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About 4,253 results

ALLMedicine™ Dementia With Lewy Bodies Center

Research & Reviews  1,528 results

Serum MicroRNAs Predict Isolated Rapid Eye Movement Sleep Behavior Disorder and Lewy Bo...
https://doi.org/10.1002/mds.29171
Movement Disorders : Official Journal of the Movement Dis... Soto M, Iranzo A et. al.

Aug 14th, 2022 - Isolated rapid eye movement sleep behavior disorder (IRBD) is a well-established clinical risk factor for Lewy body diseases (LBDs), such as Parkinson's disease (PD) and dementia with Lewy bodies (DLB). To elucidate whether serum microRNA (miRNA) ...

Late-onset mania in autopsy-confirmed Lewy body disease: a rare symptom of prodromal de...
https://doi.org/10.1111/bdi.13246
Bipolar Disorders; Koga S, Sekiya H et. al.

Aug 12th, 2022 - Late-onset mania in autopsy-confirmed Lewy body disease: a rare symptom of prodromal dementia with Lewy bodies?|2022|Koga S,Sekiya H,Martin NB,Dickson DW,|

Alteration of Vesicle-Associated Membrane Protein-Binding Protein B in α-Synuclein Aggr...
https://doi.org/10.1093/jnen/nlac070
Journal of Neuropathology and Experimental Neurology; Mori F, Nakamura Y et. al.

Aug 12th, 2022 - α-Synuclein (α-Syn) binds to vesicle-associated membrane protein-binding protein B (VAPB) in the endoplasmic reticulum membrane. Recent studies have shown that α-Syn-immunoreactive Lewy pathology is characterized by membrane crowding, including ve...

Neuroimaging Biomarkers in a Patient with Probable Psychiatric-Onset Prodromal Dementia...
https://doi.org/10.1212/WNL.0000000000201166
Neurology Urso D, Gnoni V et. al.

Aug 12th, 2022 - Psychiatric-onset prodromal Dementia with Lewy Bodies (DLB) is a recently proposed clinical entity characterized by psychiatric presentation that may predate clinical dementia by many years. It is not yet clear how to identify patients with promin...

Promoting independence in Lewy body dementia through exercise: the PRIDE study.
https://doi.org/10.1186/s12877-022-03347-2
BMC Geriatrics; Inskip MJ, Mavros Y et. al.

Aug 10th, 2022 - Lewy body dementia (LBD) is an aggressive type of dementia of rapid, fluctuating disease trajectory, higher incidence of adverse events, and poorer functional independence than observed in Alzheimer's disease dementia. Non-pharmacological treatmen...

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Drugs  6 results see all →

Clinicaltrials.gov  79 results

Study To Evaluate the Efficacy, Safety and Tolerability of E2027 (Hereinafter Referred to as Irsenontrine) in Participants With Dementia With Lewy Bodies
https://clinicaltrials.gov/ct2/show/NCT03467152

Aug 1st, 2022 - This study will be conducted to compare Irsenontrine to placebo on the cognitive endpoint of Montreal Cognitive Assessment (MoCA) and the global clinical endpoint of Clinician's Interview Based Impression of Change Plus (CIBIC-Plus) Caregiver Inpu...

A Diagnostic Test for Dementia With Lewy Bodies
https://clinicaltrials.gov/ct2/show/NCT05479552

Jul 29th, 2022 - In collaboration with approximately 10 centers that specialize in DLB and dementia we will recruit a total of 80 individuals for the study: 40 subjects with suspected MCI-DLB and 40 with suspected MCI-AD will be recruited. All subjects will be enr...

Study to Evaluate the Safety, Tolerability and Efficacy of CT1812 in Subjects With Mild to Moderate Dementia With Lewy Bodies
https://clinicaltrials.gov/ct2/show/NCT05225415

Jul 26th, 2022 - The safety and efficacy of CT1812 at doses of 300 and 100mg will be evaluated over a 24 week double-blind treatment period in patient diagnosed with dementia with Lewy bodies. Patients will be randomized 1:1:1 to placebo, 100mg CT1812 or 300mg CT1...

Neuroplasticity in RBD
https://clinicaltrials.gov/ct2/show/NCT05471960

Jul 25th, 2022 - REM sleep behavior disorder is a parasomnia that reflects the presence of alpha-synucleinopathy in the brain and is highly predictive of eventual phenoconversion to Parkinson's disease, dementia with Lewy bodies, or multiple system atrophy over th...

Optical Neuroimaging in Dementia
https://clinicaltrials.gov/ct2/show/NCT05460143

Jul 15th, 2022 - There are several different types of dementia including Alzheimer's Disease (AD) and Dementia with Lewy Bodies (DLB). Due to the overlapping symptomatology across types of dementia and the lack of objective biomarkers currently available for demen...

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News  82 results

New Finding Challenges Dementia Age-Associated Beliefs
https://www.medscape.com/viewarticle/966314

Jan 10th, 2022 - Researchers from Newcastle University have, for the first time, identified changes in the brains of deceased infants with Krabbe disease that are similar to those changes seen in dementia with Lewy bodies and Parkinson’s Disease. Dr Daniel Erskine...

AI Spots Cognitive Decline; Vax Reactions in MS; When Cutting Opioids Harms Patients
https://www.medpagetoday.com/neurology/generalneurology/95824

Nov 23rd, 2021 - A deep learning model accurately detected cognitive decline from clinical notes up to 4 years before patients were diagnosed with mild cognitive impairment. (JAMA Network Open) Subjective sleep difficulties were associated with self-perceptions of...

Positive Topline Results for Novel Parkinson's Treatment
https://www.medscape.com/viewarticle/958356

Sep 8th, 2021 - Topline results from a study that tested two lead structurally targeted allosteric regulator (STAR) compounds ― GT-02287 and GT-02329 ― are promising for the treatment of Gaucher disease (GD) and GBA1-associated Parkinson's disease (PD). "The topl...

Dementia Made Simple
https://www.medscape.com/viewarticle/951395

Jun 14th, 2021 - This transcript has been edited for clarity. Matthew F. Watto, MD: Welcome back to The Curbsiders. I'm Dr Matthew Watto, here with my good friend, Dr Paul Williams. We are going to talk about "dementia made simple" from a great conversation we had...

Mild Cognitive Impairment with Lewy Bodies or Alzheimer’s Disease and Risk of Progression to Dementia
https://www.medscape.com/viewarticle/949921

Apr 26th, 2021 - Takeaway Patients with mild cognitive impairment (MCI) and clinical characteristics of dementia with Lewy bodies (DLB) had a worse prognosis than MCI-Alzheimer’s disease (MCI-AD), with an increased annual risk of transition from MCI to dementia. M...

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Patient Education  6 results see all →