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About 15,248 results
Association of Intracerebral Hemorrhage Among Patients Taking Non-Vitamin K Antagonist ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5839299
JAMA Inohara T, Xian Y et. al.

Jan 26th, 2018 - Although non-vitamin K antagonist oral anticoagulants (NOACs) are increasingly used to prevent thromboembolic disease, there are limited data on NOAC-related intracerebral hemorrhage (ICH). To assess the association between preceding oral anticoagulant use (warfarin, NOACs, and no oral anticoagulants [OACs]) and in-hospital mortality among patients with ICH. Retrospective cohort study of 141 31...

Anticoagulation: Updated Guidelines for Outpatient Management
https://www.aafp.org/afp/2019/1001/p426.html
American Family Physician;

Sep 30th, 2019 - Anticoagulation therapy is recommended for preventing, treating, and reducing the recurrence of venous thromboembolism, and preventing stroke in persons with atrial fibrillation. Direct oral anticoagulants are first-line agents for eligible patients for treating venous thromboembolism and preventing stroke in those with nonvalvular atrial fibrillation. Vitamin K antagonists are recommended for ...

Effects of Nutritional Supplements and Dietary Interventions on Cardiovascular Outcomes: An Umbrella Review and Evidence Map
https://annals.org/aim/article-abstract/2737825/effects-nutritional-supplements-dietary-interventions-cardiovascular-outcomes-umbrella-review-evidence
Annals of Internal Medicine; Khan, S. et. al.

Jul 8th, 2019 - Background: The role of nutritional supplements and dietary interventions in preventing mortality and cardiovascular disease (CVD) outcomes is unclear. Purpose: To examine evidence about the effects of nutritional supplements and dietary interventions on mortality and cardiovascular outcomes in adults. Data Sources: PubMed, CINAHL, and the Cochrane Library from inception until March 20...

Association Among Dietary Supplement Use, Nutrient Intake, and Mortality Among U.S. Adults
https://annals.org/aim/article-abstract/2730525/association-among-dietary-supplement-use-nutrient-intake-mortality-among-u
Chen, F. et. al.

Apr 8th, 2019 - Background: The health benefits and risks of dietary supplement use are controversial. Objective: To evaluate the association among dietary supplement use, levels of nutrient intake from foods and supplements, and mortality among U.S. adults. Design: Prospective cohort study. Setting: NHANES (National Health and Nutrition Examination Survey) data from 1999 to 2010, linked to Nation...

The association between diet and glucocorticoid treatment in patients with SLE
https://lupus.bmj.com/content/3/1/e000135
Lupus Science & Medicine; Lourdudoss, C. et. al.

Jan 18th, 2019 - Background Some studies suggest that the risk for and severity of systemic lupus erythematosus (SLE) can be modified by certain nutrients. The aim of this study was to investigate the association between diet and glucocorticoid (GC) treatment, as a proxy for disease activity, in patients with SLE. Methods We included 111 patients with SLE from the SLE Vascular Impact Cohort (SLEVIC). Dietary...

Prostate Cancer, Nutrition, and Dietary Supplements (PDQ®)–Health Professional Version
https://www.cancer.gov/about-cancer/treatment/cam/hp/prostate-supplements-pdq

Jan 13th, 2019 - This summary includes the history of research, reviews of laboratory and animal studies, and results of clinical trials on the following foods or dietary supplements: Calcium. Green tea. Lycopene. Modified citrus pectin. Pomegranate. Selenium. Soy. Vitamin D. Vitamin E. Multicomponent therapies. Other prostate health supplements.

COMT and Alpha-Tocopherol Effects in Cancer Prevention: Gene-Supplement Interactions in Two Randomized Clinical Trials
https://academic.oup.com/jnci/advance-article-abstract/doi/10.1093/jnci/djy204/5260812?redirectedFrom=fulltext
Journal of the National Cancer Institute; Hall, K. et. al.

Jan 7th, 2019 - Background Vitamins are among the most frequently used supplements (48% of US adults). However, little is known about contributions of genetic variation to their efficacy and safety. Multiple pathways link catechol-O-methyltransferase (COMT) to the vitamin E supplement, alpha-tocopherol, and cancer. Methods Here we determined if COMT exerted pharmacogenetic effects on cancer prevention in ...

Significance and impact of dietary factors on systemic lupus erythematosus pathogenesis
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6327661/
Experimental and Therapeutic Medicine;

Nov 15th, 2018 - Systemic lupus erythematosus (SLE) is an autoimmune disease of unknown etiology, although its mechanisms involve genetic, epigenetic and environmental risk factors. Considering that SLE pathogenesis is yet to be explored, recent studies aimed to investigate the impact of diet, in terms of triggering or altering the course of the disease. To study the impact of diet on SLE pathogenesis, we condu...

Hen Egg as an Antioxidant Food Commodity
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4632414/
Nutrients

Sep 23rd, 2015 - Intake of antioxidants through diet is known to be important in reducing oxidative damage in cells and improving human health. Although eggs are known for their exceptional, nutritional quality, they are not generally considered as antioxidant foods. This review aims to establish the importance of eggs as an antioxidant food by summarizing the current knowledge on egg-derived antioxidants. Eggs...

Treatment With Prothrombin Complex Concentrate to Enable Emergency Lumbar Puncture in P...
https://doi.org/10.1016/j.annemergmed.2016.03.003
Annals of Emergency Medicine; Laible M, Beynon C et. al.

Apr 17th, 2016 - Lumbar punctures are frequently necessary in neurologic emergencies, but effective oral anticoagulation with vitamin K antagonists represents a contraindication. We report the effectiveness of prothrombin complex concentrates to reverse vitamin K antagonist to enable emergency lumbar punctures, as well as evaluate lumbar puncture- and prothrombin complex concentrates-related complications. Cons...

Recurrent venous thromboembolism and abnormal uterine bleeding with anticoagulant and h...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4832477
Blood Martinelli I, Lensing AW et. al.

Dec 23rd, 2015 - Women receiving vitamin K antagonists (VKAs) require adequate contraception because of the potential for fetal complications. It is unknown whether the use of hormonal therapy, especially those containing estrogens, is associated with recurrent venous thromboembolism (VTE) during anticoagulation. Despite the absence of data, World Health Organization guidelines state that use of estrogen-contai...

Idarucizumab for Dabigatran Reversal.
https://doi.org/10.1056/NEJMoa1502000
The New England Journal of Medicine; Pollack CV, Reilly PA et. al.

Jun 22nd, 2015 - Specific reversal agents for non-vitamin K antagonist oral anticoagulants are lacking. Idarucizumab, an antibody fragment, was developed to reverse the anticoagulant effects of dabigatran. We undertook this prospective cohort study to determine the safety of 5 g of intravenous idarucizumab and its capacity to reverse the anticoagulant effects of dabigatran in patients who had serious bleeding (...

Digoxin use in patients with atrial fibrillation and adverse cardiovascular outcomes: a...
https://doi.org/10.1016/S0140-6736(14)61836-5
Lancet (London, England); Washam JB, Stevens SR et. al.

Mar 9th, 2015 - Digoxin is a widely used drug for ventricular rate control in patients with atrial fibrillation (AF), despite a scarcity of randomised trial data. We studied the use and outcomes of digoxin in patients in the Rivaroxaban Once Daily Oral Direct Factor Xa Inhibition Compared with Vitamin K Antagonism for Prevention of Stroke and Embolism Trial in Atrial Fibrillation (ROCKET AF). For this retrospe...

B vitamins to enhance treatment response to antidepressants in middle-aged and older ad...
https://doi.org/10.1192/bjp.bp.114.145177
The British Journal of Psychiatry : the Journal of Mental Science; Almeida OP, Ford AH et. al.

Sep 26th, 2014 - Depression is common and the efficacy of antidepressants is suboptimal. High plasma homocysteine has been consistently associated with depression, and treatment with certain B vitamins demonstrably reduces its concentration. To determine whether vitamins B6, B12 and folic acid enhance response to antidepressant treatment over 52 weeks. Randomised, double-blind, placebo-controlled trial of cital...

Neonatal vitamin K refusal and nonimmunization.
https://doi.org/10.1542/peds.2014-1092
Pediatrics Sahni V, Lai FY et. al.

Aug 19th, 2014 - Neonatal Vitamin K prophylaxis is an effective intervention for reducing vitamin K deficiency bleeding. A recently published report of parental refusal of vitamin K prompted an investigation of the prevalence and characteristics of this group, and exploration of whether these same parents were likely to subsequently refuse immunization for their children. We conducted a retrospective population...

The Risk / Benefit Tradeoff of Antithrombotic Therapy in Patients with Atrial Fibrillat...
https://doi.org/10.1161/CIRCULATIONAHA.120.046534
Circulation Alexander JH, Wojdyla D et. al.

Mar 28th, 2020 - Background: In AUGUSTUS, patients with atrial fibrillation (AF) and a recent acute coronary syndrome (ACS) and/or those undergoing percutaneous coronary intervention (PCI) had less bleeding with apixaban than vitamin K antagonist (VKA) and with placebo than aspirin, however, the number of ischemic events was numerically higher with placebo. The aim of this analysis is to assess the tradeoff of ...

Dual Versus Triple Therapy for Atrial Fibrillation After Percutaneous Coronary Interven...
https://doi.org/10.7326/M19-3763
Annals of Internal Medicine; Khan SU, Osman M et. al.

Mar 16th, 2020 - The safety and effectiveness of dual therapy (direct oral anticoagulant [DOAC] plus P2Y12 inhibitor) versus triple therapy (vitamin K antagonist plus aspirin and P2Y12 inhibitor) in patients with nonvalvular atrial fibrillation (AF) after percutaneous coronary intervention (PCI) is unclear. To examine the effects of dual versus triple therapy on bleeding and ischemic outcomes in adults with AF ...

Ischemic Stroke despite Oral Anticoagulant Therapy in Patients with Atrial Fibrillation.
https://doi.org/10.1002/ana.25700
Annals of Neurology References; Seiffge DJ, De Marchis GM et. al.

Feb 13th, 2020 - It is not known whether patients with atrial fibrillation (AF) with ischemic stroke despite oral anticoagulant therapy are at increased risk for further recurrent strokes or how ongoing secondary prevention should be managed. We conducted an individual patient data pooled analysis of 7 prospective cohort studies that recruited patients with AF and recent cerebral ischemia. We compared patients ...

Evaluation of Bronchoalveolar Lavage Fluid from Patients in an Outbreak of E-cigarette,...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6855513
MMWR. Morbidity and Mortality Weekly Report; Blount BC, Karwowski MP et. al.

Nov 14th, 2019 - CDC, the Food and Drug Administration (FDA), state and local health departments, and multiple public health and clinical partners are investigating a national outbreak of e-cigarette, or vaping, product use-associated lung injury (EVALI). Based on data collected as of October 15, 2019, 86% of 867 EVALI patients reported using tetrahydrocannabinol (THC)-containing products in the 3 months preced...

Osteoporotic Fractures in Patients With Atrial Fibrillation Treated With Conventional V...
https://doi.org/10.1016/j.jacc.2019.08.1025
Journal of the American College of Cardiology; Binding C, Bjerring Olesen J et. al.

Oct 24th, 2019 - Elderly patients in long-term treatment with vitamin K antagonists (VKAs) are at high risk of osteoporotic fractures compared with the background population. It has been speculated that the choice of oral anticoagulant (OAC) may affect the risk of osteoporotic fractures. The risk of osteoporotic fractures was evaluated among patients with atrial fibrillation treated with VKA or direct oral anti...