About 714 results
NCCN Guidelines Insights: Kidney Cancer, Version 2.2020
JNCCN Motzer RJ, et al.

Nov 13th, 2019 - The NCCN Guidelines for Kidney Cancer provide multidisciplinary recommendations for the clinical management of patients with clear cell and non–clear cell renal cell carcinoma, and are intended to assist with clinical decision-making. These NCCN Guidelines Insights summarize the NCCN Kidney Cancer Panel discussions for the 2020 update to the guidelines regarding initial management and first-lin...

2019 AHA/ACC Clinical Performance and Quality Measures for Adults With High Blood Pressure: A Report of the American College of Cardiology/American Heart Association Task Force on Performance Measures
Circulation: Cardiovascular Quality and Outcomes; Casey E, et al.

Nov 12th, 2019 - In 2018, the Task Force convened the writing committee to begin the process of revising the existing performance measures set for hypertension that had been released in 2011.3 The writing committee also was charged with the task of developing new measures to evaluate the care of patients in accordance with the 2017 Hypertension Clinical Practice Guidelines.4 The writing committee developed a...

Renin-Angiotensin System Inhibitors vs. Other Antihypertensive Drug Classes for Hypertension
American Family Physician; JEFFREY C. LEGGIT, MD

Nov 5th, 2019 - RAS inhibitors have been widely prescribed to treat hypertension; however, it remains unclear whether they are superior to other antihypertensive drugs in terms of clinically relevant outcomes for primary hypertension.

Comprehensive comparative effectiveness and safety of first-line antihypertensive drug classes: a systematic, multinational, large-scale analysis

Oct 23rd, 2019 - Uncertainty remains about the optimal monotherapy for hypertension, with current guidelines recommending any primary agent among the first-line drug classes thiazide or thiazide-like diuretics, angiotensin-converting enzyme inhibitors, angiotensin receptor blockers, dihydropyridine calcium channel blockers, and non-dihydropyridine calcium channel blockers, in the absence of comorbid indications...

The 2019 ESC Guidelines on diabetes, pre-diabetes, and cardiovascular diseases developed in collaboration with the EASD: New features and the ‘Ten Commandments’ of the 2019 Guidelines are discussed...
European Heart Journal; Grant, P. et. al.

Oct 13th, 2019 - The prevalence of diabetes continues to increase, with 60 million thought to have diabetes in Europe in 2017 and predictions of more than 600 million individuals with diabetes worldwide by 2045. These numbers carry a huge burden of morbidity and mortality with a high prevalence of microvascular disease affecting the eyes, nerves, and kidneys and macrovascular disease leading to CV, cerebrovascu...

Spironolactone With Patiromer in the Treatment of Resistant Hypertension in Chronic Kidney Disease - AMBER

Oct 7th, 2019 - The AMBER trial showed that the potassium binder patiromer was effective at allowing more patients to remain on spironolactone.

Preventive Cardiology as a Subspecialty of Cardiovascular Medicine
Journal of the American College of Cardiology; Shapiro, M. et. al.

Oct 1st, 2019 - Although significant progress has been made to reduce the global burden of cardiovascular disease, efforts have focused primarily on treatment of manifest disease rather than on prevention of events. An enormous opportunity exists to transition focus from intervention to providing equal attention to prevention of cardiovascular disease. The nascent specialty of “preventive cardiology” is emergi...

Protecting Patients from Elder Abuse Scams
American Family Physician;

Sep 30th, 2019 - Living on my own continues to be very important to me, even though I'm getting older and am sometimes forgetful. I manage pretty well with the help of my son, who visits me weekly, and my family doctor, who I see monthly for my hypertension, stomach reflux problems, prediabetes, and high cholesterol. I try to manage my forgetfulness with the help of a pill box so that I remember to take my medi...

U.S. FDA Approves INVOKANA® (canagliflozin) to Treat Diabetic Kidney Disease (DKD) and Reduce the Risk of Hospitalization for Heart Failure in Patients with Type 2 Diabetes (T2D) and DKD

Sep 29th, 2019 - The Janssen Pharmaceutical Companies of Johnson & Johnson announced today that the U.S. Food and Drug Administration (FDA) approved a new indication for INVOKANA® (canagliflozin) to reduce the risk of end-stage kidney disease (ESKD), worsening of kidney function, cardiovascular (CV) death, and hospitalization for heart failure in adults with type 2 diabetes and diabetic kidney disease (nephropa...

Prevention, Diagnosis, Evaluation, and Treatment of Hepatitis C Virus Infection in Chronic Kidney Disease: Synopsis of the Kidney Disease: Improving Global Outcomes 2018 Clinical Practice Guideline

Sep 23rd, 2019 - Description: The Kidney Disease: Improving Global Outcomes (KDIGO) 2018 clinical practice guideline for the prevention, diagnosis, evaluation, and treatment of hepatitis C virus (HCV) infection in chronic kidney disease (CKD) is an extensive update of KDIGO's 2008 guideline on HCV infection in CKD. This update reflects the major advances since the introduction of direct-acting antivirals (DAAs...

Screening for Asymptomatic Bacteriuria in Adults: US Preventive Services Task Force Recommendation Statement

Sep 23rd, 2019 - Importance Among the general adult population, women (across all ages) have the highest prevalence of asymptomatic bacteriuria, although rates increase with age among both men and women. Asymptomatic bacteriuria is present in an estimated 1% to 6% of premenopausal women and an estimated 2% to 10% of pregnant women and is associated with pyelonephritis, one of the most common nonobstetric reaso...

Lipoprotein(a): The Next Promising CVD Risk Assessment Tool and Prevention Target Among the High-risk Population

Sep 17th, 2019 - After low density lipoprotein cholesterol (LDL-C) has been targeted to reduce cardiovascular disease (CVD) risk, other novel lipid biomarkers have become the center of attention of investigation, and on-going clinical trials are targeting these lipid markers trying to lower the so-called "residual CVD risk" in addition to conventional lipid-lowering therapy. Among them, serum lipoprotein(a) [Lp...

Hypertension Scientific Sessions 2019

Sep 6th, 2019 - Hypertension Scientific Sessions 2019, Sept. 5-8, 2019 in New Orleans, LA, explores the latest clinical and basic research on hypertension science.

Hypertension 2019 Scientific Sessions -Final Program

Sep 6th, 2019 - Sponsored and organized by the Council on Hypertension in collaboration Sponsored and organized by the Council on Hypertension in collaboration with the Council on the Kidney in Cardiovascular Disease with the Council on the Kidney in Cardiovascular Disease.

Associations between blood pressure across adulthood and late-life brain structure and pathology in the neuroscience substudy of the 1946 British birth cohort (Insight 46): an epidemiological study
The Lancet Neurology;

Aug 19th, 2019 - Midlife hypertension confers increased risk for cognitive impairment in late life. The sensitive period for risk exposure and extent that risk is mediated through amyloid or vascular-related mechanisms are poorly understood. We aimed to identify if, and when, blood pressure or change in blood pressure during adulthood were associated with late-life brain structure, pathology, and cognition.

Unraveling the Safety Profile of Proton-Pump Inhibitors
Journal Watch;

Aug 19th, 2019 - Proton-pump inhibitors (PPIs) provide important clinical benefits for many patients. However, observational studies have suggested an association between PPI use and a variety of adverse events, including dementia, osteoporosis, bone fractures, micronutrient deficiencies, pneumonia, spontaneous bacterial peritonitis, kidney disease, and enteric infections. We have observed that some patients wi...

Intensive blood pressure management may preserve brain health

Aug 13th, 2019 - Numerous large, cohort studies have linked midlife hypertension to mild cognitive impairment and dementia later on. Some of these studies found a higher risk of lesions in the brain's white matter in older age among people with high blood pressure in their 50s. The white matter of the brain consists of bundles of axons, which are the thin elongations of neurons. White matter is "white" due to m...

Use of Antibiotics and Risk of Cancer: A Systematic Review and Meta-Analysis of Observational Studies
Cancers Petrelli, F. et. al.

Jul 30th, 2019 - The association between antibiotic use and risk of cancer development is unclear, and clinical trials are lacking. We performed a systematic review and meta-analysis of observational studies to assess the association between antibiotic use and risk of cancer. PubMed, the Cochrane Library and EMBASE were searched from inception to 24 February 2019 for studies reporting antibiotic use and subsequ...

Polycystic kidney disease

Jul 15th, 2019 - Polycystic kidney disease is a disorder that affects the kidneys and other organs. Clusters of fluid-filled sacs, called cysts, develop in the kidneys and interfere with their ability to filter waste products from the blood. The growth of cysts causes the kidneys to become enlarged and can lead to kidney failure. Cysts may also develop in other organs, particularly the liver.

FDA Approves Katerzia™, the First and Only Amlodipine Oral Suspension, 1 mg/mL, for Pediatric Patients 6 Years of Age and Older

Jul 9th, 2019 - Azurity Pharmaceuticals, a specialty pharmaceutical company that makes safe, high-quality treatments for patients requiring customized formulations for their care, announced today that the U.S. Food and Drug Administration (FDA) has approved Katerzia (amlodipine) Oral Suspension, 1 mg/mL, the first and only FDA-approved amlodipine oral suspension. Katerzia is indicated for the treatment of hype...

Metoprolol: Uses, Dosage, Side Effects - Drugs.com

Jun 30th, 2019 - Metoprolol is used to treat angina (chest pain) and hypertension (high blood pressure). Learn about side effects, interactions and indications.

NIH Fact Sheets - Autosomal Dominant Polycystic Kidney Disease

Jun 29th, 2019 - Autosomal Dominant Polycystic Kidney Disease (ADPKD) resulted in end-stage renal disease (ESRD) by age 53, on average, and was responsible for 6 percent of ESRD cases in the U.S.

Pfizer Receives U.S. Fda Approval For Its Oncology Biosimilar, Zirabev™ (Bevacizumab-bvzr)

Jun 26th, 2019 - Pfizer Inc. (NYSE:PFE) today announced the United States (U.S.) Food and Drug Administration(FDA) has approved ZIRABEV™ (bevacizumab-bvzr), a biosimilar to Avastin® (bevacizumab),1 for the treatment of five types of cancer: metastatic colorectal cancer; unresectable, locally advanced, recurrent or metastatic non-squamous non-small cell lung cancer (NSCLC); recurrent glioblastoma; metastatic ren...

Physical activity associates with subarachnoid hemorrhage risk– a population-based long-term cohort study

Jun 24th, 2019 - Benefit of physical activity in prevention of aneurysmal subarachnoid hemorrhage (SAH) is unclear. We aimed to clarify this by studying how different types of physical activity associate with SAH risk. By following 65 521 population-based FINRISK participants prospectively from medical and autopsy registries since 1972 until 2014, we detected 543 incident SAHs. At baseline, we measured leisure-...

Teva Announces Launch of a Generic Version of Tracleer® (bosentan) Tablets in the United States

Jun 18th, 2019 - Teva Pharmaceutical Industries Ltd., (NYSE and TASE: TEVA) today announced the launch of a generic version of Tracleer®1 (bosentan) tablets, 62.5 mg and 125 mg, in the U.S. Bosentan Tablets are an endothelin receptor antagonist indicated for the treatment of pulmonary arterial hypertension (PAH, WHO Group 1) in adults to improve exercise ability and to decrease worsening of the condition. P...

Systolic Blood Pressure and Outcomes in Patients With Heart Failure With Reduced Ejection Fraction

Jun 16th, 2019 - Background National guidelines recommend that systolic blood pressure (SBP) in patients with heart failure with reduced ejection fraction (HFrEF) and hypertension be maintained below 130 mm Hg. Objectives This study sought to determine associations of SBP <130 mm Hg with outcomes in patients with HFrEF. Methods Of the 25,345 patients in the Medicare-linked OPTIMIZE-HF registry, 10,535 had...

Cardiovascular Events and Mortality in White Coat Hypertension: A Systematic Review and Meta-analysis
Annals of Internal Medicine; Cohen, J. et. al.

Jun 10th, 2019 - Background: The long-term cardiovascular risk of isolated elevated office blood pressure (BP) is unclear. Purpose: To summarize the risk for cardiovascular events and all-cause mortality associated with untreated white coat hypertension (WCH) and treated white coat effect (WCE). Data Sources: PubMed and EMBASE, without language restriction, from inception to December 2018. Study Sel...

FDA Approves Bavencio® (Avelumab) Plus Inlyta® (Axitinib) Combination For Patients With Advanced Renal Cell Carcinoma

May 13th, 2019 - Merck KGaA, Darmstadt, Germany, which operates its biopharmaceutical business as EMD Serono in the US and Canada, and Pfizer Inc. (NYSE: PFE) today announced that the US Food and Drug Administration (FDA) has approved BAVENCIO® (avelumab) in combination with INLYTA® (axitinib) for the first-line treatment of patients with advanced renal cell carcinoma (RCC). This is the first FDA approval for ...

Lisinopril: Uses, Dosage, Side Effects & Warnings - Drugs.com

Apr 30th, 2019 - Lisinopril is used to treat hypertension, congestive heart failure and to improve survival after a heart attack. Learn about side effects, interactions and indications.

Measurement of Blood Pressure in Humans: A Scientific Statement From the American Heart Association
Hypertension Muntner, P. et. al.

Apr 29th, 2019 - The accurate measurement of blood pressure (BP) is essential for the diagnosis and management of hypertension. This article provides an updated American Heart Association scientific statement on BP measurement in humans. In the office setting, many oscillometric devices have been validated that allow accurate BP measurement while reducing human errors associated with the auscultatory approac...

Cardio-Oncology Rehabilitation to Manage Cardiovascular Outcomes in Cancer Patients and Survivors

Apr 14th, 2019 - Cardiovascular disease is a competing cause of death in patients with cancer with early-stage disease. This elevated cardiovascular disease risk is thought to derive from both the direct effects of cancer therapies and the accumulation of risk factors such as hypertension, weight gain, cigarette smoking, and loss of cardiorespiratory fitness. Effective and viable strategies are needed to ...

Type 2 diabetes and the kidney: Insights from cardiovascular outcome trials
Diabetes, Obesity and Metabolism;

Apr 9th, 2019 - Diabetic kidney disease (DKD) still remains a progressive condition that is associated with higher risk of end‐stage kidney disease and significant cardiovascular morbidity and mortality. Twelve cardiovascular outcome trials in type 2 diabetes (T2D) have been published to date. Most trials with dipeptidyl‐peptidase inhibitors (SAVOR‐TIMI 53 with saxagliptin, EXAMINE with alogliptin, TECOS with ...

Treatment of Resistant and Refractory Hypertension
Circulation Acelajado, M. et. al.

Mar 28th, 2019 - Resistant hypertension (RHTN) is defined as uncontrolled blood pressure despite the use of ≥3 antihypertensive agents of different classes, including a diuretic, usually thiazide-like, a long-acting calcium channel blocker, and a blocker of the renin- angiotensin system, either an ACE (angiotensin-converting enzyme) inhibitor or an ARB (angiotensin receptor blocker), at maximal or maximally tol...

Clinical Practice Guideline for the Management of Asymptomatic Bacteriuria: 2019 Update by t...

Mar 20th, 2019 - Asymptomatic bacteriuria (ASB) is a common finding in many populations, including healthy women and persons with underlying urologic abnormalities. The 2005 guideline from the Infectious Diseases Society of America recommended that ASB should be screened for and treated only in pregnant women or in an individual prior to undergoing invasive urologic procedures.

Type 2 Diabetes and Hypertension: A Study on Bidirectional Causality
Circulation Sun, D. et. al.

Mar 14th, 2019 - Rationale: In observational studies, type 2 diabetes mellitus (T2D) has been associated with an increased risk of hypertension, and vice versa; however, the causality between these conditions remains to be determined. Objectives: This population-based prospective cohort study sought to investigate the bidirectional causal relations of T2D with hypertension, systolic and diastolic blood pre...

Pembrolizumab (pembro) plus axitinib (axi) versus sunitinib as first-line therapy for locally advanced or metastatic renal cell carcinoma (mRCC): phase III KEYNOTE-426 study.

Feb 15th, 2019 - A phase 1b study of pembro (anti–PD-1) plus axi (VEGFR-TKI) showed promising antitumor activity and manageable safety in patients (pts) with previously untreated mRCC. The global, open-label, phase 3 KEYNOTE-426 study assessed the efficacy and safety of pembro + axi vs sunitinib as first-line therapy for mRCC (NCT02853331).

Pivotal Phase Iii Data For Bavencio® (Avelumab) Plus Inlyta® (Axitinib) In Advanced Renal Cell Carcinoma Published In The New England Journal Of Medicine

Feb 15th, 2019 - JAVELIN Renal 101 shows significant improvement in progression-free survival with a hazard ratio of 0.69 in patients regardless of PD-L1 expression US FDA has granted Priority Review to BAVENCIO plus INLYTA for patients with advanced renal cell carcinoma Data at 2019 Genitourinary Cancers Symposium reinforce consistency of PFS and ORR benefits across broad population of patients with advanced R...

FDA Accepts sBLA and Grants Priority Review for BAVENCIO® (avelumab) Plus INLYTA® (axitinib) for the Treatment of Advanced Renal Cell Carcinoma

Feb 10th, 2019 - EMD Serono, the biopharmaceutical business of Merck KGaA, Darmstadt, Germany in the US and Canada, and Pfizer Inc. (NYSE: PFE) today announced that the US Food and Drug Administration (FDA) has accepted for Priority Review the supplemental Biologics License Application (sBLA) for BAVENCIO® (avelumab) in combination with INLYTA® (axitinib)* for patients with advanced renal cell carcinoma (RCC). ...

Comparing Automated Office Blood Pressure Readings With Other Methods of Blood Pressure Measurement for Identifying Patients With Possible Hypertension
Roerecke, M. et. al.

Feb 3rd, 2019 - Question: Should automated office blood pressure (recording several blood pressure readings using a fully automated oscillometric sphygmomanometer with the patient resting alone in a quiet place) measurement replace readings recorded by nurses and physicians in routine clinical practice? Findings: This systematic review and meta-analysis of 31 articles comprising 9279 participants compared auto...

Home Oxygen Therapy for Children. An Official American Thoracic Society Clinical Practice Guideline
Hayes, D. et. al.

Jan 31st, 2019 - Although home oxygen therapy is commonly required in the care of children, there is a striking lack of empirical evidence regarding implementation, monitoring, and discontinuation of supplemental oxygen therapy. The panel formulated and provided the rationale for clinical recommendations for home oxygen therapy based on scant empirical evidence, expert opinion, and clinical experience to aid cl...

Phosphodiesterase 5 inhibitors for pulmonary hypertension
Barnes, H. et. al.

Jan 30th, 2019 - Pulmonary hypertension (PH) comprises a group of complex and heterogenous conditions, characterised by elevated pulmonary artery pressure, and which left untreated leads to right‐heart failure and death. PH includes World Health Organisation (WHO) Group 1 pulmonary arterial hypertension (PAH); Group 2 consists of PH due to left‐heart disease (PH‐LHD); Group 3 comprises PH as a result of lung di...

The Risk of Heart Failure and Other Cardiovascular Hospitalizations After Early Stage Breast Cancer: A Matched Cohort Study
Abdel-Qadir, H.

Jan 30th, 2019 - Data are limited regarding the risk of heart failure (HF) requiring hospital-based care after early stage breast cancer (EBC) and its relationship to other types of cardiovascular disease (CVD). Atherosclerotic diagnoses, rather than HF, were the most common reasons for CVD hospitalization after EBC. HF hospital presentations were often preceded by risk factors other than chemotherapy, suggesti...

Imaging of Kidney Cysts and Cystic Kidney Diseases in Children: An International Working Gro...

Dec 31st, 2018 - Kidney cysts can manifest as focal disease (simple and complex kidney cysts), affect a whole kidney (eg, multicystic dysplastic kidney or cystic dysplasia), or manifest as bilateral cystic disease (eg, autosomal recessive polycystic kidney disease [ARPKD] or autosomal dominant polycystic kidney disease [ADPKD]). In children, as opposed to adults, a larger proportion of kidney cysts are due to g.

Cardiovascular Disease and Risk Management: Standards of Medical Care in Diabetes—2019

Dec 17th, 2018 - Atherosclerotic cardiovascular disease (ASCVD)—defined as coronary heart disease, cerebrovascular disease, or peripheral arterial disease presumed to be of atherosclerotic origin—is the leading cause of morbidity and mortality for individuals with diabetes and results in an estimated $37.3 billion in cardiovascular-related spending per year associated with diabetes (1). Common conditions coexis...

Microvascular Complications and Foot Care: Standards of Medical Care in Diabetes—2019

Dec 17th, 2018 - Chronic kidney disease (CKD) is diagnosed by the persistent presence of elevated urinary albumin excretion (albuminuria), low estimated glomerular filtration rate (eGFR), or other manifestations of kidney damage (1,2). In this section, the focus will be on CKD attributed to diabetes (diabetic kidney disease), which occurs in 20–40% of patients with diabetes (1,3–5). CKD typically develops after...

Emergent Therapy for Acute-onset, Severe Hypertension During Pregnancy and the Postpartum Pe...
Committee on Obstetric Practice

Dec 17th, 2018 - Acute-onset, severe systolic hypertension; severe diastolic hypertension; or both can occur during the prenatal, intrapartum, or postpartum periods. Pregnant women or women in the postpartum period with acute-onset, severe systolic hypertension; severe diastolic hypertension; or both require urgent antihypertensive therapy.

WHO recommendations: Drug treatment for severe hypertension in pregnancy

Dec 17th, 2018 - Improving care for women during pregnancy and around the time of childbirth to prevent and treat pre-eclampsia and eclampsia is a necessary step towards the achievement of the health targets of the Sustainable Development Goals (SDGs). Efforts to prevent and reduce morbidity and mortality due to these conditions can help address the profound inequities in maternal and perinatal health globally.

Metoprolol - StatPearls

Dec 16th, 2018 - Metoprolol is FDA-approved for the treatment of angina, heart failure, myocardial infarction, atrial fibrillation/flutter, and hypertension. Off-label uses include supraventricular tachycardia and thyroid storm. Both oral and intravenous preparations are available. There are immediate and extended-release preparations available orally. There is controversy regarding the selection of beta blocke...

Amlodipine: Drug Uses, Side Effects & Dosage - Drugs.com

Nov 30th, 2018 - Amlodipine (Norvasc) is used to treat high blood pressure (hypertension) and angina. Includes amlodipine side effects, interactions and indications.

Vibrio Cholerae - StatPearls

Nov 17th, 2018 - Cholera is a well-known disease caused by intestinal infection with the toxin-producing bacteria Vibrio cholerae. This potentially fatal diarrheal disease results in large volumes of watery stool, causing rapid dehydration that can progress to hypovolemic shock and metabolic acidosis.

Overuse of Cardiac Testing
American Family Physician; Roth, A. et. al.

Nov 14th, 2018 - A 62-year-old white man with hypertension presents for a routine physical examination. He does not smoke and has a body mass index of 32 kg per m2. After being sedentary for many years, he is about to begin an exercise program. His wife thinks he should get his heart tested before beginning to exercise. The patient does not have chest pain or pressure, dyspnea, or palpitations. His blood pressu...

Resistant Hypertension: Detection, Evaluation, and Management: A Scientific Statement From t...
Carey R.,et al

Oct 31st, 2018 - Resistant hypertension (RH) is defined as above-goal elevated blood pressure (BP) in a patient despite the concurrent use of 3 antihypertensive drug classes, commonly including a long-acting calcium channel blocker, a blocker of the renin-angiotensin system (angiotensin-converting enzyme inhibitor or angiotensin receptor blocker), and a diuretic. The antihypertensive drugs should be administere.

The SNMMI and EANM Procedural Guidelines for Diuresis Renography in Infants and Children

Sep 30th, 2018 - With the increasing use of sonography, dilatation of the pelvicalyceal system (hydronephrosis, HN) or ureter (hydroureteronephrosis, HUN) is the most common abnormality of the urinary tract detected in utero or after birth. Common causes of congenital HN and HUN include vesicoureteric reflux (VUR), ureteropelvic junction (UPJ) stenosis, ureterovesical junction (UVJ) stenosis, posterior urethral.

Polycystic Kidney Disease

Sep 13th, 2018 - What is polycystic kidney disease? Polycystic kidney disease (also called PKD) causes numerous cysts to grow in the kidneys. These cysts are filled with fluid. If too many cysts grow or if they get too big, the kidneys can become damaged. PKD cysts can slowly replace much of the kidneys, reducing kidney function and leading to kidney failure.

2017 ACC/AHA Blood Pressure Treatment Guideline Recommendations and Cardiovascular Risk
Colantonio, L.

Sep 9th, 2018 - The 2017 American College of Cardiology/American Heart Association (ACC/AHA) blood pressure (BP) guideline provides updated recommendations for antihypertensive medication initiation and intensification.

Low-Dose Aspirin Use During Pregnancy
\nCommittee on Obstetric Practice

Jun 30th, 2018 - Low-dose aspirin has been used during pregnancy, most commonly to prevent or delay the onset of preeclampsia. The American College of Obstetricians and Gynecologists issued the Hypertension in Pregnancy Task Force Report recommending daily low-dose aspirin beginning in the late first trimester for women with a history of early-onset preeclampsia and preterm delivery at less than 34 0/7 weeks of.

Physical activity and fitness for the prevention of hypertension
Current Opinion in Cardiology; Baker, E. et. al.

Jun 30th, 2018 - Purpose of review The aim of this review is to evaluate the most recent literature about the role of physical activity, exercise, and fitness in hypertension prevention. Recent findings Strong evidence indicates that performing moderate-to-vigorous physical activity, particularly aerobic exercise, and improving cardiorespiratory fitness (CRF) reduce blood pressure (BP) levels and lower hyper...

ACC/AHA/AAPA/ABC/ACPM/AGS/APhA/ASH/ASPC/NMA/PCNA Guideline for the Prevention, Detection, Ev...
Whelton P

May 14th, 2018 - The present guideline is intended to be a resource for the clinical and public health practice communities. It is designed to be comprehensive but succinct and practical in providing guidance for prevention, detection, evaluation, and management of high BP.

Cardiovascular Disease and Risk Management: Review of the American Diabetes Association Stan...
James J. Chamberlain

Apr 30th, 2018 - This synopsis focuses on guidance relating to cardiovascular disease and risk management in nonpregnant adults with diabetes. Recommendations address diagnosis and treatment of cardiovascular risk factors (hypertension and dyslipidemia), aspirin use, screening for and treatment of coronary heart disease, and lifestyle interventions.

Smart approach improves BP control for black, Hispanic patients
Sara Berg

Apr 18th, 2018 - Serving a population made up largely of African-American and Hispanic patients, a Miami primary care and multispecialty group saw the same racial and ethnic health disparities in hypertension that are rampant in the American population at large.

Hypertension Treatment Algorithm

Apr 8th, 2018 - Management of hypertension in adults based on evidence-based guidelines. Set blood pressure (BP) goal and initiate BP-lowering medication based on age, diabetes, and chronic kidney disease (CKD)

Diagnosis, Evaluation, Prevention, and Treatment of Chronic Kidney Disease–Mineral and Bone ...
Ketteler, M.,et al

Mar 19th, 2018 - The Kidney Disease: Improving Global Outcomes (KDIGO) 2017 Clinical Practice Guideline Update for the Diagnosis, Evaluation, Prevention, and Treatment of Chronic Kidney Disease–Mineral and Bone Disorder (CKD–MBD) is a selective update of the prior CKD–MBD guideline published in 2009. The guideline update and the original publication are intended to assist practitioners caring for adults with CK.

Prevention, Detection, Evaluation, and Management of High Blood Pressure in Adults: Synopsis...
Carey, R.

Mar 5th, 2018 - This article summarizes key recommendations in the following areas: BP classification, BP measurement, screening for secondary hypertension, nonpharmacologic therapy, BP thresholds and cardiac risk estimation to guide drug treatment, treatment goals (general and for patients with diabetes mellitus, chronic kidney disease, and advanced age), choice of initial drug therapy, resistant hypertension.

Malley, G. et. al.

Mar 1st, 2018 - Amphetamines are sympathomimetic drugs with CNS stimulant and euphoriant properties whose toxic adverse effects include delirium, hypertension, seizures, and hyperthermia (which can cause rhabdomyolysis and renal failure). Toxicity is managed with supportive care, including IV benzodiazepines (for agitation, hypertension, and seizures) and cooling techniques (for hyperthermia). There is no ster...

Evaluation and Management of Right-Sided Heart Failure: A Scientific Statement From the Amer...
Marvin A. Konstam

Feb 11th, 2018 - Chronic RHF is associated with decreased exercise tolerance, poor functional capacity, decreased cardiac output and progressive end-organ damage (caused by a combination of end-organ venous congestion and underperfusion), and cachexia resulting from poor absorption of nutrients, as well as a systemic proinflammatory state. It is the principal cause of death in patients with pulmonary arterial h.

A Visual Guide to the New Blood Pressure Guidelines The ACC/AHA 2017 recommendations -- in c...
Greg Von Portz

Nov 20th, 2017 - The American College of Cardiology and American Heart Association's new blood pressure guidelines came in a comprehensive, and thus ponderous, 192-page document. So here at MedPage Today we've pulled together an abridged version for visual learners.

ACR Appropriateness Criteria Renovascular Hypertension
Harvin, H.

Oct 31st, 2017 - Renovascular hypertension is the most common type of secondary hypertension and is estimated to have a prevalence between 0. 5% and 5% of the general hypertensive population, and an even higher prevalence among patients with severe hypertension and end-stage renal disease, approaching 25% in elderly dialysis patients.

Health Disparities in Patients with Pulmonary Arterial Hypertension: A Blueprint for Action
Arunabh Talwar

Oct 14th, 2017 - At present, there are few studies that address health disparities in PAH. Given the potential adverse impact of health disparities, we recommend that research efforts be undertaken to address the topics discussed in the document.

Sodium: the facts

Sep 29th, 2017 - The body needs a small amount of sodium to function, but most Americans consume too much sodium. High sodium consumption can raise blood pressure, and high blood pressure is a major risk factor for heart disease and stroke. Heart disease and stroke are the nation’s first and fifth leading causes of death. Salt and High Blood Pressure • Research shows a strong dose-dependent relationship betw...

Clinical Practice Guideline for Screening and Management of High Blood Pressure in Children ...
Flynn, J.

Aug 31st, 2017 - These pediatric hypertension guidelines are an update to the 2004 “Fourth Report on the Diagnosis, Evaluation, and Treatment of High Blood Pressure in Children and Adolescents. ” Significant changes in these guidelines include (1) the replacement of the term “prehypertension” with the term “elevated blood pressure,” (2) new normative pediatric blood pressure (BP) tables based on normal-weight ch.

Sodium Intake and Health Outcomes
Strom, B. et. al.

Aug 26th, 2017 - This chapter reviews and assesses new evidence for associations between dietary sodium intake and outcomes published in the peer-reviewed literature through 2012. The health outcomes reviewed by the committee include cardiovascular disease (CVD), including stroke CVD mortality and all-cause mortality, congestive heart failure (CHF), chronic kidney disease (CKD), diabetes, cancer, and “other” ou...

Diabetes and Hypertension: A Position Statement by the American Diabetes Association
de Boer, I. et. al.

Aug 21st, 2017 - Hypertension is common among patients with diabetes, with the prevalence depending on type and duration of diabetes, age, sex, race/ethnicity, BMI, history of glycemic control, and the presence of kidney disease, among other factors (1–3). Furthermore, hypertension is a strong risk factor for atherosclerotic cardiovascular disease (ASCVD), heart failure, and microvascular complications. ASCVD—d...

Healthful Diet and Physical Activity for Cardiovascular Disease Prevention in Adults Without...
US Preventive Services Task Force

Jun 30th, 2017 - The USPSTF recommends that primary care professionals individualize the decision to offer or refer adults without obesity who do not have hypertension, dyslipidemia, abnormal blood glucose levels, or diabetes to behavioral counseling to promote a healthful diet and physical activity. Existing evidence indicates a positive but small benefit of behavioral counseling for the prevention of cardiova.

ACR Appropriateness Criteria Nonvariceal Upper Gastrointestinal Bleeding
Singh-Bhinder, N.

Apr 30th, 2017 - Upper gastrointestinal bleeding (UGIB) remains a significant cause of morbidity and mortality with mortality rates as high as 14%. This document addresses the indications for imaging UGIB that is nonvariceal and unrelated to portal hypertension.

ACR Appropriateness Criteria Suspected Pulmonary Hypertension
Sirajuddin, A.

Apr 30th, 2017 - Pulmonary hypertension may be idiopathic or related to a large variety of diseases. Various imaging examinations that may be helpful in diagnosing and determining the etiology of pulmonary hypertension are discussed.

ACR Appropriateness Criteria Renal Transplant Dysfunction
Taffel, M.

Apr 30th, 2017 - Renal transplantation is the treatment of choice in patients with end-stage renal disease because the 5-year survival rates range from 72% to 99%. Although graft survival has improved secondary to the introduction of newer immunosuppression drugs and the advancements in surgical technique, various complications still occur.

Renal Mass and Localized Renal Cancer: AUA Guideline
Steven Campbell

Mar 31st, 2017 - Renal Mass and Localized Renal Cancer: AUA Guideline focuses on the evaluation and management of clinically localized renal masses suspicious for renal cell carcinoma (RCC). Dignosis, patient counseling, and renal biopsy are covered in addition to various management strategies, including partial and radical nephrectomy, thermal ablation, and active surveillance.

Ultrasound for the Diagnosis and Management of Ureterolithiasis in the Emergency Department
Lisa Mills

Mar 16th, 2017 - A systemic search of PubMed produced 269 articles in English using search terms “nephrolithiasis” OR “kidney calculi” AND “emergency department. ” For purposes of this review only studies which focused on emergency department patients who received point of care ultrasound (POCUS) by an attending emergency physician or emergency medicine resident for ureterolithiasis were included.

Pharmacologic Treatment of Hypertension in Adults Aged 60 Years or Older to Higher Versus Lo...
Amir Qaseem

Feb 20th, 2017 - The American College of Physicians (ACP) and the American Academy of Family Physicians (AAFP) jointly developed this guideline to present the evidence and provide clinical recommendations based on the benefits and harms of higher versus lower blood pressure targets for the treatment of hypertension in adults aged 60 years or older.

What Is Polycystic Kidney Disease? | NIDDK

Jan 1st, 2017 - Learn about causes and signs of polycystic kidney disease (PKD). The sooner you know you have PKD, the sooner you can keep your condition from getting worse.

Polycystic Kidney Disease (PKD) | NIDDK

Dec 31st, 2016 - Defines two types of polycystic kidney disease and describes their genetic origins, symptoms, diagnosis, and treatment, as well as ongoing research.

Cut Down on Sodium

Nov 30th, 2016 - Sodium is a mineral, and most of the sodium in our foods comes from salt. We all need a little sodium to stay healthy. Eating too much sodium can lead to high blood pressure (hypertension). High blood pressure can raise your risk of having a heart attack or stroke. The good news is that cutting down on sodium can help lower your blood pressure or keep it at a healthy level.

Portal hypertensive bleeding in cirrhosis: Risk stratification, diagnosis, and management: 2...

Oct 26th, 2016 - This guidance provides a data‐supported approach to risk stratification, diagnosis, and management of patients with cirrhosis and portal hypertension (PH). A guidance document is different from a guideline.

Association between resting heart rate and coronary artery disease, stroke, sudden death and noncardiovascular diseases: a meta-analysis
CMAJ Zhang, D. et. al.

Aug 21st, 2016 - Background: Resting heart rate is linked to risk of coronary artery disease, stroke, sudden death and noncardiovascular diseases. We conducted a meta-analysis to assess these associations in general populations and in populations of patients with hypertension or diabetes mellitus. Methods: We searched PubMed, Embase and MEDLINE from inception to Mar. 5, 2016. We used a random-effects model...

The Management of Primary Aldosteronism: Case Detection, Diagnosis, and Treatment: An Endocr...
John W. Funder

Apr 30th, 2016 - For high-risk groups of hypertensive patients and those with hypokalemia, we recommend case detection of primary aldosteronism by determining the aldosterone-renin ratio under standard conditions and recommend that a commonly used confirmatory test should confirm/exclude the condition. We recommend that all patients with primary aldosteronism undergo adrenal computed tomography as the initial s.

Hematuria as a Marker of Occult Urinary Tract Cancer: Advice for High-Value Care From the Am...
Matthew Nielsen

Apr 4th, 2016 - The presence of blood in the urine, or hematuria, is a common finding in clinical practice and can sometimes be a sign of occult cancer. This article describes the clinical epidemiology of hematuria and the current state of practice and science in this context and provides suggestions for clinicians evaluating patients with hematuria.

Surgical Management of Stones: AUA/Endourology Society Guideline
Dean Assimos

Mar 31st, 2016 - The purpose of this Guideline is to provide a clinical framework for the surgical management of patients with kidney and/or ureteral stones.

Stroke Mimics: Pearls and Pitfalls

Mar 22nd, 2016 - You’re working a slow Sunday morning ED shift, and you had just grabbed your coffee and sat down when EMS calls with a patient with right-sided hemiparesis. They want to activate a prehospital stroke alert, and you give them the go ahead without asking for any other patient information. The EMS crew brings in a 42 year-old female with a history of hypertension. The Cincinnati Prehospital Str...

Pediatric Pulmonary Hypertension
Steven H. Abman

Mar 14th, 2016 - Pulmonary hypertension is associated with diverse cardiac, pulmonary, and systemic diseases in neonates, infants, and older children and contributes to significant morbidity and mortality. However, current approaches to caring for pediatric patients with pulmonary hypertension have been limited by the lack of consensus guidelines from experts in the field.

Practical Approach to Detection and Management of Chronic Kidney Disease for the Primary Care Clinician
The American Journal of Medicine; Vassalotti, J. et. al.

Feb 1st, 2016 - A panel of internists and nephrologists developed this practical approach for the Kidney Disease Outcomes Quality Initiative to guide assessment and care of chronic kidney disease (CKD) by primary care clinicians. Chronic kidney disease is defined as a glomerular filtration rate (GFR) <60 mL/min/1.73 m2 and/or markers of kidney damage for at least 3 months. In clinical practice the most comm...

Diagnosis, Evaluation and Follow-up of Asymptomatic Microhematuria (AMH) in Adults
Rodney Davis

Dec 31st, 2015 - This guideline's purpose is to provide direction to clinicians and patients regarding how to work up and follow patients with the finding of asymptomatic microhematuria (AMH). The strategies and approaches recommended in this document were derived from evidence-based and consensus-based processes.

High Blood Pressure in Adults: Screening - US Preventive Services Task Force

Oct 1st, 2015 - The USPSTF recommends screening for high blood pressure in adults aged 18 years or older. The USPSTF recommends obtaining measurements outside of the clinical setting for diagnostic confirmation before starting treatment

Causes and Evaluation of Chronic Dyspnea

Jul 11th, 2015 - Chronic dyspnea is shortness of breath that lasts more than one month. The perception of dyspnea varies based on behavioral and physiologic responses. Dyspnea that is greater than expected with the degree of exertion is a symptom of disease. Most cases of dyspnea result from asthma, heart failure and myocardial ischemia, chronic obstructive pulmonary disease, interstitial lung disease, pneumoni...

Guidelines for Vaccinating Kidney Dialysis Patients and Patients with Chronic Kidney Disease

Jun 30th, 2015 - Determination of chronic kidney disease is important to the vaccine provider because incidence or severity of some vaccine-preventable diseases is higher in persons with altered immunocompetence; therefore, certain vaccines (e. g.

Elastography Assessment of Liver Fibrosis: Society of Radiologists in Ultrasound Consensus C...
Richard G. Barr

Jun 15th, 2015 - Chronic liver disease is a substantial worldwide problem. Its major consequence is increasing deposition of fibrous tissue within the liver, leading to the development of cirrhosis with its consequences, portal hypertension, hepatic insufficiency, and hepatocellular carcinoma (HCC).

The wrong white crystals: not salt but sugar as aetiological in hypertension and cardiometabolic disease

Dec 9th, 2014 - Cardiovascular disease is the leading cause of premature mortality in the developed world, and hypertension is its most important risk factor. Controlling hypertension is a major focus of public health initiatives, and dietary approaches have historically focused on sodium. While the potential benefits of sodium-reduction strategies are debatable, one fact about which there is little debate is ...

Dietary and Pharmacologic Management to Prevent Recurrent Nephrolithiasis in Adults: A Clini...
Amir Qaseem

Nov 3rd, 2014 - The American College of Physicians (ACP) developed this guideline to present the evidence and provide clinical recommendations on the comparative effectiveness and safety of preventive dietary and pharmacologic management of recurrent nephrolithiasis in adults.

Disease Risk: NAMS Guideline

Sep 30th, 2014 - Cardiovascular disease (CVD) is the leading cause of death in women worldwide. Major risk factors for CVD in women include age, hypertension, dyslipidemia, diabetes mellitus (DM), family history of premature CVD, smoking, sedentary lifestyle, and poor diet.

Clinical Practice Guideline for the Management of Chronic Kidney Disease in Patients Infecte...
Gregory M. Lucas

Sep 16th, 2014 - Chronic kidney disease (CKD) is defined as abnormalities of kidney structure or function, present for >3 months, with implications for health [1]. CKD is common in human immunodeficiency virus (HIV)–infected persons, has many potential underlying etiologies, and is associated with increased morbidity and mortality.