ALLMedicine™ Nephrotoxicity Center
Research & Reviews 2,548 results
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Clinical Pharmacokinetics; Hodiamont CJ, van den Broek AK et. al.
Jun 27th, 2022 - Gentamicin is an aminoglycoside antibiotic with a small therapeutic window that is currently used primarily as part of short-term empirical combination therapy. Gentamicin dosing schemes still need refinement, especially for subpopulations where p...
https://doi.org/10.1016/j.ecoenv.2022.113790
Ecotoxicology and Environmental Safety; Zhang Y, Hu B et. al.
Jun 27th, 2022 - Environmental pollution often releases multiple contaminants resulting in as yet largely uncharacterized additive toxicities. Cadmium (Cd) is a widespread pollutant that induces nephrotoxicity in animal models and humans. However, the combined eff...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9211130
Drug Design, Development and Therapy; Gao Y, Jiang D et. al.
Jun 25th, 2022 - Sodium valproate (VPA) is the most widely used broad-spectrum antiepileptic first-line drug in clinical practice and is effective against various types of epilepsy. However, VPA can induce severe cardiotoxicity, nephrotoxicity, hepatotoxicity, and...
https://doi.org/10.14814/phy2.15348
Physiological Reports; Kim JS, Han YK et. al.
Jun 25th, 2022 - Obesity affects acute kidney injury (AKI) induced by various clinical settings, including transplantation and cisplatin-cancer therapy. However, the effect of short-term food intake change remains to be defined. Here, we investigated the effects o...
https://doi.org/10.1007/s00467-022-05632-z 10.1007/s00280-015-2913-6 10.1053/j.seminoncol.2008.07.008 10.1007/s00467-017-3765-6 10.1038/tpj.2009.45 10.1002/pbc.21695 10.1007/s00467-017-3662-z 10.1038/ki.2015.115 10.1053/ctrv.1999.0097 10.1007/s00280-017-3392-8 10.3109/10408444.2011.602662 10.1016/S0140-6736(00)02044-4 10.1007/s00467-018-3976-5 10.1001/jamanetworkopen.2020.3639 10.1097/MD.0000000000001413 10.1016/j.ejca.2009.06.032 10.1002/pds.1772 10.1002/jcph.1336 10.1681/ASN.2008030287 10.1038/kisup.2012.1 10.1038/sj.ki.5002231 10.2307/2529310 10.2215/CJN.01900214 10.1016/j.jcrc.2019.01.010 10.3389/fphar.2020.00975 10.1016/S2352-4642(21)00020-1 10.2217/pgs.11.93 10.1002/cncr.26472 10.1007/s12094-015-1343-6 10.1007/s10157-012-0638-y 10.1371/journal.pone.0048350 10.1038/clpt.2009.139 10.3390/genes10050364 10.1002/pbc.27253 10.3389/fphar.2018.01111 10.1097/FTD.0000000000000589 10.3390/ijms21186627 10.5662/wjm.v7.i3.73 10.1152/ajprenal.00127.2014 10.1001/jamanetworkopen.2020.3612 10.1080/13577149878073
Pediatric Nephrology (Berlin, Germany); Zazuli Z, Op 't Hoog CJP et. al.
Jun 25th, 2022 - Various definitions used to describe cisplatin nephrotoxicity potentially lead to differences in determination of risk factors. This study evaluated incidence of kidney injury according to commonly used and alternative definitions in two cohorts o...
Guidelines 1 results
https://doi.org/10.1002/phar.2376
Pharmacotherapy Rybak MJ, Le J et. al.
Apr 1st, 2020 - Recent vancomycin PK/PD and toxicodynamic studies enable a reassessment of the current dosing and monitoring guideline in an attempt to further optimize the efficacy and safety of vancomycin therapy. The area-under-the-curve to minimum inhibitory ...
Drugs 47 results see all →
Clinicaltrials.gov 261 results
https://clinicaltrials.gov/ct2/show/NCT05258851
Jun 24th, 2022 - Carbapenem-Resistant Enterobacteriaceae (CRE) infections are a growing national and international challenge in healthcare settings. This is not only due to the rapid spread of resistance and paucity of options of targeted-antimicrobial agents, but...
https://clinicaltrials.gov/ct2/show/NCT05364333
Jun 22nd, 2022 - Postoperative Acute Kidney Injury (AKI) is a common complication after heart transplantation (HTX) affecting outcome of patients. Anesthesia- and surgery-related factors, but also hemodynamic instability and nephrotoxic drugs are triggering AKI an...
https://clinicaltrials.gov/ct2/show/NCT05423834
Jun 21st, 2022 - Antiviral therapy with nucleos(t)ide analogues (NAs) has revolutionized the management of chronic hepatitis B (CHB) in the last two decades.1 Entecavir (ETV), a nucleoside analogue, is one of the first-line NAs recommended by all international tre...
https://clinicaltrials.gov/ct2/show/NCT05410496
Jun 14th, 2022 - Life-long nucleos(t)ide analogue (NA) therapy has been recommended in patients with chronic HBV infection after organ transplantation, therefore the safety of long-term NA therapy is particularly important in transplant patients. Entecavir, tenofo...
https://clinicaltrials.gov/ct2/show/NCT05026905
Jun 14th, 2022 - Gemcitabine and nab-paclitaxel are one standard of care for metastatic pancreatic adenocarcinoma (mPDAC) but the progression free survival (PFS) of the regimen is only 5.5 months. Previous phase II study showed gemcitabine and nab-paclitaxel plus ...
News 123 results
https://www.mdedge.com/obgyn/article/254590/gynecology/commonly-used-antibiotics-obgyn-practice
Patrick Duff, MD
May 12th, 2022 - In this article, I provide a simplified, practical review of the principal antibiotics that we use on a daily basis to treat bacterial infections. The antibiotics are listed in alphabetical order, either individually or by group.
https://www.medpagetoday.com/infectiousdisease/tuberculosis/98532
May 3rd, 2022 - Oral treatment containing bedaquiline was associated with better outcomes for patients with drug-resistant tuberculosis (TB) compared with an injectable treatment regimen, a retrospective cohort study showed. In adjusted analyses, the rate of trea...
https://www.mdedge.com/psychiatry/article/248092/schizophrenia-other-psychotic-disorders/calcineurin-inhibitor-induced
Michael Diduch, PharmD, BCPP, Leo Batongbakal, PharmD et. al.
Oct 29th, 2021 - Mrs. C, age 68, is experiencing worsening paranoid delusions.
https://www.mdedge.com/fedprac/article/247215/mixed-topics/comparison-adverse-events-vancomycin-diluted-normal-saline-vs
Robert C. Ross, PharmD, Bridgette A. Kelly, PharmD et. al.
Oct 8th, 2021 - Vancomycin is a widely used IV antibiotic due to its broad-spectrum of activity, bactericidal nature, and low rates of resistance; however, adverse effects (AEs), including nephrotoxicity, are commonly associated with its use. 1 The vancomycin ther.
https://www.onclive.com/view/clinical-factors-help-define-use-of-radionuclide-therapy-in-neuroendocrine-tumors
Oct 6th, 2021 - Thorvardur Halfdanarson, MDe Radiopharmaceuticals have been integrated into the treatment paradigm for patients with neuroendocrine tumors (NETs), yet there are nuances in the clinical scenarios in which they are most effective, according to Thor...
