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About 8,323 results

ALLMedicine™ Antiepileptic Drugs Center

Research & Reviews  2,761 results

Pharmacokinetic changes for newer antiepileptic drugs and seizure control during pregna...
https://doi.org/10.1111/cns.13796
CNS Neuroscience & Therapeutics; Yin X, Liu Y et. al.

Jan 18th, 2022 - To investigate pharmacokinetic changes in newer antiepileptic drugs (AEDs) and assess seizure frequencies and risk factors of increased seizures during pregnancy in women with epilepsy (WWE). A total of 56 pregnancies in 53 WWE who received newer ...

Thyroid functions as a parameter in monitoring of antiepileptic drugs.
https://doi.org/10.1080/01616412.2021.2025317
Neurological Research; Ekim C, Ulufer C et. al.

Jan 13th, 2022 - Epilepsy is a chronic neurological disorder that is treated with multiple medications that can have significant side effects. This study investigated the potential effects of antiepileptic drugs on thyroid function. The participants in this study ...

Rapid versus slow withdrawal of antiepileptic drugs.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8744136
The Cochrane Database of Systematic Reviews; Ayuga Loro F, Gisbert Tijeras E et. al.

Jan 11th, 2022 - The ideal objective of treating a person with epilepsy is to induce remission (free of seizures for some time) using antiepileptic drugs (AEDs) and withdraw the AEDs without causing seizure recurrence. Prolonged usage of AEDs may have long-term ad...

All-optical monitoring of excitation-secretion coupling demonstrates that SV2A function...
https://doi.org/10.1113/JP282601
The Journal of Physiology; Bradberry MM, Chapman ER

Dec 28th, 2021 - SV2A, an essential transporter-like synaptic vesicle protein, is a major target for antiepileptic drugs and a receptor for clostridial neurotoxins including Botox. While SV2A is required for normal levels of evoked neurotransmitter release, the me...

Modulation of nociception and pain-evoked neurobehavioral responses by levetiracetam in...
https://doi.org/10.1016/j.bbr.2021.113728
Behavioural Brain Research; Tsaousi G, Pourzitaki C et. al.

Dec 25th, 2021 - Traditional and novel analgesic modalities have been extensively tested for post-craniotomy pain management, yet the role of newer antiepileptic drugs in this area remains obscure. This study investigates the impact of levetiracetam (LEV) on pain ...

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Guidelines  6 results

Practice guideline update summary: Efficacy and tolerability of the new antiepileptic d...
https://doi.org/10.1212/WNL.0000000000005755
Neurology Kanner AM, Ashman E et. al.

Jun 15th, 2018 - To update the 2004 American Academy of Neurology (AAN) guideline for treating new-onset focal or generalized epilepsy with second- and third-generation antiepileptic drugs (AEDs). The 2004 AAN criteria were used to systematically review literature...

Practice guideline update summary: Efficacy and tolerability of the new antiepileptic d...
https://doi.org/10.1212/WNL.0000000000005756
Neurology Kanner AM, Ashman E et. al.

Jun 15th, 2018 - To update the 2004 American Academy of Neurology guideline for managing treatment-resistant (TR) epilepsy with second- and third-generation antiepileptic drugs (AEDs). 2004 criteria were used to systemically review literature (January 2003 to Nove...

European Stroke Organization guideline for the diagnosis and treatment of cerebral veno...
https://doi.org/10.1111/ene.13381
European Journal of Neurology; Ferro JM, Bousser MG et. al.

Aug 24th, 2017 - Current guidelines on cerebral venous thrombosis (CVT) diagnosis and management were issued by the European Federation of Neurological Societies in 2010. We aimed to update the previous European Federation of Neurological Societies guidelines usin...

Management issues for women with epilepsy--focus on pregnancy (an evidence-based review...
https://doi.org/10.1111/j.1528-1167.2009.02130.x
Epilepsia Harden CL, Pennell PB et. al.

Jun 10th, 2009 - A committee assembled by the American Academy of Neurology (AAN) reassessed the evidence related to the care of women with epilepsy (WWE) during pregnancy, including preconceptional folic acid and prenatal vitamin K use and the clinical implicatio...

Practice parameter update: management issues for women with epilepsy--focus on pregnanc...
https://doi.org/10.1212/WNL.0b013e3181a6b325
Neurology Harden CL, Pennell PB et. al.

Apr 29th, 2009 - To reassess the evidence for management issues related to the care of women with epilepsy (WWE) during pregnancy, including preconceptional folic acid use, prenatal vitamin K use, risk of hemorrhagic disease of the newborn, clinical implications o...

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Drugs  43 results see all →

Clinicaltrials.gov  100 results

1 Week Versus 6 Weeks of Levetiracetam in Surgical Brain Tumor Patients
https://clinicaltrials.gov/ct2/show/NCT02334722

Dec 15th, 2021 - Because seizures are one of the leading neurologic complications in brain tumor patients, neurosurgeons prescribe antiepileptic drugs (AEDs) to help prevent them. Although the American Academy of Neurology (AAN) guidelines recommend that AEDs be s...

A Study to Evaluate the Efficacy and Safety of Brivaracetam in Study Participants (>=16 to 80 Years of Age) With Epilepsy
https://clinicaltrials.gov/ct2/show/NCT03083665

Dec 10th, 2021 - The purpose of the study is to evaluate the efficacy of brivaracetam (BRV) compared to placebo (PBO) as adjunctive treatment in subjects (>=16 to 80 years of age) with partial seizures with or without secondary generalization despite current treat...

Minimally Invasive Surgical Epilepsy Trial for Temporal Lobe Epilepsy
https://clinicaltrials.gov/ct2/show/NCT05019404

Nov 24th, 2021 - Temporal lobe epilepsy (TLE) is a chronically neurological disease characterized by progressive seizures, followed by a latency period of several years after various injuries including febrile seizures, infection, trauma, tumors, and vascular malf...

Epilepsy in Alzheimer's Disease: Effect on Disease Progression
https://clinicaltrials.gov/ct2/show/NCT04131491

Oct 7th, 2021 - Epilepsy is a known comorbidity of Alzheimer's disease. In the past, it was considered to be a late complication of AD. Recent literature suggest seizures to be prevalent much earlier in the time course of the disease. Systematic reviews suggest t...

Repeat-Dose Pharmacokinetics Study of NRL-1 in Epilepsy Subjects
https://clinicaltrials.gov/ct2/show/NCT02724423

Oct 5th, 2021 - Diazepam rectal gel (Diastat) is the only formulation of diazepam indicated for the management of selected, refractory patients with epilepsy on stable regimens of antiepileptic drugs (AEDs) who require intermittent use of diazepam to control bout...

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News  419 results

Whole-plant Cannabis Linked to Large Reduction in Seizures
https://www.medscape.com/viewarticle/965756

Dec 29th, 2021 - Whole-plant cannabis is linked to a significant reduction in seizures in children with severe treatment-resistant epilepsy, early research suggests. In a small case series, children with severe treatment-resistant epilepsy treated with a range of ...

More Evidence Epilepsy Tied to Risk for Major Cardiovascular Events
https://www.medscape.com/viewarticle/954347

Jul 7th, 2021 - More data link epilepsy to a significantly increased risk for major cardiovascular events, including stroke or arrhythmia. In a large retrospective cohort study, risk for cardiovascular events was 58% greater among patients with epilepsy who under...

Mom's Epilepsy Meds Did Not Impact Kids' Language Development
https://www.medpagetoday.com/neurology/seizures/92966

Jun 7th, 2021 - Language development scores at age 2 were similar for children of women with epilepsy taking antiseizure medications and children with healthy mothers, a prospective observational study found. There was no difference in the primary outcome of lang...

Prenatal Dietary Folate Not Enough to Offset AEDs' Effect on Kids' Cognition
https://www.medscape.com/viewarticle/947829

Mar 22nd, 2021 - New research underscores the importance of folic acid supplementation for pregnant women with epilepsy who are taking antiepileptic drugs (AEDs). Dietary folate alone, even in the United States, where food is fortified with folic acid, is "not suf...

More Reassurance for Certain Antiseizure Drugs in Pregnancy
https://www.medscape.com/viewarticle/947241

Mar 10th, 2021 - Further evidence supporting the safety of two antiseizure medications in pregnancy has come from a new study. The Maternal Outcomes and Neurodevelopmental Effects of Antiepileptic Drugs (MONEAD) study found no difference in neurobehavioral develop...

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