About 14,698 results

ALLMedicine™ Alzheimer Disease Center

Research & Reviews  5,148 results

Semantic coherence markers: The contribution of perplexity metrics.
Artificial Intelligence in Medicine; Colla D, Delsanto M et. al.

Dec 4th, 2022 - Devising automatic tools to assist specialists in the early detection of mental disturbances and psychotic disorders is to date a challenging scientific problem and a practically relevant activity. In this work we explore how language models (that...

What every neuropathologist needs to know: condensed protocol work-up for clinical deme...
Journal of Neuropathology and Experimental Neurology; Multz RA, Spencer C et. al.

Dec 3rd, 2022 - Concerns about the costs associated with autopsy assessment of Alzheimer disease and related dementias according to 2012 NIA-AA Guidelines have been expressed since the publication of those guidelines. For this reason, we designed and validated a ...

Cognitive resistance to and resilience against multiple comorbid neurodegenerative path...
Journal of Neuropathology and Experimental Neurology; Walker JM, Richardson TE

Dec 3rd, 2022 - Alzheimer disease (AD) is currently the leading cause of cognitive decline and dementia worldwide. Recently, studies have suggested that other neurodegenerative comorbidities such as limbic-predominant age-related TDP-43 encephalopathy neuropathol...

Effects of Carotid Artery Stiffness on Cerebral Small-Vessel Disease and Cognition.
Journal of the American Heart Association; Robert C, Ling LH et. al.

Nov 30th, 2022 - Background Carotid artery stiffness is associated with cognitive impairment and dementia, but the underlying mechanisms remain unknown. We examined the associations of carotid artery stiffness with cerebral small-vessel disease markers, cognition,...

Longitudinal Changes in Blood Biomarkers of Clinical Alzheimer Disease in a Biracial Po...
Neurology Rajan K, McAninch EA et. al.

Nov 30th, 2022 - Recent studies suggest the utility of blood biomarkers in detecting changes in neurodegenerative disorders. The objective of our research is to test the hypothesis that the longitudinal changes in total tau (t-tau), neurofilament light (Nf-L), and...

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Guidelines  5 results

ACR Appropriateness Criteria® Dementia.
Journal of the American College of Radiology : JACR; , Moonis G et. al.

May 7th, 2020 - Degenerative disease of the central nervous system is a growing public health concern. The primary role of neuroimaging in the workup of patients with probable or possible Alzheimer disease has typically been to exclude other significant intracran...

Falls Risk and Alzheimer Disease: A Patient Guide.
Archives of Physical Medicine and Rehabilitation; Kahya M, Sood P et. al.

Mar 3rd, 2020 - Falls Risk and Alzheimer Disease: A Patient Guide.|2020|Kahya M,Sood P,Devos H,Krishnan S,Hirsch MA,|

Update on appropriate use criteria for amyloid PET imaging: dementia experts, mild cogn...
Alzheimer's & Dementia : the Journal of the Alzheimer's A... Johnson KA, Minoshima S et. al.

Jul 3rd, 2013 - Amyloid PET imaging is a novel diagnostic test that can detect in living humans one of the two defining pathologic lesions of Alzheimer disease, amyloid-β deposition in the brain. The Amyloid Imaging Task Force of the Alzheimer's Association and S...

Genetic counseling and testing for Alzheimer disease: joint practice guidelines of the ...
Genetics in Medicine : Official Journal of the American C... Goldman JS, Hahn SE et. al.

May 18th, 2011 - Alzheimer disease is the most common cause of dementia. It occurs worldwide and affects all ethnic groups. The incidence of Alzheimer disease is increasing due, in part, to increased life expectancy and the aging baby boomer generation. The averag...

Responding to requests from adult patients for neuroenhancements: guidance of the Ethic...
Neurology Larriviere D, Williams MA et. al.

Sep 25th, 2009 - In the last decade, persons who have no diagnosed medical or mental health condition are increasingly seeking and utilizing, for the ostensible purpose of enhancing their memory or cognitive skills, prescription drugs that were originally develope...

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Drugs  5 results see all →

Clinicaltrials.gov  238 results

Cognitive Decline in AD

Oct 7th, 2022 - There is lack of information on the risk factors of accelerated cognitive decline in older people with Alzheimer disease (AD). The extent of neurodegeneration and white matter disease has been reported to be important factors. In addition there ma...

Mindfulness Meditation and Insomnia in Alzheimer Disease Caregivers

Oct 4th, 2022 - This randomized controlled trial aims to evaluate the non-inferiority of Mindful Awareness Practices for Insomnia (MAP-I ) vs. Cognitive Behavioral Therapy for Insomnia (CBT-I) on outcomes of insomnia, cellular and genomic markers of inflammation,...

A Comparison of Two Approaches to Developing Brain Health Programs

Sep 27th, 2022 - Overview: Participants will complete a baseline battery of self-report and cognitive measures before and after 12 weeks of weekly videoconferences and diaries of brain health-related activities completed during weeks 1, 6, and 12. They will be ran...

Neuroinflammation and Cognitive Decline in Alzheimer Disease

Sep 14th, 2022 - The purpose of this study is to assess the level of neuroinflammation in Alzheimer Disease subject (mild to moderate) estimated with Binding Potential (BP) of [18F]DPA-714 , and its relationship with the kinetics of cognitive decline over a 24-mon...

TDCS to Improve Post-Stroke Cognitive Impairment

Sep 13th, 2022 - Vascular cognitive impairment, ranging from vascular mild cognitive impairment to vascular dementia, is a leading cause of progressive cognitive dysfunction second only to Alzheimer Disease. While the accumulation of ischemic infarcts or a large c...

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News  483 results

Defining Clinical Benefit in Oncology Trials Is Not as Simple as Some May Believe

Nov 14th, 2022 - A core component of any type of therapeutic research is to enhance clinical benefit.In appropriately designed, comparative, randomized studies another goal is to determine the superiority or potential equivalence of one therapeutic strategy vs ano...

Brain Aging in Black Adults Shows Accelerated Pattern Starting in Midlife

Nov 14th, 2022 - Black individuals showed an accelerated pattern of brain aging beginning in midlife, a cross-sectional analysis of two community-based cohorts showed. Brain aging -- the association of age with cortical thickness and white matter hyperintensity (W...

Daily Aspirin No Help for Fracture Prevention in Seniors, Raises Risk of Falls

Nov 7th, 2022 - Low-dose aspirin did not reduce risks of fracture in healthy older adults, but was associated with an increased risk of serious falls, a substudy of the randomized ASPREE trial showed. Over a median follow-up of 4.6 years, there was no difference ...

Exercise Strengthens Cognitive Function in Stroke Patients

Oct 19th, 2022 - Exercise appears to significantly improve cognitive function following a stroke, bringing patients with mild to moderate cognitive impairment back to near normal cognition. Results of a new proof-of-concept trial suggest exercise had a positive ef...

Deprescribing in Older Adults in Community and Nursing Home Settings
William W. Hung, MD, MPH

Sep 16th, 2022 - Study 1 Overview (Bayliss et al) Objective: To examine the effect of a deprescribing educational intervention on medication use in older adults with cognitive impairment. Design: This was a pragmatic, cluster randomized trial conducted in 8 primar.

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