About 32,416 results
Iron Deficiency Anemia: Evaluation and Management
American Family Physician; Short, M. et. al.

Jan 14th, 2018 - Iron deficiency is the most common nutritional disorder worldwide and accounts for approximately one-half of anemia cases. The diagnosis of iron deficiency anemia is confirmed by the findings of low iron stores and a hemoglobin level two standard deviations below normal. Women should be screened during pregnancy, and children screened at one year of age. Supplemental iron may be given initially...

Liver Structure and Function - Hepatic and Biliary Disorders - Merck Manuals Professional Edition

Jan 1st, 2018 - The liver is the most metabolically complex organ. Hepatocytes (liver parenchymal cells) perform the liver’s metabolic functions: Formation and excretion of bile during bilirubin metabolism (see Overview of Bilirubin Metabolism) Regulation of carbohydrate homeostasis Lipid synthesis and secretion of plasma lipoproteins Control of cholesterol metabolism Formation of urea, serum albumin, c...

The Liver
Current Biology; Trefts, E. et. al.

Nov 4th, 2017 - The liver is a critical hub for numerous physiological processes. These include macronutrient metabolism, blood volume regulation, immune system support, endocrine control of growth signaling pathways, lipid and cholesterol homeostasis, and the breakdown of xenobiotic compounds, including many current drugs. Processing, partitioning, and metabolism of macronutrients provide the energy needed to...

Iron Deficiency Anemia

Sep 7th, 2017 - What Are the Signs and Symptoms of Iron-Deficiency Anemia? Symptoms of iron-deficiency anemia are related to decreased oxygen delivery to the entire body and may include:

Lycopene and tomato powder supplementation similarly inhibit high-fat diet induced obesity, inflammatory response, and associated metabolic disorders

Sep 5th, 2017 - SCOPE: Several studies have linked the high intake of lycopene or tomatoes products with lower risk for metabolic diseases. The aim of the present study was to evaluate and to compare the effect of lycopene and tomato powder on obesity-associated disorders. METHODS AND RESULTS: Male C57BL/J6 mice were assigned into four groups to receive: control diet (CD), high fat diet (HFD), high fat di...

Liver Test Interpretation - Approach to the Patient with Liver Disease: A Guide to Commonly Used Liver Tests
Murali, A. et. al.

Jul 31st, 2017 - Laboratory assessment of the patient with suspected or clinically obvious liver disease is context dependent. For example, the acutely ill jaundiced patient with a history of prolonged alcohol ingestion requires a different laboratory assessment than the well patient in whom one or more standard liver test results are discovered to be abnormal during routine testing. Additionally, the sequence ...

ACG Clinical Guideline: Evaluation of Abnormal Liver Chemistries
The American Journal of Gastroenterology; Kwo, P. et. al.

Jun 30th, 2017 - Clinicians are required to assess abnormal liver chemistries on a daily basis. The most common liver chemistries ordered are serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase and bilirubin. These tests should be termed liver chemistries or liver tests. Hepatocellular injury is defined as disproportionate elevation of AST and ALT levels compared with al...

Incidence Rate of Prediabetes Progression to Diabetes: Modeling an Optimum Target Group for Intervention
Population Health Management;

May 31st, 2017 - Thirty-seven percent of US adults have prediabetes. Various interventions can delay diabetes progression; however, the optimum target group for risk reduction is uncertain. This study estimated rate of progression to diabetes at 1 and 5 years among a cohort of patients from 3 primary care clinics and modeled the potential magnitude in diabetes incidence risk reduction of an intervention program...

LDL Cholesterol Calculator

Dec 31st, 2016 - The Ciccarone Center for the Prevention of Heart Disease at Johns Hopkins Hospital has developed this app to provide immediate and automated calculation of LDL cholesterol by the novel method published in the Journal of the American Medical Association.

Teaching Injection Technique to People with Diabetes

Dec 31st, 2016 - For people with diabetes who take insulin or other injectable diabetes medications, the diabetes educator can teach evidence-based standardized methods to improve clinical outcomes.

Potential Effects of Metformin on Aging and Age-Related Conditions: Small-Scale Clinical Studies and Secondary Analysis of Controlled Clinical Studies (R01)

Dec 8th, 2016 - An important goal of translational research in aging is the development of new therapeutic options to prevent or delay the onset of deleterious aging changes that contribute to morbidity and mortality among older adults. New opportunities in clinical translation could arise from the discovery of potential new therapeutic effects of already-approved drugs. The current scientific literature sugg...

Current Concepts in Adult Acute Rhinosinusitis.
American Family Physician; Aring, A. et. al.

Jul 14th, 2016 - Acute rhinosinusitis is one of the most common conditions that physicians treat in ambulatory care. Most cases of acute rhinosinusitis are caused by viral upper respiratory infections. A meta-analysis based on individual patient data found that common clinical signs and symptoms were not effective for identifying patients with rhinosinusitis who would benefit from antibiotics. C-reactive protei...

Stroke Mimics: Pearls and Pitfalls

Mar 22nd, 2016 - You’re working a slow Sunday morning ED shift, and you had just grabbed your coffee and sat down when EMS calls with a patient with right-sided hemiparesis. They want to activate a prehospital stroke alert, and you give them the go ahead without asking for any other patient information. The EMS crew brings in a 42 year-old female with a history of hypertension. The Cincinnati Prehospital Str...

A Review of Systemic Treatment in Metastatic Triple-Negative Breast Cancer
Breast Cancer; Zeichner, B. et. al.

Mar 21st, 2016 - Patients with breast cancer along with metastatic estrogen and progesterone receptor (ER/PR)- and human epidermal growth factor receptor 2 (HER2)-negative tumors are referred to as having metastatic triple-negative breast cancer (mTNBC) disease. Although there have been many new treatment options approved by the Food and Drug Administration for ER/PR-positive and Her2/neu-amplified metastatic b...

Practical Approach to Detection and Management of Chronic Kidney Disease for the Primary Care Clinician
The American Journal of Medicine; Vassalotti, J. et. al.

Feb 1st, 2016 - A panel of internists and nephrologists developed this practical approach for the Kidney Disease Outcomes Quality Initiative to guide assessment and care of chronic kidney disease (CKD) by primary care clinicians. Chronic kidney disease is defined as a glomerular filtration rate (GFR) <60 mL/min/1.73 m2 and/or markers of kidney damage for at least 3 months. In clinical practice the most comm...

Hepatocytes: a key cell type for innate immunity
Cellular & Molecular Immunology;

Dec 20th, 2015 - Hepatocytes, the major parenchymal cells in the liver, play pivotal roles in metabolism, detoxification, and protein synthesis. Hepatocytes also activate innate immunity against invading microorganisms by secreting innate immunity proteins. These proteins include bactericidal proteins that directly kill bacteria, opsonins that assist in the phagocytosis of foreign bacteria, iron-sequestering pr...

Hen Egg as an Antioxidant Food Commodity

Sep 23rd, 2015 - Intake of antioxidants through diet is known to be important in reducing oxidative damage in cells and improving human health. Although eggs are known for their exceptional, nutritional quality, they are not generally considered as antioxidant foods. This review aims to establish the importance of eggs as an antioxidant food by summarizing the current knowledge on egg-derived antioxidants. Eggs...

Causes and Evaluation of Chronic Dyspnea

Jul 11th, 2015 - Chronic dyspnea is shortness of breath that lasts more than one month. The perception of dyspnea varies based on behavioral and physiologic responses. Dyspnea that is greater than expected with the degree of exertion is a symptom of disease. Most cases of dyspnea result from asthma, heart failure and myocardial ischemia, chronic obstructive pulmonary disease, interstitial lung disease, pneumoni...

Linking diet to acne metabolomics, inflammation, and comedogenesis: an update
Melnik, B. et. al.

Jun 14th, 2015 - Acne vulgaris, an epidemic inflammatory skin disease of adolescence, is closely related to Western diet. Three major food classes that promote acne are: 1) hyperglycemic carbohydrates, 2) milk and dairy products, 3) saturated fats including trans-fats and deficient ω-3 polyunsaturated fatty acids (PUFAs). Diet-induced insulin/insulin-like growth factor (IGF-1)-signaling is superimposed on eleva...

One Egg per Day Improves Inflammation when Compared to an Oatmeal-Based Breakfast without Increasing Other Cardiometabolic Risk Factors in Diabetic Patients
Nutrients Ballesteros, M. et. al.

May 10th, 2015 - There is concern that egg intake may increase blood glucose in patients with type 2 diabetes mellitus (T2DM). However, we have previously shown that eggs reduce inflammation in patients at risk for T2DM, including obese subjects and those with metabolic syndrome. Thus, we hypothesized that egg intake would not alter plasma glucose in T2DM patients when compared to oatmeal intake. Our primary en...