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About 7,829 results

ALLMedicine™ Hyperuricemia Center

Research & Reviews  3,463 results

A phase 2 trial of single low doses of rasburicase for treatment of hyperuricemia in ad...
https://doi.org/10.1016/j.leukres.2021.106588
Leukemia Research; Vachhani P, Baron J et. al.

May 6th, 2021 - Rasburicase can markedly and rapidly decrease uric acid (UA) levels, thereby preventing and treating tumor lysis syndrome. However, rasburicase is expensive, especially when used as per the manufacturer's recommended dosage of 0.2 mg/kg/day for up...

Dotinurad: a novel selective urate reabsorption inhibitor for the treatment of hyperuri...
https://doi.org/10.1080/14656566.2021.1918102
Expert Opinion on Pharmacotherapy; Ishikawa T, Takahashi T et. al.

Apr 30th, 2021 - Gout is an inflammatory disease triggered by deposition of urate crystals secondary to longstanding hyperuricemia, and its management implies both the treatment of flares and management of hyperuricemia. Dotinurad is a selective urate reabsorption...

Efficacy and safety of gout flare prophylaxis and therapy use in people with chronic ki...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8080370
Arthritis Research & Therapy; Pisaniello HL, Fisher MC et. al.

Apr 29th, 2021 - Gout flare prophylaxis and therapy use in people with underlying chronic kidney disease (CKD) is challenging, given limited treatment options and risk of worsening renal function with inappropriate treatment dosing. This literature review aimed to...

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Guidelines  9 results

Coexistent Hyperuricemia and Gout in Rheumatoid Arthritis: Associations With Comorbidities, Disease Activity, and Mortality
https://onlinelibrary.wiley.com/doi/abs/10.1002/acr.23926
Arthritis Care & Research; Chiou A

May 9th, 2019 - Although hyperuricemia and gout can complicate the course of rheumatoid arthritis (RA ), the impact of these factors on outcomes in RA is unclear. We undertook this study to examine associations of coexistent hyperuricemia and gout with RA disease...

Management of gout and hyperuricemia: Multidisciplinary consensus in Taiwan.
https://doi.org/10.1111/1756-185X.13266
International Journal of Rheumatic Diseases; Yu KH, Chen DY et. al.

Jan 24th, 2018 - Gout is an inflammatory disease manifested by the deposition of monosodium urate (MSU) crystals in joints, cartilage, synovial bursa, tendons or soft tissues. Gout is not a new disease, which was first documented nearly 5,000 years ago. The preval...

Diagnosis and management of glycogen storage disease type I: a practice guideline of th...
https://doi.org/10.1038/gim.2014.128
Genetics in Medicine : Official Journal of the American C... Kishnani PS, Austin SL et. al.

Oct 30th, 2014 - Glycogen storage disease type I (GSD I) is a rare disease of variable clinical severity that primarily affects the liver and kidney. It is caused by deficient activity of the glucose 6-phosphatase enzyme (GSD Ia) or a deficiency in the microsomal ...

Clinical Pharmacogenetics Implementation Consortium guidelines for human leukocyte anti...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3564416
Clinical Pharmacology and Therapeutics; Hershfield MS, Callaghan JT et. al.

Dec 12th, 2012 - Allopurinol is the most commonly used drug for the treatment of hyperuricemia and gout. However, allopurinol is also one of the most common causes of severe cutaneous adverse reactions (SCARs), which include drug hypersensitivity syndrome, Stevens...

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Drugs  281 results see all →

Clinicaltrials.gov  3,865 results

A phase 2 trial of single low doses of rasburicase for treatment of hyperuricemia in ad...
https://doi.org/10.1016/j.leukres.2021.106588
Leukemia Research; Vachhani P, Baron J et. al.

May 6th, 2021 - Rasburicase can markedly and rapidly decrease uric acid (UA) levels, thereby preventing and treating tumor lysis syndrome. However, rasburicase is expensive, especially when used as per the manufacturer's recommended dosage of 0.2 mg/kg/day for up...

Dotinurad: a novel selective urate reabsorption inhibitor for the treatment of hyperuri...
https://doi.org/10.1080/14656566.2021.1918102
Expert Opinion on Pharmacotherapy; Ishikawa T, Takahashi T et. al.

Apr 30th, 2021 - Gout is an inflammatory disease triggered by deposition of urate crystals secondary to longstanding hyperuricemia, and its management implies both the treatment of flares and management of hyperuricemia. Dotinurad is a selective urate reabsorption...

Efficacy and safety of gout flare prophylaxis and therapy use in people with chronic ki...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8080370
Arthritis Research & Therapy; Pisaniello HL, Fisher MC et. al.

Apr 29th, 2021 - Gout flare prophylaxis and therapy use in people with underlying chronic kidney disease (CKD) is challenging, given limited treatment options and risk of worsening renal function with inappropriate treatment dosing. This literature review aimed to...

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News  211 results

Gout rates reduced with SGLT2 inhibitors
https://www.mdedge.com/cardiology/article/215406/gout/gout-rates-reduced-sglt2-inhibitors?channel=39313
Heidi Splete

Jan 13th, 2020 - The incidence of gout was approximately 40% lower in diabetes patients who were prescribed sodium-glucose cotransporter 2 inhibitors (SGLT2) than it was in those who were prescribed glucagonlike peptide–1 receptor (GLP-1) agonists in a population-.

Fast Five Quiz: Gout and Pseudogout
https://reference.medscape.com/viewarticle/921756_3

Dec 3rd, 2019 - Gout has an increased prevalence in some populations but is rare in others. For example, the frequency of gout is higher in populations such as the Chamorros and Maori and in the Blackfoot and Pima tribes. Many Maori and other Polynesian women hav...

Serum urate level governs management of difficult-to-treat gout
https://www.mdedge.com/internalmedicine/article/211610/gout/serum-urate-level-governs-management-difficult-treat-gout/page/0/1?channel=39313

Nov 5th, 2019 - The FAST trial The ongoing Febuxostat versus Allopurinol Streamlined Trial (FAST) has provided data about undertreatment with allopurinol and the effects of increasing the dose. The prospective, randomized, open-label study is comparing the cardio.

Modifiable risk factors account for many gout cases
https://www.mdedge.com/familymedicine/article/207612/gout/modifiable-risk-factors-account-many-gout-cases?channel=39313
MDedge Rheumatology; Bianca Nogrady

Sep 5th, 2019 - Four modifiable lifestyle risk factors account for a substantial proportion of gout cases in the United States, suggesting greater public health efforts could reduce the frequency of the condition, according to a paper published Sept. 4 in Arthrit.

Lowering hyperuricemia improved endothelial function but failed as an antihypertensive
https://www.mdedge.com/rheumatology/article/202928/gout/lowering-hyperuricemia-improved-endothelial-function-failed?channel=216
Mitchel L. Zoler

Jun 14th, 2019 - MADRID – Using allopurinol to reduce hyperuricemia in young adults with prehypertension or stage 1 hypertension failed to significantly lower blood pressure but succeeded in significantly improving endothelial function as measured by increased flo.

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