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Spironolactone With Patiromer in the Treatment of Resistant Hypertension in Chronic Kidney Disease - AMBER

Oct 7th, 2019 - The AMBER trial showed that the potassium binder patiromer was effective at allowing more patients to remain on spironolactone.

U.S. FDA Approves INVOKANA® (canagliflozin) to Treat Diabetic Kidney Disease (DKD) and Reduce the Risk of Hospitalization for Heart Failure in Patients with Type 2 Diabetes (T2D) and DKD

Sep 29th, 2019 - The Janssen Pharmaceutical Companies of Johnson & Johnson announced today that the U.S. Food and Drug Administration (FDA) approved a new indication for INVOKANA® (canagliflozin) to reduce the risk of end-stage kidney disease (ESKD), worsening of kidney function, cardiovascular (CV) death, and hospitalization for heart failure in adults with type 2 diabetes and diabetic kidney disease (nephropa...

Prevention, Diagnosis, Evaluation, and Treatment of Hepatitis C Virus Infection in Chronic Kidney Disease: Synopsis of the Kidney Disease: Improving Global Outcomes 2018 Clinical Practice Guideline

Sep 23rd, 2019 - Description: The Kidney Disease: Improving Global Outcomes (KDIGO) 2018 clinical practice guideline for the prevention, diagnosis, evaluation, and treatment of hepatitis C virus (HCV) infection in chronic kidney disease (CKD) is an extensive update of KDIGO's 2008 guideline on HCV infection in CKD. This update reflects the major advances since the introduction of direct-acting antivirals (DAAs...

Lipoprotein(a): The Next Promising CVD Risk Assessment Tool and Prevention Target Among the High-risk Population

Sep 17th, 2019 - After low density lipoprotein cholesterol (LDL-C) has been targeted to reduce cardiovascular disease (CVD) risk, other novel lipid biomarkers have become the center of attention of investigation, and on-going clinical trials are targeting these lipid markers trying to lower the so-called "residual CVD risk" in addition to conventional lipid-lowering therapy. Among them, serum lipoprotein(a) [Lp...

Unraveling the Safety Profile of Proton-Pump Inhibitors
Journal Watch;

Aug 19th, 2019 - Proton-pump inhibitors (PPIs) provide important clinical benefits for many patients. However, observational studies have suggested an association between PPI use and a variety of adverse events, including dementia, osteoporosis, bone fractures, micronutrient deficiencies, pneumonia, spontaneous bacterial peritonitis, kidney disease, and enteric infections. We have observed that some patients wi...

Polycystic kidney disease

Jul 15th, 2019 - Polycystic kidney disease is a disorder that affects the kidneys and other organs. Clusters of fluid-filled sacs, called cysts, develop in the kidneys and interfere with their ability to filter waste products from the blood. The growth of cysts causes the kidneys to become enlarged and can lead to kidney failure. Cysts may also develop in other organs, particularly the liver.

NIH Fact Sheets - Autosomal Dominant Polycystic Kidney Disease

Jun 29th, 2019 - Autosomal Dominant Polycystic Kidney Disease (ADPKD) resulted in end-stage renal disease (ESRD) by age 53, on average, and was responsible for 6 percent of ESRD cases in the U.S.

Type 2 diabetes and the kidney: Insights from cardiovascular outcome trials
Diabetes, Obesity and Metabolism;

Apr 9th, 2019 - Diabetic kidney disease (DKD) still remains a progressive condition that is associated with higher risk of end‐stage kidney disease and significant cardiovascular morbidity and mortality. Twelve cardiovascular outcome trials in type 2 diabetes (T2D) have been published to date. Most trials with dipeptidyl‐peptidase inhibitors (SAVOR‐TIMI 53 with saxagliptin, EXAMINE with alogliptin, TECOS with ...

Microvascular Complications and Foot Care: Standards of Medical Care in Diabetes—2019

Dec 17th, 2018 - Chronic kidney disease (CKD) is diagnosed by the persistent presence of elevated urinary albumin excretion (albuminuria), low estimated glomerular filtration rate (eGFR), or other manifestations of kidney damage (1,2). In this section, the focus will be on CKD attributed to diabetes (diabetic kidney disease), which occurs in 20–40% of patients with diabetes (1,3–5). CKD typically develops after...

Polycystic Kidney Disease

Sep 13th, 2018 - What is polycystic kidney disease? Polycystic kidney disease (also called PKD) causes numerous cysts to grow in the kidneys. These cysts are filled with fluid. If too many cysts grow or if they get too big, the kidneys can become damaged. PKD cysts can slowly replace much of the kidneys, reducing kidney function and leading to kidney failure.

Hypertension Treatment Algorithm

Apr 8th, 2018 - Management of hypertension in adults based on evidence-based guidelines. Set blood pressure (BP) goal and initiate BP-lowering medication based on age, diabetes, and chronic kidney disease (CKD)

Sodium Intake and Health Outcomes
Strom, B. et. al.

Aug 26th, 2017 - This chapter reviews and assesses new evidence for associations between dietary sodium intake and outcomes published in the peer-reviewed literature through 2012. The health outcomes reviewed by the committee include cardiovascular disease (CVD), including stroke CVD mortality and all-cause mortality, congestive heart failure (CHF), chronic kidney disease (CKD), diabetes, cancer, and “other” ou...

Diabetes and Hypertension: A Position Statement by the American Diabetes Association
de Boer, I. et. al.

Aug 21st, 2017 - Hypertension is common among patients with diabetes, with the prevalence depending on type and duration of diabetes, age, sex, race/ethnicity, BMI, history of glycemic control, and the presence of kidney disease, among other factors (1–3). Furthermore, hypertension is a strong risk factor for atherosclerotic cardiovascular disease (ASCVD), heart failure, and microvascular complications. ASCVD—d...

What Is Polycystic Kidney Disease? | NIDDK

Jan 1st, 2017 - Learn about causes and signs of polycystic kidney disease (PKD). The sooner you know you have PKD, the sooner you can keep your condition from getting worse.

Polycystic Kidney Disease (PKD) | NIDDK

Dec 31st, 2016 - Defines two types of polycystic kidney disease and describes their genetic origins, symptoms, diagnosis, and treatment, as well as ongoing research.

Practical Approach to Detection and Management of Chronic Kidney Disease for the Primary Care Clinician
The American Journal of Medicine; Vassalotti, J. et. al.

Feb 1st, 2016 - A panel of internists and nephrologists developed this practical approach for the Kidney Disease Outcomes Quality Initiative to guide assessment and care of chronic kidney disease (CKD) by primary care clinicians. Chronic kidney disease is defined as a glomerular filtration rate (GFR) <60 mL/min/1.73 m2 and/or markers of kidney damage for at least 3 months. In clinical practice the most comm...

KDIGO 2012 Clinical Practice Guideline for the Evaluation and Management of Chronic Kidney Disease

Dec 31st, 2012 - The Kidney Disease: Improving Global Outcomes (KDIGO) 2012 Clinical Practice Guideline for the Evaluation and Management of Chronic Kidney Disease (CKD) serves to update the 2002 KDOQI Clinical Practice Guidelines for Chronic Kidney Disease: Evaluation, Classification, and Stratification following a decade of focused research and clinical practice in CKD. The document aims to provide state-of-t...

KDIGO Clinical Practice Guideline for Anemia in Chronic Kidney Disease

Dec 30th, 2012 - The 2012 Kidney Disease: Improving Global Outcomes (KDIGO) Clinical Practice Guideline for Anemia in Chronic Kidney Disease aims to provide guidance on diagnosis, evaluation, management and treatment for all CKD patients (non-dialysis, dialysis, kidney transplant recipients and children) at risk of or with anemia. Guideline development followed an explicit process of evidence review and apprais...

Adult Polycystic Kidney Disease - American Urological Association

Welcome to the updated version of Pathology for Urologists! This program was designed to help Urology residents and fellows familiarize themselves with the pathologic features of common urologic entities. This will serve not only as a resource tool for your review but also as a quick reference guide to urologic pathology.

New Renal-Imaging Modalities Help Diagnose Congenital Anomalies Early

Jan 8th, 2020 - NEW YORK (Reuters Health) - State-of-the-art renal imaging facilitates the early diagnosis of congenital anomalies of the kidney and urinary tract (CAKUT), according to a review. CAKUT make up 20% to 30% of all anomalies identified in the prenatal period and occur in up to 60% of children with chronic kidney disease in the postnatal period. CAKUT often present with urinary tract dilation (UTD)....