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ALLMedicine™ Nephrotoxicity Center

Research & Reviews  2,548 results

Clinical Pharmacokinetics of Gentamicin in Various Patient Populations and Consequences...
https://doi.org/10.1007/s40262-022-01143-0 10.1016/j.jfma.2013.10.002 10.2165/11597020-000000000-00000 10.1093/jac/dkw461 10.1002/phar.2193 10.1111/j.1365-2125.2004.02114.x 10.1016/j.ijantimicag.2003.07.010 10.1111/j.1365-2125.2005.02547.x 10.1046/j.1365-2125.1998.00779.x 10.1177/0004563213492320 10.1111/imj.12684 10.1128/aac.00174-11 10.4187/respcare.02980 10.1016/j.jcf.2013.11.007 10.1093/jac/dkv165 10.1038/clpt.1989.4 10.1016/j.bcp.2014.05.018 10.1128/aac.43.3.623 10.1093/infdis/155.1.93 10.1016/0002-9343(84)90358-9 10.1016/j.diagmicrobio.2005.02.011 10.1016/s0149-2918(01)80103-x 10.1089/mdr.2012.0140 10.1111/1469-0691.12711 10.1007/s00134-007-0688-x 10.1016/s0009-9236(99)70103-7 10.1016/s0891-5520(03)00057-6 10.1086/520991 10.1016/j.jiac.2020.09.033 10.1159/000440867 10.1093/qjmed/95.5.291 10.1093/clinids/14.1.320 10.1592/phco.19.16.1252.30876 10.1128/aac.43.7.1549 10.1093/jac/dkab288 10.1016/0140-6736(93)90137-6 10.1016/j.addr.2006.07.028 10.1016/s0009-9236(97)90156-9 10.3109/07420528.2015.1082483 10.1002/lary.25116 10.1007/s11096-015-0066-7 10.1371/journal.pone.0210012 10.1007/s40262-019-00762-4 10.1007/bf00542215 10.1128/aac.39.2.545 10.1093/infdis/138.4.499 10.1002/j.1552-4604.1981.tb01769.x 10.1128/aac.00441-18 10.1155/2013/194389 10.1093/jac/dkaa312 10.1097/CCM.0b013e3181961bff 10.3390/antibiotics10050507 10.1007/s00134-002-1313-7 10.1016/j.ijantimicag.2020.106124 10.1007/s00228-014-1765-z 10.1179/1120009x12z.0000000006 10.1128/aac.00222-10 10.1177/0091270006292987 10.1128/aac.01762-12 10.1093/jac/dku369 10.1097/ftd.0000000000000432 10.1097/FTD.0b013e31818b6b2f 10.1016/j.ijantimicag.2016.10.022 10.1034/j.1399-6576.1999.430707.x 10.1111/j.1365-2710.1995.tb00659.x 10.1007/s40264-013-0031-0 10.1128/aac.01194-12 10.2165/11318140-000000000-00000 10.1371/journal.pone.0177324 10.14740/jocmr1858w 10.1016/j.accpm.2015.12.012 10.1016/j.medmal.2019.12.003 10.1093/jac/dkv291 10.1186/s13613-021-00834-4 10.1007/s10096-016-2652-6 10.1002/phar.1310 10.1089/sur.2020.012 10.1128/aac.03750-14 10.1007/s00134-009-1635-9 10.1097/CCM.0b013e3181ad76c2 10.1128/aac.01314-10 10.1542/peds.28.2.169 10.1056/NEJMra035092 10.1111/jcpt.12850 10.1128/aac.03464-14 10.1097/ftd.0000000000000341 10.1128/aac.01730-19 10.1002/jcph.1490 10.1007/s00467-005-2105-4 10.1007/s40262-019-00813-w 10.1111/j.1523-1755.2005.00336.x 10.1046/j.1523-1755.2003.00208.x 10.1208/ps020103 10.3389/fped.2020.00260 10.1128/aac.02629-20 10.1097/INF.0b013e3181ff023e 10.1002/phar.1899 10.5639/gabij.2013.0202.025 10.1097/pq9.0000000000000015 10.1097/INF.0b013e31821e405d 10.1097/inf.0000000000002120 10.1592/phco.30.3.248 10.1097/ftd.0000000000000505 10.1542/peds.114.1.e111 10.1592/phco.31.7.649 10.1111/bcp.12444 10.5863/1551-6776-20.2.119 10.1002/jcph.190 10.1128/aac.00577-16 10.1128/aac.01304-16 10.1111/bcp.12883 10.1002/phar.1263 10.1002/14651858.CD005091.pub4 10.1111/j.1651-2227.2012.02820.x 10.1016/j.clinthera.2017.05.343 10.1093/jac/dkv052 10.1586/14787210.2014.878648 10.2165/00003088-199937040-00004 10.1007/s13318-021-00734-9 10.1007/s00228-014-1652-7 10.1093/ageing/afu023 10.1186/s12877-021-02512-3 10.1345/aph.1G064 10.2215/cjn.02920707 10.2165/00003088-200443030-00004 10.1016/s0272-6386(99)70347-1 10.1345/aph.1G420 10.1016/s0272-6386(12)80811-0 10.1093/infdis/133.6.627 10.1046/j.1523-1755.2003.00819.x 10.1159/000339937 10.1093/jac/dkv428 10.1007/s40265-021-01469-2 10.1007/s00228-020-02867-3 10.2215/cjn.12211211 10.1128/aac.19.4.605 10.1177/089686089601600411 10.1177/089686089901900412 10.3747/pdi.2012.00318 10.1128/aac.01679-21 10.1016/j.ijantimicag.2018.04.016 10.1097/ftd.0000000000000547 10.1093/cid/cix186 10.1016/j.jtcvs.2014.05.090 10.1007/s10096-018-3376-6 10.1093/jac/dkm354 10.3109/00365548.2011.601755 10.3109/23744235.2015.1109136 10.1097/00007691-199902000-00010 10.1097/CCM.0b013e3181eb3ccd 10.1128/aac.00115-10 10.1371/journal.pone.0236864 10.3390/antibiotics9110777 10.1186/s13054-020-03284-9 10.1097/CCM.0b013e3181e96b91 10.1002/14651858.CD003344.pub3 10.1016/j.cmi.2017.09.020 10.1111/j.1445-5994.2011.02452.x 10.1016/j.ccc.2010.11.006
Clinical Pharmacokinetics; Hodiamont CJ, van den Broek AK et. al.

Jun 27th, 2022 - Gentamicin is an aminoglycoside antibiotic with a small therapeutic window that is currently used primarily as part of short-term empirical combination therapy. Gentamicin dosing schemes still need refinement, especially for subpopulations where p...

Transcriptomics-based analysis of co-exposure of cadmium (Cd) and 2,2',4,4'-tetrabromod...
https://doi.org/10.1016/j.ecoenv.2022.113790
Ecotoxicology and Environmental Safety; Zhang Y, Hu B et. al.

Jun 27th, 2022 - Environmental pollution often releases multiple contaminants resulting in as yet largely uncharacterized additive toxicities. Cadmium (Cd) is a widespread pollutant that induces nephrotoxicity in animal models and humans. However, the combined eff...

Comprehensive Analysis of Metabolic Changes in Male Mice Exposed to Sodium Valproate Ba...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9211130
Drug Design, Development and Therapy; Gao Y, Jiang D et. al.

Jun 25th, 2022 - Sodium valproate (VPA) is the most widely used broad-spectrum antiepileptic first-line drug in clinical practice and is effective against various types of epilepsy. However, VPA can induce severe cardiotoxicity, nephrotoxicity, hepatotoxicity, and...

Short-term control of diet affects cisplatin-induced acute kidney injury through modula...
https://doi.org/10.14814/phy2.15348
Physiological Reports; Kim JS, Han YK et. al.

Jun 25th, 2022 - Obesity affects acute kidney injury (AKI) induced by various clinical settings, including transplantation and cisplatin-cancer therapy. However, the effect of short-term food intake change remains to be defined. Here, we investigated the effects o...

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Guidelines  1 results

Executive Summary: Therapeutic Monitoring of Vancomycin for Serious Methicillin-Resista...
https://doi.org/10.1002/phar.2376
Pharmacotherapy Rybak MJ, Le J et. al.

Apr 1st, 2020 - Recent vancomycin PK/PD and toxicodynamic studies enable a reassessment of the current dosing and monitoring guideline in an attempt to further optimize the efficacy and safety of vancomycin therapy. The area-under-the-curve to minimum inhibitory ...

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Drugs  47 results see all →

Clinicaltrials.gov  261 results

Ceftazidime-Avibactam Use in Critically Ill Patients With Carbapenem-Resistant Enterobacteriaceae Infections
https://clinicaltrials.gov/ct2/show/NCT05258851

Jun 24th, 2022 - Carbapenem-Resistant Enterobacteriaceae (CRE) infections are a growing national and international challenge in healthcare settings. This is not only due to the rapid spread of resistance and paucity of options of targeted-antimicrobial agents, but...

Remote Ischemic Preconditioning and Acute Kidney Injury in HTX
https://clinicaltrials.gov/ct2/show/NCT05364333

Jun 22nd, 2022 - Postoperative Acute Kidney Injury (AKI) is a common complication after heart transplantation (HTX) affecting outcome of patients. Anesthesia- and surgery-related factors, but also hemodynamic instability and nephrotoxic drugs are triggering AKI an...

Chronic Kidney Disease Progression in Chronic Hepatitis B Patients on Tenofovir Alafenamide (TAF) Versus Entecavir
https://clinicaltrials.gov/ct2/show/NCT05423834

Jun 21st, 2022 - Antiviral therapy with nucleos(t)ide analogues (NAs) has revolutionized the management of chronic hepatitis B (CHB) in the last two decades.1 Entecavir (ETV), a nucleoside analogue, is one of the first-line NAs recommended by all international tre...

Tenofovir Alafenamide Switching Therapy in Kidney or Liver Transplant Recipients With Chronic HBV Infection
https://clinicaltrials.gov/ct2/show/NCT05410496

Jun 14th, 2022 - Life-long nucleos(t)ide analogue (NA) therapy has been recommended in patients with chronic HBV infection after organ transplantation, therefore the safety of long-term NA therapy is particularly important in transplant patients. Entecavir, tenofo...

A Phase II Randomized Study of Gemcitabine and Nab-paclitaxel in Combination With S- 1/LV (GASL) or Oxaliplatin (GAP) as First-line Treatment for Metastatic Pancreatic Cancer
https://clinicaltrials.gov/ct2/show/NCT05026905

Jun 14th, 2022 - Gemcitabine and nab-paclitaxel are one standard of care for metastatic pancreatic adenocarcinoma (mPDAC) but the progression free survival (PFS) of the regimen is only 5.5 months. Previous phase II study showed gemcitabine and nab-paclitaxel plus ...

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News  123 results

Commonly used antibiotics in ObGyn practice
https://www.mdedge.com/obgyn/article/254590/gynecology/commonly-used-antibiotics-obgyn-practice
Patrick Duff, MD

May 12th, 2022 - In this article, I provide a simplified, practical review of the principal antibiotics that we use on a daily basis to treat bacterial infections. The antibiotics are listed in alphabetical order, either individually or by group.

Nail in the Coffin for Injectable Therapy in Drug-Resistant TB?
https://www.medpagetoday.com/infectiousdisease/tuberculosis/98532

May 3rd, 2022 - Oral treatment containing bedaquiline was associated with better outcomes for patients with drug-resistant tuberculosis (TB) compared with an injectable treatment regimen, a retrospective cohort study showed. In adjusted analyses, the rate of trea...

Calcineurin inhibitor–induced psychosis
https://www.mdedge.com/psychiatry/article/248092/schizophrenia-other-psychotic-disorders/calcineurin-inhibitor-induced
Michael Diduch, PharmD, BCPP, Leo Batongbakal, PharmD et. al.

Oct 29th, 2021 - Mrs. C, age 68, is experiencing worsening paranoid delusions.

Comparison of Adverse Events With Vancomycin Diluted in Normal Saline vs Dextrose 5%
https://www.mdedge.com/fedprac/article/247215/mixed-topics/comparison-adverse-events-vancomycin-diluted-normal-saline-vs
Robert C. Ross, PharmD, Bridgette A. Kelly, PharmD et. al.

Oct 8th, 2021 - Vancomycin is a widely used IV antibiotic due to its broad-spectrum of activity, bactericidal nature, and low rates of resistance; however, adverse effects (AEs), including nephrotoxicity, are commonly associated with its use. 1 The vancomycin ther.

Clinical Factors Help Define Use of Radionuclide Therapy in Neuroendocrine Tumors
https://www.onclive.com/view/clinical-factors-help-define-use-of-radionuclide-therapy-in-neuroendocrine-tumors

Oct 6th, 2021 - Thorvardur Halfdanarson, MDe Radiopharmaceuticals have been integrated into the treatment paradigm for patients with neuroendocrine tumors (NETs), yet there are nuances in the clinical scenarios in which they are most effective, according to Thor...

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