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About 4,083 results

ALLMedicine™ Polycystic Kidney Disease Center

Research & Reviews  1,504 results

Heterogeneity of cell composition and origin identified by single-cell transcriptomics ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8581434
Theranostics Li Q, Wang Y et. al.

Nov 25th, 2021 - Rationale: Renal cysts in patients with autosomal dominant polycystic kidney disease (ADPKD) can originate from any nephron segments, including proximal tubules (PT), the loop of Henle (LOH), distal tubules (DT), and collecting ducts (CD). Previou...

A Study to Evaluate the Effects of GLPG2737 in Participants With Autosomal Dominant Polycystic Kidney Disease (ADPKD)
https://clinicaltrials.gov/ct2/show/NCT04578548

Nov 24th, 2021 - This is an exploratory, randomized, double-blind, placebo-controlled, parallel group, multicenter, proof of concept study (Phase 2a), evaluating orally administered GLPG2737 for a double-blind (DB) treatment period of 52 weeks and 4 weeks of follo...

Metformin Improves Relevant Disease Parameters in an Autosomal Dominant Polycystic Kidn...
https://doi.org/10.1152/ajprenal.00298.2021
American Journal of Physiology. Renal Physiology; Pastor-Soler NM, Li H et. al.

Nov 23rd, 2021 - Autosomal dominant polycystic kidney disease (ADPKD), caused by mutations in the PKD1 or PKD2 genes encoding polycystins, presents with progressive development of kidney cysts and eventual end-stage kidney disease (ESKD) with limited treatment opt...

Dietary Interventions in Autosomal Dominant Polycystic Kidney Disease.
https://doi.org/10.1093/advances/nmab131
Advances in Nutrition (Bethesda, Md.); Pickel L, Iliuta IA et. al.

Nov 11th, 2021 - Autosomal dominant polycystic kidney disease (ADPKD) is characterized by the progressive growth of renal cysts, leading to the loss of functional nephrons. Recommendations for individuals with ADPKD to maintain a healthy diet and lifestyle are lar...

Novel 3D capsule device to restrict kidney volume expansion on polycystic kidney progre...
https://doi.org/10.1007/s40620-021-01160-5 10.1056/NEJMoa1710030 10.1056/NEJMcp0804458 10.1002/jcp.26222 10.1038/nature21407 10.1038/sj.ki.5002629 10.1681/ASN.2005060601 10.1148/rg.2015140320 10.1007/s11302-007-9072-0 10.1046/j.1523-1755.2003.00755.x
Journal of Nephrology; Bae KT, Kumamoto K et. al.

Nov 11th, 2021 - Cystogenesis in polycystic kidney disease (PKD) is likely accelerated by various renal insults, including crystal deposition, that activate renal tubule obstruction and dilation. We developed a capsule-based device that can be applied to cystic ki...

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Guidelines  13 results

International consensus statement on the diagnosis and management of autosomal dominant...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7136168
Nature Reviews. Nephrology; Gimpel C, Bergmann C et. al.

May 24th, 2019 - These recommendations were systematically developed on behalf of the Network for Early Onset Cystic Kidney Disease (NEOCYST) by an international group of experts in autosomal dominant polycystic kidney disease (ADPKD) from paediatric and adult nep...

Clinical practice guideline monitoring children and young people with, or at risk of de...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6489289
BMC Nephrology; Dudley J, Winyard P et. al.

May 2nd, 2019 - Autosomal Dominant Polycystic Kidney Disease (ADPKD) is thought to affect about 1 in 1000 people in the UK. ADPKD causes a progressive decline in kidney function, with kidney failure tending to occur in middle age. Children and young people with A...

Evidence-based clinical practice guidelines for polycystic kidney disease 2014.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4956721
Clinical and Experimental Nephrology; Horie S, Mochizuki T et. al.

Apr 21st, 2016 - Evidence-based clinical practice guidelines for polycystic kidney disease 2014.|2016|Horie S,Mochizuki T,Muto S,Hanaoka K,Fukushima Y,|diagnosis,epidemiology,therapy,diagnosis,epidemiology,genetics,therapy,

KHA-CARI Autosomal Dominant Polycystic Kidney Disease Guideline: Diet and Lifestyle Man...
https://doi.org/10.1016/j.semnephrol.2015.10.008
Seminars in Nephrology; Campbell KL, Rangan GK et. al.

Jan 1st, 2016 - KHA-CARI Autosomal Dominant Polycystic Kidney Disease Guideline: Diet and Lifestyle Management.|2016|Campbell KL,Rangan GK,Lopez-Vargas P,Tong A,|administration & dosage,administration & dosage,physiology,complications,physiopathology,therapy,admi...

KHA-CARI Autosomal Dominant Polycystic Kidney Disease Guideline: Psychosocial Care.
https://doi.org/10.1016/j.semnephrol.2015.10.010
Seminars in Nephrology; Tong A, Mallett A et. al.

Jan 1st, 2016 - KHA-CARI Autosomal Dominant Polycystic Kidney Disease Guideline: Psychosocial Care.|2016|Tong A,Mallett A,Lopez-Vargas P,Rangan GK,|psychology,therapy,

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Drugs  2 results see all →

Clinicaltrials.gov  37 results

A Study to Evaluate the Effects of GLPG2737 in Participants With Autosomal Dominant Polycystic Kidney Disease (ADPKD)
https://clinicaltrials.gov/ct2/show/NCT04578548

Nov 24th, 2021 - This is an exploratory, randomized, double-blind, placebo-controlled, parallel group, multicenter, proof of concept study (Phase 2a), evaluating orally administered GLPG2737 for a double-blind (DB) treatment period of 52 weeks and 4 weeks of follo...

Efficacy and Safety of Lixivaptan in the Treatment of Autosomal Dominant Polycystic Kidney Disease
https://clinicaltrials.gov/ct2/show/NCT04064346

Nov 5th, 2021 - Part 1: Approximately 2000 participants with ADPKD will be screened in order to qualify the 1200 individuals who will then be randomized to receive lixivaptan or placebo. Each participant has a 2/3 chance of receiving lixivaptan and a 1/3 chance o...

Lixivaptan in a Single Subject With Intractable Pain Due to Polycystic Kidney Disease
https://clinicaltrials.gov/ct2/show/NCT03717181

Oct 14th, 2021 - Abdominal pain, sometimes severe, is a known symptom of polycystic kidney disease (PKD) related to the cystic expansion. This study will investigate whether the vasopressin V2 receptor antagonist lixivaptan can alleviate intractable pain in a pedi...

Daily Caloric Restriction in ADPKD
https://clinicaltrials.gov/ct2/show/NCT04907799

Oct 13th, 2021 - Autosomal dominant polycystic kidney disease (ADPKD) is characterized by development and continued growth of numerous fluid-filled renal cysts that ultimately result in renal failure. Similar to the general population, the prevalence of overweight...

The Effectiveness of Smoking Cessation in Prediabetic Smokers
https://clinicaltrials.gov/ct2/show/NCT01926041

Jul 28th, 2021 - Participants: We expect to recruit study participants at National Taiwan University Hospital and its Yunlin branch, where a systematic identification system has been applied to classify the tobacco addiction status of every patient in outpatient c...

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News  65 results

Kidney Donors Reveal What It's Like to Match for Surgery
https://www.medscape.com/viewarticle/962376

Nov 5th, 2021 - From the time they were young, Amy DeAngelis and her younger sister Laura Johnson knew that Laura would need a new kidney someday. A condition called polycystic kidney disease runs in their family, and eventually the affected organs fail. Amy had ...

Fast Five Quiz: Autosomal Dominant Polycystic Kidney Disease (ADPKD)
https://www.medscape.com/viewarticle/954016

Aug 6th, 2021 - Autosomal-dominant polycystic kidney disease (ADPKD) is the most common hereditary renal disease and the fourth leading cause of end-stage renal disease worldwide. As many as 12 million people are affected by ADPKD, which stems primarily from muta...

Fast Five Quiz: Autosomal Dominant Polycystic Kidney Disease Presentation and Diagnosis
https://www.medscape.com/viewarticle/950557

Jun 29th, 2021 - Autosomal dominant polycystic kidney disease (ADPKD) is the most common hereditary kidney disease worldwide. It is characterized by progressive development of renal cysts, hypertension, and destruction of the kidney parenchyma. Most patients with ...

Prolonged Antibiotics Cut Risk of Recurrence in Polycystic Kidney Disease
https://www.medscape.com/viewarticle/952953

Jun 11th, 2021 - A prolonged course of antibiotic therapy dramatically reduces the risk of recurrence in patients with renal cyst infections in the context of autosomal dominant polycystic kidney disease (ADPKD), a new study indicates. However, lipid-soluble antib...

FDA Awards Research Grants for 18 Rare Diseases, Including HPV-Related Oropharyngeal Cancer
https://www.onclive.com/view/fda-awards-research-grants-for-18-rare-diseases-including-hpv-related-oropharyngeal-cancer

Dec 4th, 2020 - Gayatri R. Rao, MD, JD Eighteen new research grants, totaling more than $19 million, have been awarded by the FDA for product development in rare diseases such as HPV-related head and neck cancer and recurrent glioblastoma, the regulatory agency ...

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Patient Education  12 results see all →