ALLMedicine™ Methylmalonic Acid Center

Mar 15th, 2021 - Assessing the pre and post test probability of disease in the context of routine health care is challenging. We wished to study how test performance parameters relating to clinical utility vary by clinical indication in a âreal worldâ setting. The...

Mar 9th, 2021 - The causal role of maternal nutrition in orofacial clefts is uncertain. We tested hypotheses that low maternal vitamin B12 and low folate status are each associated with an increased risk of isolated cleft lip with or without cleft palate (CL±P) i...

Feb 12th, 2021 - Vitamin B12 deficiency in children may be associated with (severe) neurological manifestations, therefore recognition is important. Diagnosing vitamin B12 deficiency in children is challenging. This study aimed to investigate plasma methylmalonic ...

Dec 10th, 2020 - Methylmalonic acid (MMA) is best known for its use as a functional marker of vitamin B12 deficiency. However, MMA concentrations not only depend on adequate vitamin B12 status, but also relate to renal function and endogenous production of propion...

Nov 6th, 2020 - Current guidelines pertaining to diagnosing macrocytic anemia in association with vitamin B12 and folate deficiency recommend that vitamin B12, folate, homocysteine, and methylmalonic acid assays should be assessed concurrently due to their close ...

Jun 19th, 2014 - The clinical picture is the most important factor in assessing the significance of test results assessing cobalamin status because there is no 'gold standard' test to define deficiency. Serum cobalamin currently remains the first-line test, with a...

Mar 15th, 2021 - Assessing the pre and post test probability of disease in the context of routine health care is challenging. We wished to study how test performance parameters relating to clinical utility vary by clinical indication in a âreal worldâ setting. The...

Mar 9th, 2021 - The causal role of maternal nutrition in orofacial clefts is uncertain. We tested hypotheses that low maternal vitamin B12 and low folate status are each associated with an increased risk of isolated cleft lip with or without cleft palate (CL±P) i...

Feb 12th, 2021 - Vitamin B12 deficiency in children may be associated with (severe) neurological manifestations, therefore recognition is important. Diagnosing vitamin B12 deficiency in children is challenging. This study aimed to investigate plasma methylmalonic ...

Dec 10th, 2020 - Methylmalonic acid (MMA) is best known for its use as a functional marker of vitamin B12 deficiency. However, MMA concentrations not only depend on adequate vitamin B12 status, but also relate to renal function and endogenous production of propion...

Nov 6th, 2020 - Current guidelines pertaining to diagnosing macrocytic anemia in association with vitamin B12 and folate deficiency recommend that vitamin B12, folate, homocysteine, and methylmalonic acid assays should be assessed concurrently due to their close ...

Mar 8th, 2020 - An 82-year-old woman complaining of fatigue has a hemoglobin level of 8 g/dL with a mean corpuscular volume of 114 fL. Her B12 level is 90 pg/mL (normal level: > 200). Folic acid level is normal. Methylmalonic acid level is high.

Mar 8th, 2020 - An 82-year-old woman complaining of fatigue has a hemoglobin level of 8 g/dL with a mean corpuscular volume of 114 fL. Her B12 level is 90 pg/mL (normal level: > 200). Folic acid level is normal. Methylmalonic acid level is high. You must Log In t...

Jan 1st, 2016 - To the Editor: In the article “ An unusual cause of vitamin B 12 and iron deficiency ,”1 the diagnosis of vitamin B 12 deficiency was made only by a vitamin B 12 level of 108 pg/mL. According to Harrison’s Principles of Internal Medicine, 18th edi.

Sep 30th, 2015 - STOCKHOLM – Clinicians might want to consider more routinely monitoring levels of vitamin B12 in their diabetic patients who are using metformin, according to new data from the HOME (Hyperinsulinaemia: the Outcome of Its Metabolic Effects) randomi.

Sep 30th, 2015 - STOCKHOLM – Clinicians might want to consider more routinely monitoring levels of vitamin B12 in their diabetic patients who are using metformin, according to new data from the HOME (Hyperinsulinaemia: the Outcome of Its Metabolic Effects) randomi.