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ALLMedicine™ Brain Cancer Center

Research & Reviews  1,899 results

Metabolic Vulnerabilities in Brain Cancer.
https://doi.org/10.1016/j.nec.2020.12.006
Neurosurgery Clinics of North America; Morrow D, Minami J et. al.

Mar 30th, 2021 - Glioblastomas (GBMs) exhibit altered metabolism to support a variety of bioenergetic and biosynthetic demands for tumor growth, invasion, and drug resistance. Changes in glycolytic flux, oxidative phosphorylation, the pentose phosphate pathway, fa...

P-selectin axis plays a key role in microglia immunophenotype and glioblastoma progress...
https://doi.org/10.1038/s41467-021-22186-0 10.1093/neuonc/nos218 10.1101/gad.187922.112 10.3390/biomedicines7030069 10.1056/NEJMra0708126 10.1038/onc.2008.271 10.1002/glia.21136 10.1016/j.neuron.2019.08.028 10.1146/annurev-immunol-051116-052358 10.1016/j.immuni.2014.06.008 10.1038/nn.4185 10.3390/ijms19020436 10.1093/cvr/cvv154 10.1016/j.semcancer.2010.04.005 10.1016/j.immuni.2016.04.015 10.7554/eLife.25281 10.1126/scitranslmed.aaf7374 10.1016/j.celrep.2017.10.030 10.7150/thno.26888 10.3390/ijms19123805 10.1182/blood.V89.9.3385 10.1152/ajpcell.00463.2007 10.1016/j.pneurobio.2015.05.003 10.3389/fimmu.2019.02093 10.1038/s41598-019-50160-w 10.18632/oncotarget.12038 10.1038/s41598-019-39564-w 10.1038/s41598-017-15045-w 10.1158/1541-7786.MCR-05-0004 10.1002/stem.1322 10.1038/ncomms5632 10.1007/s11060-009-9910-8 10.1172/JCI38596 10.6004/jnccn.2011.0038 10.1016/j.canlet.2016.10.009 10.1371/journal.pgen.1003806 10.1016/j.ccr.2013.06.004 10.1016/j.jhep.2011.02.034 10.1126/science.aad0501 10.1016/j.immuni.2017.08.008 10.1111/j.1600-065X.2009.00795.x 10.1002/path.3031 10.1093/neuonc/nov151 10.1016/j.biopha.2018.10.109 10.1074/jbc.270.39.23077 10.1126/sciadv.1501292 10.1016/j.ccr.2013.08.001 10.1038/s41598-017-14079-4 10.18632/oncotarget.21364 10.1161/01.RES.0000199295.14073.69 10.1182/blood.V90.6.2381 10.1002/ijc.31623 10.1073/pnas.1721434116 10.1093/neuonc/nos116 10.1038/sj.onc.1210683 10.1038/s41582-018-0025-8 10.1101/cshperspect.a022236 10.1111/j.1365-2567.2006.02321.x 10.3389/fncel.2019.00522 10.1007/s10522-011-9335-6 10.1126/science.aat7554 10.1074/jbc.273.49.32506 10.1371/journal.pone.0005233 10.1038/nm.1863 10.1126/science.1226929 10.1007/PL00000232 10.1016/j.canlet.2017.01.007 10.1038/s41467-019-10334-6 10.1140/epjb/e2013-40829-0 10.1016/j.immuni.2018.11.014 10.3390/ijms21217944 10.1093/bioinformatics/btz447 10.1016/j.biopsych.2006.06.019 10.1038/s41419-019-2108-x 10.1093/brain/awz044
Nature Communications; Yeini E, Ofek P et. al.

Mar 27th, 2021 - Glioblastoma (GB) is a highly invasive type of brain cancer exhibiting poor prognosis. As such, its microenvironment plays a crucial role in its progression. Among the brain stromal cells, the microglia were shown to facilitate GB invasion and imm...

Psychosocial well-being of brain cancer patients and support persons: A mapping review ...
https://doi.org/10.1111/ecc.13446
European Journal of Cancer Care; Boyd LAP, Waller AE et. al.

Mar 27th, 2021 - This review examined the: (1) number of publications exploring psychosocial outcomes of adults with brain cancer and/or support persons between 1999 and 2019 and whether there has been a change in the type of research over time; and (2) proportion...

Channeling Force in the Brain: Mechanosensitive Ion Channels Choreograph Mechanics and ...
https://doi.org/10.1016/j.tips.2021.02.006
Trends in Pharmacological Sciences; Momin A, Bahrampour S et. al.

Mar 23rd, 2021 - Force is everywhere. Through cell-intrinsic activities and interactions with the microenvironment, cells generate, transmit, and sense mechanical forces, such as compression, tension, and shear stress. These forces shape the mechanical properties ...

Prediction of LncRNA-encoded small peptides in glioma and oligomer channel functional a...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7971536
PloS One; Cao Y, Yang R et. al.

Mar 18th, 2021 - Glioma is a lethal malignant brain cancer, and many reports have shown that abnormalities in the behavior of water and ion channels play an important role in regulating tumor proliferation, migration, apoptosis, and differentiation. Recently, new ...

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Guidelines  3 results

Study Identifies Exposure to Common Food-Borne Pathogen Linked to Rare Brain Cancer
http://pressroom.cancer.org/TgondiiRiskofGlioma
American Cancer Society

Jan 10th, 2021 - A new study suggests a link between toxoplasma gondii (T. gondii) infection and the risk of glioma, a type of brain cancer, in adults. The report, appearing in the International Journal of Cancer, finds that people who have glioma are more likely ...

NCCN Guidelines Insights: Central Nervous System Cancers, Version 1.2017
http://www.jnccn.org/content/15/11/1331.full
Nabors, L.,et al

Oct 31st, 2017 - For many years, the diagnosis and classification of gliomas have been based on histology. Although studies including large populations of patients demonstrated the prognostic value of histologic phenotype, variability in outcomes within histologic.

ASTRO Guideline on Radiation Therapy for Glioblastoma
https://www.astro.org/Patient-Care-and-Research/Clinical-Practice-Statements/ASTRO-39;s-guideline-on-radiation-therapy-for-glio
Alvin R. Cabrera

Jun 30th, 2016 - The guideline addresses the following four areas regarding effective treatment of glioblastoma with radiation therapy: 1) when radiation is indicated following biopsy or resection of glioblastoma and how it is impacted by systemic therapy; 2) opti.

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Clinicaltrials.gov  2,299 results

Metabolic Vulnerabilities in Brain Cancer.
https://doi.org/10.1016/j.nec.2020.12.006
Neurosurgery Clinics of North America; Morrow D, Minami J et. al.

Mar 30th, 2021 - Glioblastomas (GBMs) exhibit altered metabolism to support a variety of bioenergetic and biosynthetic demands for tumor growth, invasion, and drug resistance. Changes in glycolytic flux, oxidative phosphorylation, the pentose phosphate pathway, fa...

P-selectin axis plays a key role in microglia immunophenotype and glioblastoma progress...
https://doi.org/10.1038/s41467-021-22186-0 10.1093/neuonc/nos218 10.1101/gad.187922.112 10.3390/biomedicines7030069 10.1056/NEJMra0708126 10.1038/onc.2008.271 10.1002/glia.21136 10.1016/j.neuron.2019.08.028 10.1146/annurev-immunol-051116-052358 10.1016/j.immuni.2014.06.008 10.1038/nn.4185 10.3390/ijms19020436 10.1093/cvr/cvv154 10.1016/j.semcancer.2010.04.005 10.1016/j.immuni.2016.04.015 10.7554/eLife.25281 10.1126/scitranslmed.aaf7374 10.1016/j.celrep.2017.10.030 10.7150/thno.26888 10.3390/ijms19123805 10.1182/blood.V89.9.3385 10.1152/ajpcell.00463.2007 10.1016/j.pneurobio.2015.05.003 10.3389/fimmu.2019.02093 10.1038/s41598-019-50160-w 10.18632/oncotarget.12038 10.1038/s41598-019-39564-w 10.1038/s41598-017-15045-w 10.1158/1541-7786.MCR-05-0004 10.1002/stem.1322 10.1038/ncomms5632 10.1007/s11060-009-9910-8 10.1172/JCI38596 10.6004/jnccn.2011.0038 10.1016/j.canlet.2016.10.009 10.1371/journal.pgen.1003806 10.1016/j.ccr.2013.06.004 10.1016/j.jhep.2011.02.034 10.1126/science.aad0501 10.1016/j.immuni.2017.08.008 10.1111/j.1600-065X.2009.00795.x 10.1002/path.3031 10.1093/neuonc/nov151 10.1016/j.biopha.2018.10.109 10.1074/jbc.270.39.23077 10.1126/sciadv.1501292 10.1016/j.ccr.2013.08.001 10.1038/s41598-017-14079-4 10.18632/oncotarget.21364 10.1161/01.RES.0000199295.14073.69 10.1182/blood.V90.6.2381 10.1002/ijc.31623 10.1073/pnas.1721434116 10.1093/neuonc/nos116 10.1038/sj.onc.1210683 10.1038/s41582-018-0025-8 10.1101/cshperspect.a022236 10.1111/j.1365-2567.2006.02321.x 10.3389/fncel.2019.00522 10.1007/s10522-011-9335-6 10.1126/science.aat7554 10.1074/jbc.273.49.32506 10.1371/journal.pone.0005233 10.1038/nm.1863 10.1126/science.1226929 10.1007/PL00000232 10.1016/j.canlet.2017.01.007 10.1038/s41467-019-10334-6 10.1140/epjb/e2013-40829-0 10.1016/j.immuni.2018.11.014 10.3390/ijms21217944 10.1093/bioinformatics/btz447 10.1016/j.biopsych.2006.06.019 10.1038/s41419-019-2108-x 10.1093/brain/awz044
Nature Communications; Yeini E, Ofek P et. al.

Mar 27th, 2021 - Glioblastoma (GB) is a highly invasive type of brain cancer exhibiting poor prognosis. As such, its microenvironment plays a crucial role in its progression. Among the brain stromal cells, the microglia were shown to facilitate GB invasion and imm...

Psychosocial well-being of brain cancer patients and support persons: A mapping review ...
https://doi.org/10.1111/ecc.13446
European Journal of Cancer Care; Boyd LAP, Waller AE et. al.

Mar 27th, 2021 - This review examined the: (1) number of publications exploring psychosocial outcomes of adults with brain cancer and/or support persons between 1999 and 2019 and whether there has been a change in the type of research over time; and (2) proportion...

Channeling Force in the Brain: Mechanosensitive Ion Channels Choreograph Mechanics and ...
https://doi.org/10.1016/j.tips.2021.02.006
Trends in Pharmacological Sciences; Momin A, Bahrampour S et. al.

Mar 23rd, 2021 - Force is everywhere. Through cell-intrinsic activities and interactions with the microenvironment, cells generate, transmit, and sense mechanical forces, such as compression, tension, and shear stress. These forces shape the mechanical properties ...

Prediction of LncRNA-encoded small peptides in glioma and oligomer channel functional a...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7971536
PloS One; Cao Y, Yang R et. al.

Mar 18th, 2021 - Glioma is a lethal malignant brain cancer, and many reports have shown that abnormalities in the behavior of water and ion channels play an important role in regulating tumor proliferation, migration, apoptosis, and differentiation. Recently, new ...

see more →

News  293 results

Toxoplasma Gondii Infection May Be Tied to Higher Risk of Brain Cancer
https://www.medscape.com/viewarticle/944017

Jan 13th, 2021 - NEW YORK (Reuters Health) - Data from two prospective studies point to an association between Toxoplasma gondii infection and the risk of glioma in adults, suggesting that reducing exposure could provide an avenue to modify glioma risk, the resear...

Study Identifies Exposure to Common Food-Borne Pathogen Linked to Rare Brain Cancer
http://pressroom.cancer.org/TgondiiRiskofGlioma
American Cancer Society

Jan 10th, 2021 - A new study suggests a link between toxoplasma gondii (T. gondii) infection and the risk of glioma, a type of brain cancer, in adults. The report, appearing in the International Journal of Cancer, finds that people who have glioma are more likely ...

Better Intellectual Outcomes After Proton Beam for Brain Cancer
https://www.staging.medscape.com/viewarticle/923576

Jan 8th, 2020 - A new study shows that children with medulloblastoma who were treated with radiotherapy had better intellectual outcomes when the radiation was delivered as proton beam therapy compared to traditional photon radiotherapy. Proton beam radiotherapy ...

Better Intellectual Outcomes After Proton Beam for Brain Cancer
https://www.medscape.com/viewarticle/923576

Jan 8th, 2020 - A new study shows that children with medulloblastoma who were treated with radiotherapy had better intellectual outcomes when the radiation was delivered as proton beam therapy compared to traditional photon radiotherapy. Proton beam radiotherapy ...

QoL good for MGMT­-methylated glioblastoma patients with lomustine-temozolide
https://www.mdedge.com/jcomjournal/article/214874/cns/brain-cancer/qol-good-mgmt-methylated-glioblastoma-patients-lomustine?channel=325
Neil Osterweil

Jan 2nd, 2020 - In addition to offering an overall survival benefit for patients with MGMT-methylated glioblastoma, the combination of lomustine and temozolomide did not impair health-related quality of life (HRQOL) compared with temozolomide alone, investigators.

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Patient Education  5 results see all →