About 610 results

ALLMedicine™ Methylmalonic Acid Center

Research & Reviews  221 results

Transcobalamin receptor deficiency in seven asymptomatic patients ascertained through n...
American Journal of Medical Genetics. Part A; Pappas KB, Younan M et. al.

Jan 4th, 2022 - We report seven cases from our clinic with transcobalamin receptor deficiency (TCRD). None of our cases have experienced health issues or metabolic decompensation. All have experienced typical growth and development throughout childhood, with our ...

Pernicious Anemia Workup

Dec 14th, 2021 - Approach Considerations The workup for pernicious anemia may include the following: Peripheral blood smear Indirect bilirubin and lactate dehydrogenase assays Evaluation of gastric secretions Serum cobalamin, folic acid, methylmalonic acid, and ho...

The roles of homocysteinemia and methylmalonic acidemia in kidney injury in atypical he...
https://doi.org/10.1007/s00467-021-05372-6 10.1681/ASN.2004100861 10.1007/s00467-016-3399-0 10.1093/hmg/ddaa044 10.1016/j.ydbio.2020.09.005 10.1055/s-2000-8472 10.1007/s10545-007-0571-5 10.1038/ng1683 10.1172/JCI129937 10.1136/bcr-2015-211989 10.1007/s004310051190 10.1007/s00467-013-2443-6 10.3390/toxins11110660 10.1212/WNL.0000000000010912
Pediatric Nephrology (Berlin, Germany); Wood WD, Elmaghrabi A et. al.

Dec 3rd, 2021 - Cobalamin C (cblC), a vitamin B12 processing protein, plays a crucial role in metabolism for the conversion of homocysteine to methionine and methylmalonyl-CoA to succinyl-CoA. CblC deficiency, an inborn error of cobalamin processing, is a rare ca...

MMAB promotes negative feedback control of cholesterol homeostasis.
Nature Communications; Goedeke L, Canfrán-Duque A et. al.

Nov 10th, 2021 - Intricate regulatory networks govern the net balance of cholesterol biosynthesis, uptake and efflux; however, the mechanisms surrounding cholesterol homeostasis remain incompletely understood. Here, we develop an integrative genomic strategy to de...

Clinical relevance of testing for metabolic vitamin B12 deficiency in patients with pol...
Nutritional Neuroscience; Warendorf JK, van Doormaal PTC et. al.

Oct 26th, 2021 - Determine vitamin B12 threshold levels below which additional testing of methylmalonic acid (MMA) and/or homocysteine (Hcy) is useful to diagnose metabolic vitamin B12 deficiency in patients with polyneuropathy, and how vitamin B12, MMA and Hcy le...

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Clinicaltrials.gov  9 results

Nutrient Bioavailability From Microalgae

Jan 13th, 2021 - The microalgae are selected depending on their contents of long-chain omega-3 fatty acids, e.g. eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), high-quality protein (focus: essential amino acids), dietary fibers but also vitamin D pre-...

The Vitamin B Status in Type 2 Diabetes (VITA) Study

May 14th, 2018 - This observational study recruited either control subjects or patients with type 2 diabetes for over 5 years and collected information on cardiovascular risk factors. Fasting blood samples and urine were collected and biomarkers of B-vitamins were...

Effect of Toothpaste Fortified With Cyanocobalamin on Vitamin B12 Status

May 11th, 2018 - A 3 months randomized, placebo-controlled study on the effect of toothpaste fortified with vitamin B12 on vitamin B12 status markers and related metabolic markers. The primary outcome variable is the difference in the change of methylmalonic acid ...


Aug 9th, 2016 - From 2008-2013 more than 5,000 patients have been seen by a community-based internist/psychiatrist specializing in treating cognitively impaired adults suffering from MCI or dementia due to Alzheimer's Disease, vascular dementia, combined DAT/VAD,...

Vitamin B12 Supplement to Prevent Cognitive Decline

Jan 28th, 2016 - Background: Older diabetic people are at greater risk of cognitive decline than non-diabetic people. Vitamin B12 deficiency in older people is associated with cognitive impairment and Alzheimer's disease. Vitamin B12 deficiency may therefore contr...

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News  14 results

Psychiatric consequences of nitrous oxide abuse
Daniel Roberts, MD, MSW, Pantea Farahmand, MA, MD et. al.

Feb 1st, 2021 - We would like to describe the case of a patient we treated who developed neuropsychiatric symptoms secondary to recreational use of nitrous oxide (N2O). Mr.

Treating Vitamin B12 Deficiency: What Formulation Is Best?

Mar 9th, 2020 - An 82-year-old woman complaining of fatigue has a hemoglobin level of 8 g/dL with a mean corpuscular volume of 114 fL. Her B12 level is 90 pg/mL (normal level: > 200). Folic acid level is normal. Methylmalonic acid level is high.

Treating Vitamin B12 Deficiency: What Formulation Is Best?

Mar 9th, 2020 - An 82-year-old woman complaining of fatigue has a hemoglobin level of 8 g/dL with a mean corpuscular volume of 114 fL. Her B12 level is 90 pg/mL (normal level: > 200). Folic acid level is normal. Methylmalonic acid level is high. You must Log In t...

The Rest of the Story on Vitamin B for Stroke Prevention

Oct 17th, 2018 - It is clear that high levels of total homocysteine (tHcy) are a strong, graded risk factor for vascular disease. This is particularly true for cardioembolic stroke; high levels of tHcy quadruple the risk of stroke in atrial fibrillation. Vitamin t...

Low Vitamin B12 Level Is Associated With Worsening in Parkinson’s Disease

May 1st, 2018 - People with early, untreated Parkinson’s disease who have low vitamin B12 levels appear to have greater worsening of mobility and cognitive decline over time, according to research published online ahead of print March 6 in Movement Disorders. The.

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