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About 3,043 results

ALLMedicine™ Generalized Tonic-clonic Seizures Center

Research & Reviews  524 results

Altered dynamic functional network connectivity within default mode network of epilepti...
https://doi.org/10.1016/j.eplepsyres.2022.106969
Epilepsy Research; Li Y, Qin B et. al.

Jun 24th, 2022 - Generalized tonic-clonic seizures (GTCS) is a group of epileptic disorders characterized by widespread generalized spike-and-waves discharges along with unresponsiveness and convulsions. Abnormal connectivity in the DMN is the common findings in c...

Case 302: Supratentorial Lymphocytic Inflammation with Parenchymal Perivascular Enhance...
https://doi.org/10.1148/radiol.204423
Radiology Vattoth S, Aker L et. al.

May 24th, 2022 - Part one of this case appeared 4 months previously and may contain larger images. A 21-year-old immunocompetent man who was a long-term resident of Qatar presented to the emergency department with recurrent episodes of unprovoked generalized tonic...

Safety and Efficacy of Lacosamide as Additional Therapy in Patients Suffering From Epileptic Tonic-Clonic Seizures
https://clinicaltrials.gov/ct2/show/NCT02408549

May 20th, 2022 - Assessment of long-term safety and efficacy of oral lacosamide (LCM) as an adjunctive therapy for uncontrolled primary generalized tonic-clonic seizures (PGTCS) in subjects >= 4 years of age with idiopathic generalized epilepsy (IGE). This study w...

Study to Evaluate the Efficacy and Safety of Perampanel as Monotherapy or First Adjunctive Therapy in Subjects With Partial Onset Seizures With or Without Secondarily Generalized Seizures or With P...
https://clinicaltrials.gov/ct2/show/NCT03288129

May 16th, 2022 - This study will assess the retention rate of perampanel when given as monotherapy or first adjunctive therapy in participants with partial-onset seizures or primary generalized tonic clonic seizures. The study consists of 4 periods: a Screening Pe...

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Guidelines  1 results

Practice guideline update summary: Efficacy and tolerability of the new antiepileptic d...
https://doi.org/10.1212/WNL.0000000000005755
Neurology Kanner AM, Ashman E et. al.

Jun 15th, 2018 - To update the 2004 American Academy of Neurology (AAN) guideline for treating new-onset focal or generalized epilepsy with second- and third-generation antiepileptic drugs (AEDs). The 2004 AAN criteria were used to systematically review literature...

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Drugs  568 results see all →

Clinicaltrials.gov  33 results

Safety and Efficacy of Lacosamide as Additional Therapy in Patients Suffering From Epileptic Tonic-Clonic Seizures
https://clinicaltrials.gov/ct2/show/NCT02408549

May 20th, 2022 - Assessment of long-term safety and efficacy of oral lacosamide (LCM) as an adjunctive therapy for uncontrolled primary generalized tonic-clonic seizures (PGTCS) in subjects >= 4 years of age with idiopathic generalized epilepsy (IGE). This study w...

Study to Evaluate the Efficacy and Safety of Perampanel as Monotherapy or First Adjunctive Therapy in Subjects With Partial Onset Seizures With or Without Secondarily Generalized Seizures or With P...
https://clinicaltrials.gov/ct2/show/NCT03288129

May 16th, 2022 - This study will assess the retention rate of perampanel when given as monotherapy or first adjunctive therapy in participants with partial-onset seizures or primary generalized tonic clonic seizures. The study consists of 4 periods: a Screening Pe...

A Study to Investigate Dosage, Effectiveness, and Safety of Perampanel When Used as First Add-on Therapy in Participants >=12 Years With Partial Onset Seizures With or Without Secondary Generalizat...
https://clinicaltrials.gov/ct2/show/NCT04252846

Apr 12th, 2022 - The primary purpose of this study is to assess the retention rate of perampanel as a reliable proxy for overall effectiveness and tolerability in participants aged at least 12 years who are prescribed perampanel (for partial onset seizures [POS] w...

Investigation of the Clinical Safety and Efficacy of Long-term Treatment With Fycompa Tablets in Adult Epilepsy Patients With Partial-onset Seizures (With or Without Secondary Generalized Seizures)...
https://clinicaltrials.gov/ct2/show/NCT03059329

Mar 2nd, 2022 - The objective of this study is to identify the following in adult epilepsy participants with partial-onset seizures (with or without secondary generalized seizures) or primary generalized Tonic-clonic seizures who receive long-term treatment with ...

Levetiracetam Versus Valproate in Idiopathic Generalized Tonic-clonic Seizures
https://clinicaltrials.gov/ct2/show/NCT03940326

Feb 17th, 2022 - This study is an open-label, active-controlled,non-inferiority trial comparing efficacy and safety of levetiracetam versus valproate in idiopathic generalized tonic-clonic epilepsy.

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News  90 results

Phase 3 Data on Fenfluramine for Lennox-Gastaut Published
https://www.medscape.com/viewarticle/973485

May 5th, 2022 - A daily dose of fenfluramine (Fintepla, UCB), when added to an existing anti-epileptic treatment regimen, significantly reduced the frequency of drop seizures associated with Lennox-Gastaut syndrome (LGS) in the phase 3 study that led to US approv...

A Sexually Active 23-Year-Old With Seizures and Tongue Pain
https://www.medscape.com/viewarticle/865890

Oct 5th, 2021 - Editor's Note: The Case Challenge series includes difficult-to-diagnose conditions, some of which are not frequently encountered by most clinicians but are nonetheless important to accurately recognize. Test your diagnostic and treatment skills us...

Seizure a First Sign of COVID in Kids?
https://www.medscape.com/viewarticle/958508

Sep 10th, 2021 - Editor's note: Find the latest COVID-19 news and guidance in Medscape's Coronavirus Resource Center. Unlike in adults, seizures, including status epilepticus (SE), may be the first and main manifestation of COVID-19 in children, new research sugge...

Deeper Sleep, Slower Heart Rate Tied to Sudden Death in Epilepsy
https://www.medscape.com/viewarticle/951137

May 14th, 2021 - Deeper sleep and slower heart rate following seizures may work synergistically to increase the risk for sudden unexpected death in epilepsy (SUDEP), new research suggests. Investigators analyzed data on 100 seizures in 42 patients with epilepsy. T...

An Update on New Epilepsy Medications
https://www.medscape.com/viewarticle/949554

Apr 20th, 2021 - At the ongoing Academy of Neurology 2021 Annual Meeting, being held virtually on April 17-22, Joseph Sirven, MD, professor of neurology at the Mayo Clinic in Jacksonville, Florida, led an epilepsy course updating viewers on new epilepsy medication...

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Patient Education  1 results see all →