About 2,168 results

ALLMedicine™ Focal Segmental Glomerulosclerosis Center

Research & Reviews  804 results

Safety and efficacy of dapagliflozin in patients with focal segmental glomerulosclerosi...
Nephrology, Dialysis, Transplantation : Official Publicat... Wheeler DC, Jongs N et. al.

Dec 2nd, 2021 - Despite renin-angiotensin-aldosterone-system blockade and immunosuppressive treatment, focal segmental glomerulosclerosis (FSGS) often progresses to kidney failure. The objective of this pre-specified analysis of DAPA-CKD was to assess efficacy an...

Collapsing focal segmental glomerulosclerosis successfully treated with combination of ...
https://doi.org/10.1007/s40620-021-01213-9 10.1038/sj.ki.5001903 10.1093/ckj/sfx029 10.1681/ASN.2006030225 10.1007/s10157-014-0996-8 10.1007/s10157-013-0930-5 10.1038/nrneph.2009.184 10.1053/j.ajkd.2004.09.013 10.1038/sj.ki.5000160 10.1097/01.ASN.0000135051.62500.97
Journal of Nephrology; Furuto Y, Hashimoto H et. al.

Dec 1st, 2021 - Collapsing focal segmental glomerulosclerosis successfully treated with combination of steroid pulse and low-density lipoprotein apheresis: lessons for the clinical nephrologist.|2021|Furuto Y,Hashimoto H,Kawamura M,Horiuchi H,Shibuya Y,|

Use of ofatumumab and eplerenone in post-transplant recurrence of FSGS.
Pediatric Transplantation; Jain NG, Chen JK et. al.

Nov 23rd, 2021 - Focal segmental glomerulosclerosis (FSGS) predisposes patients for risk of recurrent disease in allografts. We report a case of a recipient of an unrelated living donor renal transplant and discuss considerations for utilization of ofatumumab and ...

Autopsy Findings of Heterozygous Fabry Disease with the Severe Phenotype: A Case Report.
Nephron Hiratsuka M, Koyama K et. al.

Nov 23rd, 2021 - Fabry disease (FD) is an inherited X-linked lysosomal storage disorder, with hemizygous males being more severely affected than heterozygous females. Herein, we report a rare case of FD in a heterozygous female with a severe phenotype. The patient...

MAD2B-mediated cell cycle reentry of podocytes is involved in the pathogenesis of FSGS.
International Journal of Biological Sciences; Bao D, Su H et. al.

Nov 23rd, 2021 - Rationale: Focal segmental glomerulosclerosis (FSGS) is characterized by the dysfunction of "post-mitotic" podocytes. The reentry of podocytes in the cell cycle will ultimately result in cell death. Mitotic arrest deficient 2-like protein 2 (MAD2B...

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Guidelines  2 results

Executive summary of the KDIGO 2021 Guideline for the Management of Glomerular Diseases.
Kidney International; Rovin BH, Adler SG et. al.

Sep 25th, 2021 - The Kidney Disease: Improving Global Outcomes (KDIGO) Clinical Practice Guideline for the Management of Glomerular Diseases is an update to the KDIGO 2012 guideline. The aim is to assist clinicians caring for individuals with glomerulonephritis (G...

Kidney disease in the setting of HIV infection: conclusions from a Kidney Disease: Impr...
Kidney International; Swanepoel CR, Atta MG et. al.

Feb 6th, 2018 - HIV-positive individuals are at increased risk for kidney disease, including HIV-associated nephropathy, noncollapsing focal segmental glomerulosclerosis, immune-complex kidney disease, and comorbid kidney disease, as well as kidney injury resulti...

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Drugs  1 results see all →

Clinicaltrials.gov  30 results

The FOrMe Registry (The German Focal Segmental Glomerulosclerosis and Minimal Change Disease Registry)

Nov 22nd, 2021 - Idiopathic Nephrotic Syndrome is characterized by proteinuria, volume retention, hyperlipidemia, hypoalbuminemia. As Minimal Change Disease (MCD) represents by far the most prevalent underlying diagnosis in children older than 1 year, a kidney bio...

Pathogenesis of Glomerulosclerosis

Oct 29th, 2021 - The present protocol seeks to advance our understanding of sclerosing glomerular and tubulointerstitial kidney diseases, including but not limited to variants of focal segmental glomerulosclerosis (FSGS) and chronic kidney disease of unknown etiol...

Study to Assess the Efficacy and Safety of Bleselumab in Preventing the Recurrence of Focal Segmental Glomerulosclerosis in de Novo Kidney Transplant Recipients

Oct 20th, 2021 - The study will consist of the following periods: Screening (Days -21 to -1), Transplant (Day 0), Post-Transplant (Day 0/post-skin closure through 12 months post-transplant). All subjects will enter into a Screening Period (Days -21 to -1 prior to ...

Study of Sparsentan Treatment in Pediatrics With Proteinuric Glomerular Diseases

Sep 29th, 2021 - This is a multicenter, open-label, 108-week study of sparsentan in approximately 57 pediatric subjects aged ≥1 year to <18 years with selected proteinuric glomerular diseases, divided into 2 populations, defined as follows: Population 1: Subjects ...

A Study of TRPC5 Channel Inhibitor in Patients With Diabetic Nephropathy, Focal Segmental Glomerulosclerosis, and Treatment-Resistant Minimal Change Disease

Sep 23rd, 2021 - Approximately 125 patients will be enrolled in this study across the United States. Patients with DN and FSGS/TR-MCD will be randomized in 3 ascending dose cohorts to receive either GFB-887 or placebo.

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News  28 results

Nephrotic Syndrome Patients at High Risk of Kidney Failure, Vascular Problems

Jul 1st, 2021 - NEW YORK (Reuters Health) - Adults with primary nephrotic syndrome (NS) had close to a 20 times greater risk of developing kidney failure and higher risks of several cardiovascular diseases and death compared to those without NS in a large analysi...

Protein Predicts Risk of AKI in COVID-19 Patients

Oct 13th, 2020 - Editor's note: Find the latest COVID-19 news and guidance in Medscape's Coronavirus Resource Center. Admission levels of a specific protein predict the development of acute kidney injury (AKI) as well as the need for dialysis in patients hospitali...

24-year-old man • prednisone therapy for nephrotic syndrome • diffuse maculopapular rash • pruritis
MDedge Family Medicine; Neil E. Soifer, MD, Michael J. Hepner, MD

Jun 8th, 2020 - THE CASE A 24-year-old man with no past medical history was referred to a nephrologist for a 5-month history of leg swelling and weight gain. His only medication was furosemide 40 mg/d, prescribed by his primary care physician.

Rituximab for Nephrotic Syndrome in Kids: A Note of Caution

Feb 24th, 2020 - First-line Therapy for Nephrotic Syndrome: A Comparison Idiopathic nephrotic syndrome is the most common disorder of glomerular function in pediatrics.[1] Approximately 40% of children diagnosed with idiopathic nephrotic syndrome will have a relap...

Study spotlights risk factors for albuminuria in youth with T2DM
Doug Brunk

Jul 9th, 2018 - TORONTO – When Brandy Wicklow, MD, began her pediatric endocrinology fellowship at McGill University in 2006, about 12 per 100,000 children in Manitoba, Canada, were diagnosed with type 2 diabetes mellitus each year. By 2016 that rate had more tha.

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Patient Education  2 results see all →