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About 9,398 results

ALLMedicine™ Diabetic Nephropathy Center

Research & Reviews  3,200 results

Hypoxia preconditioning increases the ability of healthy but not diabetic rat-derived a...
https://doi.org/10.1016/j.prp.2021.153756
Pathology, Research and Practice; Carmona M, Paco-Meza LM et. al.

Jan 16th, 2022 - Mesenchymal stromal cells (MSC) have demonstrated ability to improve diabetic nephropathy (DN) in experimental models, as well as by improving kidney endogenous progenitor cells proliferation and differentiation. Many studies have demonstrated the...

Activation of the NLRP3 inflammasome by RAC1 mediates a new mechanism in diabetic nephr...
https://doi.org/10.1007/s00011-021-01532-4 10.2337/dc20-1688 10.1192/bjp.2020.248 10.2337/db20-0604 10.1016/j.molmet.2020.101089 10.1089/ars.2015.6372 10.1038/cddis.2016.335 10.1016/j.molmet.2019.02.007 10.1016/j.kint.2021.02.025 10.1038/s41385-019-0181-1 10.1111/bph.15532 10.1016/j.molmet.2018.02.001 10.1681/ASN.2010020143 10.1007/s00204-021-03157-2 10.1038/s41419-019-2157-1 10.4049/jimmunol.1600760 10.1002/art.41245 10.1016/j.ejphar.2020.173503 10.1016/j.metabol.2021.154748 10.1038/nrneph.2015.175 10.1038/s12276-019-0217-3 10.1681/asn.2013111213 10.1371/journal.pone.0150886 10.3390/ijms21124433 10.1016/j.ajpath.2014.06.013 10.1038/s41419-018-0353-z 10.3389/fphar.2020.587663 10.3390/ijms20184531 10.1002/art.38174 10.1016/j.mce.2018.08.002 10.1016/j.ymthe.2021.03.012 10.1016/j.phymed.2020.153314 10.1016/j.lfs.2021.119542 10.1038/ki.2014.271 10.1016/j.redox.2021.102033 10.1681/asn.2014111136 10.1681/asn.2015060676 10.2337/db15-0473 10.1016/j.kint.2016.06.035 10.1016/j.kint.2016.09.032 10.1111/joim.12548 10.1016/j.ijbiomac.2019.04.069 10.1186/s13287-019-1177-1 10.1681/asn.2016020237 10.1038/ki.2014.322 10.1016/j.kint.2017.05.013 10.1016/j.jnutbio.2018.06.002 10.1038/ki.2014.116 10.3389/fimmu.2020.01270 10.1038/s41419-021-03813-6 10.15252/embj.2019102201 10.3389/fimmu.2021.630569 10.1002/ctm2.373 10.1016/j.kint.2019.01.014 10.1073/pnas.1415756111 10.1073/pnas.1012455108 10.1016/j.freeradbiomed.2017.02.027 10.1159/000500457 10.1371/journal.pone.0030379 10.1038/s41467-020-15497-1 10.3389/fphys.2021.679166 10.1016/j.lfs.2021.119226 10.1369/jhc.7A7266.2007 10.1016/j.kint.2019.01.029 10.1371/journal.ppat.1005121 10.1038/s41589-019-0277-7 10.1038/s41423-021-00670-3
Inflammation Research : Official Journal of the European ... Ying C, Zhou Z et. al.

Jan 15th, 2022 - Inflammation is central to the development and progression of diabetic nephropathy (DN). Although the exact mechanisms of inflammation in the kidney have not been well elucidated, pyrin domain containing 3 (NLRP3) inflammasome activation is involv...

The novel anti-inflammatory activity of mcIRBP from Momordica charantia is associated w...
https://doi.org/10.1039/d1fo03620c
Food & Function; Liao PY, Lo HY et. al.

Jan 14th, 2022 - Diabetic nephropathy is an inflammatory immune disorder accompanying diabetes. A trypsin inhibitor of Momordica charantia, mcIRBP, is an abundant 68 amino acid residue protein that interacts with the insulin receptor. Here the long-term effects of...

Genetic Risk Score Enhances Coronary Artery Disease Risk Prediction in Individuals With...
https://doi.org/10.2337/dc21-0974
Diabetes Care; Lithovius R, Antikainen AA et. al.

Jan 13th, 2022 - Individuals with type 1 diabetes are at a high lifetime risk of coronary artery disease (CAD), calling for early interventions. This study explores the use of a genetic risk score (GRS) for CAD risk prediction, compares it to established clinical ...

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Guidelines  3 results

Validation of the 2007 kidney disease outcomes quality initiative clinical practice gui...
https://doi.org/10.1016/j.diabres.2018.11.008
Diabetes Research and Clinical Practice; Liu XM, Dong ZY et. al.

Nov 26th, 2018 - Diabetes mellitus (DM) has overtaken infection and immunological factors as the most common cause of end-stage renal disease. The 2007 Kidney Disease Outcomes Quality Initiative (KDOQI) guideline is a widely accepted guideline for the clinical dia...

Management of adults with diabetes on the haemodialysis unit: summary of guidance from ...
https://doi.org/10.1111/dme.13676
Diabetic Medicine : a Journal of the British Diabetic Ass... Frankel AH, Kazempour-Ardebili S et. al.

Aug 29th, 2018 - Diabetic nephropathy remains the principal cause of end-stage renal failure in the UK and its prevalence is set to increase. People with diabetes and end-stage renal failure on maintenance haemodialysis are highly vulnerable, with complex comorbid...

Cardiovascular autonomic neuropathy in diabetes: clinical impact, assessment, diagnosis...
https://doi.org/10.1002/dmrr.1239
Diabetes/metabolism Research and Reviews; Spallone V, Ziegler D et. al.

Jun 23rd, 2011 - The Cardiovascular Autonomic Neuropathy (CAN) Subcommittee of the Toronto Consensus Panel on Diabetic Neuropathy worked to update CAN guidelines, with regard to epidemiology, clinical impact, diagnosis, usefulness of CAN testing, and management. C...

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Drugs  283 results see all →

Clinicaltrials.gov  112 results

Safety, Tolerability and Efficacy of Nidufexor in Patients With Diabetic Nephropathy
https://clinicaltrials.gov/ct2/show/NCT03804879

Dec 20th, 2021 - Nidufexor addresses fibrosis, oxidative stress, inflammation and cell death, and therefore has the potential to improve the management of diabetic kidney disease when added to the standard of care (angiotensin converting enzyme inhibitor or angiot...

A Study of TRPC5 Channel Inhibitor in Patients With Diabetic Nephropathy, Focal Segmental Glomerulosclerosis, and Treatment-Resistant Minimal Change Disease
https://clinicaltrials.gov/ct2/show/NCT04387448

Dec 14th, 2021 - Approximately 125 patients will be enrolled in this study across the United States. Patients with DN and FSGS/TR-MCD will be randomized in 3 ascending dose cohorts to receive either GFB-887 or placebo.

Treatment of Graves´Ophthalmopathy With Simvastatin (GO-DS)
https://clinicaltrials.gov/ct2/show/NCT03131726

Nov 18th, 2021 - Progression of GO from mild-moderate to severe disease: Criteria for start of treatment with corticosteroids, retrobulbar irradiation, or orbital decompression are severe soft tissue swelling (NO SPECS class 2c), risk of corneal ulcers with or wit...

Tangningtongluo Tablet for People With Prediabetes
https://clinicaltrials.gov/ct2/show/NCT05126251

Nov 18th, 2021 - Prediabetes is an intermediate transition to hyperglycemia between normal blood glucose and diabetes, including impaired fasting glucose (IFG), impaired glucose tolerance (IGT)and the presence of a combination of the two. At present, the prediabet...

Observational Study to Evaluate the Relationship Between Ketonemia and Renal Function in the Diabetic Patient
https://clinicaltrials.gov/ct2/show/NCT03859817

Sep 28th, 2021 - At the beginning and during the course of the study the glycemic and ketone index obtained by the homologous blood glucose monitoring will be evaluated. During the study, prognostic biomarkers (sP2X7R, KIM-1, sTNFR1, 11-dehydro-tromoxane B2 and 6-...

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News  153 results

Lupin Recalls Irbesartan and Hydrochlorothiazide/Irbesartan Tablets
https://www.medscape.com/viewarticle/960937

Oct 14th, 2021 - Lupin Pharmaceuticals is recalling all batches of irbesartan tablets USP 75 mg, 150 mg, and 300 mg and irbesartan and hydrochlorothiazide (HCTZ) tablets USP 150 mg/12.5 mg and 300 mg/12.5 mg because of the potential presence of the N-nitrosoirbesa...

Cardiovascular Disease a Continuing Challenge in Type 1 Diabetes
https://www.medscape.com/viewarticle/957027

Aug 23rd, 2021 - Despite a significant decline in cardiovascular disease risk for people with type 1 diabetes over time, the risk remains higher than that of the general population, new data from Finland show. Findings from the study of nearly 12,000 Finnish peopl...

Waist Circumference Predicts Risk of Fatty Liver in Type 1 Diabetes
https://www.medscape.com/viewarticle/953022

Jun 14th, 2021 - Dr Erika B. Parente It follows that, as the prevalence of obesity among people with type 1 diabetes mellitus (T1DM) increases, so would the incidence of nonalcoholic fatty liver (NAFL), as it does in type 2 diabetes. However, researchers in Finlan...

How Does Phosphate Binder Type Affect the Heart in Hemodialysis?
https://www.medpagetoday.com/nephrology/esrd/92646

May 18th, 2021 - Non-calcium-based phosphate binders weren't any better at reducing cardiovascular events than calcium-based binders in dialysis patients, the LANDMARK trial determined. In the open-label randomized trial of over 2,300 Japanese patients on hemodial...

CKD: Dapagliflozin Offers Benefits Regardless of Diabetes Status
https://www.medscape.com/viewarticle/944379

Jan 22nd, 2021 - Takeaway Dapagliflozin lowers the risks of major adverse kidney and cardiovascular (CV) events and all-cause mortality in patients with chronic kidney disease (CKD), regardless of type 2 diabetes (T2D) status. These benefits also extend to patient...

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Patient Education  8 results see all →