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About 6,290 results

ALLMedicine™ Temporal Lobe Epilepsy Center

Research & Reviews  2,439 results

Neuroregenerative Gene Therapy to Treat Temporal Lobe Epilepsy in a Rat Model.
https://doi.org/10.1016/j.pneurobio.2021.102198
Progress in Neurobiology; Zheng J, Li T et. al.

Dec 2nd, 2021 - Temporal lobe epilepsy (TLE) is a common drug-resistant epilepsy associated with abundant cell death in the hippocampus. Here, we develop a novel gene therapy-mediated cell therapy that regenerates GABAergic neurons using internal hippocampal astr...

Decomposing MRI phenotypic heterogeneity in epilepsy: a step towards personalized class...
https://doi.org/10.1093/brain/awab425
Brain : a Journal of Neurology; Lee HM, Fadaie F et. al.

Dec 2nd, 2021 - In drug-resistant temporal lobe epilepsy (TLE), precise predictions of drug response, surgical outcome, and cognitive dysfunction at an individual level remain challenging. A possible explanation may lie in the dominant "one-size-fits-all" group-l...

The intellectual profile of pediatric patients with posterior cortex epilepsy.
https://doi.org/10.1016/j.yebeh.2021.108447
Epilepsy & Behavior : E&B; Lopes E Santos LE, de Angelis G et. al.

Nov 29th, 2021 - Cognitive functioning in epileptic syndromes has been widely explored in patients with temporal lobe epilepsy (TLE), but few studies have investigated the neuropsychological profile in posterior cortex epilepsy (PCE). In this study, we investigate...

Infantile status epilepticus disrupts myelin development.
https://doi.org/10.1016/j.nbd.2021.105566
Neurobiology of Disease; Petra B, Hanne L et. al.

Nov 29th, 2021 - Temporal lobe epilepsy (TLE) is the most prevalent type of epilepsy in adults; it often starts in infancy or early childhood. Although TLE is primarily considered to be a grey matter pathology, a growing body of evidence links this disease with wh...

Deep learning-based diagnosis of temporal lobe epilepsy associated with hippocampal scl...
https://doi.org/10.1016/j.eplepsyres.2021.106815
Epilepsy Research; Ito Y, Fukuda M et. al.

Nov 28th, 2021 - The currently available indicators-sensitivity and specificity of expert radiological evaluation of MRIs-to identify mesial temporal lobe epilepsy (MTLE) associated with hippocampal sclerosis (HS) are deficient, as they cannot be easily assessed. ...

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Drugs  3 results see all →

Clinicaltrials.gov  14 results

FIH Study of NRTX-1001 Neural Cell Therapy in Drug-Resistant Unilateral Mesial Temporal Lobe Epilepsy
https://clinicaltrials.gov/ct2/show/NCT05135091

Nov 26th, 2021 - Subjects will undergo a single stereotactic intracerebral administration of neural cells, called interneurons, that secrete the inhibitory neurotransmitter gamma-aminobutyric acid (GABA). Subjects will then take medicines to partially suppress the...

EASINESS-TRIAL - Enhancing Safety in Epilepsy Surgery
https://clinicaltrials.gov/ct2/show/NCT04952298

Jul 7th, 2021 - Surgeons strive for the best possible outcome of their surgeries with the greatest possible chance for recovery of the patients. Therefore, monitoring and quality improvement is increasingly important in surgery. For this purpose, different concep...

Evaluation of the 24/7 EEG SubQ System for Ultra Long-Term Recording of Patients With Temporal Lobe Epilepsy
https://clinicaltrials.gov/ct2/show/NCT04526418

May 20th, 2021 - The 24/7 EEG™ SubQ system will be compared to simultaneously recorded video-EEG in the Epilepsy Monitoring Unit (gold standard) and to self-reported seizure log books throughout 12 weeks of outpatient EEG recording. The present study is a 12-week ...

Localizing Epileptic Networks Using MRI and iEEG
https://clinicaltrials.gov/ct2/show/NCT04649008

Mar 15th, 2021 - Despite recent advances in neuroimaging, approximately 2/3 of intractable epilepsy patients that undergo surgical evaluation continue to require intracranial EEG (IEEG), arguably the most invasive diagnostic test in medicine. Clinicians currently ...

Epilepsy Surgery and Cognitive Outcome
https://clinicaltrials.gov/ct2/show/NCT04264780

Feb 24th, 2021 - All patients in Norway who have undergone temporal lobe epilepsy surgery ten years ago or more, will be invited to participate. Two groups will be compared: patients who are younger than 50 years of age vs patients who are older than 50 years of a...

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News  60 results

Functional outcomes of SLAH may be superior to those of open resection
https://www.mdedge.com/neurology/article/217175/epilepsy-seizures/functional-outcomes-slah-may-be-superior-those-open
Erik Greb

Feb 12th, 2020 - BALTIMORE – Among patients with medial temporal lobe epilepsy, functional outcomes of stereotactic laser amygdalohippocampotomy (SLAH) are superior to those of open resection, according to data presented at the annual meeting of the American Epile.

Outcomes of epilepsy surgery at 1 year may be better among older patients
https://www.mdedge.com/familymedicine/article/213808/epilepsy-seizures/outcomes-epilepsy-surgery-1-year-may-be-better-among?channel=39313
Clinical Neurology News; Erik Greb

Dec 8th, 2019 - BALTIMORE – Older patients may have better outcomes at 1 year after resective surgery for epilepsy than the general population does, according to research presented at the annual meeting of the American Epilepsy Society. A tendency toward greater.

Antiepileptic drug outcomes have remained flat for 3 decades
https://www.mdedge.com/jcomjournal/article/205888/epilepsy-seizures/antiepileptic-drug-outcomes-have-remained-flat-3/page/0/1?channel=39313

Aug 5th, 2019 - Roughly similar outcomes have been reported from Norway in a study of 600 children with epilepsy, median age 7 years, with a median follow-up of 5. 8 years that is considerably shorter than that in the Glasgow pediatric study.

Seizure Freedom in TLE Tied to Piriform Cortex Resection
https://www.medscape.com/viewarticle/910752

Mar 21st, 2019 - Removal of at least half of the piriform cortex is required to achieve freedom from seizures in the neurosurgical treatment of temporal lobe epilepsy (TLE), new research suggests. A proof-of-concept study conducted by investigators at University C...

Seizure Freedom in TLE Tied to Piriform Cortex Resection
https://www.staging.medscape.com/viewarticle/910752

Mar 21st, 2019 - Removal of at least half of the piriform cortex is required to achieve freedom from seizures in the neurosurgical treatment of temporal lobe epilepsy (TLE), new research suggests. A proof-of-concept study conducted by investigators at University C...

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