About 6,075 results

ALLMedicine™ Frontotemporal Dementia Center

Research & Reviews  2,285 results

Disruption of ER-mitochondria tethering and signalling in C9orf72-associated amyotrophi...
Aging Cell; Gomez-Suaga P, Mórotz GM et. al.

Jan 14th, 2022 - Hexanucleotide repeat expansions in C9orf72 are the most common cause of familial amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). The mechanisms by which the expansions cause disease are not properly understood but a favoure...

Photo-Oxygenation: An Innovative New Therapeutic Approach Against Amyloidoses.
https://doi.org/10.1007/978-3-030-78787-5_52 10.1002/anie.201308001
Advances in Experimental Medicine and Biology; Ikeda T, Hori Y et. al.

Jan 14th, 2022 - Many types of amyloidoses are pathologically characterized by the deposition of amyloid, which is comprised of fibrils formed by abnormally aggregated proteins, in various peripheral tissues and the central nervous system (CNS). Neurodegenerative ...

Rare variants in TP73 in a Frontotemporal Dementia cohort link this gene with primary p...
European Journal of Neurology; Tábuas-Pereira M, Santana I et. al.

Jan 13th, 2022 - TP73 was recently reported to cause Amyotrophic Lateral Sclerosis (ALS). ALS and Frontotemporal Dementia (FTD) are considered to be part of a continuum. We aimed to investigate whether TP73 variants may be associated with FTD. We studied a thoroug...

Subjective clustering in patients with fronto-temporal dementia.
Applied Neuropsychology. Adult; Perri R, Fadda L et. al.

Jan 12th, 2022 - In the behavioral variant of frontotemporal dementia (bvFTD) memory deficits have been traditionally considered as due to difficulties in encoding/retrieval frontal strategies. However, the frontal origin of memory deficits in bvFTD has been quest...

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Clinicaltrials.gov  28 results

Improving Self-Care of Behavioral Variant Frontotemporal Dementia Caregivers

Jan 11th, 2022 - Informal caregivers of persons with Frontotemporal degeneration (FTD) are an understudied population with unique needs. FTD is a common cause of young-onset dementia with no known cure. Behavioral variant FTD (bvFTD) is the most common of the FTD ...

Amyotrophic Lateral Sclerosis (ALS) Families Project

Oct 22nd, 2021 - Approximately 10% of people with amyotrophic lateral sclerosis (ALS), or Lou Gehrig's Disease, have a family history of ALS or a related condition called frontotemporal dementia (FTD). In most of these familial cases, and a significant number of "...

Low-Dose Lithium for the Treatment of Behavioral Symptoms in Frontotemporal Dementia

Oct 8th, 2021 - Behavioral symptoms of Frontotemporal dementia (FTD), including agitation, aggression, and inappropriate repetitive behaviors are common, distressing to patients and caregivers, often lead to institutionalization, and can be very difficult and exp...

A Phase 3 Study to Evaluate Efficacy and Safety of AL001 in Frontotemporal Dementia (INFRONT-3)

Sep 20th, 2021 - This is a phase 3 double blind, placebo controlled study evaluating the efficacy and safety of AL001 administered intravenously in participants at risk for or with frontotemporal dementia due to heterozygous mutations in the progranulin gene.

Intranasal Oxytocin for Frontotemporal Dementia

Aug 2nd, 2021 - The purpose of this study is to assess the safety, tolerability and effects on behaviour of Syntocinon given intranasally (by a spray into the nostrils) compared to placebo (an inactive saline substance that contains no medication) in participants...

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News  106 results

Blood Test Discerns Alzheimer's From Other Dementia With High Accuracy

Aug 23rd, 2021 - Two blood markers, phosphorylated tau 217 (p-tau217) and phosphorylated tau 181 (p-tau181), showed strong diagnostic performances for Alzheimer's disease and discriminated Alzheimer's from frontotemporal lobar denervation (FTLD) syndromes and norm...

Wisdom May Counter Loneliness, Burnout in Older Adults

Aug 16th, 2021 - Wisdom increases with age, and although this personality trait is regarded as nebulous by many, there is evidence that it has biological and neuropsychiatric underpinnings. It could even hold the key to reducing loneliness and burnout among older ...

International Push for Recognition of Unique Frontotemporal Dementia Variant

Jul 30th, 2021 - DENVER ― An international group of researchers is pushing for recognition of what they believe on the basis of new research is a unique variant of frontotemporal dementia (FTD). This distinct syndrome is characterized by right temporal atrophy and...

Staying on Pimavanserin Cut Dementia-Related Psychosis Relapse

Jul 21st, 2021 - The atypical antipsychotic pimavanserin (Nuplazid) reduced the risk of dementia-related psychosis relapse, according to the phase III HARMONY trial. Following an open-label treatment phase to determine treatment response, a double-blind phase foun...

Dementia Made Simple

Jun 14th, 2021 - This transcript has been edited for clarity. Matthew F. Watto, MD: Welcome back to The Curbsiders. I'm Dr Matthew Watto, here with my good friend, Dr Paul Williams. We are going to talk about "dementia made simple" from a great conversation we had...

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Patient Education  11 results see all →