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About 6,138 results

ALLMedicine™ Metabolic Acidosis Center

Research & Reviews  2,873 results

Biallelic loss-of-function variants in KCNJ16 presenting with hypokalemic metabolic aci...
https://doi.org/10.1038/s41431-021-00883-0 10.1152/physrev.00021.2009 10.1042/CS20190876 10.1073/pnas.1101400108 10.1172/jci.insight.92331 10.1096/fj.201802257R 10.1073/pnas.0901749106 10.1056/NEJMoa0810276 10.1097/MD.0000000000006347
European Journal of Human Genetics : EJHG; Webb BD, Hotchkiss H et. al.

Apr 12th, 2021 - KCNJ16 encodes Kir5.1 and acts in combination with Kir4.1, encoded by KCNJ10, to form an inwardly rectifying K+ channel expressed at the basolateral membrane of epithelial cells in the distal nephron. This Kir4.1/Kir5.1 channel is critical for con...

Relationship between mortality and use of sodium bicarbonate at the time of dialysis in...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8025509
BMC Nephrology; Morooka H, Yamamoto J et. al.

Apr 7th, 2021 - Patients with chronic kidney disease often experience metabolic acidosis. Whether oral sodium bicarbonate can reduce mortality in patients with metabolic acidosis has been debated for years. Hence, this study was conducted to evaluate the utility ...

Effect of Bicarbonate on Net Acid Excretion, Blood Pressure, and Metabolism in Patients...
https://doi.org/10.1053/j.ajkd.2020.10.015
American Journal of Kidney Diseases : the Official Journa... Tyson CC, Luciano A et. al.

Apr 3rd, 2021 - Patients with CKD are at elevated risk of metabolic acidosis due to impaired net acid excretion (NAE). Identifying early markers of acidosis may guide prevention in chronic kidney disease (CKD). This study compared NAE in participants with and wit...

Growth failure and metabolic acidosis due to total body sodium depletion in an infant w...
https://doi.org/10.1136/bcr-2021-241570
BMJ Case Reports; Zarraga CM, Borowitz SM

Mar 26th, 2021 - Sodium is an essential nutrient and inadequate sodium intake and/or excessive sodium losses can result in suboptimal growth. Infants with ileostomies are at significant risk of developing growth failure as a result of excessive sodium loss in thei...

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Guidelines  4 results

Vibrio Cholerae - StatPearls
https://www.ncbi.nlm.nih.gov/books/NBK526099/

Nov 17th, 2018 - Cholera is a well-known disease caused by intestinal infection with the toxin-producing bacteria Vibrio cholerae. This potentially fatal diarrheal disease results in large volumes of watery stool, causing rapid dehydration that can progress to hyp...

Diagnosis and Treatment of Metabolic Acidosis in Patients with Chronic Kidney Disease -...
https://doi.org/10.1159/000490475
Kidney & Blood Pressure Research; Adamczak M, Masajtis-Zagajewska A et. al.

Jun 12th, 2018 - Metabolic acidosis is commonly found in patients with chronic kidney disease (CKD), and its causes are: impaired ammonia excretion, reduced tubular bicarbonate reabsorption and insufficient renal bicarbonate production in relation to the amount of...

Practical Approach to Detection and Management of Chronic Kidney Disease for the Primary Care Clinician
https://www.amjmed.com/article/S0002-9343(15)00855-4/pdf
The American Journal of Medicine; Vassalotti,J.,et al

Feb 1st, 2016 - A panel of internists and nephrologists developed this practical approach for the Kidney Disease Outcomes Quality Initiative to guide assessment and care of chronic kidney disease (CKD) by primary care clinicians. Chronic kidney disease is defined...

Prevention and treatment of protein energy wasting in chronic kidney disease patients: ...
https://doi.org/10.1038/ki.2013.147
Kidney International; Ikizler TA, Cano NJ et. al.

May 23rd, 2013 - Protein energy wasting (PEW) is common in patients with chronic kidney disease (CKD) and is associated with adverse clinical outcomes, especially in individuals receiving maintenance dialysis therapy. A multitude of factors can affect the nutritio...

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Drugs  109 results see all →

Clinicaltrials.gov  3,055 results

Biallelic loss-of-function variants in KCNJ16 presenting with hypokalemic metabolic aci...
https://doi.org/10.1038/s41431-021-00883-0 10.1152/physrev.00021.2009 10.1042/CS20190876 10.1073/pnas.1101400108 10.1172/jci.insight.92331 10.1096/fj.201802257R 10.1073/pnas.0901749106 10.1056/NEJMoa0810276 10.1097/MD.0000000000006347
European Journal of Human Genetics : EJHG; Webb BD, Hotchkiss H et. al.

Apr 12th, 2021 - KCNJ16 encodes Kir5.1 and acts in combination with Kir4.1, encoded by KCNJ10, to form an inwardly rectifying K+ channel expressed at the basolateral membrane of epithelial cells in the distal nephron. This Kir4.1/Kir5.1 channel is critical for con...

Sodium bicarbonate - sodium bicarbonate injection, solution-Medical Purchasing Solutions, LLC
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=bfc9c321-665c-ca97-e053-2995a90a7954

Apr 11th, 2021 - Sodium Bicarbonate Injection, USP is indicated in the treatment of metabolic acidosis which may occur in severe renal disease, uncontrolled diabetes, circulatory insufficiency due to shock or severe dehydration, extracorporeal circulation of blood...

Relationship between mortality and use of sodium bicarbonate at the time of dialysis in...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8025509
BMC Nephrology; Morooka H, Yamamoto J et. al.

Apr 7th, 2021 - Patients with chronic kidney disease often experience metabolic acidosis. Whether oral sodium bicarbonate can reduce mortality in patients with metabolic acidosis has been debated for years. Hence, this study was conducted to evaluate the utility ...

Revonto - dantrolene sodium injection, powder, lyophilized, for solution-USWM, LLC
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=f1650487-32bd-4017-b9c2-b38829a531af

Apr 6th, 2021 - Revonto (dantrolene sodium for injection) is indicated, along with appropriate supportive measures, for the management of the fulminant hypermetabolism of skeletal muscle characteristic of malignant hyperthermia crises in patients of all ages. Rev...

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News  97 results

Solutions for Diabetic Ketoacidosis: Finding the Right Balance
https://www.staging.medscape.com/viewarticle/938029

Oct 1st, 2020 - Recent studies have shown improved renal outcomes in adult patients with sepsis receiving balanced solutions instead of "normal" saline. For years, it has been known that 0.9% saline (colloquially referred to as "abnormal saline") can cause a hype...

Solutions for Diabetic Ketoacidosis: Finding the Right Balance
https://www.medscape.com/viewarticle/938029

Oct 1st, 2020 - Recent studies have shown improved renal outcomes in adult patients with sepsis receiving balanced solutions instead of "normal" saline. For years, it has been known that 0.9% saline (colloquially referred to as "abnormal saline") can cause a hype...

Fast Five Quiz: Drowning
https://reference.medscape.com/viewarticle/932530_5

Jun 24th, 2020 - Patients are especially likely to be asymptomatic if they experience brief, witnessed submersions with immediate resuscitation. Patients who are symptomatic may exhibit: Altered vital signs (eg, hypothermia, tachycardia or bradycardia) Anxious app...

Phase III Success for CKD Complication Tx
https://www.medpagetoday.com/nephrology/generalnephrology/80747

Jun 27th, 2019 - The investigational drug veverimer was safe and effective for treating patients with metabolic acidosis from chronic kidney disease, according to phase III data. In a 40-week extension study, only 2% of those on veverimer had serious adverse event...

Sodium Bicarbonate Slows Chronic Kidney Disease Safely
https://www.staging.medscape.com/viewarticle/914574

Jun 17th, 2019 - BUDAPEST, Hungary — Sodium bicarbonate — long used, albeit sporadically, to correct metabolic acidosis in chronic kidney disease — is significantly better at slowing disease progression than standard care, and is safe, results from a large Italian...

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