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About 56,235 results

ALLMedicine™ Seizures Center

Research & Reviews  17,885 results

Risk of seizure recurrence in people with single seizures and early epilepsy - Model de...
https://doi.org/10.1016/j.seizure.2021.11.007
Seizure Bonnett LJ, Kim L et. al.

Dec 3rd, 2021 - Following a single seizure, or recent epilepsy diagnosis, it is difficult to balance risk of medication side effects with the potential to prevent seizure recurrence. A prediction model was developed and validated enabling risk stratification whic...

Apoptosis in the Dentate Nucleus Following Kindling-induced Seizures in Rats.
https://doi.org/10.2174/1871527320666211201161800
CNS & Neurological Disorders Drug Targets; Taddei E, Rosiles A et. al.

Dec 3rd, 2021 - Epilepsy is a common neurological disorder characterized by abnormal and recurrent neuronal discharges that result in epileptic seizures. The dentate nuclei of the cerebellum receive excitatory input from different brain regions. Purkinje cell los...

Involuntary MDMB-4en-PINACA intoxications following cannabis consumption: clinical and ...
https://doi.org/10.1080/15563650.2021.1994144
Clinical Toxicology (Philadelphia, Pa.); Goncalves R, Labadie M et. al.

Dec 2nd, 2021 - MDMB-4en-PINACA is a synthetic cannabinoid receptor agonist (SCRA) that has recently emerged. Data regarding clinical presentations in the event of intoxication is scarce. This study presents MDMB-4en-PINACA identification in cannabis consumers wi...

All our knowledge begins with the antisenses.
https://doi.org/10.1172/JCI155233
The Journal of Clinical Investigation; Goldberg EM

Dec 2nd, 2021 - Epilepsy is the neurological disorder defined by spontaneous recurrent seizures, which are abnormal patterns of electrical discharge in the brain. A major advance in neurology over the last 20 years is the identification of genetic variation as an...

Antisense oligonucleotide therapy reduces seizures and extends life span in an SCN2A ga...
https://doi.org/10.1172/JCI152079
The Journal of Clinical Investigation; Li M, Jancovski N et. al.

Dec 2nd, 2021 - De novo variation in SCN2A can give rise to severe childhood disorders. Biophysical gain of function in SCN2A is seen in some patients with early seizure onset developmental and epileptic encephalopathy (DEE). In these cases, targeted reduction in...

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Guidelines  20 results

ACR Appropriateness Criteria® Seizures-Child.
https://doi.org/10.1016/j.jacr.2021.02.020
Journal of the American College of Radiology : JACR; , Trofimova A et. al.

May 8th, 2021 - In children, seizures represent an extremely heterogeneous group of medical conditions ranging from benign cases, such as a simple febrile seizure, to life-threatening situations, such as status epilepticus. Underlying causes of seizures also repr...

ACR Appropriateness Criteria® Cerebrovascular Disease-Child.
https://doi.org/10.1016/j.jacr.2020.01.036
Journal of the American College of Radiology : JACR; , Robertson RL et. al.

May 7th, 2020 - Stroke is an uncommon but an important and under-recognized cause of morbidity and mortality in children. Strokes may be due to either brain ischemia or intracranial hemorrhage. Common symptoms of pediatric acute stroke include headache, vomiting,...

ACR Appropriateness Criteria® Seizures and Epilepsy.
https://doi.org/10.1016/j.jacr.2020.01.037
Journal of the American College of Radiology : JACR; , Lee RK et. al.

May 7th, 2020 - Seizures and epilepsy are a set of conditions that can be challenging to diagnose, treat, and manage. This document summarizes recommendations for imaging in different clinical scenarios for a patient presenting with seizures and epilepsy. MRI of ...

Practice guideline update summary: Efficacy and tolerability of the new antiepileptic d...
https://doi.org/10.1212/WNL.0000000000005755
Neurology Kanner AM, Ashman E et. al.

Jun 15th, 2018 - To update the 2004 American Academy of Neurology (AAN) guideline for treating new-onset focal or generalized epilepsy with second- and third-generation antiepileptic drugs (AEDs). The 2004 AAN criteria were used to systematically review literature...

SEOM clinical guidelines for diagnosis and treatment of glioblastoma (2017).
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5785619
Clinical & Translational Oncology : Official Publication ... Martínez-Garcia M, Álvarez-Linera J et. al.

Nov 1st, 2017 - Glioblastoma (GB) is the most common brain malignancy and accounts for over 50% of all high-grade gliomas. Radiotherapy (RT) with concomitant and adjuvant temozolomide (TMZ) chemotherapy is the current standard of care for patients with newly diag...

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Drugs  1,990 results see all →

Clinicaltrials.gov  477 results

Energy Expenditure and Quality of Life in Epilepsy
https://clinicaltrials.gov/ct2/show/NCT04546711

Dec 1st, 2021 - The ketogenic diet (KD) is a high fat, very low carbohydrate diet that promotes a variety of changes in the chemical processes on the body associated with reduced frequency and severity of seizures in patients with epilepsy. The reasons for this i...

A Study to Test the Efficacy and Safety of Padsevonil as Treatment of Focal-onset Seizures in Adult Subjects With Drug-resistant Epilepsy
https://clinicaltrials.gov/ct2/show/NCT03739840

Nov 30th, 2021 - The purpose of the study is to evaluate the efficacy, safety and tolerability of the 3 selected dose regimens of padsevonil (PSL) administered concomitantly with up to 3 anti-epileptic drugs (AEDs) compared with placebo for treatment of observable...

Measuring sVAP-1 as a Predictor of Pregnancy Problems
https://clinicaltrials.gov/ct2/show/NCT04891315

Nov 30th, 2021 - Pre-eclampsia is a common pregnancy disorder defined as high blood pressure and protein in the urine after 20 weeks of pregnancy. It affects the function of the placenta and can cause severe complications, e.g, stroke, multiple organ damage and se...

Minimally Invasive Surgical Epilepsy Trial for Temporal Lobe Epilepsy
https://clinicaltrials.gov/ct2/show/NCT05019404

Nov 24th, 2021 - Temporal lobe epilepsy (TLE) is a chronically neurological disease characterized by progressive seizures, followed by a latency period of several years after various injuries including febrile seizures, infection, trauma, tumors, and vascular malf...

Near-infrared Imaging Techniques for Identifying and Preserving Viable Parathyroid Glands During Thyroidectomy
https://clinicaltrials.gov/ct2/show/NCT05130476

Nov 23rd, 2021 - The most common complication after thyroidectomy is postoperative hypoparathyroidism due to unintentional intraoperative injury, excision, or devascularisation of the parathyroid glands. This complication can be either transient (≤6 months), or pe...

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News  1,977 results

Brain Inflammation Seen in Four of 10 Alzheimer's Aducanumab Patients
https://www.medpagetoday.com/neurology/alzheimersdisease/95801

Nov 22nd, 2021 - Brain inflammation known as amyloid-related imaging abnormalities (ARIA) occurred in about 40% of people with early Alzheimer's disease in the two phase III studies of aducanumab (Aduhelm), a secondary analysis of trial data showed. In an integrat...

Treating ALK-Mutant and KRAS G12C–Mutant NSCLC
https://www.onclive.com/view/treating-alk-mutant-and-kras-g12c-mutant-nsclc

Nov 16th, 2021 - John V. Heymach, MD, PhD: One other disease space where we’ve had spectacular successes recently in terms of wonderful drugs that have come along—very active drugs—has been ALK [anaplastic lymphoma kinase inhibitors]. We’ve got a lot of fantastic ...

Rosuvastatin-Induced Rhabdomyolysis, Pancreatitis, Transaminitis, and Acute Kidney Injury
https://www.mdedge.com/fedprac/article/248530/diabetes/rosuvastatin-induced-rhabdomyolysis-pancreatitis-transaminitis-and
Brent Wagner, MD, MS, G. Patricia Escobar, DVM et. al.

Nov 10th, 2021 - Attention should be paid to changing a tolerated medication to another within its class. Many drugs approved by the US Food and Drug Administration (FDA), have equivalent therapeutic properties as existing drugs.

Epilepsy
https://tools.cdc.gov/medialibrary/index.aspx#/media/id/285177

Anyone can have a seizure. Delayed recognition and inadequate treatment increases the risk for additional seizures, disability, and in rare instances, death.

Common Diabetes Drug Shrinks Brain Tumors in Mice
https://www.medscape.com/viewarticle/962161

Nov 3rd, 2021 - Many cancers with known genetic causes can be treated by targeting tumors and leaving healthy cells unscathed. But that's not the case for a rare type of brain and spinal cord cancer that primarily strikes children and has no obvious genetic cause...

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Patient Education  145 results see all →