy; Alberti MO, Hindler JA et. al.

Dec 16th, 2015 - Nutritionally variant streptococci (NVS) are fastidious Gram-positive cocci comprised of the species Abiotrophia defectiva, Granulicatella adiacens, and Granulicatella elegans. NVS are an important cause of bacteremia and infective endocarditis (IE) associated with significant morbidity and mortality. Antimicrobial susceptibility testing (AST) was performed for 14 antimicrobials using the broth...

In Vitro Activity of Retapamulin and Antimicrobial Susceptibility Patterns in a Longitu...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4775979
Antimicrobial Agents and Chemotherapy; Harrington AT, Black JA et. al.

Dec 16th, 2015 - Mupirocin is a topical antimicrobial used to decolonize patients who carry methicillin-resistant Staphylococcus aureus (MRSA), and the topical agent retapamulin may be a potential alternative therapy. The goal of this study was to determine the in vitro activity of retapamulin as well as a panel of 15 antimicrobial agents, including mupirocin, for 403 MRSA isolates collected longitudinally from...