About 810 results
Psoriatic Arthritis - StatPearls

Sep 19th, 2019 - Psoriatic arthritis (PsA) is chronic inflammatory arthritis associated with psoriasis (PsO) and found in about 20 to 30% of such patients.[1] It shares many clinical features with other spondyloarthropathies and also rheumatoid arthritis (RA). It is usually seronegative, but a small percentage of patients may be positive for rheumatoid factor (RF) and anti-cyclic citrullinated peptide antibodi...

Lupus Erythematosus - StatPearls

Apr 19th, 2019 - The acute form of systemic lupus erythematosus (SLE) differs from the chronic form. It disseminates differently, and it is highly fatal. Kaposi was the first in recognizing SLE in 1872, and then Pernet described it in 1908. Before that time SLE was considered to be a non-fatal disfiguring skin disease. It is now to be considered a chronic inflammatory disease characterized by a course of altern...

Distinguishing rheumatoid arthritis from psoriatic arthritis
RMD Open; Merola, J. et. al.

Aug 12th, 2018 - Rheumatoid arthritis (RA) and psoriatic arthritis (PsA) have key differences in clinical presentation, radiographic findings, comorbidities and pathogenesis to distinguish between these common forms of chronic inflammatory arthritis. Joint involvement is typically, but not always, asymmetric in PsA, while it is predominantly symmetric in RA. Bone erosions, without new bone growth, and cervical ...

Gout rates reduced with SGLT2 inhibitors
Heidi Splete

Jan 13th, 2020 - The incidence of gout was approximately 40% lower in diabetes patients who were prescribed sodium-glucose cotransporter 2 inhibitors (SGLT2) than it was in those who were prescribed glucagonlike peptide–1 receptor (GLP-1) agonists in a population-based new-user cohort study. Hyperuricemia is a known cause of gout and common in type 2 diabetes patients.

Diabetes Drug Class May Hold Promise for Gout Prevention

Jan 12th, 2020 - Sodium-glucose cotransporter-2 (SGLT2) inhibitors may reduce the risk for gout among adults with type 2 diabetes, new research suggests. The study, involving more than 200,000 individuals from a US commercial insurance database, was published online January 13 in Annals of Internal Medicine by Michael Fralick, MD, PhD, and colleagues. The glycosuria produced by SGLT2 inhibitors results in secre...

Fast Five Quiz: Gout and Pseudogout

Dec 3rd, 2019 - Gout is one of the oldest diseases in the medical literature, known since the time of the ancient Greeks. Pseudogout may be clinically indistinguishable from gout. If untreated, these disorders can lead to joint destruction and renal damage. Worldwide, incidence has been steadily increasing. Gout is now the most common type of inflammatory arthropathy seen in adults. Identification and treatmen...

Matrix of Factors Predicts Rapid Progression in Early RA

Dec 1st, 2019 - A matrix of four baseline factors routinely assessed in patients presenting with early rheumatoid arthritis (RA) might help clinicians identify the small proportion who are at risk for rapid radiographic progression (RRP) during the following year despite treatment with methotrexate (MTX) and who might be candidates for more aggressive intervention, researchers report. "A matrix using the predi...

Obesity, Drinking and Unhealthy Diet Add to Gout Risk

Sep 22nd, 2019 - (Reuters Health) - Behavior changes could potentially reduce a large part of the risk for developing gout, a U.S. study suggests. Based on data from more than 14,000 people, researchers calculated how much factors like being overweight, following a diet that isn't heart-healthy, drinking alcohol or taking diuretics contribute to high levels of uric acid - a precursor to gout. The findings "supp...

Obesity, drinking and unhealthy diet add to gout risk

Sep 20th, 2019 - (Reuters Health) - Behavior changes could potentially reduce a large part of the risk for developing gout, a U.S. study suggests. Based on data from more than 14,000 people, researchers calculated how much factors like being overweight, following a diet that isn’t heart-healthy, drinking alcohol or taking water pills known as diuretics contribute to high levels of uric acid, known as hyperurice...

New Criteria a 'Paradigm Shift' for Systemic Lupus Erythematosus

Sep 2nd, 2019 - NEW YORK (Reuters Health) - New classification criteria for systemic lupus erythematosus (SLE) from the American College of Rheumatology (ACR) and the European League Against Rheumatism (EULAR) represent a "paradigm shift" in how the disease is diagnosed and studied, the developers say. "The new criteria provide a simple, directed and highly accurate method for classifying SLE," Dr. Sindhu John...

RA Autoantibodies Don't Disappear With Remission

Aug 16th, 2019 - Immunologic remission in rheumatoid arthritis (RA), defined as the disappearance of anti-citrullinated protein antibodies (ACPA) and rheumatoid factor (RF), was seen infrequently among patients achieving sustained clinical remission and did not correlate with the disappearance of symptoms, a long-term Dutch study found. Among RA patients who were ACPA positive and achieved sustained remission a...

Establishing the Diagnosis of Rosacea in Skin of Color Patients

Jul 11th, 2019 - Both SLE and rosacea may be exacerbated by sun exposure, and patients may report burning and stinging. 16-18 Performing a complete physical examination, performing a skin biopsy with hematoxylin and eosin and direct immunofluorescence, and checking serologies including antinuclear antibody (ANA) can assist in making the diagnosis.

Repeated ANA testing after negative result of little diagnostic value
Sara Freeman

Jul 8th, 2019 - MADRID – Repeated antinuclear antibody testing after a negative result has limited use for the diagnosis of ANA-associated rheumatologic conditions, according to data from a multicenter, retrospective analysis that considered a 7-year period. Sara Freeman/MDEdge News Dr.

Clinically Impressive Tophaceous Gout With Significant Bony Destruction

Jul 3rd, 2019 - Discussion Tophaceous gout is characterized by collections of solid urate accompanied by chronic inflammatory and often destructive changes in the surrounding tissue brought on by periods of increased uric acid levels. Due to the patient’s 20-year history of untreated tophaceous gout, we saw the extent of bony and soft tissue destruction that this pathology created.

Using New Autoantibodies in Rheumatic Disease: An Update

May 22nd, 2019 - Antibody testing is likely to play an increasingly important role in the practice of rheumatology. The classification of lupus is enabled by antinuclear antibodies, as is rheumatoid arthritis (RA), by employing autoantibodies such as rheumatoid factor (RF) and antibodies to citrullinated protein/peptide antigens (ACPAs). Evidence suggests that autoantibodies can help determine disease manifesta...

Does Seropositivity Change With RA Therapy?

Feb 2nd, 2019 - A subanalysis of the early rheumatoid arthritis (RA) IMPROVED study has shown that changes in RA-autoantibody levels are not associated with disease activity or long-term drug response, but instead reflect the intensity of immunosuppression. Therefore, while autoantibody levels may be modifiable by our best therapies, modifying cyclic citrullinated peptide or rheumatoid factor levels may have l...

Health care costs matter to patients, and we can do something about it

Jan 8th, 2019 - High-value change #2: Stop ordering unnecessary lab work Another high-value change to consider: Examine each laboratory test order to understand if the test results will really alter the care of a patient. Providers vary, and ordering lab tests to “make sure” can add up as financial expense.

Managing Gout as a Systemic Disease

Nov 14th, 2018 - Hello. I'm Dr Arefa Cassoobhoy, a primary care internist, Medscape advisor, and senior medical director for WebMD. Welcome to Medscape Morning Report, our 1-minute news story for primary care. A new study adds more proof that gout should be managed like a chronic disease, using a treat-to-target approach to uric acid levels. The researchers looked at a cohort of almost 1200 patients attending a...

Uric Acid a Potential Predictor of Bipolar Disorder

Nov 7th, 2018 - Serum uric acid (UA) levels may help predict conversion to bipolar disorder (BD) in patients with major depressive disorder (MDD). In a study of inpatients with MDD, it was found that in those patients who converted to BD, UA blood levels were higher than in patients who did not convert. UA levels had "very good to excellent prognostic accuracy as a biomarker of conversion," senior author Nuno ...

Mortality Risk Doubles for Gout When Uric Acid Not Optimal

Oct 23rd, 2018 - Gurkirpal Singh, MD, from Stanford University in California, talks to Medscape Medical News about the challenges of treating gout. (Camera work by John Gress; video edit by John Rodriguez)   CHICAGO — Patients with gout who fail to achieve optimal levels of serum uric acid are at increased risk for premature mortality, new data show. The risk is twice as high in patients with serum uric acid le...