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About 3,330 results

ALLMedicine™ Chorea Center

Research & Reviews  1,579 results

Therapeutic targeting of Lyn kinase to treat chorea-acanthocytosis.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8091687
Acta Neuropathologica Communications; Peikert K, Federti E et. al.

May 4th, 2021 - Chorea-Acanthocytosis (ChAc) is a devastating, little understood, and currently untreatable neurodegenerative disease caused by VPS13A mutations. Based on our recent demonstration that accumulation of activated Lyn tyrosine kinase is a key pathoph...

An Update on the Phenotype, Genotype and Neurobiology of ADCY5-Related Disease.
https://doi.org/10.1002/mds.28495
Movement Disorders : Official Journal of the Movement Dis... Ferrini A, Steel D et. al.

May 2nd, 2021 - Adenylyl cyclase 5 (ADCY5)-related phenotypes comprise an expanding disease continuum, but much remains to be understood about the underlying pathogenic mechanisms of the disease. ADCY5-related disease comprises a spectrum of hyperkinetic disorder...

Neurofilament Light Chain Is a Biomarker of Neurodegeneration in Ataxia Telangiectasia.
https://doi.org/10.1007/s12311-021-01257-4 10.3389/fped.2020.00317 10.1002/ppul.22817 10.1183/16000617.0066-2015 10.3389/fimmu.2019.02785 10.1093/hmg/dds448 10.3389/fimmu.2018.02495 10.1371/journal.pone.0195388 10.1016/j.tmrv.2017.09.001 10.1007/s11010-017-3122-x 10.3389/fimmu.2018.02703 10.1038/sj.mt.6300338 10.1039/C5OB00230C 10.1002/ana.25394 10.1016/j.clim.2017.01.009 10.1007/s12519-017-0011-z 10.1136/adc.2006.094268 10.1097/00005072-196810000-00009 10.1055/s-0032-1313915 10.1097/NRL.0b013e31815fa5a7 10.1212/WNL.54.7.1505 10.1212/01.wnl.0000219042.60538.92 10.1007/s10875-012-9846-1 10.1002/ana.24954 10.1038/s41582-018-0058-z 10.1038/s41467-020-14612-6 10.1001/jamaneurol.2019.1534 10.1186/s13024-019-0338-0 10.1111/cei.12105 10.1002/mds.27319 10.1016/j.parkreldis.2017.12.009 10.1212/WNL.0000000000000794 10.1016/j.jpeds.2011.02.005 10.1016/s1071-9091(98)80007-7 10.1186/s13023-016-0543-7 10.1016/s0022-3476(00)70106-5 10.1136/archdischild-2016-310477 10.1007/s12311-014-0557-4 10.1007/s12311-009-0138-0 10.1016/j.nicl.2019.102110 10.1016/s0022-510x(96)00231-6 10.1111/dmcn.13052 10.1155/2011/578903 10.1007/s10048-018-0557-5 10.1007/s12311-020-01175-x 10.1136/jnnp-2018-320106 10.1093/brain/awaa098 10.1007/s00415-020-09722-6 10.1212/WNL.0000000000007032 10.1212/WNL.0000000000004029 10.1212/WNL.0000000000004761 10.15252/emmm.201911803 10.1002/acn3.212 10.1212/WNL.0000000000004932
Cerebellum (London, England); Donath H, Woelke S et. al.

Apr 24th, 2021 - Ataxia telangiectasia (A-T) is a progressive and life-limiting disease associated with cerebellar ataxia due to progressive cerebellar degeneration. In addition to ataxia, which is described in detail, the presence of chorea, dystonia, oculomotor ...

Tics, tremors and other movement disorders in childhood.
https://doi.org/10.1016/j.cppeds.2021.100983
Current Problems in Pediatric and Adolescent Health Care; Blackburn J, Parnes M

Apr 9th, 2021 - Movement disorders presenting in childhood include tics, dystonia, chorea, tremor, stereotypy, myoclonus, and parkinsonism, each of which can be part of various clinical syndromes with distinct etiologies.  Some of these conditions are benign and ...

Chorea as the presenting feature of acute rheumatic fever in childhood; case reports fr...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8025313
BMC Infectious Diseases; Illán Ramos M, Sagastizabal Cardelús B et. al.

Apr 8th, 2021 - Despite a notable decrease in acute rheumatic fever (ARF) incidence in the past few decades, there are still cases in our setting. Sydenham chorea (SC) may be the initial manifestation for this condition in childhood in a significant proportion of...

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Guidelines  3 results

Levodopa-induced dyskinesia: clinical features, incidence, and risk factors
https://link.springer.com/article/10.1007/s00702-018-1900-6
Neurology and Preclinical Neurological Studies;

Jul 2nd, 2018 - Symptoms of Parkinson’s disease have been controlled with levodopa for many years; however, motor complications consisting of wearing off of medication effect and dyskinesias tend to occur within a few years of starting levodopa. Motor complicatio...

Evidence-based guideline: pharmacologic treatment of chorea in Huntington disease: repo...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3413759
Neurology Armstrong MJ, Miyasaki JM et. al.

Jul 20th, 2012 - To develop an evidence-based guideline assessing pharmacologic options for treating Huntington disease (HD) chorea. We evaluated available evidence from a structured literature review performed through February 2011. If HD chorea requires treatmen...

Prominent Oromandibular Dystonia as Levodopa-induced Dyskinesia in Idiopathic Parkinson's Disease.
https://onlinelibrary.wiley.com/doi/full/10.1002/mdc3.12759
Movement Disorders;

Levodopa‐induced dyskinesia (LID) is a recognized motor response complication affecting 30% to 80% of patients with Parkinson's disease on chronic levodopa (l‐dopa) therapy.1, 2 It is typically choreiform, and involves all parts of the body, espec...

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Drugs  39 results see all →

Clinicaltrials.gov  1,657 results

Austedo - deutetrabenazine tablet, coated-Teva Neuroscience, Inc.
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=7ea3c60a-45c7-44cc-afc2-d87fa53993c0

May 6th, 2021 - AUSTEDO® is indicated for the treatment of: chorea associated with Huntington’s disease [see Clinical Studies (14.1)] tardive dyskinesia in adults [see Clinical Studies (14.2)] AUSTEDO is a vesicular monoamine transporter 2 (VMAT2) inhibitor indic...

Therapeutic targeting of Lyn kinase to treat chorea-acanthocytosis.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8091687
Acta Neuropathologica Communications; Peikert K, Federti E et. al.

May 4th, 2021 - Chorea-Acanthocytosis (ChAc) is a devastating, little understood, and currently untreatable neurodegenerative disease caused by VPS13A mutations. Based on our recent demonstration that accumulation of activated Lyn tyrosine kinase is a key pathoph...

Phenobarbital sodium - phenobarbital sodium injection-Bryant Ranch Prepack
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=860d9c27-9c73-4d2c-bc31-a37472a38f7c

May 3rd, 2021 - Sedative. Sedation is obtainable within an hour, and in adequate dosage, the duration of action is more than six hours. Included in the more common conditions in which the sedative action of this class of drugs is desired are anxiety-tension state...

An Update on the Phenotype, Genotype and Neurobiology of ADCY5-Related Disease.
https://doi.org/10.1002/mds.28495
Movement Disorders : Official Journal of the Movement Dis... Ferrini A, Steel D et. al.

May 2nd, 2021 - Adenylyl cyclase 5 (ADCY5)-related phenotypes comprise an expanding disease continuum, but much remains to be understood about the underlying pathogenic mechanisms of the disease. ADCY5-related disease comprises a spectrum of hyperkinetic disorder...

Neurofilament Light Chain Is a Biomarker of Neurodegeneration in Ataxia Telangiectasia.
https://doi.org/10.1007/s12311-021-01257-4 10.3389/fped.2020.00317 10.1002/ppul.22817 10.1183/16000617.0066-2015 10.3389/fimmu.2019.02785 10.1093/hmg/dds448 10.3389/fimmu.2018.02495 10.1371/journal.pone.0195388 10.1016/j.tmrv.2017.09.001 10.1007/s11010-017-3122-x 10.3389/fimmu.2018.02703 10.1038/sj.mt.6300338 10.1039/C5OB00230C 10.1002/ana.25394 10.1016/j.clim.2017.01.009 10.1007/s12519-017-0011-z 10.1136/adc.2006.094268 10.1097/00005072-196810000-00009 10.1055/s-0032-1313915 10.1097/NRL.0b013e31815fa5a7 10.1212/WNL.54.7.1505 10.1212/01.wnl.0000219042.60538.92 10.1007/s10875-012-9846-1 10.1002/ana.24954 10.1038/s41582-018-0058-z 10.1038/s41467-020-14612-6 10.1001/jamaneurol.2019.1534 10.1186/s13024-019-0338-0 10.1111/cei.12105 10.1002/mds.27319 10.1016/j.parkreldis.2017.12.009 10.1212/WNL.0000000000000794 10.1016/j.jpeds.2011.02.005 10.1016/s1071-9091(98)80007-7 10.1186/s13023-016-0543-7 10.1016/s0022-3476(00)70106-5 10.1136/archdischild-2016-310477 10.1007/s12311-014-0557-4 10.1007/s12311-009-0138-0 10.1016/j.nicl.2019.102110 10.1016/s0022-510x(96)00231-6 10.1111/dmcn.13052 10.1155/2011/578903 10.1007/s10048-018-0557-5 10.1007/s12311-020-01175-x 10.1136/jnnp-2018-320106 10.1093/brain/awaa098 10.1007/s00415-020-09722-6 10.1212/WNL.0000000000007032 10.1212/WNL.0000000000004029 10.1212/WNL.0000000000004761 10.15252/emmm.201911803 10.1002/acn3.212 10.1212/WNL.0000000000004932
Cerebellum (London, England); Donath H, Woelke S et. al.

Apr 24th, 2021 - Ataxia telangiectasia (A-T) is a progressive and life-limiting disease associated with cerebellar ataxia due to progressive cerebellar degeneration. In addition to ataxia, which is described in detail, the presence of chorea, dystonia, oculomotor ...

see more →

News  51 results

Fast Five Quiz: Huntington Disease Signs and Symptoms
https://reference.medscape.com/viewarticle/929783_6

May 26th, 2020 - Initiation of saccadic movements is slow and uncoordinated, and smooth pursuit is interrupted by saccadic intrusions. Patients are unable to inhibit saccades toward a peripheral stimulus when instructed to look in the opposite direction. Eye movem...

Fast Five Quiz: Huntington Disease
https://reference.medscape.com/viewarticle/929780_3

May 26th, 2020 - The initial stages of Huntington disease are often characterized by deficits in short-term memory. This is frequently followed by motor dysfunction and a variety of cognitive changes, including diminished verbal fluency and problems with attention...

Fast Five Quiz: Huntington Disease
https://reference.medscape.com/viewarticle/929780

May 26th, 2020 - Huntington disease (HD) is a genetic neurodegenerative disorder named after Dr George Huntington, who in 1872 reported his observations of dementia and chorea that ran in families on the East End of Long Island, New York. The disease is now known ...

Fast Five Quiz: Tardive Dyskinesia Differential Diagnosis
https://reference.medscape.com/viewarticle/923959_3

Feb 20th, 2020 - Postural instability frequently occurs in patients with Huntington disease, but it is uncommon in patients with neuroleptic-induced tardive dyskinesia. Unlike tardive dyskinesia, Huntington disease appears with chorea (derived from the Greek word ...

The angry disciple
https://www.mdedge.com/psychiatry/article/197698/neurology/angry-disciple/page/0/2?channel=41019

Apr 1st, 2019 - Psychiatric manifestations of Huntington’s disease Huntington’s disease is characterized by motor, cognitive, and behavioral disturbances (Table 22,4). Motor symptoms include a characteristic and well-recognized chorea, often predominating earlier.

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Patient Education  1 results see all →