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About 7,218 results

ALLMedicine™ Frontotemporal Dementia Center

Research & Reviews  2,647 results

Enhanced positive emotional reactivity in frontotemporal dementia reflects left-lateral...
https://doi.org/10.1016/j.cortex.2022.02.018
Cortex; a Journal Devoted to the Study of the Nervous Sys... Shdo SM, Roy ARK et. al.

Aug 6th, 2022 - In frontotemporal dementia (FTD), left-lateralized atrophy patterns have been associated with elevations in certain positive emotions. Here, we investigated whether positive emotional reactivity was enhanced in semantic variant primary progressive...

Pre-symptomatic radiological changes in frontotemporal dementia: propagation characteri...
https://doi.org/10.1007/s11682-022-00711-z
Brain Imaging and Behavior; McKenna MC, Lope J et. al.

Aug 4th, 2022 - Computational imaging and quantitative biomarkers offer invaluable insights in the pre-symptomatic phase of neurodegenerative conditions several years before clinical manifestation. In recent years, there has been a focused effort to characterize ...

Exploring Links Between Psychosis and Frontotemporal Dementia Using Multimodal Machine ...
https://doi.org/10.1001/jamapsychiatry.2022.2075
JAMA Psychiatry; Koutsouleris N, Pantelis C et. al.

Aug 4th, 2022 - The behavioral and cognitive symptoms of severe psychotic disorders overlap with those seen in dementia. However, shared brain alterations remain disputed, and their relevance for patients in at-risk disease stages has not been explored so far. To...

Distinct disease trajectories in FTD-MND and bvFTD: a longitudinal study.
https://doi.org/10.1111/ene.15518
European Journal of Neurology; Long Z, Irish M et. al.

Aug 4th, 2022 - The heterogeneity of cognitive and behavioural disturbances in frontotemporal dementia-motor neuron disease (FTD-MND), and clinical differences between FTD-MND and FTD subtypes, have been illustrated cross-sectionally. This study aimed to examine ...

An Open-Label, Expanded Access Protocol of LAM-002A in C9ORF72-Associated Frontotemporal Dementia (FTD)
https://clinicaltrials.gov/ct2/show/NCT05483322

Aug 2nd, 2022 - LAM-002A will be provided for expanded access for an individual patient under 21 CFR 312.310. It will be administered BID orally at a dose of 125 mg. Assessment of safety will include clinical observations and monitoring following administration.

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Clinicaltrials.gov  104 results

An Open-Label, Expanded Access Protocol of LAM-002A in C9ORF72-Associated Frontotemporal Dementia (FTD)
https://clinicaltrials.gov/ct2/show/NCT05483322

Aug 2nd, 2022 - LAM-002A will be provided for expanded access for an individual patient under 21 CFR 312.310. It will be administered BID orally at a dose of 125 mg. Assessment of safety will include clinical observations and monitoring following administration.

OCT-Angiography and Adaptive Optics in Patients With Memory Impairment
https://clinicaltrials.gov/ct2/show/NCT04389437

Jul 25th, 2022 - Studies suggest an association between retinal abnormalities and NCD (Neuro Cognitive Disorders) whether they are linked to proven or prodromal Alzheimer's disease (aMCI : amnestic mild cognitive impairment), or to other neurodegenerative diseases...

Study of WVE-004 in Patients With C9orf72-associated Amyotrophic Lateral Sclerosis (ALS) or Frontotemporal Dementia (FTD)
https://clinicaltrials.gov/ct2/show/NCT04931862

Jul 20th, 2022 - This is a Phase 1b/2a multicenter, randomized, double-blind, placebo-controlled study to evaluate the safety, tolerability, PK, and PD of intrathecal (IT) WVE-004 in adult patients with C9orf72-associated ALS or FTD. To participate in the study, p...

Dopaminergic Therapy for Frontotemporal Dementia Patients
https://clinicaltrials.gov/ct2/show/NCT04937452

Jul 11th, 2022 - The current study has the ambition to provide the first-time evidence of the clinical impact, at cognitive and behavioral level, of a dopamine-based treatment in newly diagnosed bvFTD patients. To evaluate the cognitive and behavioral effects of R...

Natural History and Biomarkers of Amyotrophic Lateral Sclerosis and Frontotemporal Dementia Caused by the C9ORF72 Gene Mutation
https://clinicaltrials.gov/ct2/show/NCT01925196

Jul 8th, 2022 - Objective The primary objective of this study is to characterize the natural history of disease in patients who carry a repeat expansion in the C9ORF72 gene, which causes amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). The s...

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News  126 results

Can a Single Brain Scan Accurately Diagnose Alzheimer's?
https://www.medscape.com/viewarticle/975975

Jun 21st, 2022 - Updated June 22, 2022 // Editor's note: This story has been updated with comments from Dr Rebecca Edelmayer of the Alzheimer's Association. A machine learning algorithm can determine whether an individual has Alzheimer's disease (AD) based on a si...

Late-Onset Alcohol Abuse Could Be a Sign of Dementia
https://www.medscape.com/viewarticle/972000

Apr 12th, 2022 - People who start abusing alcohol later in life may have an underlying neurologic condition such as dementia, according to researchers from the Icahn School of Medicine at Mount Sinai and the University of California, San Francisco. What to know: A...

Brainwaves of a Dying Man; Omicron, MS, and COVID Vax; CRISPR Treatment Shows Effect
https://www.medpagetoday.com/neurology/generalneurology/97434

Mar 1st, 2022 - Electroencephalography (EEG) recordings from the dying human brain of an 87-year-old man with seizures and cardiac arrest found coordinated low- and high-frequency activity near death, which researchers speculated may represent a "last recall of l...

New Research Offers Hope for Future ALS and Frontotemporal Dementia Treatments
https://www.medscape.com/viewarticle/969162

Feb 25th, 2022 - A new study from University College London (UCL) and National Institutes of Health (NIH) has revealed why a common genetic variant worsens disease outcomes for people with amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). The ...

Blood Biomarkers May Distinguish Dementia Disorders
https://www.medpagetoday.com/neurology/dementia/96915

Jan 28th, 2022 - Blood-based biomarkers may help differentiate people with different dementias and monitor disease changes over time, a longitudinal study showed. Plasma markers showed different profiles in Alzheimer's disease, frontotemporal dementia, Lewy body d...

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Patient Education  10 results see all →