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About 573 results

ALLMedicine™ 5'-nucleotidase Center

Research & Reviews  228 results

CD73 induces GM-CSF/MDSC-mediated suppression of T cells to accelerate pancreatic cance...
https://doi.org/10.1038/s41388-021-02132-6
Oncogene King RJ, Shukla SK et. al.

Jan 11th, 2022 - Metabolic alterations regulate cancer aggressiveness and immune responses. Given the poor response of pancreatic ductal adenocarcinoma (PDAC) to conventional immunotherapies, we investigated the link between metabolic alterations and immunosuppres...

Genetic variations of adenosine kinase as predictable biomarkers of efficacy of vagus n...
https://doi.org/10.3171/2021.3.JNS21141
Journal of Neurosurgery; Zhang Y, Wang X et. al.

Sep 4th, 2021 - Vagus nerve stimulation (VNS) is an alternative treatment option for individuals with refractory epilepsy, with nearly 40% of patients showing no benefit after VNS and only 6%-8% achieving seizure freedom. It is presently unclear why some patients...

Bispecific antibody CD73xEpCAM selectively inhibits the adenosine-mediated immunosuppre...
https://doi.org/10.1016/j.canlet.2021.08.037
Cancer Letters; Ploeg EM, Ke X et. al.

Sep 1st, 2021 - Tumor-derived extracellular vesicles (EVs) carry potent immunosuppressive factors that affect the antitumor activities of immune cells. A significant part of the immunoinhibitory activity of EVs is attributable to CD73, a GPI-anchored ecto-5'-nucl...

Diagnostic Accuracy of Anti-CN1A on the Diagnosis of Inclusion Body Myositis. A Hierarc...
https://doi.org/10.1097/CND.0000000000000353
Journal of Clinical Neuromuscular Disease; Mavroudis I, Knights M et. al.

Aug 26th, 2021 - Sporadic inclusion body myositis (IBM) is an acquired muscle disease and the most common idiopathic inflammatory myopathy over the age of 50. It is characterized by male predominance, with a prevalence rate between 1 and 71 cases per million, reac...

CD73 induces gemcitabine resistance in pancreatic ductal adenocarcinoma: A promising ta...
https://doi.org/10.1016/j.canlet.2021.07.024
Cancer Letters; Yu X, Liu W et. al.

Jul 25th, 2021 - CD73, a cell surface-localized ecto-5'-nucleotidase, is the major enzymatic source of extracellular adenosine. Canonically, it plays multiple roles in cancer-related processes via its metabolite. As a druggable target, clinical trials targeting CD...

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Clinicaltrials.gov  1 results

Is Augmentation of PORH by Rosuvastatin Adenosine-receptor Mediated?
https://clinicaltrials.gov/ct2/show/NCT00851175

Oct 1st, 2009 - Rationale: Statins form a class of drugs that is widely prescribed for hypercholesterolaemia, specifically to reduce the risk on atherosclerosis by lowering LDL-cholesterol. Next to the effect for which the drug was originally developed, it became...

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