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About 8,549 results

ALLMedicine™ Polycystic Kidney Disease Center

Research & Reviews  4,145 results

Primary cilia control endothelial permeability by regulating expression and location of...
https://doi.org/10.1093/cvr/cvab165
Cardiovascular Research; Diagbouga MR, Morel S et. al.

May 11th, 2021 - Wall shear stress (WSS) determines intracranial aneurysm (IA) development. Polycystic kidney disease (PKD) patients have a high IA incidence and risk of rupture. Dysfunction/absence of primary cilia in PKD endothelial cells (ECs) may impair mechan...

Inward calcium current through the polycystin-2-dependent channels of renal primary cilia.
https://doi.org/10.1152/ajprenal.00062.2021
American Journal of Physiology. Renal Physiology; Kleene SJ, Kleene NK

May 10th, 2021 - In 15% of cases, autosomal dominant polycystic kidney disease (ADPKD) arises from defects in polycystin-2 (PC2). PC2 is a member of the TRPP subfamily of cation-conducting channels and is expressed in the endoplasmic reticulum and primary cilium o...

Regional Variations in Prevalence and Severity of Autosomal Dominant Polycystic Kidney ...
https://doi.org/10.1080/03007995.2021.1927690
Current Medical Research and Opinion; Willey C, Gauthier-Loiselle M et. al.

May 10th, 2021 - To evaluate geographic variation in the prevalence of autosomal dominant polycystic kidney disease (ADPKD) in the US, including ADPKD at risk of rapid progression. Claims data from the IBM® MarketScan® Commercial and Medicare Supplemental database...

Refining genotype-phenotype correlations in 304 patients with autosomal recessive polyc...
https://doi.org/10.1016/j.kint.2021.04.019
Kidney International; Burgmaier K, Brinker L et. al.

May 3rd, 2021 - Autosomal recessive polycystic kidney disease (ARPKD) is a severe disease of early childhood that is clinically characterized by fibrocystic changes of the kidneys and the liver. The main cause of ARPKD are variants in the PKHD1 gene encoding the ...

A comprehensive PGT-M strategy for ADPKD patients with de novo PKD1 mutations using aff...
https://doi.org/10.1007/s10815-021-02188-z
Journal of Assisted Reproduction and Genetics; Wang Y, Zhai F et. al.

May 3rd, 2021 - Autosomal dominant polycystic kidney disease (ADPKD) is the most common inherited kidney disease characterized by the development of renal cysts and progression to renal failure. Preimplantation genetic testing-monogenic disease (PGT-M) is an alte...

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Guidelines  43 results

Polycystic kidney disease
https://ghr.nlm.nih.gov/condition/polycystic-kidney-disease

Jul 15th, 2019 - Polycystic kidney disease is a disorder that affects the kidneys and other organs. Clusters of fluid-filled sacs, called cysts, develop in the kidneys and interfere with their ability to filter waste products from the blood. The growth of cysts ca...

NIH Fact Sheets - Autosomal Dominant Polycystic Kidney Disease
https://www.report.nih.gov/nihfactsheets/ViewFactSheet.aspx?csid=29

Jun 29th, 2019 - Autosomal Dominant Polycystic Kidney Disease (ADPKD) resulted in end-stage renal disease (ESRD) by age 53, on average, and was responsible for 6 percent of ESRD cases in the U.S.

International consensus statement on the diagnosis and management of autosomal dominant...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7136168
Nature Reviews. Nephrology; Gimpel C, Bergmann C et. al.

May 23rd, 2019 - These recommendations were systematically developed on behalf of the Network for Early Onset Cystic Kidney Disease (NEOCYST) by an international group of experts in autosomal dominant polycystic kidney disease (ADPKD) from paediatric and adult nep...

Clinical practice guideline monitoring children and young people with, or at risk of de...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6489289
BMC Nephrology; Dudley J, Winyard P et. al.

May 1st, 2019 - Autosomal Dominant Polycystic Kidney Disease (ADPKD) is thought to affect about 1 in 1000 people in the UK. ADPKD causes a progressive decline in kidney function, with kidney failure tending to occur in middle age. Children and young people with A...

Imaging of Kidney Cysts and Cystic Kidney Diseases in Children: An International Working Gro...
https://pubs.rsna.org/doi/full/10.1148/radiol.2018181243

Dec 31st, 2018 - Kidney cysts can manifest as focal disease (simple and complex kidney cysts), affect a whole kidney (eg, multicystic dysplastic kidney or cystic dysplasia), or manifest as bilateral cystic disease (eg, autosomal recessive polycystic kidney disease.

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Drugs  2 results see all →

Clinicaltrials.gov  4,245 results

Primary cilia control endothelial permeability by regulating expression and location of...
https://doi.org/10.1093/cvr/cvab165
Cardiovascular Research; Diagbouga MR, Morel S et. al.

May 11th, 2021 - Wall shear stress (WSS) determines intracranial aneurysm (IA) development. Polycystic kidney disease (PKD) patients have a high IA incidence and risk of rupture. Dysfunction/absence of primary cilia in PKD endothelial cells (ECs) may impair mechan...

Inward calcium current through the polycystin-2-dependent channels of renal primary cilia.
https://doi.org/10.1152/ajprenal.00062.2021
American Journal of Physiology. Renal Physiology; Kleene SJ, Kleene NK

May 10th, 2021 - In 15% of cases, autosomal dominant polycystic kidney disease (ADPKD) arises from defects in polycystin-2 (PC2). PC2 is a member of the TRPP subfamily of cation-conducting channels and is expressed in the endoplasmic reticulum and primary cilium o...

Regional Variations in Prevalence and Severity of Autosomal Dominant Polycystic Kidney ...
https://doi.org/10.1080/03007995.2021.1927690
Current Medical Research and Opinion; Willey C, Gauthier-Loiselle M et. al.

May 10th, 2021 - To evaluate geographic variation in the prevalence of autosomal dominant polycystic kidney disease (ADPKD) in the US, including ADPKD at risk of rapid progression. Claims data from the IBM® MarketScan® Commercial and Medicare Supplemental database...

Refining genotype-phenotype correlations in 304 patients with autosomal recessive polyc...
https://doi.org/10.1016/j.kint.2021.04.019
Kidney International; Burgmaier K, Brinker L et. al.

May 3rd, 2021 - Autosomal recessive polycystic kidney disease (ARPKD) is a severe disease of early childhood that is clinically characterized by fibrocystic changes of the kidneys and the liver. The main cause of ARPKD are variants in the PKHD1 gene encoding the ...

A comprehensive PGT-M strategy for ADPKD patients with de novo PKD1 mutations using aff...
https://doi.org/10.1007/s10815-021-02188-z
Journal of Assisted Reproduction and Genetics; Wang Y, Zhai F et. al.

May 3rd, 2021 - Autosomal dominant polycystic kidney disease (ADPKD) is the most common inherited kidney disease characterized by the development of renal cysts and progression to renal failure. Preimplantation genetic testing-monogenic disease (PGT-M) is an alte...

see more →

News  93 results

Polycystic kidney disease
https://ghr.nlm.nih.gov/condition/polycystic-kidney-disease

Jul 15th, 2019 - Polycystic kidney disease is a disorder that affects the kidneys and other organs. Clusters of fluid-filled sacs, called cysts, develop in the kidneys and interfere with their ability to filter waste products from the blood. The growth of cysts ca...

NIH Fact Sheets - Autosomal Dominant Polycystic Kidney Disease
https://www.report.nih.gov/nihfactsheets/ViewFactSheet.aspx?csid=29

Jun 29th, 2019 - Autosomal Dominant Polycystic Kidney Disease (ADPKD) resulted in end-stage renal disease (ESRD) by age 53, on average, and was responsible for 6 percent of ESRD cases in the U.S.

FDA Boxed Warnings Updates: October 2018
https://www.mdedge.com/fedprac/article/176365/fda-actions/fda-boxed-warnings-updates-october-2018/page/0/2

Oct 3rd, 2018 - PROGRAF (TACROLIMUS) Edited boxed warning, May 2018 Increased risk for developing serious infections and malignancies with PROGRAF or other immunosuppressants that may lead to hospitalization or death [(see Warnings and Precautions 5. 1,5.

Polycystic Kidney Disease
https://www.kidney.org/atoz/content/polycystic

Sep 13th, 2018 - What is polycystic kidney disease? Polycystic kidney disease (also called PKD) causes numerous cysts to grow in the kidneys. These cysts are filled with fluid. If too many cysts grow or if they get too big, the kidneys can become damaged. PKD cyst...

Fast Five Quiz: Test Your Knowledge on Key Aspects of Hemorrhagic Stroke
https://reference.medscape.com/viewarticle/896189_2

May 9th, 2018 - The most common cause of atraumatic hemorrhage into the subarachnoid space is rupture of an intracranial aneurysm. Aneurysms are focal dilatations of arteries, with the most frequently encountered intracranial type being the berry (saccular) aneur...

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Patient Education  21 results see all →